Echinocandin B (BioDeep_00000178606)
human metabolite blood metabolite
代谢物信息卡片
化学式: C52H81N7O16 (1059.5739506)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC=CCC=CCCCCCCCC(=O)NC1CC(O)C(O)NC(=O)C2C(O)C(C)CN2C(=O)C(NC(=O)C(NC(=O)C2CC(O)CN2C(=O)C(NC1=O)C(C)O)C(O)C(O)C1=CC=C(O)C=C1)C(C)O
InChI: InChI=1S/C52H81N7O16/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-38(65)53-35-26-37(64)48(71)57-50(73)42-43(66)29(2)27-59(42)52(75)40(31(4)61)55-49(72)41(45(68)44(67)32-21-23-33(62)24-22-32)56-47(70)36-25-34(63)28-58(36)51(74)39(30(3)60)54-46(35)69/h9-10,12-13,21-24,29-31,34-37,39-45,48,60-64,66-68,71H,5-8,11,14-20,25-28H2,1-4H3,(H,53,65)(H,54,69)(H,55,72)(H,56,70)(H,57,73)
描述信息
同义名列表
3 个代谢物同义名
N-{6-[1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-5,8,11,17,20,21,23,25-octahydroxy-3,15-bis(1-hydroxyethyl)-26-methyl-2,14-dioxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0⁹,¹³]heptacosa-4,7,16,22-tetraen-18-yl}octadeca-9,12-dienimidate; N-{6-[1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,21,25-tetrahydroxy-3,15-bis(1-hydroxyethyl)-26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0⁹,¹³]heptacosan-18-yl}octadeca-9,12-dienamide; Echinocandin B
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Heng Tang, Han-Yue Zhu, Yin-Feng Huang, Ze-Yu Wu, Shu-Ping Zou, Zhi-Qiang Liu, Yu-Guo Zheng. Hydrophobic substrate binding pocket remodeling of echinocandin B deacylase based on multi-dimensional rational design.
International journal of biological macromolecules.
2024 May; 267(Pt 1):131473. doi:
10.1016/j.ijbiomac.2024.131473. [PMID: 38614185] - Zhong-Ce Hu, Wen-Jun Li, Shu-Ping Zou, Kun Niu, Yu-Guo Zheng. Mutagenesis of echinocandin B overproducing Aspergillus nidulans capable of using starch as main carbon source.
Preparative biochemistry & biotechnology.
2020; 50(8):745-752. doi:
10.1080/10826068.2020.1734940. [PMID: 32125248] - Taoling Min, Lei Xiong, Yan Liang, Rui Xu, Chenchang Fa, Sheng Yang, Haifeng Hu. Disruption of stcA blocks sterigmatocystin biosynthesis and improves echinocandin B production in Aspergillus delacroxii.
World journal of microbiology & biotechnology.
2019 Jul; 35(7):109. doi:
10.1007/s11274-019-2687-9. [PMID: 31280382] - Arvind Kumar, Vinay Kumar, Antresh Kumar. Functional characterization of host toxic EcdB transcription factor protein of echinocandin B biosynthetic gene cluster.
Biotechnology and applied biochemistry.
2019 Jul; 66(4):626-633. doi:
10.1002/bab.1763. [PMID: 31069846] - Antigoni Elefanti, Johan W Mouton, Paul E Verweij, Athanassios Tsakris, Loukia Zerva, Joseph Meletiadis. Amphotericin B- and voriconazole-echinocandin combinations against Aspergillus spp.: Effect of serum on inhibitory and fungicidal interactions.
Antimicrobial agents and chemotherapy.
2013 Oct; 57(10):4656-63. doi:
10.1128/aac.00597-13. [PMID: 23856768] - Pedro Póvoa, João Gonçalves-Pereira. Treatment of candidemia in adult patients without neutropenia--an inconvenient truth.
Critical care (London, England).
2011; 15(1):114. doi:
10.1186/cc9414. [PMID: 21345263] - Jack D Sobel. Design of clinical trials of empiric antifungal therapy in patients with persistent febrile neutropenia: considerations and critiques.
Pharmacotherapy.
2006 Jun; 26(6 Pt 2):47S-54S. doi:
10.1592/phco.26.6part2.47s. [PMID: 16716122] - Aimee K Zaas, Barbara D Alexander. Echinocandins: role in antifungal therapy, 2005.
Expert opinion on pharmacotherapy.
2005 Aug; 6(10):1657-68. doi:
10.1517/14656566.6.10.1657. [PMID: 16086652] - Teresa T Liu, Robin E B Lee, Katherine S Barker, Richard E Lee, Lai Wei, Ramin Homayouni, P David Rogers. Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.
Antimicrobial agents and chemotherapy.
2005 Jun; 49(6):2226-36. doi:
10.1128/aac.49.6.2226-2236.2005. [PMID: 15917516] - John R Perfect. Management of invasive mycoses in hematology patients: current approaches.
Oncology (Williston Park, N.Y.).
2004 Nov; 18(13 Suppl 7):5-14. doi:
". [PMID: 15651177] - David A Stevens, Marife Espiritu, Rachana Parmar. Paradoxical effect of caspofungin: reduced activity against Candida albicans at high drug concentrations.
Antimicrobial agents and chemotherapy.
2004 Sep; 48(9):3407-11. doi:
10.1128/aac.48.9.3407-3411.2004. [PMID: 15328104] - John R Wingard, Helen Leather. A new era of antifungal therapy.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2004 Feb; 10(2):73-90. doi:
10.1016/j.bbmt.2003.09.014. [PMID: 14750074] - Daniel A C Frattarelli, Michael D Reed, George P Giacoia, Jacob V Aranda. Antifungals in systemic neonatal candidiasis.
Drugs.
2004; 64(9):949-68. doi:
10.2165/00003495-200464090-00003. [PMID: 15101785] - D P Kontoyiannis, E Mantadakis, G Samonis. Systemic mycoses in the immunocompromised host: an update in antifungal therapy.
The Journal of hospital infection.
2003 Apr; 53(4):243-58. doi:
10.1053/jhin.2002.1278. [PMID: 12660121] - D M Kuhn, T George, J Chandra, P K Mukherjee, M A Ghannoum. Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins.
Antimicrobial agents and chemotherapy.
2002 Jun; 46(6):1773-80. doi:
10.1128/aac.46.6.1773-1780.2002. [PMID: 12019089] - D J Frost, K Brandt, J Capobianco, R Goldman. Characterization of (1,3)-beta-glucan synthase in Candida albicans: microsomal assay from the yeast or mycelial morphological forms and a permeabilized whole-cell assay.
Microbiology (Reading, England).
1994 Sep; 140 ( Pt 9)(?):2239-46. doi:
10.1099/13500872-140-9-2239. [PMID: 7952175] - L D Boeck, D S Fukuda, B J Abbott, M Debono. Deacylation of echinocandin B by Actinoplanes utahensis.
The Journal of antibiotics.
1989 Mar; 42(3):382-8. doi:
10.7164/antibiotics.42.382. [PMID: 2708131]
