Dropropizine (BioDeep_00000178551)
human metabolite blood metabolite
代谢物信息卡片
3-(4-phenylpiperazin-1-yl)propane-1,2-diol
化学式: C13H20N2O2 (236.15247000000002)
中文名称: 羟丙哌嗪
谱图信息:
最多检出来源 Homo sapiens(blood) 95.83%
分子结构信息
SMILES: c1ccc(cc1)N1CCN(CC1)CC(CO)O
InChI: InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2
描述信息
R - Respiratory system > R05 - Cough and cold preparations > R05D - Cough suppressants, excl. combinations with expectorants
C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent
D019141 - Respiratory System Agents > D000996 - Antitussive Agents
D002491 - Central Nervous System Agents
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:93837
- PubChem: 3169
- HMDB: HMDB0251622
- DrugBank: DB13785
- ChEMBL: CHEMBL151445
- Wikipedia: Dropropizine
- CAS: 117067-01-3
- CAS: 17692-31-8
- RefMet: Dropropizine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Anna Karolina Mouzer da Silva Machado, Marina Cardoso Nemitz, Vitor Todeschini, Maximiliano da Silva Sangoi. Characteristics, Properties and Analytical Methods for Determination of Dropropizine and Levodropropizine: A Review.
Critical reviews in analytical chemistry.
2021; 51(2):174-182. doi:
10.1080/10408347.2019.1700098. [PMID: 31814444] - Gian Luigi Marseglia, Sara Manti, Elena Chiappini, Ilaria Brambilla, Carlo Caffarelli, Mauro Calvani, Fabio Cardinale, Claudio Cravidi, Marzia Duse, Alberto Martelli, Domenico Minasi, Michele Miraglia Del Giudice, Giovanni Pajno, Diego G Peroni, Maria Angela Tosca, Amelia Licari, Giorgio Ciprandi. Acute cough in children and adolescents: A systematic review and a practical algorithm by the Italian Society of Pediatric Allergy and Immunology.
Allergologia et immunopathologia.
2021; 49(2):155-169. doi:
10.15586/aei.v49i2.45. [PMID: 33641306] - Bhavesh Babulal Gabani, Umesh Todmal, Neeraj Kumar Saini, Vinod A Balakrishna, Suresh P Sulochana, Ashok Timmapuram, Mohd Zainuddin, Narayanan Balaji, Praharaj Shuvranshu, Nuggehally R Srinivas, Ramesh Mullangi. Stereoselective pharmacokinetics and tissue distribution of levodropropizine after administration of pure levodropropizine and the rac-dropropizine to Sprague-Dawley rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Feb; 50(2):135-144. doi:
10.1080/00498254.2019.1599148. [PMID: 30896275] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Narayanan Balaji, Bhavesh Babulal Gabani, Umesh Todmal, Suresh P Sulochana, Neeraj Kumar Saini, Rajesh Chandran, Ramesh Mullangi. Enantioselective LC-ESI-MS/MS determination of dropropizine enantiomers in rat plasma and application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2019 Mar; 33(3):e4434. doi:
10.1002/bmc.4434. [PMID: 30426526] - Yu-long Luo, Pei-bo Li, Chen-chen Zhang, Yan-fang Zheng, Sheng Wang, Yi-chu Nie, Ke-jian Zhang, Wei-wei Su. Effects of four antitussives on airway neurogenic inflammation in a guinea pig model of chronic cough induced by cigarette smoke exposure.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2013 Dec; 62(12):1053-61. doi:
10.1007/s00011-013-0664-6. [PMID: 24085318] - Jae-Won Jang, Ji-Hyung Seo, Min-Ho Jo, Young-Joo Lee, Young-Wuk Cho, Sung-Vin Yim, Kyung-Tae Lee. Relative bioavailability of levodropropizine 60 mg capsule and syrup formulations in healthy male Korean volunteers: a singledose, randomized-sequence, open-label, two-way crossover study.
International journal of clinical pharmacology and therapeutics.
2013 Feb; 51(2):152-60. doi:
10.5414/cp201730. [PMID: 23351597] - Lin Yan, Tongling Li, Rongqin Zhang, Xiaohong Xu, Pengcheng Zheng. HPLC determination and steady-state bioavailability study of levodropropizine sustained-release tablets in dogs.
Archives of pharmacal research.
2006 Jun; 29(6):514-9. doi:
10.1007/bf02969426. [PMID: 16833021] - Yunbiao Tang, Limei Zhao, Yingwu Wang, J Paul Fawcett, Jingkai Gu. Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of levodropropizine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 May; 819(1):185-9. doi:
10.1016/j.jchromb.2005.01.029. [PMID: 15797538] - Li-mei Zhao, Li Zhao, Ya-xin Sun, Feng Qiu, Shan-bin Guo. [Determination of levodropropizine and its pharmacokinetics in human plasma using LC/MS/MS].
Yao xue xue bao = Acta pharmaceutica Sinica.
2004 Dec; 39(12):993-6. doi:
NULL. [PMID: 15813028] - Roland F Staack, Denis S Theobald, Hans H Maurer. Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.
Therapeutic drug monitoring.
2004 Aug; 26(4):441-9. doi:
10.1097/00007691-200408000-00015. [PMID: 15257075] - Roland F Staack, Hans H Maurer. Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Dec; 798(2):333-42. doi:
10.1016/j.jchromb.2003.10.004. [PMID: 14643514] - G Nosál'ová, J Mokrý, K M Tareq Hassan. Antitussive activity of the fruit extract of Emblica officinalis Gaertn. (Euphorbiaceae).
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2003; 10(6-7):583-9. doi:
10.1078/094471103322331872. [PMID: 13678247] - F Tagliaro, M Moffa, Z De Battisti, F P Smith, M Gentile. High-performance liquid chromatographic determination of levodropropizine in human plasma with fluorometric detection.
Journal of chromatography. B, Biomedical applications.
1996 Oct; 685(1):165-70. doi:
10.1016/0378-4347(96)00163-6. [PMID: 8930765] - I Yamawaki, P Geppetti, C Bertrand, O Huber, L Daffonchio, C Omini, J A Nadel. Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea.
European journal of pharmacology.
1993 Oct; 243(1):1-6. doi:
10.1016/0014-2999(93)90159-f. [PMID: 7504629] - M Borsa, G Glavenna, M P Ferrari, S Canali, C Giachetti, G Zanolo. Linearity of levodropropizine, a new antitussive drug, in the healthy volunteer.
European journal of drug metabolism and pharmacokinetics.
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NULL. [PMID: 1820875] - P Zaratin, L De Angelis, F Cattabeni. Gas chromatographic-mass spectrometric determination of levodropropizine plasma levels in healthy volunteers.
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