Trimipramine (BioDeep_00000017877)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(3-{2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}-2-methylpropyl)dimethylamine

化学式: C20H26N2 (294.2095876)
中文名称: 曲米帕明
谱图信息: 最多检出来源 Homo sapiens(blood) 18.75%

分子结构信息

SMILES: CC(CN(C)C)CN1C2=CC=CC=C2CCC2=CC=CC=C12
InChI: InChI=1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3

描述信息

Trimipramine is only found in individuals that have used or taken this drug. It is a tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. [PubChem]Trimipramines mechanism of action differs from other tricyclic antidepressants. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT).
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators

同义名列表

72 个代谢物同义名

(3-{2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}-2-methylpropyl)dimethylamine; 5-(gamma-Dimethylamino-beta-methylpropyl)-10,11-dihydro-5H-dibenzo[b,F]azepine; 5-[3-(Dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenz[b,F]azepine; 5-(Γ-dimethylamino-β-methylpropyl)-10,11-dihydro-5H-dibenzo[b,F]azepine; 5-(g-Dimethylamino-b-methylpropyl)-10,11-dihydro-5H-dibenzo[b,F]azepine; 10,11-Dihydro-N,N,beta-trimethyl-5H-dibenz[b,F]azepine-5-propanamine; 10,11 Dihydro-N,N,beta-trimethyl-5H-dibenz(b,F)azepine-5-propanamine; 10,11-Dihydro-N,N,b-trimethyl-5H-dibenz[b,F]azepine-5-propanamine; 10,11-Dihydro-N,N,β-trimethyl-5H-dibenz[b,F]azepine-5-propanamine; Rhone poulenc rorer brand OF trimipramine maleate; Rhone-poulenc rorer brand OF trimipramine maleate; Neurazpharm brand OF trimipramine maleate; Neuro hexal brand OF trimipramine maleate; Rhodiapharm brand OF trimipramine maleate; Merck dura brand OF trimipramine maleate; AWD.pharma brand OF trimipramine maleate; Stadapharm brand OF trimipramine maleate; Betapharm brand OF trimipramine maleate; Novopharm brand OF trimipramine maleate; Trimipramine maleate (1:1), (+-)-isomer; Azupharma brand OF trimipramine maleate; Nu-pharm brand OF trimipramine maleate; Nu pharm brand OF trimipramine maleate; Trimipramine maleate (1:1), (-)-isomer; Trimipramine maleate (1:1), (+)-isomer; Aventis brand OF trimipramine maleate; Temmler brand OF trimipramine maleate; Odyssey brand OF trimipramine maleate; Apotex brand OF trimipramine maleate; Trimipramine monohydrochloride; Aventis brand OF trimipramine; Hexal brand OF trimipramine; Trimipramine maleate (1:1); Trimipramine aventis brand; Trimipramine, (+-)-isomer; Trimipramine hexal brand; Trimipramine, (-)-isomer; Trimipramin-neurazpharm; Trimipramin neurazpharm; Trimipraminneurazpharm; Trimipramine mesylate; beta-Methylimipramine; Trimipramine maleate; Trimineurin maleate; Β-methylimipramine; b-Methylimipramine; Surmontil maleate; Trimipramin stada; beta, Trimipramin; Trimipramin beta; Novo tripramine; Trimeproprimine; Trimipramin azu; Nu-trimipramine; Novo-tripramine; Nu trimipramine; NuTrimipramine; NovoTripramine; Trimeprimine; trimipramine; Trimineurin; Rhotrimine; Apo-trimip; Apo trimip; Surmontil; Trimidura; Herphonal; ApoTrimip; Sapilent; Eldoral; Stangyl; RP-7162



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yasamin Nasiri Khonsari, Shiguo Sun. A novel MIP-ECL sensor based on RGO-CeO2NP/Ru(bpy)32+-chitosan for ultratrace determination of trimipramine. Journal of materials chemistry. B. 2021 01; 9(2):471-478. doi: 10.1039/d0tb01666g. [PMID: 33289771]
  • Anssi Lipponen, Teemu Natunen, Mika Hujo, Robert Ciszek, Elina Hämäläinen, Jussi Tohka, Mikko Hiltunen, Jussi Paananen, David Poulsen, Emilia Kansanen, Xavier Ekolle Ndode-Ekane, Anna-Liisa Levonen, Asla Pitkänen. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned. International journal of molecular sciences. 2019 Oct; 20(21):. doi: 10.3390/ijms20215395. [PMID: 31671916]
  • Christoph Kowalewski, Ekkehard Haen, Christoph Hiemke, Florian Ridders, Katharina Endres, Gerhard Gründer, Michael Paulzen, Georgios Schoretsanitis. Cytochrome P450-mediated inhibition of venlafaxine metabolism by trimipramine. International clinical psychopharmacology. 2019 09; 34(5):241-246. doi: 10.1097/yic.0000000000000268. [PMID: 31094902]
  • Hadi Tabani, Ali Shokri, Shakila Tizro, Saeed Nojavan, Pakorn Varanusupakul, Michal Alexovič. Evaluation of dispersive liquid-liquid microextraction by coupling with green-based agarose gel-electromembrane extraction: An efficient method to the tandem extraction of basic drugs from biological fluids. Talanta. 2019 Jul; 199(?):329-335. doi: 10.1016/j.talanta.2019.02.078. [PMID: 30952267]
  • Maedeh Akhoundian, Taher Alizadeh, Mohammad Reza Ganjali, Faride Rafiei. A new carbon paste electrode modified with MWCNTs and nano-structured molecularly imprinted polymer for ultratrace determination of trimipramine: The crucial effect of electrode components mixing on its performance. Biosensors & bioelectronics. 2018 Jul; 111(?):27-33. doi: 10.1016/j.bios.2018.03.061. [PMID: 29631160]
  • Saied Saeed Hosseiny Davarani, Hamid Reza Moazami, Elham Memarian, Saeed Nojavan. Electromembrane extraction through a virtually rotating supported liquid membrane. Electrophoresis. 2016 Jan; 37(2):339-46. doi: 10.1002/elps.201500296. [PMID: 26462723]
  • Mojtaba Shamsipur, Mehrosadat Mirmohammadi. High performance liquid chromatographic determination of ultra traces of two tricyclic antidepressant drugs imipramine and trimipramine in urine samples after their dispersive liquid-liquid microextraction coupled with response surface optimization. Journal of pharmaceutical and biomedical analysis. 2014 Nov; 100(?):271-278. doi: 10.1016/j.jpba.2014.08.008. [PMID: 25178259]
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  • Bankim J Sanghavi, Ashwini K Srivastava. Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode. The Analyst. 2013 Mar; 138(5):1395-404. doi: 10.1039/c2an36330e. [PMID: 23324861]
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  • Xiao-Pen Lee, Chika Hasegawa, Takeshi Kumazawa, Natsuko Shinmen, Yukiko Shoji, Hiroshi Seno, Keizo Sato. Determination of tricyclic antidepressants in human plasma using pipette tip solid-phase extraction and gas chromatography-mass spectrometry. Journal of separation science. 2008 Jul; 31(12):2265-71. doi: 10.1002/jssc.200700627. [PMID: 18546392]
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  • M Flechtner-Mors, C P Jenkinson, A Alt, G Adler, H H Ditschuneit. Metabolism in adipose tissue in response to citalopram and trimipramine treatment--an in situ microdialysis study. Journal of psychiatric research. 2008 Jun; 42(7):578-86. doi: 10.1016/j.jpsychires.2007.06.003. [PMID: 17692337]
  • Annette Thierauf, Reinhard Dettmeyer, Heike Wollersen, Burkhard Madea. Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old woman. Forensic science international. 2007 Dec; 173(2-3):178-81. doi: 10.1016/j.forsciint.2007.01.001. [PMID: 17317059]
  • Donald F Smith, Bo S Stork, Gregers Wegener, Steen Jakobsen, Dirk Bender, Hélène Audrain, Svend B Jensen, Søren B Hansen, Anders Rodell, Raben Rosenberg. Receptor occupancy of mirtazapine determined by PET in healthy volunteers. Psychopharmacology. 2007 Nov; 195(1):131-8. doi: 10.1007/s00213-007-0877-x. [PMID: 17653532]
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  • H Kirchherr, W N Kühn-Velten. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Oct; 843(1):100-13. doi: 10.1016/j.jchromb.2006.05.031. [PMID: 16798119]
  • Tatsuo Shinozuka, Masaru Terada, Einosuke Tanaka. Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method. Forensic science international. 2006 Oct; 162(1-3):108-12. doi: 10.1016/j.forsciint.2006.03.038. [PMID: 16859851]
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