Dilazep (BioDeep_00000178337)
human metabolite blood metabolite
代谢物信息卡片
3-[4-[3-(3,4,5-Trimethoxybenzoyl)oxypropyl]-1,4-diazepan-1-yl]propyl 3,4,5-trimethoxybenzoic acid
化学式: C31H44N2O10 (604.2995804)
中文名称: 双酯嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC(=CC(=C1OC)OC)C(=O)OCCCN2CCCN(CC2)CCCOC(=O)C3=CC(=C(C(=C3)OC)OC)OC
InChI: InChI=1S/C31H44N2O10/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4/h18-21H,7-17H2,1-6H3
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
11 个代谢物同义名
3-[4-[3-(3,4,5-Trimethoxybenzoyl)oxypropyl]-1,4-diazepan-1-yl]propyl 3,4,5-trimethoxybenzoic acid; 3-[4-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]-1,4-diazepan-1-yl]propyl 3,4,5-trimethoxybenzoate; 3-{4-[3-(3,4,5-trimethoxybenzoyloxy)propyl]-1,4-diazepan-1-yl}propyl 3,4,5-trimethoxybenzoate; Trimethoxybenzoate, biopropazepan; Biopropazepan trimethoxybenzoate; Dilazep dihydrochloride; 4898, Asta C; C 4898, Asta; Asta C 4898; Cormelian; Dilazep
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:92842
- PubChem: 3074
- HMDB: HMDB0251363
- DrugBank: DB13715
- ChEMBL: CHEMBL126075
- Wikipedia: Dilazep
- MeSH: Dilazep
- CAS: 20153-98-4
- CAS: 35898-87-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 03; 33(3):3841-3850. doi:
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Pediatrics international : official journal of the Japan Pediatric Society.
2018 Feb; 60(2):162-167. doi:
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Medical science monitor : international medical journal of experimental and clinical research.
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Nephrology (Carlton, Vic.).
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2013 May; 28(5):1135-49. doi:
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Internal medicine (Tokyo, Japan).
2013; 52(2):193-9. doi:
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Biochemical pharmacology.
2012 Aug; 84(3):383-90. doi:
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Clinical and experimental nephrology.
2008 Jun; 12(3):224-7. doi:
10.1007/s10157-008-0029-6. [PMID: 18224274] - Hiroshi Nakamoto, Yasuo Ogasawara, Fumihiko Kajiya. Visualisation of the effects of dilazep on rat afferent and efferent arterioles in vivo.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Feb; 31(2):315-24. doi:
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Clinical and experimental nephrology.
2006 Dec; 10(4):268-73. doi:
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International heart journal.
2005 Jul; 46(4):701-10. doi:
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2005 May; 63(5):368-74. doi:
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Hypertension research : official journal of the Japanese Society of Hypertension.
2004 Jun; 27(6):409-15. doi:
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European journal of pharmacology.
2004 Apr; 491(1):9-19. doi:
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American journal of nephrology.
2004 Jan; 24(1):147-53. doi:
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European journal of pharmacology.
2003 Aug; 475(1-3):139-47. doi:
10.1016/s0014-2999(03)02109-5. [PMID: 12954370] - Atsushi Numabe, Nusrat Ara, Rie Hakamada-Taguchi, Noriko Suzuki, Nobuhito Hirawa, Yukari Kawabata, Toshiyuki Negoro, Taiji Nagata, Atsuo Goto, Teruhiko Toyo-Oka, Toshiro Fujita, Yoshio Uehara. Effects of the anti-platelet aggregation drug dilazep on cognitive function in Dahl salt-sensitive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2003 Feb; 26(2):185-91. doi:
10.1291/hypres.26.185. [PMID: 12627880] - Tsukasa Nakamura, Kaoru Hirokawa, Takaharu Matsuda, Shiori Osada, Yutaka Takahashi, Noriaki Shimada, Hikaru Koide. Combination AST-120 and dilazep dihydrochloride therapy reduced urinary protein excretion and serum creatinine levels in patients with chronic renal failure.
Renal failure.
2002 Sep; 24(5):683-5. doi:
10.1081/jdi-120013975. [PMID: 12380917] - Masahiko Kawabata, Manabu Haneda, Tao Wang, Michiru Imai, Toshikazu Takabatake. Effects of a nucleoside transporter inhibitor, dilazep, on renal microcirculation in rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2002 Jul; 25(4):615-21. doi:
10.1291/hypres.25.615. [PMID: 12358150] - Tsukasa Nakamura, Chifuyu Ushiyama, Shiwori Osada, Kazuya Ugai, Yutaka Takahashi, Araki Tanaka, Noriaki Shimada, Isao Ebihara, Hikaru Koide. Effect of dilazep dihydrochloride on serum cardiac troponin T levels in hemodialysis patients.
Kidney & blood pressure research.
2002; 25(1):50-4. doi:
10.1159/000049435. [PMID: 11834877] - S Yamagishi, K Koga, Y Inagaki, S Amano, T Okamoto, M Takeuchi. Dilazep hydrochloride, an antiplatelet drug, prevents progression of diabetic nephropathy in Otsuka Long-Evans Tokushima fatty rats.
Drugs under experimental and clinical research.
2002; 28(6):221-7. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2001 Dec; 38(6):1191-8. doi:
10.1053/ajkd.2001.29209. [PMID: 11728950] - T Nakamura, C Ushiyama, Y Takahashi, A Tanaka, N Shimada, I Ebihara, H Koide. Effect of dilazep dihydrochloride on urinary albumin excretion in patients with autosomal dominant polycystic kidney disease.
Nephron.
2001 May; 88(1):80-2. doi:
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The Journal of biological chemistry.
2001 Jan; 276(4):2914-27. doi:
10.1074/jbc.m007746200. [PMID: 11032837] - T Gohda, Y Makita, T Shike, K Funabiki, I Shirato, Y Tomino. Dilazep hydrochloride, an antiplatelet drug, inhibits lipopolysaccharide-induced mouse mesangial cell IL-6 secretion and proliferation.
Kidney & blood pressure research.
2001; 24(1):33-8. doi:
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Diabetes care.
2000 Aug; 23(8):1168-71. doi:
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Nephron.
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1999 Apr; 21(3):213-22. doi:
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European journal of clinical investigation.
1998 Nov; 28(11):877-83. doi:
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Japanese journal of pharmacology.
1997 Apr; 73(4):365-9. doi:
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1997 Apr; 15(7):997-1000. doi:
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The Southeast Asian journal of tropical medicine and public health.
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The Biochemical journal.
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