Eddha (BioDeep_00000178615)

   

human metabolite blood metabolite


代谢物信息卡片


2-[(2-{[carboxy(2-hydroxyphenyl)methyl]amino}ethyl)amino]-2-(2-hydroxyphenyl)acetic acid

化学式: C18H20N2O6 (360.13213)
中文名称: N,N-乙基双(2-[2-羟基苯基]甘氨酸)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(C(=O)O)NCCNC(C2=CC=CC=C2O)C(=O)O)O
InChI: InChI=1S/C18H20N2O6/c21-13-7-3-1-5-11(13)15(17(23)24)19-9-10-20-16(18(25)26)12-6-2-4-8-14(12)22/h1-8,15-16,19-22H,9-10H2,(H,23,24)(H,25,26)

描述信息

D064449 - Sequestering Agents > D002614 - Chelating Agents > D007502 - Iron Chelating Agents

同义名列表

15 个代谢物同义名

2-[(2-{[carboxy(2-hydroxyphenyl)methyl]amino}ethyl)amino]-2-(2-hydroxyphenyl)acetic acid; 2-[(2-{[carboxy(2-hydroxyphenyl)methyl]amino}ethyl)amino]-2-(2-hydroxyphenyl)acetate; Ethylenediamine-N,n-bis(2-hydroxyphenylacetic acid), iron, sodium salt; Ethylenediamine-N,n-bis(2-hydroxyphenylacetic acid), dihydrochloride; Ethylenediamine-N,n-bis(2-hydroxyphenylacetic acid), iron (+3) salt; Ethylenediamine-N,n-bis(2-hydroxyphenylacetic acid), disodium salt; Ethylenediamine-N,N-bis((2-hydroxyphenyl)acetic acid); Ethylenediamine-N,n-bis(2-hydroxyphenylacetic acid); Ethylenediamine-N,n-bis(2-hydroxyphenyl)glycine; Ethylenediaminedi-O-hydroxyphenylacetic acid; N,N-ethylenebis(O-hydroxyphenyl)glycine; EDBPHA; EDBHA; Eddha; EHPG



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lauren A E Erland, Christina E Turi, Praveen K Saxena, Susan J Murch. Metabolomics and hormonomics to crack the code of filbert growth. Metabolomics : Official journal of the Metabolomic Society. 2020 04; 16(5):62. doi: 10.1007/s11306-020-01684-0. [PMID: 32335734]
  • Zhe Chen, Ye-Tao Tang, Can Zhou, Shu-Ting Xie, Shi Xiao, Alan J M Baker, Rong-Liang Qiu. Mechanisms of Fe biofortification and mitigation of Cd accumulation in rice (Oryza sativa L.) grown hydroponically with Fe chelate fertilization. Chemosphere. 2017 May; 175(?):275-285. doi: 10.1016/j.chemosphere.2017.02.053. [PMID: 28232138]
  • Levi M Bin, Liping Weng, Marcel H J Bugter. Effectiveness of FeEDDHA, FeEDDHMA, and FeHBED in Preventing Iron-Deficiency Chlorosis in Soybean. Journal of agricultural and food chemistry. 2016 Nov; 64(44):8273-8281. doi: 10.1021/acs.jafc.6b01382. [PMID: 27690423]
  • Marta Fuentes, María F Ortuño, Francisco Pérez-Sarmiento, Eva Bacaicoa, Roberto Baigorri, Wenceslao Conejero, Arturo Torrecillas, José M García-Mina. Efficiency of a new strategy involving a new class of natural hetero-ligand iron(III) chelates (Fe(III)-NHL) to improve fruit tree growth in alkaline/calcareous soils. Journal of the science of food and agriculture. 2012 Dec; 92(15):3065-71. doi: 10.1002/jsfa.5726. [PMID: 22674185]
  • Jeremy G Owen, David F Ackerley. Characterization of pyoverdine and achromobactin in Pseudomonas syringae pv. phaseolicola 1448a. BMC microbiology. 2011 Oct; 11(?):218. doi: 10.1186/1471-2180-11-218. [PMID: 21967163]
  • Lourdes Hernández-Apaolaza, Juan J Lucena. Influence of irradiation time and solution concentration on the photochemical degradation of EDDHA/Fe3+: effect of its photodecomposition products on soybean growth. Journal of the science of food and agriculture. 2011 Aug; 91(11):2024-30. doi: 10.1002/jsfa.4414. [PMID: 21495040]
  • Hamdi El-Jendoubi, Juan Carlos Melgar, Ana Alvarez-Fernández, Manuel Sanz, Anunciación Abadía, Javier Abadía. Setting good practices to assess the efficiency of iron fertilizers. Plant physiology and biochemistry : PPB. 2011 May; 49(5):483-8. doi: 10.1016/j.plaphy.2011.02.013. [PMID: 21398136]
  • Jessica Köster, Heiko Hayen, Nicolaus von Wirén, Günther Weber. Isoelectric focusing of small non-covalent metal species from plants. Electrophoresis. 2011 Mar; 32(6-7):772-81. doi: 10.1002/elps.201000529. [PMID: 21192102]
  • Ana de Santiago, Antonio Delgado. Interaction between beet vinasse and iron fertilisers in the prevention of iron deficiency in lupins. Journal of the science of food and agriculture. 2010 Oct; 90(13):2188-94. doi: 10.1002/jsfa.4068. [PMID: 20607794]
  • Fatma Tajini, Porntip Suriyakup, Hélène Vailhe, Jan Jansa, Jean-Jacques Drevon. Assess suitability of hydroaeroponic culture to establish tripartite symbiosis between different AMF species, beans, and rhizobia. BMC plant biology. 2009 Jun; 9(?):73. doi: 10.1186/1471-2229-9-73. [PMID: 19534785]
  • Irene Orera, Anunciación Abadía, Javier Abadía, Ana Alvarez-Fernández. Determination of o,oEDDHA - a xenobiotic chelating agent used in Fe fertilizers - in plant tissues by liquid chromatography/electrospray mass spectrometry: overcoming matrix effects. Rapid communications in mass spectrometry : RCM. 2009 Jun; 23(11):1694-702. doi: 10.1002/rcm.4056. [PMID: 19412919]
  • David Martínez Domínguez, Rafael Torronteras Santiago, Francisco Córdoba García. Modulation of the antioxidative response of Spartina densiflora against iron exposure. Physiologia plantarum. 2009 Jun; 136(2):169-79. doi: 10.1111/j.1399-3054.2009.01227.x. [PMID: 19453507]
  • Carmen L Rojas, Francisco J Romera, Esteban Alcántara, Rafael Pérez-Vicente, Cristina Sariego, J Ignacio Garcaí-Alonso, Javier Boned, Gabriel Marti. Efficacy of Fe(o,o-EDDHA) and Fe(o,p-EDDHA) isomers in supplying Fe to strategy I plants differs in nutrient solution and calcareous soil. Journal of agricultural and food chemistry. 2008 Nov; 56(22):10774-8. doi: 10.1021/jf8022589. [PMID: 18975970]
  • Mohamed Samai, Theresa Hague, Declan P Naughton, Paul R Gard, Prabal K Chatterjee. Reduction of paraquat-induced renal cytotoxicity by manganese and copper complexes of EGTA and EHPG. Free radical biology & medicine. 2008 Feb; 44(4):711-21. doi: 10.1016/j.freeradbiomed.2007.11.001. [PMID: 18067869]
  • Christina D Moon, Xue-Xian Zhang, Sandra Matthijs, Mathias Schäfer, Herbert Budzikiewicz, Paul B Rainey. Genomic, genetic and structural analysis of pyoverdine-mediated iron acquisition in the plant growth-promoting bacterium Pseudomonas fluorescens SBW25. BMC microbiology. 2008 Jan; 8(?):7. doi: 10.1186/1471-2180-8-7. [PMID: 18194565]
  • Yue Xuan, Enrico B Scheuermann, Anderson R Meda, Peter Jacob, Nicolaus von Wirén, Günther Weber. CE of phytosiderophores and related metal species in plants. Electrophoresis. 2007 Oct; 28(19):3507-19. doi: 10.1002/elps.200700117. [PMID: 17768721]
  • Patricio Rivera Ortiz, Blanca I Castro Meza, Francisco R de la Garza Requena, Guillermo Mendoza Flores, Jorge D Etchevers Barra. Evaluation of different iron compounds in chlorotic Italian lemon trees (Citrus lemon). Plant physiology and biochemistry : PPB. 2007 May; 45(5):330-4. doi: 10.1016/j.plaphy.2007.03.015. [PMID: 17467284]
  • Ana Alvarez-Fernández, Irene Orera, Javier Abadía, Anunciación Abadía. Determination of synthetic ferric chelates used as fertilizers by liquid chromatography-electrospray/mass spectrometry in agricultural matrices. Journal of the American Society for Mass Spectrometry. 2007 Jan; 18(1):37-47. doi: 10.1016/j.jasms.2006.08.018. [PMID: 17010641]
  • B Krajncic, J Kristl, I Janzekovic. Possible role of jasmonic acid in the regulation of floral induction, evocation and floral differentiation in Lemna minor L. Plant physiology and biochemistry : PPB. 2006 Nov; 44(11-12):752-8. doi: 10.1016/j.plaphy.2006.10.029. [PMID: 17107812]
  • Marta Vasconcelos, Helene Eckert, Venancio Arahana, George Graef, Michael A Grusak, Tom Clemente. Molecular and phenotypic characterization of transgenic soybean expressing the Arabidopsis ferric chelate reductase gene, FRO2. Planta. 2006 Oct; 224(5):1116-28. doi: 10.1007/s00425-006-0293-1. [PMID: 16741749]
  • Brian M Waters, Heng-Hsuan Chu, Raymond J Didonato, Louis A Roberts, Robynn B Eisley, Brett Lahner, David E Salt, Elsbeth L Walker. Mutations in Arabidopsis yellow stripe-like1 and yellow stripe-like3 reveal their roles in metal ion homeostasis and loading of metal ions in seeds. Plant physiology. 2006 Aug; 141(4):1446-58. doi: 10.1104/pp.106.082586. [PMID: 16815956]
  • Jörg Schönherr, Victoria Fernández, Lukas Schreiber. Rates of cuticular penetration of chelated Fe(III): role of humidity, concentration, adjuvants, temperature, and type of chelate. Journal of agricultural and food chemistry. 2005 Jun; 53(11):4484-92. doi: 10.1021/jf050453t. [PMID: 15913315]
  • Miguel A Sierra, Mar Gómez-Gallego, Roberto Alcázar, Juan J Lucena, Felipe Yunta, Sonia García-Marco. Effect of the tether on the Mg(II), Ca(II), Cu(II) and Fe(III) stability constants and pM values of chelating agents related to EDDHA. Dalton transactions (Cambridge, England : 2003). 2004 Nov; ?(21):3741-7. doi: 10.1039/b408730e. [PMID: 15510301]
  • Esteban Alcántara, Antonio Manuel Cordeiro, Diego Barranco. Selection of olive varieties for tolerance to iron chlorosis. Journal of plant physiology. 2003 Dec; 160(12):1467-72. doi: 10.1078/0176-1617-01013. [PMID: 14717439]
  • José M Alvarez, María I Rico. Effects of zinc complexes on the distribution of zinc in calcareous soil and zinc uptake by maize. Journal of agricultural and food chemistry. 2003 Sep; 51(19):5760-7. doi: 10.1021/jf030092m. [PMID: 12952430]
  • Bozidar Krajncic, Joze Nemec. Mechanisms of EDDHA effects on the promotion of floral induction in the long-day plant Lemna minor (L.). Journal of plant physiology. 2003 Feb; 160(2):143-51. doi: 10.1078/0176-1617-00794. [PMID: 12685030]
  • L M López-Valdivia, M D Fernández, A Obrador, J M Alvarez. Zinc transformations in acidic soil and zinc efficiency on maize by adding six organic zinc complexes. Journal of agricultural and food chemistry. 2002 Mar; 50(6):1455-60. doi: 10.1021/jf010978v. [PMID: 11879020]
  • L Graff, G Muller, D Burnel. In vitro and in vivo evaluation of potential aluminum chelators. Veterinary and human toxicology. 1995 Oct; 37(5):455-61. doi: NULL. [PMID: 8592836]
  • G C Liu, Y M Wang, T S Jaw, H M Chen, R S Sheu. Fe(III)-EHPG and Fe(III)-5-Br-EHPG as contrast agents in MRI: an animal study. Journal of the Formosan Medical Association = Taiwan yi zhi. 1993 Apr; 92(4):359-66. doi: NULL. [PMID: 8104585]
  • G N Stradling, S A Gray, J C Moody, M Ellender. Efficacy of tiron for enhancing the excretion of uranium from the rat. Human & experimental toxicology. 1991 May; 10(3):195-8. doi: 10.1177/096032719101000308. [PMID: 1678949]
  • M L Thakur, M D Richard, F W White. Monoclonal antibodies as agents for selective radiolabeling of human neutrophils. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1988 Nov; 29(11):1817-25. doi: NULL. [PMID: 3141596]
  • R B Lauffer, D R Betteridge, S Padmanabhan, T J Brady. Albumin binding of paramagnetic hepatobiliary contrast agents: enhancement of outer sphere relaxivity. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 1988; 15(1):45-6. doi: 10.1016/0883-2897(88)90159-6. [PMID: 3350695]
  • H Rosenkrantz, J J Metterville, R W Fleischman. Preliminary toxicity findings in dogs and rodents given the iron chelator ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid) (EDHPA). Fundamental and applied toxicology : official journal of the Society of Toxicology. 1986 Feb; 6(2):292-8. doi: 10.1016/0272-0590(86)90243-5. [PMID: 3699319]
  • J Schuhmacher, R Matys, H Hauser, W Maier-Borst, S Matzku. Labeling of monoclonal antibodies with a 67Ga-phenolic aminocarboxylic acid chelate. Part I. Chemistry and labeling technique. European journal of nuclear medicine. 1986; 12(8):397-404. doi: 10.1007/bf00252198. [PMID: 3792374]
  • M C Theodorakis, A J Bermudez, J P Manning, G D Koritz, C J Hillidge. Liver scintigraphy in ponies. American journal of veterinary research. 1982 Sep; 43(9):1561-5. doi: NULL. [PMID: 7149402]
  • H Rosenkrantz, J J Metterville. Iron tissue and excreta changes induced by ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid) in dogs. The Journal of laboratory and clinical medicine. 1980 May; 95(5):771-6. doi: NULL. [PMID: 7365318]
  • J R Behari, S K Tandon. Chelation in metal intoxication. VIII. Removal of chromium from organs of potassium chromate administered rats. Clinical toxicology. 1980 Mar; 16(1):33-40. doi: 10.3109/15563658008989921. [PMID: 6771085]
  • A Guarino, G Rotondi Aufiero, A Todisco, G Buonopane, F Rotondi Aufiero, D R Ziccardi. ['Pseudomonas aeruginosa' in the hospital of Avellino, and the presence of colonies in the obstetric, pediatric and neonatal wards. A microbiological and epidemiological study (author's transl)]. Quaderni Sclavo di diagnostica clinica e di laboratorio. 1979 Jun; 15 Suppl 1(?):704-21. doi: NULL. [PMID: 122156]