Erdosteine (BioDeep_00000178776)
human metabolite blood metabolite
代谢物信息卡片
2-({[(2-oxothiolan-3-yl)-C-hydroxycarbonimidoyl]methyl}sulphanyl)acetic acid
化学式: C8H11NO4S2 (249.0129486)
中文名称: 厄多司坦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CSC(=O)C1NC(=O)CSCC(=O)O
InChI: InChI=1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12)
描述信息
R - Respiratory system > R05 - Cough and cold preparations > R05C - Expectorants, excl. combinations with cough suppressants > R05CB - Mucolytics
C78273 - Agent Affecting Respiratory System > C74536 - Mucolytic Agent
D019141 - Respiratory System Agents > D005100 - Expectorants
同义名列表
11 个代谢物同义名
2-({[(2-oxothiolan-3-yl)-C-hydroxycarbonimidoyl]methyl}sulphanyl)acetic acid; 2-({[(2-oxothiolan-3-yl)-C-hydroxycarbonimidoyl]methyl}sulphanyl)acetate; 2-({[(2-oxothiolan-3-yl)-C-hydroxycarbonimidoyl]methyl}sulfanyl)acetate; S-(2-(N-3-(2-oxo-Tetrahydrothienyl)acetamido))thioglycolic acid; 2-({[(2-oxothiolan-3-yl)carbamoyl]methyl}sulfanyl)acetic acid; Erdosteine; Vectrine; Esteclin; Mucotec; Dostein; Edirel
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135014
- PubChem: 65632
- HMDB: HMDB0251904
- DrugBank: DB05057
- ChEMBL: CHEMBL1697744
- Wikipedia: Erdosteine
- CAS: 105426-14-0
- CAS: 84611-23-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Heying Liu, Xin Xiong, Jie Wang, Kun Pei, Zhenhua Zhong, Zhiqiang Zhou, Qizhen Cheng. Determination, Isolation, and Identification of Related Impurities in Erdosteine Bulk Drug.
Journal of AOAC International.
2022 Apr; 105(3):696-702. doi:
10.1093/jaoacint/qsab131. [PMID: 34677591] - Yavuz Osman Birdane, Gulcan Avci, Fatih Mehmet Birdane, Ruhi Turkmen, Orkun Atik, Hulya Atik. The protective effects of erdosteine on subacute diazinon-induced oxidative stress and inflammation in rats.
Environmental science and pollution research international.
2022 Mar; 29(15):21537-21546. doi:
10.1007/s11356-021-17398-2. [PMID: 34766221] - Lei Cao, Fen Ping, Fengrui Zhang, Haixiang Gao, Ping Li, Xiaohui Ning, Guohuan Cui, Zheng Ma, Xin Jiang, Suyan Li, Shuzhi Han. Tissue-Protective Effect of Erdosteine on Multiple-Organ Injuries Induced by Fine Particulate Matter.
Medical science monitor : international medical journal of experimental and clinical research.
2021 Dec; 27(?):e930909. doi:
10.12659/msm.930909. [PMID: 34873140] - Cem Onal, Serife Evrim Kepekci Tekkeli. Ultrafast liquid chromatographic analysis of erdosteine in human plasma based on fluorimetric detection and precolumn derivatization with 4-bromomethyl-7-methoxycoumarin: Application to pharmacokinetic studies.
Luminescence : the journal of biological and chemical luminescence.
2020 Aug; 35(5):748-753. doi:
10.1002/bio.3780. [PMID: 31970861] - Atilla Karateke, Recep Dokuyucu, Hatice Dogan, Tumay Ozgur, Zeynel Abidin Tas, Okan Tutuk, Gokhan Agturk, Cemil Tumer. Investigation of Therapeutic Effects of Erdosteine on Polycystic Ovary Syndrome in a Rat Model.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre.
2018; 27(6):515-522. doi:
10.1159/000494300. [PMID: 30293079] - Roberto W Dal Negro, Maria Visconti. Erdosteine reduces the exercise-induced oxidative stress in patients with severe COPD: Results of a placebo-controlled trial.
Pulmonary pharmacology & therapeutics.
2016 12; 41(?):48-51. doi:
10.1016/j.pupt.2016.09.007. [PMID: 27651323] - A A Elkady, I M Ibrahim. Protective effects of erdosteine against nephrotoxicity caused by gamma radiation in male albino rats.
Human & experimental toxicology.
2016 Jan; 35(1):21-8. doi:
10.1177/0960327115574919. [PMID: 25716170] - R W Dal Negro, M Visconti, P Turco. Efficacy of erdosteine 900 versus 600 mg/day in reducing oxidative stress in patients with COPD exacerbations: Results of a double blind, placebo-controlled trial.
Pulmonary pharmacology & therapeutics.
2015 Aug; 33(?):47-51. doi:
10.1016/j.pupt.2015.06.004. [PMID: 26116425] - Maurizio Moretti, Stefano Fagnani. Erdosteine reduces inflammation and time to first exacerbation postdischarge in hospitalized patients with AECOPD.
International journal of chronic obstructive pulmonary disease.
2015; 10(?):2319-25. doi:
10.2147/copd.s87091. [PMID: 26604731] - Rana Sirmali, Abdullah Armağan, Faruk Öktem, Efkan Uz, Aynur Kirbas, Soner Dönmezs, Hacı Ramazan Yilmaz, Mesrur Selçuk Silay, Mehmet Sirmali. Protective effects of erdosteine, vitamin E, and vitamin C on renal injury induced by the ischemia-reperfusion of the hind limbs in rats.
Turkish journal of medical sciences.
2015; 45(1):33-7. doi:
10.3906/sag-1310-38. [PMID: 25790527] - Jing Jin, Xiao-Yan Chen, Yi-Fan Zhang, Zhi-Yu Ma, Da-Fang Zhong. [Simultaneous determination of erdosteine and its active metabolite in human plasma by liquid chromatography-tandem mass spectrometry with pre-column derivatization].
Yao xue xue bao = Acta pharmaceutica Sinica.
2013 Mar; 48(3):395-400. doi:
NULL. [PMID: 23724654] - M Tutanc, V Arica, N Yılmaz, A Nacar, I Zararsiz, F Basarslan, O D Tutanc, E Nacar. Effects of erdosteine on cyclosporin-A-induced nephrotoxicity.
Human & experimental toxicology.
2012 Jun; 31(6):565-73. doi:
10.1177/0960327111417907. [PMID: 21813577] - Irfan Rahman, William MacNee. Antioxidant pharmacological therapies for COPD.
Current opinion in pharmacology.
2012 Jun; 12(3):256-65. doi:
10.1016/j.coph.2012.01.015. [PMID: 22349417] - Irfan Rahman. Pharmacological antioxidant strategies as therapeutic interventions for COPD.
Biochimica et biophysica acta.
2012 May; 1822(5):714-28. doi:
10.1016/j.bbadis.2011.11.004. [PMID: 22101076] - Hui Chen, Julie-Thu A Tran, Robert E Anderson, Md Nawajes A Mandal. Caffeic acid phenethyl ester protects 661W cells from H2O2-mediated cell death and enhances electroretinography response in dim-reared albino rats.
Molecular vision.
2012; 18(?):1325-38. doi:
. [PMID: 22690111] - Mohamed M Sayed-Ahmed, Meshan Lafi Aldelemy, Mohamed M Hafez, Othman A Al-Shabanah. Inhibition of gene expression of organic cation/carnitine transporter and antioxidant enzymes in oxazaphosphorines-induced acute cardiomyopathic rat models.
Oxidative medicine and cellular longevity.
2012; 2012(?):452902. doi:
10.1155/2012/452902. [PMID: 22701146] - Muhammad R Khan, Iram Badar, Aisha Siddiquah. Prevention of hepatorenal toxicity with Sonchus asper in gentamicin treated rats.
BMC complementary and alternative medicine.
2011 Nov; 11(?):113. doi:
10.1186/1472-6882-11-113. [PMID: 22082144] - Hayati Kandiş, Melih Engin Erkan, Umran Yildirim, Harun Güneş, Mesut Erbaş, Hayriye A K Yildirim, Suat Gezer, Ismail Hamdi Kara. Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication.
Human & experimental toxicology.
2011 Sep; 30(9):1350-8. doi:
10.1177/0960327110391384. [PMID: 21115557] - Ahmet Yesilyurt, Ismail Aydın Erden, Ismail Bilgiç, Gönül Erden, Aynur Albayrak. The protective effect of erdosteine on radiocontrast induced nephrotoxicity in rats.
Environmental toxicology.
2011 Aug; 26(4):395-402. doi:
10.1002/tox.20691. [PMID: 21384492] - Narin Derin, Deniz Akpınar, Filiz Ozcan, Piraye Yargıçoğlu, Mutay Aslan. Protective effects of erdosteine on amikacin induced visual evoked potentials and lipid peroxidation alterations.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2011 Apr; 27(2):131-5. doi:
10.1089/jop.2010.0122. [PMID: 21323471] - Sule Ayla, Ismail Seckin, Gamze Tanriverdi, Mujgan Cengiz, Mediha Eser, B C Soner, Gulperi Oktem. Doxorubicin induced nephrotoxicity: protective effect of nicotinamide.
International journal of cell biology.
2011; 2011(?):390238. doi:
10.1155/2011/390238. [PMID: 21789041] - R W Dal Negro, M Visconti, S Tognella, C Micheletto. Erdosteine affects eicosanoid production in COPD.
International journal of clinical pharmacology and therapeutics.
2011 Jan; 49(1):41-5. doi:
10.5414/cpp49041. [PMID: 21176724] - Pier Carlo Braga, Monica Dal Sasso, Maria Culici, Alessandra Spallino, Laura Marabini, Tiziana Bianchi, Giuseppe Nappi. Effects of sulphurous water on human neutrophil elastase release.
Therapeutic advances in respiratory disease.
2010 Dec; 4(6):333-40. doi:
10.1177/1753465810376783. [PMID: 20650977] - Talat Yurdakul, Haluk Kulaksizoglu, Mehmet Mesut Pişkin, Mustafa Cihat Avunduk, Esra Ertemli, Gürhan Gokçe, Hülagü Barişkaner, Sadik Byükbaş, Volkan Kocabas. Combination antioxidant effect of α-tocoferol and erdosteine in ischemia-reperfusion injury in rat model.
International urology and nephrology.
2010 Sep; 42(3):647-55. doi:
10.1007/s11255-009-9641-y. [PMID: 19789992] - Süleyman Oktar, Ahmet Gökçe, Mehmet Aydin, Mürsel Davarci, Sedat Meydan, Oktay Hasan Oztürk, Ahmet Koç. Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice.
Toxicology and industrial health.
2010 Aug; 26(7):433-8. doi:
10.1177/0748233710369666. [PMID: 20504824] - Jitendra D Vaghasiya, Navin R Sheth, Yagnik S Bhalodia, Nurudin P Jivani. Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: effect of exenatide.
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.
2010 Jul; 16(3):174-80. doi:
10.4103/1319-3767.65187. [PMID: 20616412] - Jae-Yeon Lee, Hyun-Soo Kim, Chang-Sik Park, Myung-Cheol Kim. Erdosteine in renal ischemia-reperfusion injury: an experimental study in pigs.
The Journal of veterinary medical science.
2010 Jan; 72(1):127-30. doi:
10.1292/jvms.09-0255. [PMID: 19915323] - Ahmet Korkmaz, Sukru Oter, Melik Seyrek, Turgut Topal. Molecular, genetic and epigenetic pathways of peroxynitrite-induced cellular toxicity.
Interdisciplinary toxicology.
2009 Dec; 2(4):219-28. doi:
10.2478/v10102-009-0020-4. [PMID: 21217858] - Ahmet Koyu, Osman Gokalp, Faruk Oktem, Soner Donmez, Mustafa Dogan, Nermin Karahan, Nurhan Gumral, Nigar Yilmaz, Ahmet Kocak. The protective effect of erdosteine on vancomycin-induced pancreatic damage in rats.
Molecular and cellular biochemistry.
2009 Nov; 331(1-2):43-8. doi:
10.1007/s11010-009-0143-0. [PMID: 19421713] - Turan Tunc, Bulent Uysal, Cuneyt Atabek, Vural Kesik, Bahadir Caliskan, Emin Oztas, Nail Ersoz, Sukru Oter, Ahmet Guven. Erdosteine and ebselen as useful agents in intestinal ischemia/reperfusion injury.
The Journal of surgical research.
2009 Aug; 155(2):210-6. doi:
10.1016/j.jss.2008.06.017. [PMID: 19505699] - Ahmet Yesildağ, Ahmet Ozden, H Ramazan Yilmaz, Efkan Uz, Yetkin Ağackiran, Mihrican Yesildağ, Nigar Yilmaz, Rana Sirmali, Hüseyin Vural, Mustafa Naziroğlu. Erdosteine modulates radiocontrast-induced hepatotoxicity in rat.
Cell biochemistry and function.
2009 Apr; 27(3):142-7. doi:
10.1002/cbf.1546. [PMID: 19277994] - Turan Tunc, Sükrü Oter, Ahmet Güven, Turgut Topal, Mustafa Kul, Ahmet Korkmaz, Onder Ongürü, Umit Sarici. Protective effect of sulfhydryl-containing antioxidants against ischemia/reperfusion injury of prepubertal rat intestine.
Journal of gastroenterology and hepatology.
2009 Apr; 24(4):681-7. doi:
10.1111/j.1440-1746.2008.05673.x. [PMID: 19054265] - Elif Ozerol, Sedat Bilgic, Mustafa Iraz, Ahmet Cigli, Atilla Ilhan, Omer Akyol. The protective effect of erdosteine on short-term global brain ischemia/reperfusion injury in rats.
Progress in neuro-psychopharmacology & biological psychiatry.
2009 Feb; 33(1):20-4. doi:
10.1016/j.pnpbp.2008.09.024. [PMID: 18930779] - Roberto Dal Negro, Maria Visconti, Fiorenza Trevisan, Stefano Bertacco, Claudio Micheletto, Silvia Tognella. Erdosteine enhances airway response to salbutamol in patients with mild-to-moderate COPD.
Therapeutic advances in respiratory disease.
2008 Oct; 2(5):271-7. doi:
10.1177/1753465808096109. [PMID: 19124377] - Guven Kuvandik, Mehmet Duru, Ahmet Nacar, Zafer Yonden, Rami Helvaci, Ahmet Koc, Tolunay Kozlu, Hasan Kaya, Sadik Sogüt. Effects of erdosteine on acetaminophen-induced hepatotoxicity in rats.
Toxicologic pathology.
2008 Jul; 36(5):714-9. doi:
10.1177/0192623308320800. [PMID: 18648099] - Jun Wen, Yiwen Wu, Linli Zhang, Yunpeng Qi, Guorong Fan, Yutian Wu, Zhen Li. High-throughput determination of fudosteine in human plasma by liquid chromatography-tandem mass spectrometry, following protein precipitation in the 96-well plate format.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 May; 867(1):153-9. doi:
10.1016/j.jchromb.2008.03.017. [PMID: 18407809] - Mehmet Cabuk, Ahmet Gurel, Feyza Sen, Nejat Demircan. Renoprotective effect of erdosteine in rats against gentamicin nephrotoxicity: a comparison of 99mTc-DMSA uptake with biochemical studies.
Molecular and cellular biochemistry.
2008 Jan; 308(1-2):35-42. doi:
10.1007/s11010-007-9609-0. [PMID: 17899318] - Ersin Sükrü Erden, Gamze Kirkil, Figen Deveci, Nevin Ilhan, Bengü Cobanoğlu, Teyfik Turgut, Mehmet Hamdi Muz. [Effects of erdosteine on inflammation and fibrosis in rats with pulmonary fibrosis induced by bleomycin].
Tuberkuloz ve toraks.
2008; 56(2):127-38. doi:
". [PMID: 18701972] - Tunay Kurtoglu, Mustafa Sacar, Bilal Kaan Inan, M Harun Duver, Adem Guler, Alper Ucak, Melih Hulusi Us, Ahmet Turan Yilmaz. Erdosteine ameliorates lung injury induced by transient aortic occlusion in rats.
Cardiovascular journal of Africa.
2007 Nov; 18(6):367-70. doi:
". [PMID: 18092111] - Ferah Armutcu, Banu Dogan Gun, Remzi Altin, Ahmet Gurel. Examination of lung toxicity, oxidant/antioxidant status and effect of erdosteine in rats kept in coal mine ambience.
Environmental toxicology and pharmacology.
2007 Sep; 24(2):106-13. doi:
10.1016/j.etap.2007.03.002. [PMID: 21783797] - Mehmet Sirmali, Efkan Uz, Rana Sirmali, Aynur Kilbaş, H Ramazan Yilmaz, Irfan Altuntaş, Mustafa Naziroğlu, Namik Delibaş, Hüseyin Vural. Protective effects of erdosteine and vitamins C and E combination on ischemia-reperfusion-induced lung oxidative stress and plasma copper and zinc levels in a rat hind limb model.
Biological trace element research.
2007 Jul; 118(1):43-52. doi:
10.1007/s12011-007-0010-3. [PMID: 17848730] - Murat Yagmurca, Orhan Bas, Hakan Mollaoglu, Onder Sahin, Ahmet Nacar, Ozcan Karaman, Ahmet Songur. Protective effects of erdosteine on doxorubicin-induced hepatotoxicity in rats.
Archives of medical research.
2007 May; 38(4):380-5. doi:
10.1016/j.arcmed.2007.01.007. [PMID: 17416283] - Maurizio Moretti, Carlo Felice Marchioni. An overview of erdosteine antioxidant activity in experimental research.
Pharmacological research.
2007 Apr; 55(4):249-54. doi:
10.1016/j.phrs.2006.12.006. [PMID: 17267240] - Göksel Sener, A Ozer Sehirli, Hale Z Toklu, Meral Yuksel, Feriha Ercan, Nursal Gedik. Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction.
Pediatric surgery international.
2007 Mar; 23(3):233-41. doi:
10.1007/s00383-006-1872-8. [PMID: 17216233] - Aysegül Alkan, Füsun Eroğlu, Erol Eroğlu, Cağri Ergin, Celal Cerçi, Güleren Alsancak. Protective effects of N-acetylcysteine and erdosteine on hemorrhagic shock-induced acute lung injury.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine.
2006 Oct; 13(5):281-5. doi:
10.1097/00063110-200610000-00007. [PMID: 16969233] - Mehmet Sahin, Hakan Cam, Seref Olgar, Sevket Ercan Tunc, Cagatay Arslan, Efkan Uz, H Ramazan Yilmaz. Protective role of erdosteine on vancomycin-induced oxidative stress in rat liver.
Molecular and cellular biochemistry.
2006 Oct; 291(1-2):155-60. doi:
10.1007/s11010-006-9209-4. [PMID: 16733804] - I Rahman, I M Adcock. Oxidative stress and redox regulation of lung inflammation in COPD.
The European respiratory journal.
2006 Jul; 28(1):219-42. doi:
10.1183/09031936.06.00053805. [PMID: 16816350] - Bunyamin Isik, Reyhan Bayrak, Ali Akcay, Sadik Sogut. Erdosteine against acetaminophen induced renal toxicity.
Molecular and cellular biochemistry.
2006 Jul; 287(1-2):185-91. doi:
10.1007/s11010-005-9110-6. [PMID: 16532256] - Irfan Rahman, Iain Kilty. Antioxidant therapeutic targets in COPD.
Current drug targets.
2006 Jun; 7(6):707-20. doi:
10.2174/138945006777435254. [PMID: 16787173] - Hasan Erdogan, Ersin Fadillioglu, Murat Yagmurca, Muharrem Uçar, M Kemal Irmak. Protein oxidation and lipid peroxidation after renal ischemia-reperfusion injury: protective effects of erdosteine and N-acetylcysteine.
Urological research.
2006 Feb; 34(1):41-6. doi:
10.1007/s00240-005-0031-3. [PMID: 16429300] - Haşim Boyaci, Hale Maral, Gupse Turan, Ilknur Başyiğit, Meltem O Dillioğlugil, Füsun Yildiz, Melih Tugay, Ayşe Pala, Cengiz Erçin. Effects of erdosteine on bleomycin-induced lung fibrosis in rats.
Molecular and cellular biochemistry.
2006 Jan; 281(1-2):129-37. doi:
10.1007/s11010-006-0640-3. [PMID: 16328965] - Irfan Rahman. Antioxidant therapies in COPD.
International journal of chronic obstructive pulmonary disease.
2006; 1(1):15-29. doi:
10.2147/copd.2006.1.1.15. [PMID: 18046899] - Ahmet Koc, Adnan Narci, Mehmet Duru, H Serdar Gergerlioglu, Yesim Akaydin, Sadik Sogut. The protective role of erdosteine on testicular tissue after testicular torsion and detorsion.
Molecular and cellular biochemistry.
2005 Dec; 280(1-2):193-9. doi:
10.1007/s11010-005-8911-y. [PMID: 16311923] - Faruk Oktem, Meltem Koyuncu Arslan, Fehmi Ozguner, Ozden Candir, H Ramazan Yilmaz, Metin Ciris, Efkan Uz. In vivo evidences suggesting the role of oxidative stress in pathogenesis of vancomycin-induced nephrotoxicity: protection by erdosteine.
Toxicology.
2005 Nov; 215(3):227-33. doi:
10.1016/j.tox.2005.07.009. [PMID: 16112787] - Ekrem Cicek, Recep Sutcu, Osman Gokalp, H Ramazan Yilmaz, M Kaya Ozer, Efkan Uz, Nurten Ozcelik, Namik Delibas. The effects of isoniazid on hippocampal NMDA receptors: protective role of erdosteine.
Molecular and cellular biochemistry.
2005 Sep; 277(1-2):131-5. doi:
10.1007/s11010-005-5778-x. [PMID: 16132724] - Ilknur Basyigit, Fusun Yildiz, Mustafa Cekmen, Can Duman, Olcay Bulut. Effects of erdosteine on smoking-induced lipid peroxidation in healthy smokers.
Drugs in R&D.
2005; 6(2):83-9. doi:
10.2165/00126839-200506020-00003. [PMID: 15777101] - Yolanda I Chirino, Rogelio Hernández-Pando, José Pedraza-Chaverrí. Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats.
BMC pharmacology.
2004 Sep; 4(?):20. doi:
10.1186/1471-2210-4-20. [PMID: 15458572] - Alpaslan Terzi, Mustafa Iraz, Semsettin Sahin, Atilla Ilhan, Nuri Idiz, Ersin Fadillioglu. Protective effects of erdosteine on rotenone-induced oxidant injury in liver tissue.
Toxicology and industrial health.
2004 Sep; 20(6-10):141-7. doi:
10.1191/0748233704th208oa. [PMID: 15941011] - H Ramazan Yilmaz, Mustafa Iraz, Sadik Sogut, Huseyin Ozyurt, Zeki Yildirim, Omer Akyol, Serdar Gergerlioglu. The effects of erdosteine on the activities of some metabolic enzymes during cisplatin-induced nephrotoxicity in rats.
Pharmacological research.
2004 Sep; 50(3):287-90. doi:
10.1016/j.phrs.2004.03.003. [PMID: 15225672] - Hüseyin Ozyurt, Zeki Yildirim, Mahir Kotuk, H Ramazan Yilmaz, Murat Yağmurca, Mustafa Iraz, Sad Söğüt, Serdar Gergerlioglu. Cisplatin-induced acute renal failure is ameliorated by erdosteine in a dose-dependent manner.
Journal of applied toxicology : JAT.
2004 Jul; 24(4):269-75. doi:
10.1002/jat.983. [PMID: 15300714] - A Gurel, F Armutcu, A Cihan, K V Numanoglu, M Unalacak. Erdosteine improves oxidative damage in a rat model of renal ischemia-reperfusion injury.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes.
2004 Jul; 36(4):206-9. doi:
10.1159/000078854. [PMID: 15263825] - Sadik Sogut, Huseyin Ozyurt, Ferah Armutcu, Levent Kart, Mustafa Iraz, Omer Akyol, Suleyman Ozen, Suleyman Kaplan, Ismail Temel, Zeki Yildirim. Erdosteine prevents bleomycin-induced pulmonary fibrosis in rats.
European journal of pharmacology.
2004 Jun; 494(2-3):213-20. doi:
10.1016/j.ejphar.2004.04.045. [PMID: 15212977] - Sadik Söğüt, Mahir Kotuk, H Ramazan Yilmaz, Ramazan Ulu, Hüseyin Ozyurt, Zeki Yildirim. In vivo evidence suggesting a role for purine-catabolizing enzymes in the pathogenesis of cisplatin-induced nephrotoxicity in rats and effect of erdosteine against this toxicity.
Cell biochemistry and function.
2004 May; 22(3):157-62. doi:
10.1002/cbf.1069. [PMID: 15124180] - Hohyun Kim, Kyu Young Chang, Hee Joo Lee, Sang Beom Han, Kyung Ryul Lee. Sensitive determination of erdosteine in human plasma by use of automated 96-well solid-phase extraction and LC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2004 Feb; 34(3):661-9. doi:
10.1016/j.jpba.2003.11.003. [PMID: 15127822] - Ersin Fadillioğlu, Hasan Erdoğan. Effects of erdosteine treatment against doxorubicin-induced toxicity through erythrocyte and plasma oxidant/antioxidant status in rats.
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