Amisulpride (BioDeep_00000017866)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulphonyl)-2-methoxybenzamide

化学式: C17H27N3O4S (369.1722182)
中文名称: 阿米舒必利, 氨磺必利
谱图信息: 最多检出来源 Homo sapiens(urine) 75%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Amisulpride. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/amisulpride (retrieved 2024-11-03) (BioDeep RN: BioDeep_00000017866). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCN1C(CNC(C2=CC(S(=O)(CC)=O)=C(N)C=C2OC)=O)CCC1
InChI: InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21)

描述信息

Amisulpride (trade name Solian) is an antipsychotic drug sold by Sanofi-Aventis. It is not approved for use in the United States, but is approved for use in Europe and Australia for the treatment of psychoses and schizophrenia. Additionally, it is approved in Italy for the treatment of dysthymia (under the brand name Deniban). Amisulpride is a selective dopamine antagonist.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AL - Benzamides
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively.

同义名列表

16 个代谢物同义名

4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulphonyl)-2-methoxybenzamide; 4-amino-5-(ethanesulfonyl)-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxybenzamide; 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide; 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulphonyl)-O-anisamide; 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide; N-(Ethyl-1-pyrrolidinyl- 2-methyl)methoxy-2-ethylsulfonyl-5-benzamide; Sultopride hydrochloride; Aminosultopride; Amisulpridum; amisulpride; Amisulprida; Sultopride; Barnetil; Deniban; Solian; DAN 2163



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jingda Cai, Li Li, Tiannan Shao, Mengxi Sun, Weiyan Wang, Peng Xie, Xiaoyi Wang, Ye Yang, Yujun Long, Dongyu Kang, Jingmei Xiao, Yuhan Su, Xingjie Peng, Yuyan Huang, Menghui Gao, Qiongqiong Wu, Chuhan Song, Furu Liu, Ping Shao, Jianjun Ou, Yidong Shen, Jing Huang, Renrong Wu. Relapse in patients with schizophrenia and amisulpride-induced hyperprolactinemia or olanzapine-induced metabolic disturbance after switching to other antipsychotics. Psychiatry research. 2023 Mar; 322(?):115138. doi: 10.1016/j.psychres.2023.115138. [PMID: 36871411]
  • Hae-Jung Yang, Seung-Gon Kim, Eun Hyun Seo, Hyung-Jun Yoon. Amisulpride withdrawal akathisia responding to aripiprazole with propranolol in first-onset psychosis: a case report. BMC psychiatry. 2022 01; 22(1):74. doi: 10.1186/s12888-022-03721-9. [PMID: 35093063]
  • Bozhi Yuan, Mei Yuan. Changes of Mental State and Serum Prolactin Levels in Patients with Schizophrenia and Depression after Receiving the Combination Therapy of Amisulpride and Chloroprothixol Tablets. Computational and mathematical methods in medicine. 2022; 2022(?):6580030. doi: 10.1155/2022/6580030. [PMID: 35242209]
  • Jinchi Zheng, Zeya Lin, Chih-Yuan Ko, Jian-Hua Xu, Yichuan Lin, Jinyi Wang. Analysis of Gut Microbiota in Patients with Exacerbated Symptoms of Schizophrenia following Therapy with Amisulpride: A Pilot Study. Behavioural neurology. 2022; 2022(?):4262094. doi: 10.1155/2022/4262094. [PMID: 35287288]
  • Kankan Qu, Feng Wang, Zhiqiang Du, Shushan Wang, Zhongdong Zhang, Yuan Shen. A novel and sensitive method for determination of amisulpride in human plasma by two-dimensional liquid chromatography. Biomedical chromatography : BMC. 2021 Oct; 35(10):e5149. doi: 10.1002/bmc.5149. [PMID: 33928659]
  • Daniel A Hussar. New Drugs 2021, Part 2. Nursing. 2021 Oct; 51(10):18-29. doi: 10.1097/01.nurse.0000791756.56705.dd. [PMID: 34580258]
  • Dnyandev Gadhave, Shrikant Tupe, Amol Tagalpallewar, Bapi Gorain, Hira Choudhury, Chandrakant Kokare. Nose-to-brain delivery of amisulpride-loaded lipid-based poloxamer-gellan gum nanoemulgel: In vitro and in vivo pharmacological studies. International journal of pharmaceutics. 2021 Sep; 607(?):121050. doi: 10.1016/j.ijpharm.2021.121050. [PMID: 34454028]
  • Fengli Sun, Fang Yu, Zhihan Gao, Zhibin Ren, Weidong Jin. Study on the relationship among dose, concentration and clinical response in Chinese schizophrenic patients treated with Amisulpride. Asian journal of psychiatry. 2021 Aug; 62(?):102694. doi: 10.1016/j.ajp.2021.102694. [PMID: 34052710]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Fenglin Wang, Sandong Yang, Xinying Zhou, Jiao Feng, Tao Tang, Tong Li. [Integrated multi-column two-dimensional liquid chromatographic system for determination of amisulpride in serum]. Se pu = Chinese journal of chromatography. 2021 Feb; 39(2):197-202. doi: 10.3724/sp.j.1123.2020.07035. [PMID: 34227352]
  • Shanqing Huang, Lu Li, Zhanzhang Wang, Tao Xiao, Xiaolin Li, Shujing Liu, Ming Zhang, Haoyang Lu, Yuguan Wen, Dewei Shang. Modeling and Simulation for Individualized Therapy of Amisulpride in Chinese Patients with Schizophrenia: Focus on Interindividual Variability, Therapeutic Reference Range and the Laboratory Alert Level. Drug design, development and therapy. 2021; 15(?):3903-3913. doi: 10.2147/dddt.s327506. [PMID: 34548782]
  • Erik Johnsen, Rune A Kroken, Else-Marie Løberg, Maria Rettenbacher, Inge Joa, Tor Ketil Larsen, Solveig Klæbo Reitan, Berit Walla, Renata Alisauskiene, Liss Gøril Anda, Christoffer Bartz-Johannessen, Jan Øystein Berle, Jill Bjarke, Farivar Fathian, Kenneth Hugdahl, Eirik Kjelby, Igne Sinkeviciute, Silje Skrede, Lena Stabell, Vidar M Steen, W Wolfgang Fleischhacker. Amisulpride, aripiprazole, and olanzapine in patients with schizophrenia-spectrum disorders (BeSt InTro): a pragmatic, rater-blind, semi-randomised trial. The lancet. Psychiatry. 2020 11; 7(11):945-954. doi: 10.1016/s2215-0366(20)30341-2. [PMID: 33069317]
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  • Noha N Atia, Mostafa A Marzouq, Ahmed I Hassan, Walid E Eltoukhi. A rapid FTIR spectroscopic assay for quantitative determination of Memantine hydrochloride and Amisulpride in human plasma and pharmaceutical formulations. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Aug; 236(?):118377. doi: 10.1016/j.saa.2020.118377. [PMID: 32330826]
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  • Gayathri Nair Sekhar, Alice L Fleckney, Sevda Tomova Boyanova, Huzefa Rupawala, Rachel Lo, Hao Wang, Doaa B Farag, Khondaker Miraz Rahman, Martin Broadstock, Suzanne Reeves, Sarah Ann Thomas. Region-specific blood-brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer's disease. Fluids and barriers of the CNS. 2019 Dec; 16(1):38. doi: 10.1186/s12987-019-0158-1. [PMID: 31842924]
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  • Noha N Atia, Mostafa A Marzouq, Ahmed I Hassan, Walid E Eltoukhi. A new sensitive approach for spectrofluorimetric assay of Milnacipran and Amisulpride in real plasma and pharmaceutical preparations via complexation with Eosin Y dye. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 May; 214(?):399-406. doi: 10.1016/j.saa.2019.02.071. [PMID: 30802797]
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  • Abd El-Halim I El Assasy, Niha F Younes, Amal I A Makhlouf. Enhanced Oral Absorption of Amisulpride Via a Nanostructured Lipid Carrier-Based Capsules: Development, Optimization Applying the Desirability Function Approach and In Vivo Pharmacokinetic Study. AAPS PharmSciTech. 2019 Jan; 20(2):82. doi: 10.1208/s12249-018-1283-x. [PMID: 30652198]
  • Prajapati Jagruti B, Sawant Krutika K, Bhramanand Dubey. Oral Bioavailability Enhancement of Amisulpride: Complexation and its Pharmacokinetics and Pharmacodynamics Evaluations. Drug metabolism letters. 2019; 13(2):132-144. doi: 10.2174/1872312813666191018152226. [PMID: 31975684]
  • Marwa H Shukr, Omar A Ahmed Farid. Amisulpride-CD-Loaded Liposomes: Optimization and In Vivo Evaluation. AAPS PharmSciTech. 2018 Aug; 19(6):2658-2671. doi: 10.1208/s12249-018-1079-z. [PMID: 29943282]
  • Si-Si Cao, Yan-Xia Ma, Ping-Fei Fang, Hua-Lin Cai, Yang Deng, Zhen-Yan Hou, Ying Chen, Miao Yan, Bi-Kui Zhang. Pharmacokinetics and relative bioavailability of a generic amisulpride tablet in healthy Chinese volunteers
. International journal of clinical pharmacology and therapeutics. 2017 Oct; 55(10):825-831. doi: 10.5414/cp203000. [PMID: 28793958]
  • Teng Wang, Yajun Zheng, Xiaoting Wang, Daniel E Austin, Zhiping Zhang. Sub-ppt Mass Spectrometric Detection of Therapeutic Drugs in Complex Biological Matrixes Using Polystyrene-Microsphere-Coated Paper Spray. Analytical chemistry. 2017 08; 89(15):7988-7995. doi: 10.1021/acs.analchem.7b01296. [PMID: 28686424]
  • Piotr Skrobecki, Anna Chmielińska, Piotr Bonarek, Piotr Stepien, Anna Wisniewska-Becker, Marta Dziedzicka-Wasylewska, Agnieszka Polit. Sulpiride, Amisulpride, Thioridazine, and Olanzapine: Interaction with Model Membranes. Thermodynamic and Structural Aspects. ACS chemical neuroscience. 2017 07; 8(7):1543-1553. doi: 10.1021/acschemneuro.7b00057. [PMID: 28375612]
  • Li-Juan Gao, Hua-Gui Guo, Zhen-Tao Liang, Xiao-Xiao Zhong, Jin-Cai Zhu, Yu Yang. [Aripiprazole for drug-induced sexual dysfunction in schizophrenic males]. Zhonghua nan ke xue = National journal of andrology. 2017 Jul; 23(7):615-619. doi: NULL. [PMID: 29723454]
  • Danielle S Fisher, Chad Beyer, Gerrit van Schalkwyk, Soraya Seedat, Robert J Flanagan. Measurement of Clozapine, Norclozapine, and Amisulpride in Plasma and in Oral Fluid Obtained Using 2 Different Sampling Systems. Therapeutic drug monitoring. 2017 04; 39(2):109-117. doi: 10.1097/ftd.0000000000000377. [PMID: 28125503]
  • Jörg Täubel, Georg Ferber, Gabriel Fox, Sara Fernandes, Ulrike Lorch, A John Camm. Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects. British journal of clinical pharmacology. 2017 02; 83(2):339-348. doi: 10.1111/bcp.13128. [PMID: 27618796]
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  • Sean J OʼHalloran, Antonia Wong, David A Joyce. A Liquid Chromatography-Tandem Mass Spectrometry Method for Quantifying Amisulpride in Human Plasma and Breast Milk, Applied to Measuring Drug Transfer to a Fully Breast-Fed Neonate. Therapeutic drug monitoring. 2016 08; 38(4):493-8. doi: 10.1097/ftd.0000000000000300. [PMID: 27027463]
  • Chun-Yen Chen, Yi-Wei Yeh, Shin-Chang Kuo, Pei-Shen Ho, Chih-Sung Liang, Che-Hung Yen, Ru-Band Lu, San-Yuan Huang. Catechol-O-methyltransferase gene variants may associate with negative symptom response and plasma concentrations of prolactin in schizophrenia after amisulpride treatment. Psychoneuroendocrinology. 2016 Mar; 65(?):67-75. doi: 10.1016/j.psyneuen.2015.12.003. [PMID: 26724569]
  • Mucahit Avcil, Mucahit Kapçı, Irfan Yavaşoğlu, Burçak Kantekin, Mahmut Akpek. Simultaneous Use of Intravenous Lipid Emulsion and Plasma Exchange Therapies in Multiple Drug Toxicity. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2016; 25(6):577-579. doi: 10.1159/000449250. [PMID: 27548660]
  • Ying Liang, Yun-Ai Su, Zhen-Guo Zhao, Nan Gao, Ji-Zhong Huang, Mao-Qin Tang, Ke-Qing Li, Fu-De Yang, Xin Yu, Tian-Mei Si. Acute Effects of Haloperidol, Amisulpride, and Quetiapine on Bone Turnover Markers in Patients With Schizophrenia. Journal of clinical psychopharmacology. 2015 Oct; 35(5):583-6. doi: 10.1097/jcp.0000000000000379. [PMID: 26270200]
  • Coraline D Metzger, Maike Wiegers, Martin Walter, Birgit Abler, Heiko Graf. Local and Global Resting State Activity in the Noradrenergic and Dopaminergic Pathway Modulated by Reboxetine and Amisulpride in Healthy Subjects. The international journal of neuropsychopharmacology. 2015 Jul; 19(2):. doi: 10.1093/ijnp/pyv080. [PMID: 26209860]
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