Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (BioDeep_00000178869)
human metabolite blood metabolite
代谢物信息卡片
1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-, ethyl ester
化学式: C15H17ClFNO4S (361.05508040000007)
中文名称: 6-[N-(4-氯-2-氟苯基)磺酰基]-1-环己烯-1-羧酸乙酯
谱图信息:
最多检出来源 Homo sapiens(blood) 87.5%
分子结构信息
SMILES: CCOC(=O)C1=CCCCC1S(=O)(=O)NC1=C(Cl)C=C(F)C=C1
InChI: InChI=1S/C15H17ClFNO4S/c1-2-22-15(19)11-5-3-4-6-14(11)23(20,21)18-13-8-7-10(17)9-12(13)16/h5,7-9,14,18H,2-4,6H2,1H3
描述信息
同义名列表
17 个代谢物同义名
1-Cyclohexene-1-carboxylic acid, 6-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-, ethyl ester; Ethyl (6R)-6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate; Ethyl 6-[(2-chloro-4-fluorophenyl)sulphamoyl]cyclohex-1-ene-1-carboxylic acid; Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulphamoyl)cyclohex-1-enecarboxylic acid; Ethyl 6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylic acid; Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylic acid; Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate; Ethyl 6-[(2-chloro-4-fluorophenyl)sulphamoyl]cyclohex-1-ene-1-carboxylate; Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulphamoyl)cyclohex-1-enecarboxylate; ethyl 6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate; Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate; Ethyl CFSCC; Resatorvid; CLI 095; TAK-242; CLI-095; TAK 242
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 9919285
- HMDB: HMDB0252033
- ChEMBL: CHEMBL426184
- chemspider: 8094926
- CAS: 243983-70-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Priyankar Dey, Nisha Tewari, Somit Dutta, Robert A Newman, Tapas Kumar Chaudhuri. Oleander attenuates hepatic inflammation in a TLR4-independent manner and by favorable modulation of hepatocellular global metabolome that supports cytoprotection.
Journal of ethnopharmacology.
2024 Apr; 323(?):117717. doi:
10.1016/j.jep.2024.117717. [PMID: 38181937] - Yanping Hu, Xin Zhao, Mingyang Chen, Fan Zhou, Xuelong Zhang, Changhuan Chen, Qi Wan, Shenghua He. Massage ameliorates lumbar disc herniation-related radicular pain in rats by suppressing TLR4/NLRP3 inflammasome signaling transduction.
Journal of orthopaedic surgery (Hong Kong).
2024 Jan; 32(1):10225536241238638. doi:
10.1177/10225536241238638. [PMID: 38479435] - Xirong Zhou, Hongfeng Quan, Lingling Zang, Lin Dong. Dichotomine B Attenuates Neuroinflammatory Responses by Regulating TLR4/MyD88-mTOR Signaling Pathway in BV2 Cells.
Neurochemical research.
2023 Apr; ?(?):. doi:
10.1007/s11064-023-03920-0. [PMID: 37010732] - Meng Wang, Yong Zhu, Shujuan Liu, Zhaochun Tian, Pengfei Zhu, Yunjie Zhang, Yongkun Zhou. Qingchang Mixture Prevents the Intestinal Ischemia-reperfusion Injury through TLR4/NF-kB Pathway.
Combinatorial chemistry & high throughput screening.
2023; 26(1):49-57. doi:
10.2174/1386207325666220328090126. [PMID: 35345995] - Yu Xia, Yun Wei Lu, Ren Juan Hao, Gu Ran Yu. Catalpol relieved angiotensin II-induced blood-brain barrier destruction via inhibiting the TLR4 pathway in brain endothelial cells.
Pharmaceutical biology.
2022 Dec; 60(1):2210-2218. doi:
10.1080/13880209.2022.2142801. [PMID: 36369944] - Yan-Jing Liang, Yuan-Rui Yang, Chuan-Yuan Tao, Su-Hao Yang, Xin-Xiao Zhang, Jing Yuan, Yuan-Hong Deng, Zhan-Qiong Zhong, Shu-Guang Yu, Xiao-Yi Xiong. Deep Succinylproteomics of Brain Tissues from Intracerebral Hemorrhage with Inhibition of Toll-Like Receptor 4 Signaling.
Cellular and molecular neurobiology.
2022 Nov; 42(8):2791-2804. doi:
10.1007/s10571-021-01144-w. [PMID: 34460038] - Sujie Liu, Juan Wu, Pingping Chen, Shadi A D Mohammed, Jingbo Zhang, Shumin Liu. TAK-242 Ameliorates Hepatic Fibrosis by Regulating the Liver-Gut Axis.
BioMed research international.
2022; 2022(?):4949148. doi:
10.1155/2022/4949148. [PMID: 36017390] - Xiujiang Sun, Peng Li, Xiaoyi Qu, Wenguang Liu. Isovitexin alleviates acute gouty arthritis in rats by inhibiting inflammation via the TLR4/MyD88/NF-κB pathway.
Pharmaceutical biology.
2021 Dec; 59(1):1326-1333. doi:
10.1080/13880209.2021.1979595. [PMID: 34582722] - Xiaoqin Zhang, Qing Zhang, Lili Huang, Mingzhen Liu, Zaixing Cheng, Yanfang Zheng, Wen Xu, Jinjian Lu, Jian Liu, Mingqing Huang. Pien-Tze-Huang attenuates neuroinflammation in cerebral ischaemia-reperfusion injury in rats through the TLR4/NF-κB/MAPK pathway.
Pharmaceutical biology.
2021 Dec; 59(1):828-839. doi:
10.1080/13880209.2021.1942926. [PMID: 34196587] - Dan Wang, Jinling Zhang, Daye Yang, Junying Wang, Jia Li, Yongli Han, Zhaoxia Kang, Hongxing Zhang. Electroacupuncture restores intestinal mucosal barrier through TLR4/NF-κB p65 pathway in functional dyspepsia-like rats.
Anatomical record (Hoboken, N.J. : 2007).
2021 Oct; ?(?):. doi:
10.1002/ar.24800. [PMID: 34713984] - Ziyang Liu, Kai Yang, Ting Deng, Peng Peng. [Protective effect of TAK242 blocking Toll-like receptor 4 pathway on septic myocardial injury and cardiac dysfunction].
Zhonghua wei zhong bing ji jiu yi xue.
2021 Oct; 33(10):1226-1231. doi:
10.3760/cma.j.cn121430-20210620-00915. [PMID: 34955133] - Haiyan Wang, Xuehui Li, Guanjun Dong, Fenglian Yan, Junfeng Zhang, Hui Shi, Zhaochen Ning, Min Gao, Dalei Cheng, Qun Ma, Changying Wang, Mingsheng Zhao, Jun Dai, Chunxia Li, Zhihua Li, Hui Zhang, Huabao Xiong. Toll-like Receptor 4 Inhibitor TAK-242 Improves Fulminant Hepatitis by Regulating Accumulation of Myeloid-Derived Suppressor Cell.
Inflammation.
2021 Apr; 44(2):671-681. doi:
10.1007/s10753-020-01366-y. [PMID: 33083887] - Laura Kate Gadanec, Tawar Qaradakhi, Kristen Renee McSweeney, Benazir Ashiana Ali, Anthony Zulli, Vasso Apostolopoulos. Dual targeting of Toll-like receptor 4 and angiotensin-converting enzyme 2: a proposed approach to SARS-CoV-2 treatment.
Future microbiology.
2021 03; 16(?):205-209. doi:
10.2217/fmb-2021-0018. [PMID: 33569984] - Jinxiang Wang, Zhiguo Chen, Shike Hou, Ziquan Liu, Qi Lv. TAK-242 Attenuates Crush Injury Induced Acute Kidney Injury through Inhibiting TLR4/NF-κB Signaling Pathways in Rats.
Prehospital and disaster medicine.
2020 Dec; 35(6):619-628. doi:
10.1017/s1049023x20001132. [PMID: 32967743] - Haihua Zhang, Wuying Lang, Shiyong Wang, Binru Li, Guangyu Li, Qiumei Shi. Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
International immunopharmacology.
2020 Nov; 88(?):106974. doi:
10.1016/j.intimp.2020.106974. [PMID: 33182056] - Jiajia Wang, Guannan Zhu, Cheng Sun, Kangwei Xiong, Tingting Yao, Yuan Su, Haiming Fang. TAK-242 ameliorates DSS-induced colitis by regulating the gut microbiota and the JAK2/STAT3 signaling pathway.
Microbial cell factories.
2020 Aug; 19(1):158. doi:
10.1186/s12934-020-01417-x. [PMID: 32762699] - Tingting Li, Lili Hai, Bo Liu, Wei Mao, Kun Liu, Yuan Shen, Qianru Li, Yuli Guo, Yan Jia, Haixia Bao, Jinshan Cao. TLR2/4 promotes PGE2 production to increase tissue damage in Escherichia coli-infected bovine endometrial explants via MyD88/p38 MAPK pathway.
Theriogenology.
2020 Aug; 152(?):129-138. doi:
10.1016/j.theriogenology.2020.04.004. [PMID: 32408026] - Cornelius Engelmann, Mohammed Sheikh, Shreya Sharma, Takayuki Kondo, Henry Loeffler-Wirth, Yu Bao Zheng, Simone Novelli, Andrew Hall, Annarein J C Kerbert, Jane Macnaughtan, Rajeshwar Mookerjee, Abeba Habtesion, Nathan Davies, Tauhid Ali, Saurabh Gupta, Fausto Andreola, Rajiv Jalan. Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure.
Journal of hepatology.
2020 07; 73(1):102-112. doi:
10.1016/j.jhep.2020.01.011. [PMID: 31987990] - Sangam Rajak, Yusuf Hussain, Khushboo Singh, Swasti Tiwari, Basir Ahmad, Sachi Bharti, Prem Prakash. Cellular Fibronectin Containing Extra Domain A Causes Insulin Resistance via Toll-like Receptor 4.
Scientific reports.
2020 06; 10(1):9102. doi:
10.1038/s41598-020-65970-6. [PMID: 32499562] - Dalila Khemili, Fatima Laraba-Djebari, Djelila Hammoudi-Triki. Involvement of Toll-like Receptor 4 in Neutrophil-Mediated Inflammation, Oxidative Stress and Tissue Damage Induced by Scorpion Venom.
Inflammation.
2020 Feb; 43(1):155-167. doi:
10.1007/s10753-019-01105-y. [PMID: 31654297] - Yu-Pu Hong, Jia Yu, Ying-Ru Su, Fang-Chao Mei, Man Li, Kai-Liang Zhao, Liang Zhao, Wen-Hong Deng, Chen Chen, Wei-Xing Wang. High-Fat Diet Aggravates Acute Pancreatitis via TLR4-Mediated Necroptosis and Inflammation in Rats.
Oxidative medicine and cellular longevity.
2020; 2020(?):8172714. doi:
10.1155/2020/8172714. [PMID: 31998444] - Kie Horioka, Hiroki Tanaka, Shotaro Isozaki, Hiroaki Konishi, Mikihiro Fujiya, Katsuhiro Okuda, Masaru Asari, Hiroshi Shiono, Katsuhiro Ogawa, Keiko Shimizu. Acute Colchicine Poisoning Causes Endotoxemia via the Destruction of Intestinal Barrier Function: The Curative Effect of Endotoxin Prevention in a Murine Model.
Digestive diseases and sciences.
2020 01; 65(1):132-140. doi:
10.1007/s10620-019-05729-w. [PMID: 31312993] - Chao He, Guiting Zhang, Hang Ouyang, Peng Zhang, Yudan Chen, Ren Wang, Hong Zhou. Effects of β2/aβ2 on oxLDL-induced CD36 activation in THP-1 macrophages.
Life sciences.
2019 Dec; 239(?):117000. doi:
10.1016/j.lfs.2019.117000. [PMID: 31654747] - Zhen Tang, Shaowu Cheng, Yanyan Sun, Yunqiao Zhang, Xiying Xiang, Zhicui Ouyang, Xing Zhu, Bo Wang, Mingyan Hei. Early TLR4 inhibition reduces hippocampal injury at puberty in a rat model of neonatal hypoxic-ischemic brain damage via regulation of neuroimmunity and synaptic plasticity.
Experimental neurology.
2019 11; 321(?):113039. doi:
10.1016/j.expneurol.2019.113039. [PMID: 31442443] - Yi-Qi Wang, Jin-Bo Mao, Ming-Qian Zhou, Ya-Wei Jin, Cheng-Hua Lou, Yu Dong, Dan Shou, Ying Hu, Bo Yang, Chao-Ying Jin, Han-Cheng Shi, Hua-Jun Zhao, Cheng-Ping Wen. Polysaccharide from Phellinus Igniarius activates TLR4-mediated signaling pathways in macrophages and shows immune adjuvant activity in mice.
International journal of biological macromolecules.
2019 Feb; 123(?):157-166. doi:
10.1016/j.ijbiomac.2018.11.066. [PMID: 30439422] - Ying-Ru Su, Yu-Pu Hong, Fang-Chao Mei, Chen-Yang Wang, Man Li, Yu Zhou, Kai-Liang Zhao, Jia Yu, Wei-Xing Wang. High-Fat Diet Aggravates the Intestinal Barrier Injury via TLR4-RIP3 Pathway in a Rat Model of Severe Acute Pancreatitis.
Mediators of inflammation.
2019; 2019(?):2512687. doi:
10.1155/2019/2512687. [PMID: 31933540] - Benjamin Kramer, Lucas Martins França, Youhua Zhang, Antonio Marcus de Andrade Paes, A Martin Gerdes, Maria Alicia Carrillo-Sepulveda. Western diet triggers Toll-like receptor 4 signaling-induced endothelial dysfunction in female Wistar rats.
American journal of physiology. Heart and circulatory physiology.
2018 12; 315(6):H1735-H1747. doi:
10.1152/ajpheart.00218.2018. [PMID: 30265151] - Jiao-Jiao Yang, Shu-Juan Wang, Xiaoling Gao, Bei Wang, Yan-Ting Dong, Yang Bai, Yan Chen, Jian-Nan Gong, Ya-Qiong Huang, Dong-Dong An. Toll-Like Receptor 4 (TLR-4) Pathway Promotes Pulmonary Inflammation in Chronic Intermittent Hypoxia-Induced Obstructive Sleep Apnea.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Oct; 24(?):7152-7161. doi:
10.12659/msm.910632. [PMID: 30293084] - Bassim I Mohammad, Abdulla K Raheem, Najah R Hadi, Dina A Jamil, Hayder A Al-Aubaidy. Reno-protective effects of TAK-242 on acute kidney injury in a rat model.
Biochemical and biophysical research communications.
2018 09; 503(1):304-308. doi:
10.1016/j.bbrc.2018.06.020. [PMID: 29902463] - Mo-Lin Wang, Xiao-Jing Yu, Xiao-Guang Li, De-Zhi Pang, Qing Su, Roland Osei Saahene, Hong-Bao Li, Xu-Ying Mao, Kai-Li Liu, Li-Yan Fu, Ying Li, Guo-Qing Zhu, Yu-Ming Kang. Blockade of TLR4 Within the Paraventricular Nucleus Attenuates Blood Pressure by Regulating ROS and Inflammatory Cytokines in Prehypertensive Rats.
American journal of hypertension.
2018 08; 31(9):1013-1023. doi:
10.1093/ajh/hpy074. [PMID: 29767672] - Karl A Nath, John D Belcher, Meryl C Nath, Joseph P Grande, Anthony J Croatt, Allan W Ackerman, Zvonimir S Katusic, Gregory M Vercellotti. Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins.
American journal of physiology. Renal physiology.
2018 05; 314(5):F906-F914. doi:
10.1152/ajprenal.00432.2017. [PMID: 28978536] - Charles A Chang, Babatope Akinbobuyi, Jeremy M Quintana, Gumpei Yoshimatsu, Bashoo Naziruddin, Robert R Kane. Ex-vivo generation of drug-eluting islets improves transplant outcomes by inhibiting TLR4-Mediated NFkB upregulation.
Biomaterials.
2018 03; 159(?):13-24. doi:
10.1016/j.biomaterials.2017.12.020. [PMID: 29309990] - Tsuyoshi Yokoi, Yukihiro Yokoyama, Toshio Kokuryo, Junpei Yamaguchi, Masato Nagino. Inhibition of Toll-like receptor 4 ameliorates experimental postischemic injury in the cholestatic liver through inhibition of high-mobility group box protein b1 (HMGB1) signaling.
Surgery.
2018 02; 163(2):270-276. doi:
10.1016/j.surg.2017.08.025. [PMID: 29191677] - Hang Ouyang, Hong Zhou, Chao He, Guiting Zhang, Yudan Chen, Ting Wang, Xiaoyan Wang, Peng Zhang. [The oxLDL/β2GPI/anti-β2GPI antibody complex promotes A7r5 chemotaxis, migration and lipid accumulation].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2017 Dec; 33(12):1622-1627. doi:
". [PMID: 29382421] - Rong-Shuang Huang, Jiao-Jiao Zhou, Yu-Ying Feng, Min Shi, Fan Guo, Shen-Ju Gou, Stephen Salerno, Liang Ma, Ping Fu. Pharmacological Inhibition of Macrophage Toll-like Receptor 4/Nuclear Factor-kappa B Alleviates Rhabdomyolysis-induced Acute Kidney Injury.
Chinese medical journal.
2017 Sep; 130(18):2163-2169. doi:
10.4103/0366-6999.213406. [PMID: 28836571] - Avi Fellner, Yael Barhum, Ariel Angel, Nisim Perets, Israel Steiner, Daniel Offen, Nirit Lev. Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model.
International journal of molecular sciences.
2017 Aug; 18(8):. doi:
10.3390/ijms18081666. [PMID: 28763002] - Jiao Liu, Guang Li, Wen-Jie Xie, Lu Wang, Rui Zhang, Ke-Sheng Huang, Qing-Shan Zhou, De-Chang Chen. Lipopolysaccharide Stimulates Surfactant Protein-A in Human Renal Epithelial HK-2 Cells through Upregulating Toll-like Receptor 4 Dependent MEK1/2-ERK1/2-NF-κB Pathway.
Chinese medical journal.
2017 May; 130(10):1236-1243. doi:
10.4103/0366-6999.205853. [PMID: 28485325] - Cristian González-Guerrero, Pablo Cannata-Ortiz, Consuelo Guerri, Jesús Egido, Alberto Ortiz, Adrián M Ramos. TLR4-mediated inflammation is a key pathogenic event leading to kidney damage and fibrosis in cyclosporine nephrotoxicity.
Archives of toxicology.
2017 Apr; 91(4):1925-1939. doi:
10.1007/s00204-016-1830-8. [PMID: 27585667] - Lei Chen, Ming-Lei Sha, Deng Li, Yi-Ping Zhu, Xing-Jie Wang, Chen-Yi Jiang, Shu-Jie Xia, Yi Shao. Relaxin abrogates renal interstitial fibrosis by regulating macrophage polarization via inhibition of Toll-like receptor 4 signaling.
Oncotarget.
2017 Mar; 8(13):21044-21053. doi:
10.18632/oncotarget.15483. [PMID: 28416741] - Long-Fei Pan, Lei Yu, Li-Ming Wang, Jun-Tao He, Jiang-Li Sun, Xiao-Bo Wang, Zheng-Hai Bai, Li-Juan Su, Hong-Hong Pei. The toll-like receptor 4 antagonist transforming growth factor-β-activated kinase(TAK)-242 attenuates taurocholate-induced oxidative stress through regulating mitochondrial function in mice pancreatic acinar cells.
The Journal of surgical research.
2016 12; 206(2):298-306. doi:
10.1016/j.jss.2016.08.011. [PMID: 27884323] - Jing Xiao, Chensheng Fu, Xiaoli Zhang, Dingyu Zhu, Weijun Chen, Yijun Lu, Zhibin Ye. Soluble monosodium urate, but not its crystal, induces toll like receptor 4-dependent immune activation in renal mesangial cells.
Molecular immunology.
2015 Aug; 66(2):310-8. doi:
10.1016/j.molimm.2015.03.250. [PMID: 25909495] - Fang Hua, Huiling Tang, Jun Wang, Megan C Prunty, Xiaodong Hua, Iqbal Sayeed, Donald G Stein. TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia/reperfusion injury in mice.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2015 Mar; 35(4):536-42. doi:
10.1038/jcbfm.2014.240. [PMID: 25586141] - Yide Zhang, Weisheng Peng, Xiang Ao, Houyong Dai, Li Yuan, Xinzhong Huang, Qiaoling Zhou. TAK-242, a Toll-Like Receptor 4 Antagonist, Protects against Aldosterone-Induced Cardiac and Renal Injury.
PloS one.
2015; 10(11):e0142456. doi:
10.1371/journal.pone.0142456. [PMID: 26556241] - Ning Zhang, Hanyu Liang, Robert V Farese, Ji Li, Nicolas Musi, Sophie E Hussey. Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats.
PloS one.
2015; 10(7):e0132575. doi:
10.1371/journal.pone.0132575. [PMID: 26196892] - Johan Fenhammar, Mats Rundgren, Kjell Hultenby, Jakob Forestier, Micael Taavo, Ellinor Kenne, Eddie Weitzberg, Stefan Eriksson, Volkan Ozenci, Annika Wernerson, Robert Frithiof. Renal effects of treatment with a TLR4 inhibitor in conscious septic sheep.
Critical care (London, England).
2014 Sep; 18(5):488. doi:
10.1186/s13054-014-0488-y. [PMID: 25182709] - Shingo Oya, Yukihiro Yokoyama, Toshio Kokuryo, Masanori Uno, Kohei Yamauchi, Masato Nagino. Inhibition of Toll-like receptor 4 suppresses liver injury induced by biliary obstruction and subsequent intraportal lipopolysaccharide injection.
American journal of physiology. Gastrointestinal and liver physiology.
2014 Feb; 306(3):G244-52. doi:
10.1152/ajpgi.00366.2013. [PMID: 24356883] - Lei Tian, Qi Wen, Xiaoqian Dang, Wulin You, Lihong Fan, Kunzheng Wang. Immune response associated with Toll-like receptor 4 signaling pathway leads to steroid-induced femoral head osteonecrosis.
BMC musculoskeletal disorders.
2014 Jan; 15(?):18. doi:
10.1186/1471-2474-15-18. [PMID: 24428851] - Iciar Gárate, Borja García-Bueno, José Luis Muñoz Madrigal, Javier R Caso, Luis Alou, María Luisa Gómez-Lus, Juan Carlos Leza. Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress.
Journal of neuroinflammation.
2014 Jan; 11(?):8. doi:
10.1186/1742-2094-11-8. [PMID: 24410883] - Dominique de Seny, Gaël Cobraiville, Edith Charlier, Sophie Neuville, Nathalie Esser, Denis Malaise, Olivier Malaise, Florence Quesada Calvo, Biserka Relic, Michel G Malaise. Acute-phase serum amyloid a in osteoarthritis: regulatory mechanism and proinflammatory properties.
PloS one.
2013; 8(6):e66769. doi:
10.1371/journal.pone.0066769. [PMID: 23776697] - Hanyu Liang, Sophie E Hussey, Alicia Sanchez-Avila, Puntip Tantiwong, Nicolas Musi. Effect of lipopolysaccharide on inflammation and insulin action in human muscle.
PloS one.
2013; 8(5):e63983. doi:
10.1371/journal.pone.0063983. [PMID: 23704966] - Sophie E Hussey, Hanyu Liang, Sheila R Costford, Amira Klip, Ralph A DeFronzo, Alicia Sanchez-Avila, Brian Ely, Nicolas Musi. TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells.
Bioscience reports.
2012 Nov; 33(1):37-47. doi:
10.1042/bsr20120098. [PMID: 23050932] - Fumihiro Jinno, Toshiyuki Takeuchi, Yoshihiko Tagawa, Takahiro Kondo, Tomoo Itoh, Satoru Asahi. Differences in the pharmacokinetics of 4-amino-3-chlorophenyl hydrogen sulfate, a metabolite of resatorvid, in rats and dogs.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Apr; 40(4):648-54. doi:
10.1124/dmd.111.043729. [PMID: 22203697] - Fumihiro Jinno, Tomoki Yoneyama, Akio Morohashi, Takahiro Kondo, Satoru Asahi. Chemical reactivity of ethyl (6R)-6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242) in vitro.
Biopharmaceutics & drug disposition.
2011 Oct; 32(7):408-25. doi:
10.1002/bdd.769. [PMID: 21887787] - Johan Fenhammar, Mats Rundgren, Jakob Forestier, Sigridur Kalman, Stefan Eriksson, Robert Frithiof. Toll-like receptor 4 inhibitor TAK-242 attenuates acute kidney injury in endotoxemic sheep.
Anesthesiology.
2011 May; 114(5):1130-7. doi:
10.1097/aln.0b013e31820b8b44. [PMID: 21394006] - Takuryu Sha, Yuji Iizawa, Masayuki Ii. Combination of imipenem and TAK-242, a Toll-like receptor 4 signal transduction inhibitor, improves survival in a murine model of polymicrobial sepsis.
Shock (Augusta, Ga.).
2011 Feb; 35(2):205-9. doi:
10.1097/shk.0b013e3181f48942. [PMID: 20720515] - Fumihiro Jinno, Masaaki Kakehi, Toshiyuki Takeuchi, Yoshihiko Tagawa, Takahiro Kondo, Satoru Asahi. Investigation of the unique metabolic fate of ethyl (6R)-6- [N- (2-chloro-4-fluorophenyl) sulfamoyl] cyclohex-1-ene-1-carboxylate (TAK-242) in rats and dogs using two types of 14C-labeled compounds having different labeled positions.
Arzneimittel-Forschung.
2011; 61(8):458-71. doi:
10.1055/s-0031-1296228. [PMID: 21950150] - Naoko Matsunaga, Noboru Tsuchimori, Tatsumi Matsumoto, Masayuki Ii. TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules.
Molecular pharmacology.
2011 Jan; 79(1):34-41. doi:
10.1124/mol.110.068064. [PMID: 20881006] - Todd W Rice, Arthur P Wheeler, Gordon R Bernard, Jean-Louis Vincent, Derek C Angus, Naoki Aikawa, Ignace Demeyer, Stephen Sainati, Nicholas Amlot, Charlie Cao, Masayuki Ii, Hideyasu Matsuda, Kouji Mouri, Jon Cohen. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis.
Critical care medicine.
2010 Aug; 38(8):1685-94. doi:
10.1097/ccm.0b013e3181e7c5c9. [PMID: 20562702] - Takukyu Sha, Mie Sunamoto, Tomoyuki Kitazaki, Jun Sato, Masayuki Ii, Yuji Iizawa. Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model.
European journal of pharmacology.
2007 Oct; 571(2-3):231-9. doi:
10.1016/j.ejphar.2007.06.027. [PMID: 17632100]