enprostil (BioDeep_00000178710)

   

human metabolite blood metabolite


代谢物信息卡片


methyl 7-[3-hydroxy-2-(3-hydroxy-4-phenoxybut-1-en-1-yl)-5-oxocyclopentyl]hepta-4,5-dienoate

化学式: C23H28O6 (400.1885788)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: COC(=O)CCC=C=CCC1C(C=CC(O)COC2=CC=CC=C2)C(O)CC1=O
InChI: InChI=1S/C23H28O6/c1-28-23(27)12-8-3-2-7-11-19-20(22(26)15-21(19)25)14-13-17(24)16-29-18-9-5-4-6-10-18/h3-7,9-10,13-14,17,19-20,22,24,26H,8,11-12,15-16H2,1H3

描述信息

同义名列表

12 个代谢物同义名

methyl 7-[3-hydroxy-2-(3-hydroxy-4-phenoxybut-1-en-1-yl)-5-oxocyclopentyl]hepta-4,5-dienoate; Enprostil, (1S-(1alpha(r*),2beta(1E,3R*),3alpha))-isomer; Enprostil, (1R-(1alpha(s*),2beta(1E,3R*),3alpha))-isomer; Enprostil, (1S-(1alpha(s*),2beta(1E,3R*),3alpha))-isomer; Enprostil, (1alpha(r*),2beta(1E,3S*),3alpha)-(+-)-isomer; Enprostil, (1alpha(r*),2beta(1E,3R*),3alpha)-(+-)-isomer; Enprostil, (1alpha,2alpha(1E,3S*),3beta)-(+-)-isomer; Enprostil, (1R-(1alpha,2beta(1E,3R*),3alpha))-isomer; Enprostil, (1alpha,2beta(1E,3R*),3alpha)-(+-)-isomer; Enprostil, (1R-(1(r*),2beta(1E,3R*),3alpha))-isomer; Enprostil; Gardrin



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Y Onizuka, K Murase, H Furusu, H Isomoto, Y Mizuta, F Takeshima, K Makiyama, S Kohno. Effect of intrarectal prostaglandin E2 analogue (enprostil) on trinitrobenzenesulphonic acid-induced colitis in rats. The Journal of international medical research. 2000; 28(1):28-35. doi: 10.1177/147323000002800105. [PMID: 10815645]
  • N Omura, H Kashiwagi, T Aoki, K Omura, Y Fukuchi. Effects of enprostil on gastric endocrine secretion during chronic administration of lansoprazole. Journal of gastroenterology. 1997 Dec; 32(6):740-6. doi: 10.1007/bf02936949. [PMID: 9430011]
  • A Tari, M Hamada, T Kamiyasu, K Sumii, K Haruma, M Inoue, S Kishimoto, G Kajiyama, J H Walsh. Effect of enprostil on omeprazole-induced hypergastrinemia and inhibition of gastric acid secretion in peptic ulcer patients. Digestive diseases and sciences. 1997 Aug; 42(8):1741-6. doi: 10.1023/a:1018825902055. [PMID: 9286243]
  • A Murai, A E Murakami, J Okumura, M Furuse. Prostaglandin E2 derivative, enprostil, reduces hepatic triacylglycerol content in Japanese quail. Biochemistry and molecular biology international. 1996 May; 39(2):329-34. doi: 10.1080/15216549600201351. [PMID: 8799460]
  • J L Payen, P Cales, P Pienkowski, P Sozzani, A Kervran, J Frexinos, J P Pascal. Weakness of mucosal barrier in portal hypertensive gastropathy of alcoholic cirrhosis. Effects of propranolol and enprostil. Journal of hepatology. 1995 Dec; 23(6):689-96. doi: 10.1016/0168-8278(95)80035-2. [PMID: 8750168]
  • T Korhonen, M J Savolainen, T Jääskeläinen, Y A Kesäniemi. Effect of a synthetic prostaglandin E2 analogue, RS-86505-007, on plasma lipids and lipoproteins in patients with moderate hypercholesterolaemia: efficacy and tolerance of treatment and response in different apolipoprotein polymorphism groups. European journal of clinical pharmacology. 1995; 48(2):97-102. doi: 10.1007/bf00192732. [PMID: 7589035]
  • H Vanhanen, T A Miettinen. Enprostil impairs cholesterol and fat absorption. Scandinavian journal of gastroenterology. 1995 Jan; 30(1):33-7. doi: 10.3109/00365529509093232. [PMID: 7701247]
  • J L Meijer, J B Jansen, I Biemond, I J Kuijpers, C B Lamers. Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole. Alimentary pharmacology & therapeutics. 1994 Apr; 8(2):221-7. doi: 10.1111/j.1365-2036.1994.tb00282.x. [PMID: 8038355]
  • J L Meijer, L F Crobach, J B Jansen, C B Lamers. Effect of synthetic prostaglandin E2 analog enprostil on omeprazole-induced hypergastrinemia and hyperpepsinogenemia. Digestive diseases and sciences. 1994 Mar; 39(3):609-16. doi: 10.1007/bf02088350. [PMID: 8131700]
  • A Bado, F Corrion, P Bernades, T Chevalier, J P Galmiche, C Laverdant, M Mignon, Y Minaire, A Pariente, F Vicari. [Variations of plasma gastrin (basal and postprandial) in ththtreatmentof duodenal ulcer with either enprostil or ranitidine. Correlations with rates of relapse]. Gastroenterologie clinique et biologique. 1994; 18(6-7):623-9. doi: NULL. [PMID: 7875420]
  • L C Baak, J B Jansen, J L Meijer, C B Lamers. Attenuation of the gastric acid and serum gastrin-lowering effects of the prostaglandin E2 analog enprostil. Clinical pharmacology and therapeutics. 1993 Jun; 53(6):668-4. doi: 10.1038/clpt.1993.88. [PMID: 8513659]
  • J Delwaide, P Latour, P Gast, E Louis, J Belaïche. Effects of proglumide and enprostil on omeprazole-induced fundic endocrine cell hyperplasia in rats. Gastroenterologie clinique et biologique. 1993; 17(11):792-6. doi: NULL. [PMID: 8143943]
  • S Bang, J Myren, P Linnestad, A Serck-Hanssen, J H Strømme, K Beraki. Effects of the prostaglandin E2 analogue enprostil on the carbon tetrachloride-induced necrosis of liver cells in mice. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 1992 Nov; 100(11):963-6. doi: 10.1111/j.1699-0463.1992.tb04026.x. [PMID: 1472364]
  • C H Kiang, T Nolan, B L Huang, C P Lee. Determination of femtomole/milliliter concentrations of enprostil acid in human plasma using high-performance liquid chromatography-laser-induced fluorescence detection. Journal of chromatography. 1991 Jun; 567(1):195-212. doi: 10.1016/0378-4347(91)80323-5. [PMID: 1918246]
  • S Yactayo, T Patrice, M T Foultier, A Berrada, X N Xu. [Effect of gastrin and enprostil, a PGE2 analog, on colonic cancerous cell growth]. Gastroenterologie clinique et biologique. 1991; 15(6-7):519-24. doi: NULL. [PMID: 1916130]
  • F L Lanza, M G Robinson, J I Isenberg, P M Basuk, D A Karlin. Effect of enprostil on the gastroduodenal mucosa of healthy volunteers. Alimentary pharmacology & therapeutics. 1990 Dec; 4(6):601-13. doi: 10.1111/j.1365-2036.1990.tb00508.x. [PMID: 2129647]
  • C Florent, C Cogoni, M Joubert, B Desaint. Effect of two-week treatment with enprostil (35 micrograms twice a day) on 24-hour serum gastrin levels. Digestive diseases and sciences. 1990 Nov; 35(11):1352-7. doi: 10.1007/bf01536740. [PMID: 2121423]
  • S A Watson, L G Durrant, D L Morris. The effect of the E2 prostaglandin enprostil, and the somatostatin analogue SMS 201 995, on the growth of a human gastric cell line, MKN45G. International journal of cancer. 1990 Jan; 45(1):90-4. doi: 10.1002/ijc.2910450117. [PMID: 2105279]
  • H G Heijerman, C B Lamers, J H Dijkman, W Bakker. Ranitidine compared with the dimethylprostaglandin E2 analogue enprostil as adjunct to pancreatic enzyme replacement in adult cystic fibrosis. Scandinavian journal of gastroenterology. Supplement. 1990; 178(?):26-31. doi: 10.3109/00365529009093147. [PMID: 2126147]
  • M Keelan, A B Thomson, M T Clandinin, M Tavernini, K Walker, C I Cheeseman. Effect of oral enprostil, a synthetic prostaglandin E2, on intestinal brush border membrane lipid composition following abdominal irradiation in the rat. Clinical and investigative medicine. Medecine clinique et experimentale. 1989 Dec; 12(6):350-6. doi: ". [PMID: 2515020]
  • L G Johnson, J J Bruno, M C Allely, R M Eglen, K Chang, D Yang, B J Alps, R P Rosenkranz, A M Strosberg. Effects of enprostil on cardiovascular and respiratory parameters in the dog, and on hematologic parameters in the rat, monkey, and human. Arzneimittel-Forschung. 1989 Nov; 39(11):1443-8. doi: NULL. [PMID: 2515862]
  • W Inauen, C Rohner, H R Koelz, J Herdmann, C C Schürer-Maly, L Varga, F Halter. Enprostil reduces the increase of gastric corpus mucosal mass induced by the hydrogen-potassium-stimulated adenosine triphosphatase inhibitor BY 831-78 in the rat. Gastroenterology. 1989 Oct; 97(4):846-52. doi: 10.1016/0016-5085(89)91487-x. [PMID: 2570729]
  • J E McGuigan. Inhibition of hydrogen-potassium-stimulated adenosine triphosphatase: effects on acid secretion, plasma gastrin, and the gastric mucosa. Gastroenterology. 1989 Oct; 97(4):1045-8. doi: 10.1016/0016-5085(89)91519-9. [PMID: 2550308]
  • K E Schwartz, T Saito. Suppression of alimentary lipemia in man by a prostaglandin analogue (enprostil). Atherosclerosis. 1989 Oct; 79(2-3):231-6. doi: 10.1016/0021-9150(89)90128-7. [PMID: 2512938]
  • A B Thomson, M Keelan, M T Clandinin, M Tavernini, T Lam, K Walker, C I Cheeseman. Lack of protective effect of oral enprostil, a synthetic prostaglandin E2, on intestinal transport and morphology following abdominal irradiation in the rat. Canadian journal of physiology and pharmacology. 1989 Oct; 67(10):1351-6. doi: 10.1139/y89-215. [PMID: 2514980]
  • T M Davis, C Proby, J A Strong, G R Thompson, H Massey, R Scott, S R Bloom. Effect of enprostil on glucose and lipid metabolism in type 2 diabetes. Diabetic medicine : a journal of the British Diabetic Association. 1989 Jul; 6(5):400-5. doi: 10.1111/j.1464-5491.1989.tb01193.x. [PMID: 2527675]
  • M O Pulkkinen. Acute and chronic effects of oral enprostil, a synthetic dehydroprostaglandin E2, on uterine contractility. Prostaglandins, leukotrienes, and essential fatty acids. 1989 Apr; 36(1):15-9. doi: 10.1016/0952-3278(89)90156-7. [PMID: 2500670]
  • M Moriga, M Aono, H Narusawa, Y Kohli, T Kato, G Kajiyama, M Inoue, A Miyoshi. Inhibitory action of enprostil (4,5-dehydro-16-phenoxy-17,18,19,20-tetranor-PGE2) on tetra-gastrin stimulated acid secretion in human subjects. Gastroenterologia Japonica. 1989 Apr; 24(2):115-9. doi: 10.1007/bf02774184. [PMID: 2501133]
  • M Kohno, K Naito, Y Yamada, M Nakahara, M Otsuka, O Takaiti, H Parnes, M Chaplin. Metabolic fate of the new anti-ulcer drug enprostil in animals. 3rd communication: tissue accumulation after consecutive oral administration of [3H]-enprostil in rats. Arzneimittel-Forschung. 1989 Mar; 39(3):350-6. doi: NULL. [PMID: 2502988]
  • S Smith, P Teitelbaum, L Bowen, R Tomlinson, P Berry, A Yani, H Parnes, M Chaplin. Metabolic fate of the new anti-ulcer drug enprostil in animals. 1st communication: absorption, distribution and excretion in the mouse, rat and rabbit. Arzneimittel-Forschung. 1989 Mar; 39(3):335-41. doi: NULL. [PMID: 2502986]
  • K Naito, M Nakahara, Y Yamada, M Otsuka, O Takaiti, S Harigaya, H Parnes, M Chaplin. Metabolic fate of the new anti-ulcer drug enprostil in animals. 2nd communication: whole-body autoradiographic distribution of [3H]-enprostil in rats. Arzneimittel-Forschung. 1989 Mar; 39(3):342-9. doi: NULL. [PMID: 2502987]
  • C G Nicholl, G Carolan, H Sevelius, S R Bloom. Effect of enprostil on gastric emptying, intestinal transit time and post-prandial release of gastro-intestinal peptides. Digestion. 1989; 43(1-2):47-55. doi: 10.1159/000199860. [PMID: 2509267]
  • K E Schwartz, B Zaro, J Reynolds, J Duffy, T Saito, J S Hunt, H Sevelius. Suppression of postprandial glucose, insulin, C-peptide, and glucose-dependent insulinotropic peptide (GIP) in man by oral administration of a prostaglandin analogue (enprostil). Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1988 Oct; 20(10):637-40. doi: 10.1055/s-2007-1010904. [PMID: 3146539]
  • G M Reaven, A L Swislocki, C Y Jeng, C B Hollenbeck, K Schwartz, Y D Chen. Effect of enprostil on plasma glucose, insulin and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1988 Oct; 20(10):633-6. doi: 10.1055/s-2007-1010903. [PMID: 3146538]
  • S Lanzon-Miller, M C Allison, R E Pounder, S Ball, M R Hamilton, N A Chronos. Enprostil inhibits post-prandial gastrin release: a dose-response study. Alimentary pharmacology & therapeutics. 1988 Aug; 2(4):317-23. doi: 10.1111/j.1365-2036.1988.tb00703.x. [PMID: 2979254]
  • K E Schwartz, B Zaro, P Burton, J Hunt, L Pennelly, H Sevelius. Reduction of serum lipoproteins in man by the oral administration of a prostaglandin analogue (enprostil). Atherosclerosis. 1988 May; 71(1):9-16. doi: 10.1016/0021-9150(88)90297-3. [PMID: 3132181]
  • K Berstad, H Massey, A Berstad. Effect of enprostil on basal and meal-stimulated gastric acid and pepsin secretion, serum gastrin and gastric emptying in healthy persons. Alimentary pharmacology & therapeutics. 1988 Feb; 2(1):65-72. doi: 10.1111/j.1365-2036.1988.tb00673.x. [PMID: 2979235]
  • K L Goa, J P Monk. Enprostil. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of peptic ulcer disease. Drugs. 1987 Nov; 34(5):539-59. doi: 10.2165/00003495-198734050-00003. [PMID: 3121276]
  • J S Redfern, A J Blair, E Lee, M Feldman. Gastrointestinal ulcer formation in rabbits immunized with prostaglandin E2. Gastroenterology. 1987 Oct; 93(4):744-52. doi: 10.1016/0016-5085(87)90436-7. [PMID: 3114037]
  • L D Jewell, W Yacoub, M L Salkie, R Sherbaniuk, K Walker, V Mahachai, P Kirdeikis, I Simpson, L Zuk, M K Brunet. Enprostil reduces G-cell hyperplasia and hypergastrinemia in duodenal ulcer. Clinical therapeutics. 1987; 9(3):281-95. doi: NULL. [PMID: 3111703]
  • I Bunce, M Ward, E Solomon, A Cowen. Platelet function in patients receiving enprostil. The American journal of medicine. 1986 Aug; 81(2A):85-8. doi: 10.1016/s0002-9343(86)80018-3. [PMID: 2944380]
  • R Sherbaniuk, L D Jewell, W Yacoub, B Pinchbeck, M L Salkie, K Walker, V Mahachai, P Kirdeikis, L Zuk, M K Brunet. Synergistic interaction between an H2-receptor antagonist and enprostil on 24-hour intragastric pH, serum gastrin concentration, and tissue immunoperoxidase staining for gastrin, somatostatin, and serotonin in a patient with metastatic gastrinoma. Clinical therapeutics. 1986; 8(6):667-88. doi: NULL. [PMID: 2878726]
  • C J Hawkey, P J Prichard, K W Somerville. Strategies for preventing aspirin-induced gastric bleeding. Scandinavian journal of gastroenterology. Supplement. 1986; 125(?):170-3. doi: 10.3109/00365528609093834. [PMID: 3103204]
  • V Mahachai, K Walker, H Sevelius, A B Thomson. Antisecretory and serum gastrin lowering effect of enprostil in patients with duodenal ulcer disease. Gastroenterology. 1985 Sep; 89(3):555-61. doi: 10.1016/0016-5085(85)90451-2. [PMID: 3926591]
  • M M Cohen, D R McCready, L Clark, H Sevelius. Protection against aspirin-induced antral and duodenal damage with enprostil. A double-blind endoscopic study. Gastroenterology. 1985 Jan; 88(1 Pt 2):382-6. doi: 10.1016/s0016-5085(85)80193-1. [PMID: 3917264]