Diisopropyl methylphosphonate (BioDeep_00000178332)

   

human metabolite blood metabolite


代谢物信息卡片


Methylphosphonic acid bis(1-methylethyl)ester

化学式: C7H17O3P (180.0915)
中文名称: 甲基膦酸二异丙酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)OP(=O)(C)OC(C)C
InChI: InChI=1S/C7H17O3P/c1-6(2)9-11(5,8)10-7(3)4/h6-7H,1-5H3

描述信息

同义名列表

13 个代谢物同义名

Methylphosphonic acid bis(1-methylethyl)ester; Methylphosphonate bis(1-methylethyl)ester; Bis(1-methylethyl) methylphosphonic acid; Bis(1-methylethyl) methylphosphonate; Methylphosphonate diisopropyl ester; Diisopropyl methanephosphonic acid; bis(propan-2-yl) methylphosphonate; Diisopropyl methylphosphonic acid; Diisopropyl methanephosphonate; DIISOPROPYL METHYLPHOSPHONATE; isopropyl methylphosphonate; dIMP; Diisopropyl methylphosphonate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Valentina Dinca, Cristian Viespe, Simona Brajnicov, Izabela Constantinoiu, Antoniu Moldovan, Anca Bonciu, Constantin Nicolae Toader, Raluca Elena Ginghina, Nicoleta Grigoriu, Maria Dinescu, Nicu Doinel Scarisoreanu. MAPLE Assembled Acetylcholinesterase⁻Polyethylenimine Hybrid and Multilayered Interfaces for Toxic Gases Detection. Sensors (Basel, Switzerland). 2018 Dec; 18(12):. doi: 10.3390/s18124265. [PMID: 30518102]
  • R A Evans, E M Jakubowski, W T Muse, K Matson, S W Hulet, R J Mioduszewski, S A Thomson, A L Totura, J A Renner, C L Crouse. Quantification of sarin and cyclosarin metabolites isopropyl methylphosphonic acid and cyclohexyl methylphosphonic acid in minipig plasma using isotope-dilution and liquid chromatography- time-of-flight mass spectrometry. Journal of analytical toxicology. 2008 Jan; 32(1):78-85. doi: 10.1093/jat/32.1.78. [PMID: 18269798]
  • Douglas D Richardson, Joseph A Caruso. Screening organophosphorus nerve agent degradation products in pesticide mixtures by GC-ICPMS. Analytical and bioanalytical chemistry. 2007 Oct; 389(3):679-82. doi: 10.1007/s00216-007-1408-7. [PMID: 17602212]
  • Douglas D Richardson, Joseph A Caruso. Derivatization of organophosphorus nerve agent degradation products for gas chromatography with ICPMS and TOF-MS detection. Analytical and bioanalytical chemistry. 2007 Jun; 388(4):809-23. doi: 10.1007/s00216-007-1164-8. [PMID: 17356819]
  • Qing Li, Yukiyo Hirata, Tomoyuki Kawada, Masayasu Minami. Elevated frequency of sister chromatid exchanges of lymphocytes in sarin-exposed victims of the Tokyo sarin disaster 3 years after the event. Toxicology. 2004 Sep; 201(1-3):209-17. doi: 10.1016/j.tox.2004.04.014. [PMID: 15297034]
  • Thomas J Bucci, Robert M Kovatch, Michael D Mercieca, Victor Perman, J S Klingensmith. Two-generation reproductive study in mink fed diisopropyl methylphosphonate (DIMP). Reproductive toxicology (Elmsford, N.Y.). 2003 May; 17(3):327-34. doi: 10.1016/s0890-6238(03)00004-2. [PMID: 12759102]
  • Edward J Calabrese. The effects of diisopropylmethylphosphonate, a by-product of the production of sarin and a contaminant in drinking water at the Rocky Mountain Arsenal, on female mink. Regulatory toxicology and pharmacology : RTP. 2003 Apr; 37(2):191-201. doi: 10.1016/s0273-2300(02)00033-8. [PMID: 12726753]
  • Q Li, Y Hirata, S Piao, M Minami. The by-products generated during sarin synthesis in the Tokyo sarin disaster induced inhibition of natural killer and cytotoxic T lymphocyte activity. Toxicology. 2000 May; 146(2-3):209-20. doi: 10.1016/s0300-483x(00)00174-8. [PMID: 10814853]
  • Q Li, M Minami, J G Clement, C A Boulet. Elevated frequency of sister chromatid exchanges in lymphocytes of victims of the Tokyo sarin disaster and in experiments exposing lymphocytes to by-products of sarin synthesis. Toxicology letters. 1998 Sep; 98(1-2):95-103. doi: 10.1016/s0378-4274(98)00108-8. [PMID: 9776566]
  • D J Weiss, R S Geary, W Wustenberg, T J Bucci, V Perman, I P Baumel, J C Dacre. The comparative metabolism of diisopropyl methylphosphonate in mink and rats. Archives of environmental contamination and toxicology. 1994 Oct; 27(3):420-5. doi: 10.1007/bf00213181. [PMID: 7944557]
  • T J Bucci, W Wustenberg, V Perman, D J Weiss, J C Dacre, I P Baumel, R M Parker. Subchronic oral toxicity study of diisopropyl methylphosphonate in mink. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1994 Feb; 22(2):220-30. doi: 10.1006/faat.1994.1026. [PMID: 8005374]
  • H L Snodgrass, L M Metker. Dermal penetration of 14C-labeled diisopropyl methylphosphonate in swine. Journal of toxicology and environmental health. 1992 Aug; 36(4):367-76. doi: 10.1080/15287399209531645. [PMID: 1507268]
  • D M McPhillips, T A Armer, D R Owen. Grafted synthetic sorbents for enhanced removal of toxic chemical agents from plasma. Journal of biomedical materials research. 1983 Nov; 17(6):993-1002. doi: 10.1002/jbm.820170609. [PMID: 6654935]
  • S J Cysewski, J S Palmer, H R Crookshank, E G Steel. Toxicologic evaluation of diisopropyl methylphosphonate and dicyclopentadiene in cattle. Archives of environmental contamination and toxicology. 1981 Sep; 10(5):605-15. doi: 10.1007/bf01054883. [PMID: 7305451]
  • G W Ivie. Fate of diisopropyl methylphosphonate (DIMP) in a lactating cow. Bulletin of environmental contamination and toxicology. 1980 Jan; 24(1):40-8. doi: 10.1007/bf01608073. [PMID: 7188866]