Clonidine (BioDeep_00000017842)
human metabolite blood metabolite
代谢物信息卡片
N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
化学式: C9H9Cl2N3 (229.0173494)
中文名称: 可乐定
谱图信息:
最多检出来源 Homo sapiens(blood) 6.67%
分子结构信息
SMILES: C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl
InChI: InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
描述信息
Clonidine, an imidazoline-derivative hypotensive agent is a centrally-acting α2-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone. Clonidine may be used for differential diagnosis of pheochromocytoma in hypertensive patients. Other uses for clonidine include prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD). Clonidine also exhibits some peripheral activity.
C - Cardiovascular system > C02 - Antihypertensives > C02A - Antiadrenergic agents, centrally acting > C02AC - Imidazoline receptor agonists
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01EA - Sympathomimetics in glaucoma therapy
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
N - Nervous system > N02 - Analgesics > N02C - Antimigraine preparations
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Clonidine is an alpha 2-adrenergic agonist[1].
同义名列表
31 个代谢物同义名
N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine; Boehringer ingelheim brand OF clonidine hydrochloride; 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine; 2-[(2,6-Dichlorophenyl)imino]imidazoline; Monohydrochloride, clonidine; Monohydrobromide, clonidine; Clonidine monohydrochloride; Clonidine monohydrobromide; Dihydrochloride, clonidine; Clonidine dihydrochloride; Hydrochloride, clonidine; Clonidine hydrochloride; Clonidinhydrochlorid; Catarpres-TTS; Chlophazolin; Chlornidinum; Catapressan; Isoglaucon; Clopheline; Catapresan; clonidine; Klofelin; Klofenil; Clofelin; Clofenil; Catapres; Clonidin; ST 155BS; Dixarit; Gemiton; Hemiton
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:46631
- ChEBI: CHEBI:46632
- ChEBI: CHEBI:3757
- PubChem: 2803
- HMDB: HMDB0014714
- DrugBank: DB00575
- ChEMBL: CHEMBL134
- Wikipedia: Clonidine
- MeSH: Clonidine
- chemspider: 2701
- CAS: 4205-90-7
- PMhub: MS000000551
- medchemexpress: HY-12721
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Xingyu Su, Fan Lu, Yihua Chen, Miao Wang, Guoqing Tang, Wan Lin, Yingwen Liu, Huadong Wang, Haiyan Yin, Yiyang Wang. α2-Adrenoreceptor antagonist ameliorates sepsis-associated pulmonary fibrosis by suppressing norepinephrine-mediated fibroblast differentiation via inhibiting PKC activation.
Shock (Augusta, Ga.).
2023 Oct; ?(?):. doi:
10.1097/shk.0000000000002240. [PMID: 37878498] - Jing Chen, Juan Zhang, Dan-Dan Yang, Zi-Cheng Li, Bo Zhao, Yue Chen, Zhi He. Clonidine ameliorates cerebral ischemia-reperfusion injury by up-regulating the GluN3 subunits of NMDA receptor.
Metabolic brain disease.
2022 08; 37(6):1829-1841. doi:
10.1007/s11011-022-01028-y. [PMID: 35727521] - Mian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Y Bois, Masoud Jamei. Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.
Drug metabolism and disposition: the biological fate of chemicals.
2022 07; 50(7):957-967. doi:
10.1124/dmd.121.000818. [PMID: 35504655] - Hanna Remde, Christina Pamporaki, Marcus Quinkler, Svenja Nölting, Aleksander Prejbisz, Henri J L M Timmers, Jimmy Masjkur, Carmina T Fuss, Martin Fassnacht, Graeme Eisenhofer, Timo Deutschbein. Improved Diagnostic Accuracy of Clonidine Suppression Testing Using an Age-Related Cutoff for Plasma Normetanephrine.
Hypertension (Dallas, Tex. : 1979).
2022 06; 79(6):1257-1264. doi:
10.1161/hypertensionaha.122.19019. [PMID: 35378989] - Jonathan Hanna, Lama Ghazi, Yu Yamamoto, Michael Simonov, Tayyab Shah, Francis P Wilson, Aldo J Peixoto. Excessive Blood Pressure Response to Clonidine in Hospitalized Patients With Asymptomatic Severe Hypertension.
American journal of hypertension.
2022 05; 35(5):433-440. doi:
10.1093/ajh/hpac004. [PMID: 35038322] - Theodoros V Giannouchos, Ainhoa Gómez-Lumbreras, Daniel C Malone. Risk of tizanidine-induced adverse events after concomitant exposure to ciprofloxacin: A cohort study in the U.S.
The American journal of emergency medicine.
2022 05; 55(?):147-151. doi:
10.1016/j.ajem.2022.03.008. [PMID: 35325788] - Dan Longrois, Fabrice Petitjeans, Olivier Simonet, Marc de Kock, Marc Belliveau, Cyrille Pichot, Thomas Lieutaud, Marco Ghignone, Luc Quintin. How should dexmedetomidine and clonidine be prescribed in the critical care setting?.
Revista Brasileira de terapia intensiva.
2022; 33(4):600-615. doi:
10.5935/0103-507x.20210087. [PMID: 35081245] - Constance Guille, Courtney King, Viswanathan Ramakrishnan, Nathaniel Baker, Bernadette Cortese, Lisa Nunn, Taylor Rogers, Aimee McRae-Clark, Kathleen Brady. The impact of lofexidine on stress-related opioid craving and relapse: Design and methodology of a randomized clinical trial.
Contemporary clinical trials.
2021 12; 111(?):106616. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Oct; 165(?):105920. doi:
10.1016/j.ejps.2021.105920. [PMID: 34192586] - Marcelo Daniel Sciorra, Elisa Fantino, Cecilia Eugenia María Grossi, Rita María Ulloa. Characterization of two group III potato CDPKs, StCDPK22 and StCDPK24, that contain three EF-Hand motifs in their CLDs.
Plant physiology and biochemistry : PPB.
2021 May; 162(?):716-729. doi:
10.1016/j.plaphy.2021.03.008. [PMID: 33799183] - Michael J Brucculeri, Juan Garcia. Potassium wasting nephropathy in the setting of tizanidine overdose: a case report.
Journal of medical case reports.
2021 May; 15(1):250. doi:
10.1186/s13256-021-02811-8. [PMID: 33931107] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
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Drug development and industrial pharmacy.
2021 Mar; 47(3):394-402. doi:
10.1080/03639045.2021.1890110. [PMID: 33615926] - Seo-Yeon Yoon, Dae-Hyun Roh, Ji-Hee Yeo, Jiwan Woo, Se Hee Han, Key-Sun Kim. Analgesic Efficacy of α2 Adrenergic Receptor Agonists Depends on the Chronic State of Neuropathic Pain: Role of Regulator of G Protein Signaling 4.
Neuroscience.
2021 02; 455(?):177-194. doi:
10.1016/j.neuroscience.2020.12.021. [PMID: 33359660] - Sanjiv K Hyoju, Olga Zaborina, Harry van Goor. SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol).
Medical hypotheses.
2020 Nov; 144(?):110039. doi:
10.1016/j.mehy.2020.110039. [PMID: 32758881] - Tiran Golani, Boris Fishman, Yehonatan Sharabi, Yael Olswang-Kutz, Avshalom Leibowitz, Ehud Grossman, Gadi Shlomai. The association between systolic blood pressure reduction during clonidine suppression testing and the decrease in plasma catecholamines and metanephrines.
Journal of clinical hypertension (Greenwich, Conn.).
2020 10; 22(10):1924-1931. doi:
10.1111/jch.14014. [PMID: 32882089] - Tyler J Loftus, Kolenkode B Kannan, Juan C Mira, Scott C Brakenridge, Philip A Efron, Alicia M Mohr. Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.
Shock (Augusta, Ga.).
2020 10; 54(4):482-487. doi:
10.1097/shk.0000000000001506. [PMID: 31904616] - Fabrice Petitjeans, Jean-Yves Martinez, Marc Danguy des Déserts, Sandrine Leroy, Luc Quintin, Jacques Escarment. A Centrally Acting Antihypertensive, Clonidine, Sedates Patients Presenting With Acute Respiratory Distress Syndrome Evoked by Severe Acute Respiratory Syndrome-Coronavirus 2.
Critical care medicine.
2020 10; 48(10):e991-e993. doi:
10.1097/ccm.0000000000004503. [PMID: 32618691] - Saskia Floerl, Annett Kuehne, Yohannes Hagos. Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction.
International journal of molecular sciences.
2020 Sep; 21(18):. doi:
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Molecules (Basel, Switzerland).
2020 Sep; 25(18):. doi:
10.3390/molecules25184109. [PMID: 32911847] - Abbu Stephanie, Curtis D Caldwell, Debbie Fraser, Rachel Joseph, Heather D Goodall, Jody Ridky, Kathryn Rudd, Lori Williams. Academy News.
Neonatal network : NN.
2020 08; 39(5):306-311. doi:
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British journal of clinical pharmacology.
2020 08; 86(8):1620-1631. doi:
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Analytical chemistry.
2020 07; 92(13):8965-8973. doi:
10.1021/acs.analchem.0c00958. [PMID: 32436691] - Weijiang Zhang, Christine McIntyre, Todd Riehl, Harper Forbes, Enric Bertran, Hye Jin Choi, Dae Ho Lee, Jeeyun Lee. Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine (a CYP1A2 Substrate) in Patients With BRAFV600 Mutation-Positive Malignancies.
Clinical pharmacology in drug development.
2020 07; 9(5):651-658. doi:
10.1002/cpdd.788. [PMID: 32311241] - Xuan Zou, Yang Wang, Yuheng Wang, Junting Yang, Huishu Guo, Zhengxu Cai. Paeoniflorin Alleviates Abnormalities in Rats with Functional Dyspepsia by Stimulating the Release of Acetylcholine.
Drug design, development and therapy.
2020; 14(?):5623-5632. doi:
10.2147/dddt.s260703. [PMID: 33376306] - Hetal Thakkar, Kartik Pandya, Brijesh Patel. Microneedle-Mediated Transdermal Delivery of Tizanidine Hydrochloride.
Methods in molecular biology (Clifton, N.J.).
2020; 2059(?):239-258. doi:
10.1007/978-1-4939-9798-5_13. [PMID: 31435926] - Huub L A van den Oever, Marieke Zeeman, Polina Nassikovker, Carmen Bles, Fred A L van Steveninck, Arthur R de Meijer, Arriette Kruisdijk-Gerritsen, Maurits Arbouw. In vivo Elimination of Clonidine by Continuous Venovenous Hemofiltration in Critically Ill Patients.
Blood purification.
2020; 49(5):622-626. doi:
10.1159/000505610. [PMID: 31962323] - Michael Doumas, Konstantinos P Imprialos, Manolis S Kallistratos, Athanasios J Manolis. Recent advances in understanding and managing resistant/refractory hypertension.
F1000Research.
2020; 9(?):. doi:
10.12688/f1000research.21669.1. [PMID: 32201574] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Gretchen Hermes, Scott M Hyman, Nia Fogelman, Thomas R Kosten, Rajita Sinha. Lofexidine in Combination With Oral Naltrexone for Opioid Use Disorder Relapse Prevention: A Pilot Randomized, Double-Blind, Placebo-Controlled Study.
The American journal on addictions.
2019 11; 28(6):480-488. doi:
10.1111/ajad.12942. [PMID: 31448846] - Zhipei Sang, Keren Wang, Pengfei Zhang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2019 Oct; 180(?):238-252. doi:
10.1016/j.ejmech.2019.07.021. [PMID: 31310916] - John C Hayden, Maddlie Bardol, Dermot R Doherty, Ian Dawkins, Martina Healy, Cormac V Breatnach, Paul J Gallagher, Gráinne Cousins, Joseph F Standing. Optimizing clonidine dosage for sedation in mechanically ventilated children: A pharmacokinetic simulation study.
Paediatric anaesthesia.
2019 10; 29(10):1002-1010. doi:
10.1111/pan.13715. [PMID: 31373752] - Nazari Pari, Yaghmaei Parichehreh, Rangin Alireza, Abbasi Naser. The role of Smyrnium cordifolium Boiss extract and curzerene on withdrawal syndrome in mice.
Cellular and molecular biology (Noisy-le-Grand, France).
2019 Sep; 65(7):77-83. doi:
10.14715/cmb/2019.65.7.14. [PMID: 31880522] - Zhipei Sang, Keren Wang, Jian Shi, Wenmin Liu, Zhenghuai Tan. Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2019 Sep; 178(?):726-739. doi:
10.1016/j.ejmech.2019.06.026. [PMID: 31229875] - Fei Tang, Henrietta Bada, Chee M Ng, Markos Leggas. Validation of a HPLC/MS method for simultaneous quantification of clonidine, morphine and its metabolites in human plasma.
Biomedical chromatography : BMC.
2019 Jul; 33(7):e4527. doi:
10.1002/bmc.4527. [PMID: 30830964] - WingYee Wan, Bichle Nguyen, Sky Graybill, Jonathan Kim. Clonidine suppression testing for pheochromocytoma in neurofibromatosis type 1.
BMJ case reports.
2019 Jun; 12(6):. doi:
10.1136/bcr-2018-228263. [PMID: 31243023] - Hongyan Liu, Xiaoming Qiang, Qing Song, Wei Li, Yuxi He, Chanyuan Ye, Zhenghuai Tan, Yong Deng. Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Bioorganic & medicinal chemistry.
2019 03; 27(6):991-1001. doi:
10.1016/j.bmc.2019.01.040. [PMID: 30772129] - Jennifer M Crawford, John A Loadsman, Kenny Xf Yang, Peter Ca Kam. Adding low concentrations of clonidine to ropivacaine for transversus abdominis plane blocks does not reduce plasma ropivacaine levels, suggesting a lack of vasoconstrictor effect.
Anaesthesia and intensive care.
2019 Mar; 47(2):134-140. doi:
10.1177/0310057x19838731. [PMID: 31070463] - Paolo Calzavacca, Lindsea C Booth, Yugeesh R Lankadeva, Simon R Bailey, Louise M Burrell, Michael Bailey, Rinaldo Bellomo, Clive N May. Effects of Clonidine on the Cardiovascular, Renal, and Inflammatory Responses to Experimental Bacteremia.
Shock (Augusta, Ga.).
2019 03; 51(3):348-355. doi:
10.1097/shk.0000000000001134. [PMID: 29489737] - Prafull Bandopant Ninave, Savita Dattatray Patil. Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma.
Respiratory physiology & neurobiology.
2019 02; 260(?):28-36. doi:
10.1016/j.resp.2018.12.001. [PMID: 30521862] - Guangzhong Zhou, Rongzeng Du. Dynamic Ghrelin and GH serum levels during combined simultaneous arginine clonidine stimulation test in children with dwarfism.
Italian journal of pediatrics.
2019 Jan; 45(1):17. doi:
10.1186/s13052-019-0610-5. [PMID: 30691498] - Qing Song, Yan Li, Zhongcheng Cao, Hongyan Liu, Chaoquan Tian, Ziyi Yang, Xiaoming Qiang, Zhenghuai Tan, Yong Deng. Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry.
2018 12; 26(23-24):6115-6127. doi:
10.1016/j.bmc.2018.11.015. [PMID: 30470598] - Marieke Jepma, Stephen B R E Brown, Peter R Murphy, Stephany C Koelewijn, Boukje de Vries, Arn M van den Maagdenberg, Sander Nieuwenhuis. Noradrenergic and Cholinergic Modulation of Belief Updating.
Journal of cognitive neuroscience.
2018 12; 30(12):1803-1820. doi:
10.1162/jocn_a_01317. [PMID: 30063180] - Ardeshir Moayeri, Maryam Azimi, Elahe Karimi, Ali Aidy, Naser Abbasi. Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats.
Medical science monitor basic research.
2018 10; 24(?):151-158. doi:
10.12659/msmbr.909930. [PMID: 30297685] - Karen Roksund Hov, Bjørn Erik Neerland, Anders Mikal Andersen, Øystein Undseth, Vegard Bruun Wyller, Alasdair M J MacLullich, Eva Skovlund, Eirik Qvigstad, Torgeir Bruun Wyller. The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses.
BMC pharmacology & toxicology.
2018 06; 19(1):29. doi:
10.1186/s40360-018-0218-1. [PMID: 29884231] - Nandini Bhat, Eric Dulmovits, Andrew Lane, Catherine Messina, Thomas Wilson. Combined simultaneous arginine clonidine stimulation test: Timing of peak growth hormone (GH) concentration and correlation with clinical indices of GH status.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
2018 06; 40(?):28-31. doi:
10.1016/j.ghir.2018.04.002. [PMID: 29702359] - Rui Xu, Ganyuan Xiao, Yan Li, Hongyan Liu, Qing Song, Xiaoyu Zhang, Ziyi Yang, Yunxiaozhu Zheng, Zhenghuai Tan, Yong Deng. Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2018 05; 26(8):1885-1895. doi:
10.1016/j.bmc.2018.02.037. [PMID: 29500132] - Xi Han, Yang Liu, Wendy R Kam, David A Sullivan. Effect of brimonidine, an α2 adrenergic agonist, on human meibomian gland epithelial cells.
Experimental eye research.
2018 05; 170(?):20-28. doi:
10.1016/j.exer.2018.02.009. [PMID: 29452108] - Sunayana Vikhe, Sunil Nirmal. Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma.
Journal of ethnopharmacology.
2018 Apr; 216(?):251-258. doi:
10.1016/j.jep.2017.12.007. [PMID: 29247697] - Nesreen M I M Elkomy, Islam A A E-H Ibrahim, Shimaa M Elshazly, Hassan M El-Fayoumi. Ameliorative effects of clonidine on ethanol induced kidney injury in rats: Potential role for imidazoline-1 receptor.
European journal of pharmacology.
2018 Apr; 824(?):148-156. doi:
10.1016/j.ejphar.2018.02.001. [PMID: 29452086] - Alexis L Cates, Scott M Wheatley, Kenneth D Katz. Clonidine Overdose in a Toddler Due to Accidental Ingestion of a Compounding Cream.
Pediatric emergency care.
2018 Apr; 34(4):e79-e81. doi:
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Scientific reports.
2018 03; 8(1):4631. doi:
10.1038/s41598-018-22927-0. [PMID: 29545586] - Zhongcheng Cao, Jie Yang, Rui Xu, Qin Song, Xiaoyu Zhang, Hongyan Liu, Xiaoming Qiang, Yan Li, Zhenghuai Tan, Yong Deng. Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Bioorganic & medicinal chemistry.
2018 03; 26(5):1102-1115. doi:
10.1016/j.bmc.2018.01.030. [PMID: 29409707] - Fathalla Belal, Mahmoud A Omar, Sayed Derayea, Mohamed A Hammad, Sahar Zayed, Safaa F Saleh. Simultaneous Determination of Tizanidine, Nimesulide, Aceclofenac and Paracetamol in Tablets and Biological Fluids Using Micellar Liquid Chromatography.
Journal of chromatographic science.
2018 Mar; 56(3):233-241. doi:
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European journal of medicinal chemistry.
2018 Feb; 146(?):287-298. doi:
10.1016/j.ejmech.2018.01.055. [PMID: 29407958] - Gustav Folmer Genét, Peter Bentzer, Morten Bagge Hansen, Sisse Rye Ostrowski, Pär Ingemar Johansson. Effects of propranolol and clonidine on brain edema, blood-brain barrier permeability, and endothelial glycocalyx disruption after fluid percussion brain injury in the rat.
The journal of trauma and acute care surgery.
2018 01; 84(1):89-96. doi:
10.1097/ta.0000000000001708. [PMID: 28930945] - William J Kowalczyk, Landhing M Moran, Jeremiah W Bertz, Karran A Phillips, Udi E Ghitza, Massoud Vahabzadeh, Jia-Ling Lin, David H Epstein, Kenzie L Preston. Using ecological momentary assessment to examine the relationship between craving and affect with opioid use in a clinical trial of clonidine as an adjunct medication to buprenorphine treatment.
The American journal of drug and alcohol abuse.
2018; 44(5):502-511. doi:
10.1080/00952990.2018.1454933. [PMID: 29634425] - Mahroo Baharfar, Yadollah Yamini, Shahram Seidi, Monireh Karami. Quantitative analysis of clonidine and ephedrine by a microfluidic system: On-chip electromembrane extraction followed by high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Nov; 1068-1069(?):313-321. doi:
10.1016/j.jchromb.2017.10.062. [PMID: 29127057] - Natalia Malikowska, Łukasz Fijałkowski, Alicja Nowaczyk, Piotr Popik, Kinga Sałat. Antidepressant-like activity of venlafaxine and clonidine in mice exposed to single prolonged stress - A model of post-traumatic stress disorder. Pharmacodynamic and molecular docking studies.
Brain research.
2017 Oct; 1673(?):1-10. doi:
10.1016/j.brainres.2017.08.001. [PMID: 28797691] - Kaïs Rtibi, Imen Hammami, Slimen Selmi, Dhekra Grami, Hichem Sebai, Mohamed Amri, Lamjed Marzouki. Phytochemical properties and pharmacological effects of Quercus ilex L. aqueous extract on gastrointestinal physiological parameters in vitro and in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Oct; 94(?):787-793. doi:
10.1016/j.biopha.2017.08.008. [PMID: 28802231] - Fergus D Law, Alison M Diaper, Jan K Melichar, Simon Coulton, David J Nutt, Judy S Myles. Buprenorphine/naloxone versus methadone and lofexidine in community stabilisation and detoxification: A randomised controlled trial of low dose short-term opiate-dependent individuals.
Journal of psychopharmacology (Oxford, England).
2017 08; 31(8):1046-1055. doi:
10.1177/0269881117711710. [PMID: 28631527] - Mascha Thurm, Britt-Inger Kröger Dahlin, Ola Winsö, Börje Ljungberg. Spinal analgesia improves surgical outcome after open nephrectomy for renal cell carcinoma: a randomized controlled study.
Scandinavian journal of urology.
2017 Aug; 51(4):277-281. doi:
10.1080/21681805.2017.1318300. [PMID: 28532200] - Bérangère Vasseur, Alain Dufour, Laetitia Houdas, Helen Goodwin, Kathryn Harries, Neslihan Yesiltas Emul, Simon Hutchings. Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial.
Advances in therapy.
2017 08; 34(8):2022-2032. doi:
10.1007/s12325-017-0585-9. [PMID: 28726169] - Jane Woyka. Consensus statement for non-hormonal-based treatments for menopausal symptoms.
Post reproductive health.
2017 Jun; 23(2):71-75. doi:
10.1177/2053369117711646. [PMID: 28643614] - Miguel Carlos Sanchez Munoz, Marc De Kock, Patrice Forget. What is the place of clonidine in anesthesia? Systematic review and meta-analyses of randomized controlled trials.
Journal of clinical anesthesia.
2017 May; 38(?):140-153. doi:
10.1016/j.jclinane.2017.02.003. [PMID: 28372656] - Rūta Veigure, Rudolf Aro, Tuuli Metsvaht, Joseph F Standing, Irja Lutsar, Koit Herodes, Karin Kipper. A highly sensitive method for the simultaneous UHPLC-MS/MS analysis of clonidine, morphine, midazolam and their metabolites in blood plasma using HFIP as the eluent additive.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 May; 1052(?):150-157. doi:
10.1016/j.jchromb.2017.03.007. [PMID: 28388512] - Matthew Emile Li Kam Wa, Patricia Taraborrelli, Sajad Hayat, Phang Boon Lim. Respiration driven excessive sinus tachycardia treated with clonidine.
BMJ case reports.
2017 Apr; 2017(?):. doi:
10.1136/bcr-2016-216818. [PMID: 28455405] - Zhipei Sang, Wanli Pan, Keren Wang, Qinge Ma, Lintao Yu, Yan Yang, Ping Bai, Chaoliang Leng, Qian Xu, Xiaoqing Li, Zhenghuai Tan, Wenmin Liu. Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2017 Apr; 130(?):379-392. doi:
10.1016/j.ejmech.2017.02.039. [PMID: 28279845] - Lawrence C Creemer, Natalie C Giampietro, William Lambert, Maurice C Yap, Gerrit J deBoer, Yelena Adelfinskaya, Scott Castetter, Frank J Wessels. Pro-insecticidal approach towards increasing in planta activity.
Pest management science.
2017 Apr; 73(4):752-760. doi:
10.1002/ps.4358. [PMID: 27414472] - Li Luo, Yan Li, Xiaoming Qiang, Zhongcheng Cao, Rui Xu, Xia Yang, Ganyuan Xiao, Qing Song, Zhenghuai Tan, Yong Deng. Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Bioorganic & medicinal chemistry.
2017 03; 25(6):1997-2009. doi:
10.1016/j.bmc.2017.02.027. [PMID: 28237559] - Ines G Alamo, Kolenkode B Kannan, Harry Ramos, Tyler J Loftus, Philip A Efron, Alicia M Mohr. Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress.
Surgery.
2017 03; 161(3):795-802. doi:
10.1016/j.surg.2016.08.043. [PMID: 27742030] - Dan Fan, Ting-Jun Fan. Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 03; 156(1):252-260. doi:
10.1093/toxsci/kfw249. [PMID: 28115640] - Xiaoming Qiang, Yan Li, Xia Yang, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Deng. DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Bioorganic & medicinal chemistry letters.
2017 02; 27(4):718-722. doi:
10.1016/j.bmcl.2017.01.050. [PMID: 28131710] - Yan Li, Xiaoming Qiang, Li Luo, Xia Yang, Ganyuan Xiao, Qi Liu, Jiachen Ai, Zhenghuai Tan, Yong Deng. Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
European journal of medicinal chemistry.
2017 Jan; 126(?):762-775. doi:
10.1016/j.ejmech.2016.12.009. [PMID: 27951485] - E V Eliseeva, E F Romanchenko, I V Dyuizen, A V Tyrtyshnikova, Yu I Pigolkin. Effect of Hypotensive Drugs on Dynamics of Nitroxide-Producing Renal Function in Rats with Nephrogenic Hypertension.
Bulletin of experimental biology and medicine.
2017 Jan; 162(3):357-361. doi:
10.1007/s10517-017-3615-3. [PMID: 28091926] - Amanda C Capino, Jamie L Miller, Peter N Johnson. Clonidine for Sedation and Analgesia and Withdrawal in Critically Ill Infants and Children.
Pharmacotherapy.
2016 12; 36(12):1290-1299. doi:
10.1002/phar.1850. [PMID: 27779775] - Miki Fukao, Eri Kondo, Hiroki Nishino, Ryutaro Hattori, Asuka Horie, Yukiya Hashimoto. Presence of an H+/Quinidine Antiport System in Madin-Darby Canine Kidney Cells.
European journal of drug metabolism and pharmacokinetics.
2016 Dec; 41(6):819-824. doi:
10.1007/s13318-015-0314-1. [PMID: 26628429] - Lujin Li, Ling Xu, Junyi Wu, Lidan Dong, Shuiyu Zhao, Qingshan Zheng. Comparative efficacy of nonhormonal drugs on menopausal hot flashes.
European journal of clinical pharmacology.
2016 Sep; 72(9):1051-8. doi:
10.1007/s00228-016-2090-5. [PMID: 27450233] - Su-Min Lim, Soo-Hyun Park, Naveen Sharma, Sung-Su Kim, Jae-Ryeong Lee, Jun-Sub Jung, Hong-Won Suh. Blood glucose regulation mechanism in depressive disorder animal model during hyperglycemic states.
Brain research bulletin.
2016 06; 124(?):116-22. doi:
10.1016/j.brainresbull.2016.03.014. [PMID: 27034116] - Yan Li, Xiaoming Qiang, Li Luo, Yuxing Li, Ganyuan Xiao, Zhenghuai Tan, Yong Deng. Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Bioorganic & medicinal chemistry.
2016 05; 24(10):2342-51. doi:
10.1016/j.bmc.2016.04.012. [PMID: 27079124] - Royce J Lee, Jennifer R Fanning, Emil F Coccaro. GH response to intravenous clonidine challenge correlates with history of childhood trauma in personality disorder.
Journal of psychiatric research.
2016 May; 76(?):38-43. doi:
10.1016/j.jpsychires.2015.11.009. [PMID: 26874268] - Alessandro R Nascimento, Marcus V Machado, Fabiana Gomes, Aline B Vieira, Cassiano F Gonçalves-de-Albuquerque, Marcos A Lessa, Pascal Bousquet, Eduardo Tibiriçá. Central Sympathetic Modulation Reverses Microvascular Alterations in a Rat Model of High-Fat Diet-Induced Metabolic Syndrome.
Microcirculation (New York, N.Y. : 1994).
2016 05; 23(4):320-9. doi:
10.1111/micc.12280. [PMID: 27086551] - C W Locuson, P Williams, J M Adcock, J S Daniels. Evaluation of tizanidine as a marker of canine CYP1A2 activity.
Journal of veterinary pharmacology and therapeutics.
2016 Apr; 39(2):122-30. doi:
10.1111/jvp.12256. [PMID: 26228837] - Aldo A Rodríguez-Menchaca, Ivan A Aréchiga-Figueroa, José A Sánchez-Chapula. The molecular basis of chloroethylclonidine block of inward rectifier (Kir2.1 and Kir4.1) K(+) channels.
Pharmacological reports : PR.
2016 Apr; 68(2):383-9. doi:
10.1016/j.pharep.2015.10.005. [PMID: 26922543] - A A El-Ebiary, S A Gad, A A Wahdan, I H El-Mehallawi. Clonidine as an adjuvant in the management of acute poisoning by anticholinesterase pesticides.
Human & experimental toxicology.
2016 Apr; 35(4):371-6. doi:
10.1177/0960327115586822. [PMID: 25986645] - Hwee Min D Lee, Varuna Ruggoo, Andis Graudins. Intrathecal Clonidine Pump Failure Causing Acute Withdrawal Syndrome With 'Stress-Induced' Cardiomyopathy.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2016 Mar; 12(1):134-8. doi:
10.1007/s13181-015-0505-9. [PMID: 26370679] - John Eden. ENDOCRINE DILEMMA: Managing menopausal symptoms after breast cancer.
European journal of endocrinology.
2016 Mar; 174(3):R71-7. doi:
10.1530/eje-15-0814. [PMID: 26466611] - Bohui Xu, Yubin Wang, Hongyan Zhu. Mini-tablet combination for sustained release of clonidine hydrochloride and hydrochlorothiazide: Preparation and pharmacokinetics in beagle dogs.
Die Pharmazie.
2016 Feb; 71(2):76-83. doi:
NULL. [PMID: 27004371] - Golaleh Sheykhaghaei, Moayad Hossainisadr, Salah Khanahmadzadeh, Mirabdollah Seyedsajadi, Awat Alipouramjad. Magnetic molecularly imprinted polymer nanoparticles for selective solid phase extraction and pre-concentration of Tizanidine in human urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Feb; 1011(?):1-5. doi:
10.1016/j.jchromb.2015.12.013. [PMID: 26744788] - Giovanni Sansoè, Manuela Aragno, Raffaella Mastrocola, Maurizio Parola. Dose-dependency of clonidine's effects in ascitic cirrhotic rats: comparison with α1-adrenergic agonist midodrine.
Liver international : official journal of the International Association for the Study of the Liver.
2016 Feb; 36(2):205-11. doi:
10.1111/liv.12905. [PMID: 26121993] - Mitsunori Shimmura, Nobutoshi Kawamura, Takahisa Tateishi, Hiroshi Shigeto, Hiroyuki Murai, Jun-Ichi Kira. [A case of paroxysmal sympathetic storm after acute disseminated encephalomyelitis and hypoxic encephalopathy responding to clonidine hydrochloride].
Rinsho shinkeigaku = Clinical neurology.
2016; 56(2):108-11. doi:
10.5692/clinicalneurol.cn-000793. [PMID: 26754594] - Michael Haupts, Carlos Vila, Anna Jonas, Kerstin Witte, Lourdes Álvarez-Ossorio. Influence of Previous Failed Antispasticity Therapy on the Efficacy and Tolerability of THC:CBD Oromucosal Spray for Multiple Sclerosis Spasticity.
European neurology.
2016; 75(5-6):236-43. doi:
10.1159/000445943. [PMID: 27160412] - Ashfaq Ahmad, Munavvar A Sattar, Maleeha Azam, Mohammed H Abdulla, Safia A Khan, Fayyaz Hashmi, Nor A Abdullah, Edward J Johns. Cystathione gamma lyase/Hydrogen Sulphide Pathway Up Regulation Enhances the Responsiveness of α1A and α1B-Adrenoreceptors in the Kidney of Rats with Left Ventricular Hypertrophy.
PloS one.
2016; 11(5):e0154995. doi:
10.1371/journal.pone.0154995. [PMID: 27191852] - John M Stewart, Alice F Tarantal, Wayne J Hawthorne, Evelyn J Salvaris, Philip J O'Connell, Mark B Nottle, Anthony J F d'Apice, Peter J Cowan, Mary Kearns-Jonker. Clonidine inhibits anti-non-Gal IgM xenoantibody elicited in multiple pig-to-primate models.
Xenotransplantation.
2015 Nov; 22(6):413-26. doi:
10.1111/xen.12199. [PMID: 26490547] - Rémi Goupil, Stelios Fountoulakis, Richard D Gordon, Michael Stowasser. Urinary clonidine suppression testing for the diagnosis of pheochromocytoma.
Journal of hypertension.
2015 Nov; 33(11):2286-93. doi:
10.1097/hjh.0000000000000705. [PMID: 26335433] - S Sugin Lal Jabaris, Haridass Sumathy, Ramesh Girish, Shridhar Narayanan, Mani Sugumar, Chidambaram Saravana Babu, Sadagopan Thanikachalam, Mohan Thanikachalam. Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system.
Brain research.
2015 Oct; 1622(?):279-91. doi:
10.1016/j.brainres.2015.07.003. [PMID: 26168894] - Jialang Zhuang, Jiangying Chen, Xueding Wang, Yin Pang, Huichang Bi, Lihui Huang, Guixiong Zeng, Xiaoxing Liao, Zhongfu Ma, Xiao Chen, Guoping Zhong, Min Huang, Xianglan Zhao. Validation of a HPLC-ESI MS/MS method for the determination of clonidine in human plasma and its application in a bioequivalence study in Chinese healthy volunteers.
Biomedical chromatography : BMC.
2015 Oct; 29(10):1506-13. doi:
10.1002/bmc.3450. [PMID: 25776729] - Even Fagermoen, Dag Sulheim, Anette Winger, Anders M Andersen, Johannes Gjerstad, Kristin Godang, Peter C Rowe, J Philip Saul, Eva Skovlund, Vegard Bruun Wyller. Effects of low-dose clonidine on cardiovascular and autonomic variables in adolescents with chronic fatigue: a randomized controlled trial.
BMC pediatrics.
2015 Sep; 15(?):117. doi:
10.1186/s12887-015-0428-2. [PMID: 26357864] - Philip M Finch, Peter D Drummond. Topical treatment in pain medicine: from ancient remedies to modern usage.
Pain management.
2015 Sep; 5(5):359-71. doi:
10.2217/pmt.15.23. [PMID: 26196538]