Enecadin (BioDeep_00000178702)

   

human metabolite blood metabolite


代谢物信息卡片


4-(4-Fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride

化学式: C21H28FN3O (357.221629)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 14.29%

分子结构信息

SMILES: CC1=NC(=CC(=N1)OCCCCCN2CCCCC2)C3=CC=C(C=C3)F
InChI: InChI=1S/C21H28FN3O/c1-17-23-20(18-8-10-19(22)11-9-18)16-21(24-17)26-15-7-3-6-14-25-12-4-2-5-13-25/h8-11,16H,2-7,12-15H2,1H3

描述信息

C26170 - Protective Agent > C1509 - Neuroprotective Agent

同义名列表

5 个代谢物同义名

4-(4-Fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride; 4-(4-fluorophenyl)-2-methyl-6-{[5-(piperidin-1-yl)pentyl]oxy}pyrimidine; Enecadin; NS-7; NS 7



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Elke Detre, Morten B Thomsen, Jet D Beekman, Karl-Uwe Petersen, Marc A Vos. Decreasing the infusion rate reduces the proarrhythmic risk of NS-7: confirming the relevance of short-term variability of repolarisation in predicting drug-induced torsades de pointes. British journal of pharmacology. 2005 Jun; 145(3):397-404. doi: 10.1038/sj.bjp.0706203. [PMID: 15778734]
  • Kiyoko Nonaka, Tomoo Tsujioka, Katsuhiko Tougou, Hideya Mukai. Pharmacokinetics of the new pyrimidine derivative NS-7, a novel Na+/Ca2+ channel blocker. 1st communication: plasma concentrations and excretions after a single intravenous 14C-NS-7 injection to rats, dogs and monkeys. Arzneimittel-Forschung. 2003; 53(9):612-20. doi: 10.1055/s-0031-1297157. [PMID: 14558434]
  • Kiyoko Nonaka, Tomoo Tsujioka, Katsuhiko Tougou, Hideya Mukai. Pharmacokinetics of the new pyrimidine derivative NS-7, a novel Na+/Ca2+ channel blocker. 2nd communication: tissue distributions, placental transfer and milk secretion of radioactivity after a single intravenous 14C-NS-7 injection to rats. Arzneimittel-Forschung. 2003; 53(10):695-700. doi: 10.1055/s-0031-1299814. [PMID: 14650361]
  • Y Aoki, M Tamura, Y Itoh, T Seto, K Nonaka, H Mukai, Y Ukai. Effective plasma concentration of a novel Na+/Ca2+ channel blocker NS-7 for its cerebroprotective actions in rats with a transient middle cerebral artery occlusion. The Journal of pharmacology and experimental therapeutics. 2001 Feb; 296(2):306-11. doi: NULL. [PMID: 11160611]