Clopidogrel (BioDeep_00000017843)
human metabolite
代谢物信息卡片
methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate
化学式: C16H16ClNO2S (321.0590226)
中文名称: 氯吡格雷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: ClC1=C(C=CC=C1)[C@H](N2CCC3=C(C2)C=CS3)C(OC)=O
InChI: InChI=1S/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/m0/s1
描述信息
Clopidogrel is a potent oral antiplatelet agent often used in the treatment of coronary artery disease, peripheral vascular disease, and cerebrovascular disease. It is marketed by Bristol-Myers Squibb and Sanofi-Aventis under the trade name Plavix. -- Wikipedia; Clopidogrel is a potent oral antiplatelet agent often used in the treatment of coronary artery disease, peripheral vascular disease, and cerebrovascular disease. It is marketed by Bristol-Myers Squibb and Sanofi-Aventis under the trade name Plavix. It is also marketed in the generic form by Apotex, a large Canadian generic pharmaceutical company, though an injunction to withhold further shipments of their form is in effect while patent issues are dealt with. In 2005 it was the worlds second highest selling pharmaceutical with sales of US$5.9 billion. [HMDB]
Clopidogrel is a potent oral antiplatelet agent often used in the treatment of coronary artery disease, peripheral vascular disease, and cerebrovascular disease. It is marketed by Bristol-Myers Squibb and Sanofi-Aventis under the trade name Plavix. -- Wikipedia; Clopidogrel is a potent oral antiplatelet agent often used in the treatment of coronary artery disease, peripheral vascular disease, and cerebrovascular disease. It is marketed by Bristol-Myers Squibb and Sanofi-Aventis under the trade name Plavix. It is also marketed in the generic form by Apotex, a large Canadian generic pharmaceutical company, though an injunction to withhold further shipments of their form is in effect while patent issues are dealt with. In 2005 it was the worlds second highest selling pharmaceutical with sales of US$5.9 billion.
B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AC - Platelet aggregation inhibitors excl. heparin
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent > C190801 - P2Y12 Inhibitor
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Clopidogrel is an orally active platelet inhibitor that targets P2Y12 receptor. Clopidogrel is used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
同义名列表
21 个代谢物同义名
methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate; BMS Brand 2 OF clopidogrel bisulfate; BMS Brand 1 OF clopidogrel bisulfate; Clopidogrel, (+)(S)-isomer; Clopidogrel hydrochloride; Clopidogrel napadisilate; Clopidogrel bisulphate; Clopidogrel bisulfate; Clopidogrel besilate; Clopidogrel besylate; (+)-(S)-Clopidogrel; Clopidogrel sandoz; Clopidogrel-mepha; Clopidogrel mepha; (S)-Clopidogrel; (+)-Clopidogrel; Clopidogrelum; Clopidogrel; Isocover; Iscover; Plavix
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:37941
- PubChem: 60606
- HMDB: HMDB0005011
- DrugBank: DB00758
- ChEMBL: CHEMBL1083385
- ChEMBL: CHEMBL1771
- Wikipedia: Clopidogrel
- MeSH: Clopidogrel
- foodb: FDB023584
- chemspider: 54632
- CAS: 113665-84-2
- PMhub: MS000000552
- medchemexpress: HY-15283
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Clopidogrel Action Pathway:
Clopidogrel + Oxygen + Water ⟶ 2-Oxoclopidogrel + Hydrogen peroxide - Clopidogrel Metabolism Pathway:
Clopidogrel + Oxygen + Water ⟶ 2-Oxoclopidogrel + Hydrogen peroxide
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hui-Sheng Chen, Yu Cui, Xin-Hong Wang, Yu-Tong Ma, Jing Han, Ying-Jie Duan, Jiang Lu, Li-Ying Shen, Yong Liang, Wei-Zhong Wang, Hui Wang, Yong Zhao, Jin-Tao Zhang, Yu-Lin Song, Xiao-Mei He, Run-Hui Li, Ding-Bo Tao, Jing Li, Shu-Man Huang, Ni Wang, Mei Hong, Chong Meng, Wei Zhang, Duo-Lao Wang, Thanh N Nguyen. Clopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke: The ATAMIS Randomized Clinical Trial.
JAMA neurology.
2024 May; 81(5):450-460. doi:
10.1001/jamaneurol.2024.0146. [PMID: 38466274] - Yongkang Zhang, Qingzhi Ran, Kangli Yin, Yinkai Wang, Jiarui Liu, Yuan Zong, Yuzhen Wang, Yemin Cao. The effects of CYP2C19 genotype polymorphism and clopidogrel resistance on ischemic event occurrence in patients with peripheral arterial disease undergoing revascularization: A prospective cohort study.
Thrombosis research.
2024 Apr; 236(?):37-50. doi:
10.1016/j.thromres.2024.02.010. [PMID: 38387302] - Chayakrit Krittanawong, Johao Escobar, Hafeez Ul Hassan Virk, Mahboob Alam, Salim Virani, Carl J Lavie, K M Venkat Narayan, Raman Sharma. Lifestyle Approach and Medical Therapy of Lower Extremity Peripheral Artery Disease.
The American journal of medicine.
2024 Mar; 137(3):202-209. doi:
10.1016/j.amjmed.2023.10.028. [PMID: 37980970] - Hongwei Li, Yizhen Fang, Yongquan Chen, Yuning Lin, Zanxi Fang, Zhiyuan Lin, Huabin Xie, Zhongying Zhang. A novel AllGlo probe-quantitative PCR method for detecting single nucleotide polymorphism in CYP2C19 to evaluate the antiplatelet activity of clopidogrel.
Scientific reports.
2024 01; 14(1):2358. doi:
10.1038/s41598-024-52540-3. [PMID: 38286794] - Ruoyan Yu, Qinglin Yu, Zhenwei Li, Jiyi Li, Jin Yang, Yingchu Hu, Nan Zheng, Xiaojin Li, Yudie Song, Jiahui Li, Xiaomin Chen, Weiping Du, Jia Su. Transcriptome-wide map of N6-methyladenosine (m6A) profiling in coronary artery disease (CAD) with clopidogrel resistance.
Clinical epigenetics.
2023 Dec; 15(1):194. doi:
10.1186/s13148-023-01602-w. [PMID: 38098098] - Yinxue Guo, Pingyu Ge, Ziju Li, Jingxia Xiao, Lirui Xie. Ticagrelor or Clopidogrel as Antiplatelet Agents in Patients with Chronic Kidney Disease and Cardiovascular Disease: A Meta-analysis.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2023 Sep; 23(5):533-546. doi:
10.1007/s40256-023-00600-w. [PMID: 37530990] - Miaohan Qiu, Kun Na, Zizhao Qi, He Zhou, Pengxiao Li, Kai Xu, Bin Wang, Haiwei Liu, Jing Li, Yi Li, Yaling Han. Contemporary Use of Ticagrelor vs Clopidogrel in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A GRACE Risk Score Stratification-Based Analysis in a Large-Scale, Real-World Study From China.
Mayo Clinic proceedings.
2023 Jul; 98(7):1021-1032. doi:
10.1016/j.mayocp.2023.02.004. [PMID: 37419570] - Yiting Luo, Yunli Xia, Haonan Zhang, Yunzhu Lin, Lili He, Tao Gong, Zhirong Zhang, Li Deng. Human Serum Albumin-enriched Clopidogrel Bisulfate Nanoparticle Alleviates Cerebral Ischemia-Reperfusion Injury in Rats.
Pharmaceutical research.
2023 Jul; 40(7):1821-1833. doi:
10.1007/s11095-023-03543-8. [PMID: 37291463] - Hui-Sheng Chen, Yu Cui, Zhong-He Zhou, Hong Zhang, Li-Xia Wang, Wei-Zhong Wang, Li-Ying Shen, Li-Yan Guo, Er-Qiang Wang, Rui-Xian Wang, Jing Han, Yu-Ling Dong, Jing Li, Yong-Zhong Lin, Qing-Cheng Yang, Li Zhang, Jing-Yu Li, Jin Wang, Lei Xia, Guang-Bin Ma, Jiang Lu, Chang-Hao Jiang, Shu-Man Huang, Li-Shu Wan, Xiang-Yu Piao, Zhuo Li, Yan-Song Li, Kui-Hua Yang, Duo-Lao Wang, Thanh N Nguyen. Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial.
JAMA.
2023 06; 329(24):2135-2144. doi:
10.1001/jama.2023.7827. [PMID: 37367978] - Ziwei Xi, Yong Wang, Qianhong Lu, Hong Qiu, Yanan Gao, Ang Gao, Runlin Gao. Implementation of CYP2C19 genotyping and clinical outcomes following percutaneous coronary intervention in East Asian patients treated with oral P2Y12 inhibitors.
Thrombosis research.
2023 May; 228(?):85-93. doi:
10.1016/j.thromres.2023.05.023. [PMID: 37301117] - Anxin Wang, Xia Meng, Xue Tian, Yingting Zuo, Philip M Bath, Hao Li, Xuewei Xie, Jing Jing, Jinxi Lin, Yilong Wang, Xingquan Zhao, Liping Liu, Zixiao Li, Yong Jiang, Jie Xu, Feng Wang, Weifeng Chen, Minghua Cao, Jianhua Li, Yongjun Wang. Ticagrelor Aspirin vs Clopidogrel Aspirin in CYP2C19 Loss-of-Function Carriers With Minor Stroke or TIA Stratified by Risk Profile.
Neurology.
2023 01; 100(5):e497-e504. doi:
10.1212/wnl.0000000000201454. [PMID: 36535779] - Yongkang Zhang, Yuan Zong, Jiarui Liu, Kangli Yin, Yuzhen Wang, Yuefeng Bian, Yichen Huang, Wei Liu, Yemin Cao. Clopidogrel-Related High Residual Platelet Reactivity Associated with Estimated Glomerular Filtration Rate in Patients with Acute Ischemic Stroke.
Cerebrovascular diseases extra.
2023; 13(1):83-89. doi:
10.1159/000534466. [PMID: 37812922] - Xiao-Wen Yuan, Shi-Yun Yuan, Guo-Xin Wu, Zhi-Xin Wu, Zi-Yun Guan. Genetic polymorphism of clopidogrel metabolism related gene CYP2C19 gene in Chinese from Foshan area of Guangdong Province.
Hematology (Amsterdam, Netherlands).
2022 Dec; 27(1):1056-1061. doi:
10.1080/16078454.2022.2121899. [PMID: 36112003] - Bangqing Wu, Jiaojiao Yu, Yiting Luo, Lijun Wu, Zhirong Zhang, Li Deng. An Albumin-Enriched Nanocomplex Achieves Systemic Delivery of Clopidogrel Bisulfate to Ameliorate Renal Ischemia Reperfusion Injury in Rats.
Molecular pharmaceutics.
2022 11; 19(11):3934-3947. doi:
10.1021/acs.molpharmaceut.2c00401. [PMID: 36067352] - Dayong Zheng, Xiao Li, Yang Chu, Yazhuo Li, Dekun Li, Aichun Ju, Yi Wu, Yuesheng Xie, Wei Li. Interaction study of salvianolic acids for injection on pharmacokinetics of clopidogrel in rats using LC-MS/MS.
Biomedical chromatography : BMC.
2022 Nov; 36(11):e5463. doi:
10.1002/bmc.5463. [PMID: 35895507] - Jiyi Li, Jin Yang, Qinglin Yu, Lian Chen, Xiliang Shi, Jia Su, Keqi Zhu. The DNAm levels of CREB5 (cg11301281) were associated with clopidogrel resistance.
Journal of clinical laboratory analysis.
2022 Oct; 36(10):e24690. doi:
10.1002/jcla.24690. [PMID: 36087301] - Juan Tamargo, Juan Carlos Kaski, Takeshi Kimura, Jack Charles Barton, Ko Yamamoto, Maki Komiyama, Heinz Drexel, Basil S Lewis, Stefan Agewall, Koji Hasegawa. Racial and ethnic differences in pharmacotherapy to prevent coronary artery disease and thrombotic events.
European heart journal. Cardiovascular pharmacotherapy.
2022 Sep; 8(7):738-751. doi:
10.1093/ehjcvp/pvac040. [PMID: 35848895] - Anxin Wang, Xia Meng, Xue Tian, S Claiborne Johnston, Hao Li, Philip M Bath, Yingting Zuo, Xuewei Xie, Jing Jing, Jinxi Lin, Yilong Wang, Xingquan Zhao, Zixiao Li, Yong Jiang, Liping Liu, Feng Wang, Yanxia Wang, Panbing Huang, Guofang Chen, Yongjun Wang. Effect of Hypertension on Efficacy and Safety of Ticagrelor-Aspirin Versus Clopidogrel-Aspirin in Minor Stroke or Transient Ischemic Attack.
Stroke.
2022 09; 53(9):2799-2808. doi:
10.1161/strokeaha.122.038662. [PMID: 35656824] - Manish B Shah. Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges.
Biomolecules.
2022 09; 12(9):. doi:
10.3390/biom12091218. [PMID: 36139056] - Yuesong Pan, Runqi Wangqin, Hao Li, Aoming Jin, Jiejie Li, Jinxi Lin, Xia Meng, Ying Xian, Daniel T Laskowitz, Yongjun Wang. LDL-C levels, lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA.
Stroke and vascular neurology.
2022 08; 7(4):276-284. doi:
10.1136/svn-2021-001317. [PMID: 35256525] - Xiao-Yan Sheng, Hui-Jie An, Yong-Yang He, Yong-Feng Ye, Jia-Lan Zhao, Sai Li. High-Dose Clopidogrel versus Ticagrelor in CYP2C19 intermediate or poor metabolizers after percutaneous coronary intervention: A Meta-Analysis of Randomized Trials.
Journal of clinical pharmacy and therapeutics.
2022 Aug; 47(8):1112-1121. doi:
10.1111/jcpt.13665. [PMID: 35396752] - Yuesong Pan, Xia Meng, Aoming Jin, S Claiborne Johnston, Hao Li, Philip M Bath, Xuewei Xie, Jing Jing, Jinxi Lin, Yilong Wang, Xingquan Zhao, Zixiao Li, Yong Jiang, Liping Liu, Hongqin Yang, Jiwei Cheng, Zhimin Wang, Yongjun Wang. Time Course for Benefit and Risk With Ticagrelor and Aspirin in Individuals With Acute Ischemic Stroke or Transient Ischemic Attack Who Carry CYP2C19 Loss-of-Function Alleles: A Secondary Analysis of the CHANCE-2 Randomized Clinical Trial.
JAMA neurology.
2022 08; 79(8):739-745. doi:
10.1001/jamaneurol.2022.1457. [PMID: 35727586] - Carol Anne Graham, Mary K Tan, Derek P Chew, Christopher P Gale, Keith A A Fox, Akshay Bagai, Mark A Henderson, Ata Ur Rehman Quraishi, Jean-Pierre Déry, Asim N Cheema, Harold Fisher, David Brieger, Sohrab R Lutchmedial, Shahar Lavi, Brian Y L Wong, Tomas Cieza, Shamir R Mehta, Neil Brass, Shaun G Goodman, Andrew T Yan. Use and outcomes of dual antiplatelet therapy for acute coronary syndrome in patients with chronic kidney disease: insights from the Canadian Observational Antiplatelet Study (COAPT).
Heart and vessels.
2022 Aug; 37(8):1291-1298. doi:
10.1007/s00380-022-02029-8. [PMID: 35089380] - Yuichi Saito, Takeshi Nishi, Shinichi Wakabayashi, Yuji Ohno, Hideki Kitahara, Noritaka Ariyoshi, Yoshio Kobayashi. Differential Impact of Clinical and Genetic Factors on High Platelet Reactivity in Patients with Coronary Artery Disease Treated with Clopidogrel and Prasugrel.
Journal of atherosclerosis and thrombosis.
2022 Jul; 29(7):1031-1039. doi:
10.5551/jat.63035. [PMID: 34234079] - Cameron D Thomas, Francesco Franchi, Ellen C Keeley, Joseph S Rossi, Marshall Winget, R David Anderson, Alyssa L Dempsey, Yan Gong, Megan N Gower, Richard A Kerensky, Natasha Kulick, Jean G Malave, Caitrin W McDonough, Ian R Mulrenin, Petr Starostik, Amber L Beitelshees, Julie A Johnson, George A Stouffer, Almut G Winterstein, Dominick J Angiolillo, Craig R Lee, Larisa H Cavallari. Impact of the ABCD-GENE Score on Clopidogrel Clinical Effectiveness after PCI: A Multi-Site, Real-World Investigation.
Clinical pharmacology and therapeutics.
2022 Jul; 112(1):146-155. doi:
10.1002/cpt.2612. [PMID: 35429163] - Ozkan Ates, Ibrahim Yilmaz, Numan Karaarslan, Emel Ersoz, Fatma Bahar Hacioglu Kasim, Mustafa Dogan, Hanefi Ozbek. Coexistence of SARS-CoV-2 and cerebrovascular diseases: does COVID-19 positivity trigger cerebrovascular pathologies?.
Journal of infection in developing countries.
2022 Jun; 16(6):981-992. doi:
10.3855/jidc.15800. [PMID: 35797292] - Huihui Lv, Zidong Yang, Haibo Wu, Mingyuan Liu, Xiaowei Mao, Xu Liu, Hongyan Ding, Zhuqing Shi, Yang Zhou, Qianyun Liu, Yongkang Zhang, Yinting Zhou, Kai Chen, Zezhi Li, Qiang Dong, Jianpeng Ma, Yan Han. High On-Treatment Platelet Reactivity as Predictor of Long-term Clinical Outcomes in Stroke Patients with Antiplatelet Agents.
Translational stroke research.
2022 06; 13(3):391-398. doi:
10.1007/s12975-021-00949-7. [PMID: 34596891] - Tomohiro Higuchi, Mihoko Yamade, Satoru Takahashi, Satoshi Tamura, Shinya Tani, Takuma Kagami, Takahiro Uotani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Takahisa Furuta. Influence of daily versus alternate-day dosing of vonoprazan on intragastric pH, serum gastrin, and the antiplatelet function of clopidogrel : Influence of alternate-day dosing of vonoprazan.
European journal of clinical pharmacology.
2022 Jun; 78(6):955-963. doi:
10.1007/s00228-022-03313-2. [PMID: 35445847] - Jean Marie N Mwiza, Robert H Lee, David S Paul, Lori A Holle, Brian C Cooley, Bernhard Nieswandt, Wyatt J Schug, Tomohiro Kawano, Nigel Mackman, Alisa S Wolberg, Wolfgang Bergmeier. Both G protein-coupled and immunoreceptor tyrosine-based activation motif receptors mediate venous thrombosis in mice.
Blood.
2022 05; 139(21):3194-3203. doi:
10.1182/blood.2022015787. [PMID: 35358299] - Lei Zhang, Zhanhui Li, Yuewen Wu, Yanming Fan, Zhicong He, Peng He, Jingxing Liang. Cinnamon and Aspirin for Mild Ischemic Stroke or Transient Ischemic Attack: A Pilot Trial.
Clinical therapeutics.
2022 04; 44(4):482-490. doi:
10.1016/j.clinthera.2022.02.012. [PMID: 35346499] - S H Verhulst, E Boerrigter, S Ras, N P van Erp, P Hamberg. Unintentional combining enzalutamide with a moderate CYP2C8 inhibitor in a patient with metastatic castration-resistant prostate cancer: a case report.
Cancer chemotherapy and pharmacology.
2022 04; 89(4):539-542. doi:
10.1007/s00280-021-04379-y. [PMID: 35059789] - Janna K Duong, Romina A Nand, Aarti Patel, Oscar Della Pasqua, Annette S Gross. A physiologically based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: An evaluation of CYP2C19 activity.
Pharmacology research & perspectives.
2022 04; 10(2):e00946. doi:
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Annals of neurology.
2022 03; 91(3):380-388. doi:
10.1002/ana.26287. [PMID: 34951042] - Fabio Mangiacapra, Luca Paolucci, Michele M Viscusi, Roberto Mangiacapra, Pietro M Ferraro, Annunziata Nusca, Rosetta Melfi, Leonardo De Luca, Domenico Gabrielli, Gian P Ussia, Francesco Grigioni. Prevalence and clinical impact of high platelet reactivity in patients with chronic kidney disease treated with percutaneous coronary intervention: An updated systematic review and meta-analysis.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
2022 03; 99(4):1086-1094. doi:
10.1002/ccd.30071. [PMID: 35088526] - Yan-Jun Lin, Kun-Li Jiao, Bo Liu, Lu Fang, Shu Meng. Antiplatelet and myocardial protective effect of Shexiang Tongxin Dropping Pill in patients undergoing percutaneous coronary intervention: A randomized controlled trial.
Journal of integrative medicine.
2022 03; 20(2):126-134. doi:
10.1016/j.joim.2022.01.001. [PMID: 35101369] - Firas Kobeissy, Khalil Mallah, Kazem Zibara, Fatima Dakroub, Zeinab Dalloul, Mohammad Nasser, Leila Nasrallah, Zahraa Mallah, Ghewa A El-Achkar, Naify Ramadan, Wael Mohamed, Stefania Mondello, Hala Darwish, Eva Hamade, Aida Habib. The effect of clopidogrel and aspirin on the severity of traumatic brain injury in a rat model.
Neurochemistry international.
2022 03; 154(?):105301. doi:
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Blood advances.
2022 02; 6(4):1271-1277. doi:
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Journal of the American Heart Association.
2022 02; 11(4):e024156. doi:
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BMC cardiovascular disorders.
2022 02; 22(1):40. doi:
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Journal of the American Heart Association.
2022 02; 11(3):e023223. doi:
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Translational stroke research.
2022 02; 13(1):46-55. doi:
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Stroke.
2022 02; 53(2):465-472. doi:
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2022 Feb; 73(1):. doi:
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The Annals of thoracic surgery.
2022 02; 113(2):562. doi:
10.1016/j.athoracsur.2021.04.088. [PMID: 34022214] - Jeffrey S Berger, Lucy Z Kornblith, Michelle N Gong, Harmony R Reynolds, Mary Cushman, Yu Cheng, Bryan J McVerry, Keri S Kim, Renato D Lopes, Bassel Atassi, Scott Berry, Grant Bochicchio, Murillo de Oliveira Antunes, Michael E Farkouh, Yonatan Greenstein, Erinn M Hade, Kristin Hudock, Robert Hyzy, Pooja Khatri, Andrei Kindzelski, Bridget-Anne Kirwan, Lisa Baumann Kreuziger, Patrick R Lawler, Eric Leifer, Jose Lopez-Sendon Moreno, Jose Lopez-Sendon, James F Luther, Lilia Nigro Maia, John Quigley, Robert Sherwin, Lana Wahid, Jennifer Wilson, Judith S Hochman, Matthew D Neal. Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non-Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
JAMA.
2022 01; 327(3):227-236. doi:
10.1001/jama.2021.23605. [PMID: 35040887] - Ali Tafazoli, Shreya Anil Kumar, Maha Othman. Thrombocytopathy vs Platelet hyper-reactivity in COVID-19: diverse pathologies, disease outcomes and therapeutic implications.
Platelets.
2022 Jan; 33(1):48-53. doi:
10.1080/09537104.2021.1961718. [PMID: 34847829] - Aleksi Tornio, Anne M Filppula, Janne T Backman. Translational aspects of cytochrome P450-mediated drug-drug interactions: A case study with clopidogrel.
Basic & clinical pharmacology & toxicology.
2022 Jan; 130 Suppl 1(?):48-59. doi:
10.1111/bcpt.13647. [PMID: 34410044] - Abdullah Alkattan, Ahmed Alkhalifah, Eman Alsalameen, Fatimah Alghanim, Nashwa Radwan. Polymorphisms of genes related to phase II metabolism and resistance to clopidogrel.
Pharmacogenomics.
2022 01; 23(1):61-79. doi:
10.2217/pgs-2021-0092. [PMID: 34866404] - Lifang Ma, Zhe Chen, Yan'e Li, Xin Meng, Yongsheng Ma. Clinical Study of Clopidogrel Combined with Huoxue Tongluo Prescription in Improving Transient Ischemic Attack and the Effect on MMP-9, Hcy, and CRP.
Journal of healthcare engineering.
2022; 2022(?):6368219. doi:
10.1155/2022/6368219. [PMID: 35399851] - Zahra Lotfollahi, Ana P Q Mello, Francisco A H Fonseca, Luciene O Machado, Andressa F Mathias, Maria C Izar, Nagila R T Damasceno, Cristiano L P Oliveira, Antônio M F Neto. Changes in lipoproteins associated with lipid-lowering and antiplatelet strategies in patients with acute myocardial infarction.
PloS one.
2022; 17(8):e0273292. doi:
10.1371/journal.pone.0273292. [PMID: 36040917] - Xuan Jiang, Fareed Khan, Enyi Shi, Ruixin Fan, Ximing Qian, Hongjia Zhang, Tianxiang Gu. Outcomes of preoperative antiplatelet therapy in patients with acute type A aortic dissection.
Journal of cardiac surgery.
2022 Jan; 37(1):53-61. doi:
10.1111/jocs.16080. [PMID: 34657299] - Youwen Yang, Zongtao Huang, Xueji Zhang. Efficacy and safety of clopidogrel and/or aspirin for ischemic stroke/transient ischemic attack: An overview of systematic reviews and meta-analysis.
Medicine.
2021 Dec; 100(50):e27804. doi:
10.1097/md.0000000000027804. [PMID: 34918630] - Hongyu Xu, Qinglin Yu, Honglin Zhou, Jin Yang, Nan Zheng, Zhifeng Xu, Jia Su. Polymorphisms in the GCK gene increase the risk of clopidogrel resistance in stable coronary artery disease (SCAD) patients.
Hematology (Amsterdam, Netherlands).
2021 Dec; 26(1):447-452. doi:
10.1080/16078454.2021.1945789. [PMID: 34165031] - Yan-Ling Liu, Xiao-Lei Hu, Pei-Yuan Song, He Li, Mu-Peng Li, Yin-Xiao Du, Mo-Yun Li, Qi-Lin Ma, Li-Ming Peng, Ming-Yu Song, Xiao-Ping Chen. Influence of GAS5/MicroRNA-223-3p/P2Y12 Axis on Clopidogrel Response in Coronary Artery Disease.
Journal of the American Heart Association.
2021 11; 10(21):e021129. doi:
10.1161/jaha.121.021129. [PMID: 34713722] - Jinyan Zhong, Qinglin Yu, Nan Zheng, Jia Su, Xiaowei Zheng, Liangrong Zheng, Xiaomin Chen. Gene polymorphisms of insulin secretion signaling pathway associated with clopidogrel resistance in Han Chinese population.
Journal of clinical laboratory analysis.
2021 Nov; 35(11):e23970. doi:
10.1002/jcla.23970. [PMID: 34609028] - Li Deng, Hai-Zhen Jia, Mao-Chun Li, Wei Zhu. Comparison of the effect of ticagrelor combined with tirofiban versus clopidogrel combined with tirofiban on inflammation response and prognosis of patients with unstable angina pectoris in long term follow-up.
The Kaohsiung journal of medical sciences.
2021 Nov; 37(11):1010-1015. doi:
10.1002/kjm2.12421. [PMID: 34338425] - Ying-Chang Tung, Chi-Jen Chang, Jia-Rou Liu, Shu-Hao Chang, Yi-Hsin Chan, Chi-Tai Kuo, Lai-Chu See. Outcomes after ticagrelor versus clopidogrel treatment in end-stage renal disease patients with acute myocardial infarction: a nationwide cohort study.
Scientific reports.
2021 10; 11(1):20826. doi:
10.1038/s41598-021-00360-0. [PMID: 34675293] - Yutaka Hatakeyama, Taro Horino, Tatsuki Matsumoto, Yoshio Terada, Yoshiyasu Okuhara. Long-term continuous use of proton-pump inhibitors is associated with renal function decline in patients without acute kidney injury.
Clinical and experimental nephrology.
2021 Oct; 25(10):1087-1092. doi:
10.1007/s10157-021-02066-z. [PMID: 34089392] - Mate Petricevic, Jadranka Knezevic, Bojan Biocina, Mislav Mikus, Lucija Konosic, Mario Rasic, Milan Milosevic, Cecilija Rotim, Tomislav Madzar, Ante Rotim, Hrvoje Gasparovic, Klaus Goerlinger. Association among Clopidogrel Cessation, Platelet Function, and Bleeding in Coronary Bypass Surgery: An Observational Trial.
The Thoracic and cardiovascular surgeon.
2021 Oct; 69(7):630-638. doi:
10.1055/s-0039-1693122. [PMID: 31362327] - Jose C Alonso-Escalante, Lorenzo Machado, Kiumars R Tabar, Rachell Tindall, Ngoc Thai, Tadahiro Uemura. Is Continuing Anticoagulation or Antiplatelet Therapy Safe Prior to Kidney Transplantation?.
Annals of transplantation.
2021 Sep; 26(?):e931648. doi:
10.12659/aot.931648. [PMID: 34580271] - Levent Altınay, Erdem Çetin. The comparison between the effects of aspirin and clopidogrel monotherapy on postoperative bleeding in diabetic patients after off-pump coronary artery bypass surgery.
Reviews in cardiovascular medicine.
2021 Sep; 22(3):975-981. doi:
10.31083/j.rcm2203106. [PMID: 34565098] - Yuan-Dong Zheng, Hua Zhang, Yan Zhan, Yi-Cong Bian, Sheng Ma, Hai-Xian Gan, Xiao-Juan Lai, Yong-Qiang Liu, Yan-Chun Gong, Xue-Fang Liu, Hong-Bin Sun, Yong-Guo Li, Da-Fang Zhong, Li-Yan Miao, Xing-Xing Diao. Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans.
Acta pharmacologica Sinica.
2021 Sep; 42(9):1535-1546. doi:
10.1038/s41401-020-00547-7. [PMID: 33244163] - Jia Su, Qinglin Yu, Jin Yang, Nan Zheng, Jinyan Zhong, Lindan Ji, Jiyi Li, Xiaomin Chen. The association of polymorphisms in related circadian rhythm genes and clopidogrel resistance susceptibility.
Basic & clinical pharmacology & toxicology.
2021 Sep; 129(3):196-209. doi:
10.1111/bcpt.13622. [PMID: 34117726] - Jiajing Wang, Mengqi Han, Jie Kuang, Jianglong Tu, Katherine Starcevich, Peter Gao, Chen Peng, Shujuan Yin, Jibiao Chen, Xiaolin Zhang, Weijie Jia, Yifan Wu, Yingping Yi. Personalized antiplatelet therapy based on clopidogrel/aspirin resistance tests in acute ischemic stroke and transient ischemic attack: Study protocol of a multi-center, single-blinded and randomized controlled trial.
Contemporary clinical trials.
2021 09; 108(?):106507. doi:
10.1016/j.cct.2021.106507. [PMID: 34274496] - Hui Wu, Xinli Chen, Yongli Ding, Yanglin Deng, Ruilan Ma, Xinyuan Chen, Xuesong Li. Study on the effect of CYP2C19 genetic polymorphism and plasma concentration on clopidogrel resistance.
Pakistan journal of pharmaceutical sciences.
2021 Sep; 34(5):1685-1691. doi:
NULL. [PMID: 34803003] - Blanca Trejo-Velasco, Antonio Tello-Montoliu, Ignacio Cruz-González, Raul Moreno, Jose A Baz-Alonso, Pablo J Salvadores, Rafael Romaguera, Eduardo Molina-Navarro, Emilio Paredes-Galán, Saleta Fernández-Barbeira, Alberto Ortiz-Saez, Guillermo Bastos-Fernandez, Antonio De Miguel-Castro, Adolfo Figueiras-Guzman, Andres Iñiguez-Romo, Victor A Jimenez-Diaz. Impact of Comorbidities and Antiplatelet Regimen on Platelet Reactivity Levels in Patients Undergoing Transcatheter Aortic Valve Implantation.
Journal of cardiovascular pharmacology.
2021 09; 78(3):463-473. doi:
10.1097/fjc.0000000000001075. [PMID: 34117181] - Peng-Xin Ge, Li-Ping Jiang, Ting Tai, Ting Zhu, Jin-Zi Ji, Yi-Fei Li, Qiong-Yu Mi, Hong-Guang Xie. Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice.
Life sciences.
2021 Aug; 279(?):119268. doi:
10.1016/j.lfs.2021.119268. [PMID: 33626394] - Ahmad Makhdoum, Nitish K Dhingra, Aathmika Kirubaharan, Rachel Eikelboom, Jessica Luc, Olina Dagher, Joel Bierer, Andreanne Cartier, Olivier Vaillancourt, Thin X Vo, Keir Forgie, Gianluigi Bisleri, Terrence M Yau, Subodh Verma, Bobby Yanagawa. Ticagrelor use and practice patterns among Canadian cardiac surgeons.
Journal of cardiac surgery.
2021 Aug; 36(8):2793-2801. doi:
10.1111/jocs.15636. [PMID: 34028081] - Kais Mnafgui, Lakhdar Ghazouani, Raouf Hajji, Abir Tlili, Fatma Derbali, Francisco Ivan da Silva, Joabe Lima Araújo, Bianca de Oliveira Schinoff, José Fernando Ruggiero Bachega, Antônia Laíres da Silva Santos, Noureddine Allouche. Oleuropein Protects Against Cerebral Ischemia Injury in Rats: Molecular Docking, Biochemical and Histological Findings.
Neurochemical research.
2021 Aug; 46(8):2131-2142. doi:
10.1007/s11064-021-03351-9. [PMID: 34008118] - Yu Ueda, Ronald H L Li, Nghi Nguyen, Eric S Ontiveros, Samantha L Kovacs, Maureen S Oldach, Karen M Vernau, Michael H Court, Joshua A Stern. A genetic polymorphism in P2RY1 impacts response to clopidogrel in cats with hypertrophic cardiomyopathy.
Scientific reports.
2021 06; 11(1):12522. doi:
10.1038/s41598-021-91372-3. [PMID: 34131167] - Karla N Samman, Pamela Mehanna, Emad Takla, Jean-Christophe Grenier, Mark Y Chan, Renato D Lopes, Megan Lee Neely, Tracy Y Wang, L Kristin Newby, Richard C Becker, Marie Lordkipanidzé, Matthieu Ruiz, Julie G Hussin, E Marc Jolicœur. Differential modulation of polyunsaturated fatty acids in patients with myocardial infarction treated with ticagrelor or clopidogrel.
Cell reports. Medicine.
2021 06; 2(6):100299. doi:
10.1016/j.xcrm.2021.100299. [PMID: 34195679] - Xiaojing Li, Qi Yao, Hanbin Cui, Jun Yang, Nan Wu, Yahui Liu, Ying Zhou, Yinwei Zhang, Jia Su, Yezi Xia, Xiaomin Chen. MiR-223 or miR-126 predicts resistance to dual antiplatelet therapy in patients with ST-elevation myocardial infarction.
The Journal of international medical research.
2021 Jun; 49(6):3000605211016209. doi:
10.1177/03000605211016209. [PMID: 34098766] - Qing Li, Yinong Chen, Ying Liu, Luyao Yu, Jingang Zheng, Yihong Sun. Impact of renal function on residual platelet reactivity and clinical outcomes in patients with acute coronary syndrome treated with clopidogrel.
Clinical cardiology.
2021 Jun; 44(6):789-796. doi:
10.1002/clc.23588. [PMID: 33978269] - Stephen A Clarkson, Brittain Heindl, Anping Cai, Mark Beasley, Chrisly Dillon, Nita Limdi, Todd M Brown. Outcomes of Individuals With and Without Heart Failure Presenting With Acute Coronary Syndrome.
The American journal of cardiology.
2021 06; 148(?):1-7. doi:
10.1016/j.amjcard.2021.02.027. [PMID: 33667441] - Yicong Ye, Xiliang Zhao, Yong Zeng. Serum Free Triiodothyronine and the Responsiveness to Clopidogrel in Patients Undergoing Elective Percutaneous Coronary Intervention.
Advances in therapy.
2021 06; 38(6):3077-3088. doi:
10.1007/s12325-021-01749-z. [PMID: 33913121] - Thomas A Mavrakanas, Omer Kamal, David M Charytan. Prasugrel and Ticagrelor in Patients with Drug-Eluting Stents and Kidney Failure.
Clinical journal of the American Society of Nephrology : CJASN.
2021 05; 16(5):757-764. doi:
10.2215/cjn.12120720. [PMID: 33811128] - Shulan Pi, Ling Mao, Jiefang Chen, Hanqing Shi, Yuxiao Liu, Xiaoqing Guo, Yuanyuan Li, Lian Zhou, Hui He, Cheng Yu, Jianyong Liu, Yiping Dang, Yuanpeng Xia, Quanwei He, Huijuan Jin, Yanan Li, Yu Hu, Yiliang Miao, Zhenyu Yue, Bo Hu. The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
Autophagy.
2021 04; 17(4):980-1000. doi:
10.1080/15548627.2020.1741202. [PMID: 32160082] - Nan Zheng, Fengying Yin, Qinglin Yu, Jinyan Zhong, Jin Yang, Zhifeng Xu, Jia Su, Xiaomin Chen. Associations of PER3 polymorphisms with clopidogrel resistance among Chinese Han people treated with clopidogrel.
Journal of clinical laboratory analysis.
2021 Apr; 35(4):e23713. doi:
10.1002/jcla.23713. [PMID: 33501709] - Shaoyi Lin, Xiaofeng Xu, Haochang Hu, Ji Cheng, Ruoyu Chen, Yingchu Hu, Xiaomin Chen. The expression profile of platelet-derived miRNA in coronary artery disease patients with clopidogrel resistance.
Pharmacology research & perspectives.
2021 04; 9(2):e00751. doi:
10.1002/prp2.751. [PMID: 33724726] - Ying Xue, Zi Wang, Hongyi Wu, Xiaoye Li, Jiahui Chen, Qianzhou Lv. Cilostazol increases adenosine plasma concentration in patients with acute coronary syndrome.
Journal of clinical pharmacy and therapeutics.
2021 Apr; 46(2):328-332. doi:
10.1111/jcpt.13284. [PMID: 33052628] - Naoki Katayama, Keiichi Odagiri, Akio Hakamata, Chiaki Kamiya, Shinya Uchida, Shimako Tanaka, Naoki Inui, Noriyuki Namiki, Koichiro Tatsumi, Hiroshi Watanabe. Clinical evaluation of drug-drug interactions between the cytochrome P450 substrates selexipag and clopidogrel in Japanese volunteers.
British journal of clinical pharmacology.
2021 04; 87(4):1903-1911. doi:
10.1111/bcp.14579. [PMID: 32997809] - Taiki Masuyama, Masashi Sakuma, Ryutaro Waku, Suguru Hirose, Keijiro Kitahara, Jin Naganuma, Hiroko Yazawa, Shigeru Toyoda, Shichiro Abe, Toshiaki Nakajima, Teruo Inoue. Effects of switching from clopidogrel to prasugrel at the chronic phase after coronary stenting on antiplatelet action and vascular endothelial function: Switch-Pras study.
Heart and vessels.
2021 Apr; 36(4):442-451. doi:
10.1007/s00380-020-01714-w. [PMID: 33113567] - Urszula Adamiak-Giera, Anna Czerkawska, Szymon Olędzki, Mateusz Kurzawski, Krzysztof Safranow, Maria Jastrzębska, Barbara Gawrońska-Szklarz. Impact of selected genetic factors on clopidogrel inactive metabolite level and antiplatelet response in patients after percutaneous coronary intervention.
Pharmacological reports : PR.
2021 Apr; 73(2):583-593. doi:
10.1007/s43440-020-00197-w. [PMID: 33270185] - Jian He, Wenxia Liu, Yu Zhang, Zunjian Zhang, Yuan Tian. Development and validation of a LC-MS/MS method for the enantioseparation and determination of clopidogrel bisulfate in beagle plasma and its application to a stereoselective pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2021 Mar; 196(?):113901. doi:
10.1016/j.jpba.2021.113901. [PMID: 33493742] - Asami Kamada, Mie Shimizu, Kazumasa Oura, Makiko Yoshida, Keisuke Tsuda, Kiyotaka Oi, Yoko Ishigaku, Tatsunori Natori, Shinsuke Narumi, Ryo Itabashi, Tetsuya Maeda, Yasuo Terayama. Inhibitory Effects of P2Y12 Receptor Antagonist on PAR1- and PAR4-AP-Induced Platelet Aggregation in Patients with Stroke or TIA.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2021 Mar; 30(3):105547. doi:
10.1016/j.jstrokecerebrovasdis.2020.105547. [PMID: 33360254] - Guillaume Vial, Noémie Gensous, Hélène Savel, Christophe Richez, Estibaliz Lazaro, Marie-Elise Truchetet, Fabrice Bonnet, Isabelle Pellegrin, Rodolphe Thiebaut, Patrick Blanco, Pierre Duffau. The impact of clopidogrel on plasma-soluble CD40 ligand levels in systemic lupus erythematosus patients: the CLOPUS phase I/II pilot study.
Joint bone spine.
2021 03; 88(2):105097. doi:
10.1016/j.jbspin.2020.105097. [PMID: 33152483] - Guo-Xian Shi, Zi-He Zhao, Xiao-Yan Yang, Mu Lin, Zhou-Xue Chen. Correlation study of CYP2C19 gene polymorphism and clopidogrel resistance in Han Chinese patients with cerebral infarction in Guizhou region.
Medicine.
2021 Feb; 100(6):e24481. doi:
10.1097/md.0000000000024481. [PMID: 33578542] - Wanbing He, Xiaorong Shu, Enyi Zhu, Bingqing Deng, Yongqing Lin, Xiaoying Wu, Zenan Zhou, Jingfeng Wang, Ruqiong Nie. Intermittent concurrent use of clopidogrel and proton pump inhibitors did not increase risk of adverse clinical outcomes in Chinese patients with coronary artery disease.
BMC cardiovascular disorders.
2021 02; 21(1):75. doi:
10.1186/s12872-021-01884-z. [PMID: 33546595] - Pious D Patel, Praveen Vimalathas, Xinnan Niu, Chevis N Shannon, Joshua C Denny, Josh F Peterson, Rohan V Chitale, Matthew R Fusco. CYP2C19 Loss-of-Function is Associated with Increased Risk of Ischemic Stroke after Transient Ischemic Attack in Intracranial Atherosclerotic Disease.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2021 Feb; 30(2):105464. doi:
10.1016/j.jstrokecerebrovasdis.2020.105464. [PMID: 33246208] - Ting Zhu, Xiang-Bao Meng, Dong-Xia Dong, Li-Yu Zhao, Mu-Wen Qu, Gui-Bo Sun, Xiao-Bo Sun. Xuesaitong injection (lyophilized) combined with aspirin and clopidogrel protect against focal cerebral ischemic/reperfusion injury in rats by suppressing oxidative stress and inflammation and regulating the NOX2/IL-6/STAT3 pathway.
Annals of palliative medicine.
2021 Feb; 10(2):1650-1667. doi:
10.21037/apm-20-1681. [PMID: 33222458] - Naveen L Pereira, Robert Avram, Derek Y So, Erin Iturriaga, Julia Byrne, Ryan J Lennon, Vishakantha Murthy, Nancy Geller, Shaun G Goodman, Charanjit Rihal, Yves Rosenberg, Kent Bailey, Mark J Pletcher, Gregory M Marcus, Michael E Farkouh, Jeffrey E Olgin. Rationale and design of the TAILOR-PCI digital study: Transitioning a randomized controlled trial to a digital registry.
American heart journal.
2021 02; 232(?):84-93. doi:
10.1016/j.ahj.2020.10.069. [PMID: 33129990] - Adam Wiśniewski. Multifactorial Background for a Low Biological Response to Antiplatelet Agents Used in Stroke Prevention.
Medicina (Kaunas, Lithuania).
2021 Jan; 57(1):. doi:
10.3390/medicina57010059. [PMID: 33435185] - Jing Shi, Meijiao He, Wennan Wang, Guangzhong Liu, Haiyu Zhang, Danghui Sun, Jianqiang Li, Hongyuan Mu, Minglu Xu, Chenyang Zhao, Jiayu Wang, Chongyang Zhang, Hai Cang, Shiqi Zhao, Zhiren Zhang, Yue Li. Efficacy and safety of different ticagrelor regimens versus clopidogrel in patients with coronary artery disease: a retrospective multicenter study (SUPERIOR).
Platelets.
2021 Jan; 32(1):120-129. doi:
10.1080/09537104.2020.1732328. [PMID: 32090650] - Jia Yu, Wei Fang, Xing Guo, Haiyang Jiang, Peng Sun, Yufeng Liu, Xin Jin. The Clinical Efficacy of Clopidogrel Bisulfate Tablets Combined with Olmesartan Medoxomil for Ischemic Stroke with Hypertension and the Effect of Angiotensin II Type 1 Receptor Level on Prognosis.
Computational and mathematical methods in medicine.
2021; 2021(?):4487393. doi:
10.1155/2021/4487393. [PMID: 34745325] - Khalid Alkharfy, Basit Jan, Khalid Alotaibi, Ayedh Alotaibi, Saeed Alqahtani, Mohammad Raish, Ajaz Ahmad. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model.
Current drug metabolism.
2021; 22(12):969-977. doi:
10.2174/1389200222666211029152151. [PMID: 34719359] - David Corredor-Orlandelli, Santiago Sambracos-Parrado, Santiago Mantilla-García, Josué Tovar-Tirado, Valentina Vega-Ramírez, Santiago David Mendoza-Ayús, Laura Catalina Peña, María Fernanda Leal, Juliana Rodríguez-Carrillo, Juanita León-Torres, Juan Mauricio Pardo-Oviedo, Katherine Parra Abaunza, Nora Contreras Contreras Bravo, Oscar Ortega-Recalde, Dora Janeth Fonseca Mendoza. Association between Paraoxonase-1 p.Q192R Polymorphism and Coronary Artery Disease susceptibility in the Colombian Population.
Vascular health and risk management.
2021; 17(?):689-699. doi:
10.2147/vhrm.s330766. [PMID: 34764653] - Lene Nygaard Axelsen, Italo Poggesi, Freya Rasschaert, Juan Jose Perez Ruixo, Shirin Bruderer. Clopidogrel, a CYP2C8 inhibitor, causes a clinically relevant increase in the systemic exposure to the active metabolite of selexipag in healthy subjects.
British journal of clinical pharmacology.
2021 01; 87(1):119-128. doi:
10.1111/bcp.14365. [PMID: 32415684] - Italo Linfante, Kaushik Ravipati, Amy Kathryn Starosciak, Dennys Reyes, Guilherme Dabus. Intravenous cangrelor and oral ticagrelor as an alternative to clopidogrel in acute intervention.
Journal of neurointerventional surgery.
2021 Jan; 13(1):30-32. doi:
10.1136/neurintsurg-2020-015841. [PMID: 32414891] - Nichole Orr-Burks, Jackelyn Murray, Kyle V Todd, Abhijeet Bakre, Ralph A Tripp. Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro.
PloS one.
2021; 16(10):e0259129. doi:
10.1371/journal.pone.0259129. [PMID: 34714852]