Phentolamine (BioDeep_00000017860)

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds

代谢物信息卡片

3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol

化学式: C17H19N3O (281.1528044)
中文名称: 酚妥拉明
谱图信息: 最多检出来源 Homo sapiens(blood) 31.03%

分子结构信息

SMILES: CC1=CC=C(C=C1)N(CC1=NCCN1)C1=CC(O)=CC=C1
InChI: InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)

描述信息

Phentolamine is only found in individuals that have used or taken this drug. It is a nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of raynaud disease and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease (PubChem). Phentolamine produces its therapeutic actions by competitively blocking alpha-adrenergic receptors (primarily excitatory responses of smooth muscle and exocrine glands), leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure. The action of phentolamine on the alpha adrenergic receptors is relatively transient and the blocking effect is incomplete. The drug is more effective in antagonizing responses to circulating epinephrine and/or norepinephrine than in antagonizing responses to mediator released at the adrenergic nerve ending. Phentolamine also stimulates β-adrenergic receptors and produces a positive inotropic and chronotropic effect on the heart and increases cardiac output.
C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators > C04AB - Imidazoline derivatives
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the research of erectile dysfunction[1][2][3].

同义名列表

26 个代谢物同义名

3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol; 2-(N-(m-Hydroxyphenyl)-p-toluidinomethyl)imidazoline; Schering-plough brand OF phentolamine mesylate; Novartis brand OF phentolamine mesylate; Alliance brand OF phentolamine mesylate; Paladin brand OF phentolamine mesylate; mono-Hydrochloride, phentolamine; Phentolamine mono-hydrochloride; Phentolamine mono hydrochloride; Methanesulfonate, phentolamine; Phentolamine methanesulfonate; Phentolamine mesylic acid; Mesilate, phentolamine; Mesylate, phentolamine; Phentolamine mesylate; Phentolamine mesilate; Phentolaminum; phentolamine; Fentolamina; Fentolamin; Regitina; Rogitine; Regitine; Regityn; Z-Max; Phentolamine

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:8081
PubChem: 5775
HMDB: HMDB0014830
DrugBank: DB00692
ChEMBL: CHEMBL597
Wikipedia: Phentolamine
MeSH: Phentolamine
chemspider: 5571
CAS: 50-60-2
PMhub: MS000000676
medchemexpress: HY-12717

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Qian Liu, Shengwei Wu, Zhenlin Chen, Jin Cai. Phentolamine Protects against Apoptosis and Inflammation in a Neonatal Pneumonia Cell Model Induced by LPS by Regulating the TrkA/Akt Signaling Pathways. Discovery medicine. 2024 Mar; 36(182):581-590. doi: 10.24976/discov.med.202436182.54. [PMID: 38531798]
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