Eltoprazine (BioDeep_00000178667)

   

human metabolite blood metabolite


代谢物信息卡片


1-(2,3-dihydro-1,4-Benzodioxin-5-yl)piperazine

化学式: C12H16N2O2 (220.1212)
中文名称: 盐酸依托拉嗪, 盐酸艾托拉嗪
谱图信息: 最多检出来源 Mus musculus(blood) 81.25%

分子结构信息

SMILES: C1CN(CCN1)C1=C2OCCOC2=CC=C1
InChI: InChI=1S/C12H16N2O2/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12/h1-3,13H,4-9H2

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist

同义名列表

4 个代谢物同义名

1-(2,3-dihydro-1,4-Benzodioxin-5-yl)piperazine; Eltoprazine hydrochloride; Eltoprazine; Eltoprazine hydrochloride



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Andreas Gravius, Andrzej Dekundy, Anita Vanaga, Lutz Franke, Wojciech Danysz. Further pharmacological characterization of eltoprazine: focus on its anxiolytic, anorexic, and adverse‑effect potential. Acta neurobiologiae experimentalis. 2017; 77(1):77-85. doi: 10.21307/ane-2017-038. [PMID: 28379218]
  • T G Amstislavskaya, N K Popova. The roles of different types of serotonin receptors in activation of the hypophyseal-testicular complex induced in mice by the presence of a female. Neuroscience and behavioral physiology. 2004 Oct; 34(8):833-7. doi: 10.1023/b:neab.0000038136.27999.3d. [PMID: 15587814]
  • S Perez Silanes, L Orús, A M Oficialdegui, J Martínez Esparza, B Lasheras, J Del Río, A Monge. New 3-[4-(2,3-dihydro-14-benzodioxin-5-yl)piperazin-1-yl]-1-(5-substituted benzo[b]thiophen-3-yl)propanol derivatives with dual action at 5-HT(1A) serotonin receptors and serotonin transporter as a new class of antidepressants. Die Pharmazie. 2004 Jul; 59(7):499-501. doi: NULL. [PMID: 15296084]
  • B J van Steen, I van Wijngaarden, M T Tulp, W Soudijn. A series of N4-imidoethyl derivatives of 1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine as 5-HT1A receptor ligands: synthesis and structure-affinity relationships. Journal of medicinal chemistry. 1995 Oct; 38(21):4303-8. doi: 10.1021/jm00021a020. [PMID: 7473558]
  • P de Koning, M Mak, M H de Vries, L F Allsopp, R B Stevens, R Verbruggen, R Van den Borre, P van Peteghem, D Kohen, M Arumainayagam. Eltoprazine in aggressive mentally handicapped patients: a double-blind, placebo- and baseline-controlled multi-centre study. The Eltoprazine Aggression Research Group. International clinical psychopharmacology. 1994 Sep; 9(3):187-94. doi: 10.1097/00004850-199409000-00007. [PMID: 7814828]
  • M H de Vries, P de Koning, H L Floot, A Grahnén, S A Eckernäs, M Raghoebar, B Dahlström, L Ekman. Dose-proportionality of eltoprazine. Pharmacokinetics of single oral doses in healthy subjects. European journal of clinical pharmacology. 1991; 41(5):485-8. doi: 10.1007/bf00626375. [PMID: 1761079]
  • M Raghoebar, M Mak, A Cournot, M C Pistorius, J Van Harten, H Roseboom. Pharmacokinetics of eltoprazine in healthy male subjects after single dose oral and intravenous administration. British journal of clinical pharmacology. 1990 Dec; 30(6):879-83. doi: 10.1111/j.1365-2125.1990.tb05454.x. [PMID: 2288834]
  • R Lammers, J van Harten. Pharmacokinetics of eltoprazine in the dog. Drug metabolism and drug interactions. 1990; 8(1-2):141-8. doi: 10.1515/dmdi.1990.8.1-2.141. [PMID: 2091887]
  • J van Harten, I S Mathlener, M Raghoebar. Pharmacokinetics of eltoprazine in healthy subjects. Drug metabolism and drug interactions. 1990; 8(1-2):149-58. doi: 10.1515/dmdi.1990.8.1-2.149. [PMID: 2091888]
  • N de Lange, M Raghoebar. Distribution of radioactively labelled eltoprazine in rat and dog. Drug metabolism and drug interactions. 1990; 8(1-2):115-27. doi: 10.1515/dmdi.1990.8.1-2.115. [PMID: 2091885]
  • H J Koster, L de Greef, F Klerks, M Raghoebar. The metabolite patterns of eltoprazine in man, dog, rat and rabbit. Drug metabolism and drug interactions. 1990; 8(1-2):129-39. doi: 10.1515/dmdi.1990.8.1-2.129. [PMID: 2091886]