Quinocarmycin analog (BioDeep_00000178574)

   

human metabolite blood metabolite


代谢物信息卡片


12-cyano-10-(hydroxymethyl)-8-methoxy-16-methyl-11,16-diazatetracyclo[11.2.1.0^{2,11}.0^{4,9}]hexadeca-4(9),5,7-triene-15-carboxylic acid

  化学式: C19H23N3O4 (357.1688)
中文名称:
  谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: CN1C2CC(C1C3CC4=C(C(N3C2C#N)CO)C(=CC=C4)OC)C(=O)O
InChI: InChI=1S/C19H23N3O4/c1-21-12-7-11(19(24)25)18(21)13-6-10-4-3-5-16(26-2)17(10)15(9-23)22(13)14(12)8-20/h3-5,11-15,18,23H,6-7,9H2,1-2H3,(H,24,25)


描述信息

D000970 - Antineoplastic Agents

同义名列表

4 个代谢物同义名

12-cyano-10-(hydroxymethyl)-8-methoxy-16-methyl-11,16-diazatetracyclo[11.2.1.0^{2,11}.0^{4,9}]hexadeca-4(9),5,7-triene-15-carboxylic acid; Quinocarmycin analog; DX-52-1; DX 52-1



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Alem W Kahsai, Shoutian Zhu, Gabriel Fenteany. G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. Biochimica et biophysica acta. 2010 Feb; 1803(2):300-10. doi: 10.1016/j.bbamcr.2009.11.002. [PMID: 19913059]
  • Alem W Kahsai, Junru Cui, H Umit Kaniskan, Philip P Garner, Gabriel Fenteany. Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. The Journal of biological chemistry. 2008 Sep; 283(36):24534-45. doi: 10.1074/jbc.m800006200. [PMID: 18556657]
  • Jon C Mirsalis, Janice Schindler-Horvat, James R Hill, Carol E Green, Chozo Mitoma, Joseph E Tomaszewski, Charles A Tyson, Susan J Donohue. Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome. Cancer chemotherapy and pharmacology. 2003 Mar; 51(3):193-201. doi: 10.1007/s00280-002-0553-0. [PMID: 12655436]
  • C A Bunnell, J G Supko, J P Eder, J W Clark, T J Lynch, D W Kufe, L N Shulman. Phase I clinical trial of 7-cyanoquinocarcinol (DX-52-1) in adult patients with refractory solid malignancies. Cancer chemotherapy and pharmacology. 2001 Nov; 48(5):347-55. doi: 10.1007/s002800100319. [PMID: 11761451]
  • J G Supko, J R Soglia, R V Nair. Assay for the quinocarmycin analog DX-52-1 in human plasma using high-performance liquid chromatography with automated column switching and low wavelength ultraviolet detection. Journal of chromatography. B, Biomedical sciences and applications. 1998 Sep; 714(2):341-53. doi: 10.1016/s0378-4347(98)00214-x. [PMID: 9766875]
  • K Yamaguchi, E Fuse, M Takashima, T Yasuzawa, T Kuwabara, S Kobayashi. Development of a sensitive liquid chromatography-electrospray ionization tandem mass spectrometry method for the measurement of 7-cyanoquinocarcinol in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 1998 Aug; 713(2):447-51. doi: 10.1016/s0378-4347(98)00185-6. [PMID: 9746263]
  • E Fuse, H Nishiie, H Kobayashi, S Ikeda, H Saito, J Covey, S Kobayashi. Disposition of DX-52-1, a novel anticancer agent, after intravenous administration to mice and dogs. European journal of drug metabolism and pharmacokinetics. 1997 Jan; 22(1):53-63. doi: 10.1007/bf03189785. [PMID: 9179561]