DL-Homocysteic acid (BioDeep_00000178464)

   

human metabolite blood metabolite


代谢物信息卡片


Homocysteic acid, monosodium salt, (+-)-isomer

化学式: C4H9NO5S (183.0201424)
中文名称: DL-高磺基丙氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 25%

分子结构信息

SMILES: C(CS(=O)(=O)O)C(C(=O)O)N
InChI: InChI=1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Hendrik Nieraad, Natasja de Bruin, Olga Arne, Martine C J Hofmann, Robert Gurke, Dominik Schmidt, Marcel Ritter, Michael J Parnham, Gerd Geisslinger. Effects of Alzheimer-Like Pathology on Homocysteine and Homocysteic Acid Levels-An Exploratory In Vivo Kinetic Study. International journal of molecular sciences. 2021 Jan; 22(2):. doi: 10.3390/ijms22020927. [PMID: 33477684]
  • Hendrik Nieraad, Natasja de Bruin, Olga Arne, Martine C J Hofmann, Mike Schmidt, Takashi Saito, Takaomi C Saido, Robert Gurke, Dominik Schmidt, Uwe Till, Michael J Parnham, Gerd Geisslinger. Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer's Disease. Nutrients. 2020 Oct; 12(11):. doi: 10.3390/nu12113248. [PMID: 33114054]
  • Tohru Hasegawa, Yoshinori Kosoku, Yuka Sano, Hiroshi Yoshida, Chiaki Kudoh, Takeshi Tabira. Homocysteic Acid in Blood Can Detect Mild Cognitive Impairment: A Preliminary Study. Journal of Alzheimer's disease : JAD. 2020; 77(2):773-780. doi: 10.3233/jad-200234. [PMID: 32741817]
  • R Gurke, D Schmidt, D Thomas, S C Fleck, G Geisslinger, N Ferreirós. A validated LC-MS/MS method for the determination of homocysteic acid in biological samples. Journal of pharmaceutical and biomedical analysis. 2019 Sep; 174(?):578-587. doi: 10.1016/j.jpba.2019.06.008. [PMID: 31261039]
  • Daolin Mou, Jun Wang, Hong Liu, Yuling Chen, Lianqiang Che, Zhengfeng Fang, Shengyu Xu, Yan Lin, Bin Feng, Jian Li, De Wu. Maternal methyl donor supplementation during gestation counteracts bisphenol A-induced oxidative stress in sows and offspring. Nutrition (Burbank, Los Angeles County, Calif.). 2018 Jan; 45(?):76-84. doi: 10.1016/j.nut.2017.03.012. [PMID: 29129240]
  • Tohru Hasegawa, Wataru Ukai. Targeting therapy for homocysteic acid in the blood represents a potential recovery treatment for cognition in Alzheimer's disease patients. Aging. 2016 09; 8(9):1838-1843. doi: 10.18632/aging.101046. [PMID: 27632569]
  • E Stone, J H Coote, T A Lovick. Effect of electrical vs. chemical deep brain stimulation at midbrain sites on micturition in anaesthetized rats. Acta physiologica (Oxford, England). 2015 May; 214(1):135-45. doi: 10.1111/apha.12491. [PMID: 25778550]
  • Min Tan, Ying Ouyang, Minghua Jin, Meihui Chen, Peiqing Liu, Xiaojuan Chao, Ziwei Chen, Xiaohong Chen, Charles Ramassamy, Youheng Gao, Rongbiao Pi. Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells. Toxicology letters. 2013 Oct; 223(1):1-8. doi: 10.1016/j.toxlet.2013.08.011. [PMID: 23994730]
  • Yu-Peng Liu, Jin-Qing Song, Yan-Yan Ma, Tong-Fei Wu, Qiao Wang, Yu Huang, Yan-Ling Yang. [Skin lesions induced by malnutrition in an infant with methylmalonic aciduria and homocysteic acidemia]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. 2012 Mar; 14(3):233-4. doi: NULL. [PMID: 22433417]
  • Tohru Hasegawa, Masayoshi Ichiba, Shin-Ei Matsumoto, Koji Kasanuki, Taku Hatano, Hiroshige Fujishiro, Eizo Iseki, Nobutaka Hattori, Tatsuo Yamada, Takeshi Tabira. Urinary homocysteic acid levels correlate with mini-mental state examination scores in Alzheimer's disease patients. Journal of Alzheimer's disease : JAD. 2012; 31(1):59-64. doi: 10.3233/jad-2012-120022. [PMID: 22531414]
  • C Dean. Cannabinoid and GABA modulation of sympathetic nerve activity and blood pressure in the dorsal periaqueductal gray of the rat. American journal of physiology. Regulatory, integrative and comparative physiology. 2011 Dec; 301(6):R1765-72. doi: 10.1152/ajpregu.00398.2011. [PMID: 21940402]
  • Tomoko Nakamoto, Kanji Matsukawa, Nan Liang, Rie Wakasugi, L Britt Wilson, Jouji Horiuchi. Coactivation of renal sympathetic neurons and somatic motor neurons by chemical stimulation of the midbrain ventral tegmental area. Journal of applied physiology (Bethesda, Md. : 1985). 2011 May; 110(5):1342-53. doi: 10.1152/japplphysiol.01233.2010. [PMID: 21393462]
  • Kamon Iigaya, Jouji Horiuchi, Lachlan M McDowall, Roger A L Dampney. Topographical specificity of regulation of respiratory and renal sympathetic activity by the midbrain dorsolateral periaqueductal gray. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 Sep; 299(3):R853-61. doi: 10.1152/ajpregu.00249.2010. [PMID: 20504909]
  • Asya Makhro, Jue Wang, Johannes Vogel, Alexander A Boldyrev, Max Gassmann, Lars Kaestner, Anna Bogdanova. Functional NMDA receptors in rat erythrocytes. American journal of physiology. Cell physiology. 2010 Jun; 298(6):C1315-25. doi: 10.1152/ajpcell.00407.2009. [PMID: 20457837]
  • Sanda Mustapic, Tomislav Radocaj, Antonio Sanchez, Zoran Dogas, Astrid G Stucke, Francis A Hopp, Eckehard A E Stuth, Edward J Zuperku. Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region. Journal of neurophysiology. 2010 Jan; 103(1):409-18. doi: 10.1152/jn.00188.2009. [PMID: 19906886]
  • Mao-ping Chu, Xing Rong, Rong-zhou Wu, Ru-lian Xiang, Qiang Xu, Yuan-hai Zhang. [Reducing plasma homocysteic acid lowers serum C-reactive protein level in children with Kawasaki disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2007 Nov; 27(11):1762-3. doi: . [PMID: 18024309]
  • Jaroslava Folbergrová, Pavel Jesina, Zdenĕk Drahota, Václav Lisý, Renata Haugvicová, Alena Vojtísková, Josef Houstĕk. Mitochondrial complex I inhibition in cerebral cortex of immature rats following homocysteic acid-induced seizures. Experimental neurology. 2007 Apr; 204(2):597-609. doi: 10.1016/j.expneurol.2006.12.010. [PMID: 17270175]
  • Zhou Yang, J H Coote. Paraventricular nucleus influence on renal sympathetic activity in vasopressin gene-deleted rats. Experimental physiology. 2007 Jan; 92(1):109-17. doi: 10.1113/expphysiol.2006.034884. [PMID: 17012145]
  • Savita Khanna, Sashwati Roy, Narasimham L Parinandi, Mariah Maurer, Chandan K Sen. Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. Journal of neurochemistry. 2006 Sep; 98(5):1474-86. doi: 10.1111/j.1471-4159.2006.04000.x. [PMID: 16923160]
  • Derek Hayes, Michael Wiessner, Thomas Rauen, Gethin J McBean. Transport of L-[14C]cystine and L-[14C]cysteine by subtypes of high affinity glutamate transporters over-expressed in HEK cells. Neurochemistry international. 2005 Jun; 46(8):585-94. doi: 10.1016/j.neuint.2005.03.001. [PMID: 15863236]
  • Changjin Liu, Ai Li, Xinwu Hu, Ming Tang, Yimei Du, Liangpin Zhang, Lei Chen. Characterization of monoclonal antibody to L-homocysteic acid and its immunohistochemistry in rat hippocampus. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2005; 25(1):1-4. doi: 10.1007/bf02831371. [PMID: 15934293]
  • Z Yang, L Smith, J H Coote. Paraventricular nucleus activation of renal sympathetic neurones is synaptically depressed by nitric oxide and glycine acting at a spinal level. Neuroscience. 2004; 124(2):421-8. doi: 10.1016/j.neuroscience.2003.10.032. [PMID: 14980391]
  • Zhuo Yang, John H Coote. Role of GABA and NO in the paraventricular nucleus-mediated reflex inhibition of renal sympathetic nerve activity following stimulation of right atrial receptors in the rat. Experimental physiology. 2003 May; 88(3):335-42. doi: 10.1113/eph8802561. [PMID: 12719758]
  • Linda F Hayward, Alecia P Riley, Robert B Felder. alpha(2)-Adrenergic receptors in NTS facilitate baroreflex function in adult spontaneously hypertensive rats. American journal of physiology. Heart and circulatory physiology. 2002 Jun; 282(6):H2336-45. doi: 10.1152/ajpheart.00167.2001. [PMID: 12003844]
  • Hong Wang, Teresa P Germanson, Patrice G Guyenet. Depressor and tachypneic responses to chemical stimulation of the ventral respiratory group are reduced by ablation of neurokinin-1 receptor-expressing neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 May; 22(9):3755-64. doi: 20026344. [PMID: 11978851]
  • A K Topaloglu, C Sansaricq, S E Snyderman. Influence of metabolic control on growth in homocystinuria due to cystathionine B-synthase deficiency. Pediatric research. 2001 Jun; 49(6):796-8. doi: 10.1203/00006450-200106000-00014. [PMID: 11385140]
  • M Bago, C Dean. Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT(1A) receptors in the RVLM. American journal of physiology. Regulatory, integrative and comparative physiology. 2001 Apr; 280(4):R976-84. doi: 10.1152/ajpregu.2001.280.4.r976. [PMID: 11247817]
  • M Fritzer-Szekeres, H J Blom, G H Boers, T Szekeres, B Lubec. Growth promotion by homocysteine but not by homocysteic acid: a role for excessive growth in homocystinuria or proliferation in hyperhomocysteinemia?. Biochimica et biophysica acta. 1998 Jul; 1407(1):1-6. doi: 10.1016/s0925-4439(98)00008-8. [PMID: 9639661]
  • C T Quinn, J C Griener, T Bottiglieri, K Hyland, A Farrow, B A Kamen. Elevation of homocysteine and excitatory amino acid neurotransmitters in the CSF of children who receive methotrexate for the treatment of cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 1997 Aug; 15(8):2800-6. doi: 10.1200/jco.1997.15.8.2800. [PMID: 9256122]
  • K S Butcher, D F Cechetto. Insular lesion evokes autonomic effects of stroke in normotensive and hypertensive rats. Stroke. 1995 Mar; 26(3):459-65. doi: 10.1161/01.str.26.3.459. [PMID: 7886725]
  • K S Butcher, D F Cechetto. Autonomic responses of the insular cortex in hypertensive and normotensive rats. The American journal of physiology. 1995 Jan; 268(1 Pt 2):R214-22. doi: 10.1152/ajpregu.1995.268.1.r214. [PMID: 7840324]
  • G Frauscher, E Karnaukhova, A Muehl, H Hoeger, B Lubec. Oral administration of homocysteine leads to increased plasma triglycerides and homocysteic acid-additional mechanisms in homocysteine induced endothelial damage?. Life sciences. 1995; 57(8):813-7. doi: 10.1016/0024-3205(95)02009-8. [PMID: 7637554]
  • C R Santhosh-Kumar, J C Deutsch, J C Kolhouse, K L Hassell, J F Kolhouse. Measurement of excitatory sulfur amino acids, cysteine sulfinic acid, cysteic acid, homocysteine sulfinic acid, and homocysteic acid in serum by stable isotope dilution gas chromatography-mass spectrometry and selected ion monitoring. Analytical biochemistry. 1994 Aug; 220(2):249-56. doi: 10.1006/abio.1994.1335. [PMID: 7978266]
  • C Dean, J P Kampine. A role for serotonin in the elaboration of a differential pattern of activity in sympathetic nerves to kidney and skeletal muscle vasculature. Journal of the autonomic nervous system. 1993 Aug; 44(2-3):207-15. doi: 10.1016/0165-1838(93)90033-q. [PMID: 8227956]
  • R Griffiths, A Grieve, S Allen, H J Olverman. Neuronal and glial plasma membrane carrier-mediated uptake of L-homocysteate is not selectively blocked by beta-p-chlorophenylglutamate. Neuroscience letters. 1992 Dec; 147(2):175-8. doi: 10.1016/0304-3940(92)90588-x. [PMID: 1491803]
  • R B Taylor, L C Weaver. Spinal stimulation to locate preganglionic neurons controlling the kidney, spleen, or intestine. The American journal of physiology. 1992 Oct; 263(4 Pt 2):H1026-33. doi: 10.1152/ajpheart.1992.263.4.h1026. [PMID: 1415750]
  • A Grieve, R Griffiths. Simultaneous measurement by HPLC of the excitatory amino acid transmitter candidates homocysteate and homocysteine sulphinate supports a predominant astrocytic localisation. Neuroscience letters. 1992 Sep; 145(1):1-5. doi: 10.1016/0304-3940(92)90189-e. [PMID: 1361042]
  • C Dean, J L Seagard, F A Hopp, J P Kampine. Differential control of sympathetic activity to kidney and skeletal muscle by ventral medullary neurons. Journal of the autonomic nervous system. 1992 Jan; 37(1):1-10. doi: 10.1016/0165-1838(92)90139-8. [PMID: 1593089]
  • N Zhang, O P Ottersen. Differential cellular distribution of two sulphur-containing amino acids in rat cerebellum. An immunocytochemical investigation using antisera to taurine and homocysteic acid. Experimental brain research. 1992; 90(1):11-20. doi: 10.1007/bf00229251. [PMID: 1521599]
  • D J Beluli, L C Weaver. Differential control of renal and splenic nerves without medullary topography. The American journal of physiology. 1991 Apr; 260(4 Pt 2):H1072-9. doi: 10.1152/ajpheart.1991.260.4.h1072. [PMID: 2012213]
  • W O Boggan, J G Ondo. Effect of central administration of phencyclidine on plasma concentrations of luteinizing hormone. Brain research. 1989 Jan; 478(2):382-4. doi: 10.1016/0006-8993(89)91521-7. [PMID: 2564302]
  • C Dean, D R Kostreva. Cardiac, respiratory, and renal responses to stimulation of the external cuneate nucleus. Journal of applied physiology (Bethesda, Md. : 1985). 1987 Jul; 63(1):158-66. doi: 10.1152/jappl.1987.63.1.158. [PMID: 3305465]
  • A F Sved, G Felsten. Stimulation of the locus coeruleus decreases arterial pressure. Brain research. 1987 Jun; 414(1):119-32. doi: 10.1016/0006-8993(87)91332-1. [PMID: 2887237]
  • S M Hilton, W S Redfern. A search for brain stem cell groups integrating the defence reaction in the rat. The Journal of physiology. 1986 Sep; 378(?):213-28. doi: 10.1113/jphysiol.1986.sp016215. [PMID: 3795103]
  • R M McAllen. Action and specificity of ventral medullary vasopressor neurones in the cat. Neuroscience. 1986 May; 18(1):51-9. doi: 10.1016/0306-4522(86)90178-8. [PMID: 2874523]
  • R M McAllen. Location of neurones with cardiovascular and respiratory function, at the ventral surface of the cat's medulla. Neuroscience. 1986 May; 18(1):43-9. doi: 10.1016/0306-4522(86)90177-6. [PMID: 2874522]
  • M T Price, J W Olney, T J Cicero. Acute elevations of serum luteinizing hormone induced by kainic acid, N-methyl aspartic acid or homocysteic acid. Neuroendocrinology. 1978; 26(6):352-8. doi: 10.1159/000122790. [PMID: 692809]
  • P Clopath, V C Smith, K S McCully. Growth promotion by homocysteic acid. Science (New York, N.Y.). 1976 Apr; 192(4237):372-4. doi: 10.1126/science.1257770. [PMID: 1257770]