N-Nitrosobis(2-hydroxypropyl)amine (BioDeep_00000178330)
human metabolite blood metabolite
代谢物信息卡片
1-[(2-hydroxypropyl)(nitroso)amino]propan-2-ol
化学式: C6H14N2O3 (162.1004374)
中文名称: N-亚硝基双(2-羟丙基)胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CN(CC(C)O)N=O)O
InChI: InChI=1S/C6H14N2O3/c1-5(9)3-8(7-11)4-6(2)10/h5-6,9-10H,3-4H2,1-2H3
描述信息
D009676 - Noxae > D002273 - Carcinogens
D009676 - Noxae > D009153 - Mutagens
同义名列表
18 个代谢物同义名
1-[(2-hydroxypropyl)(nitroso)amino]propan-2-ol; N-Nitroso-N,N-di(2-hydroxypropyl)amine; 2,2-Dihydroxy-di-N-propylnitrosoamine; 2,2-Dihydroxy-di-N-propylnitrosamine; N-Nitroso-bis(2-hydroxypropyl)amine; N,N-Di-(2-hydroxypropyl)nitrosamine; N-Nitrosobis(2-hydroxypropyl)amine; N-Bis(2-hydroxypropyl)nitrosamine; 1,1-(Nitrosoimino)bis(2-propanol); 2,2-Dihydroxydipropylnitrosamine; Nitrosobis(2-hydroxypropyl)amine; 2,2-Bishydroxypropylnitrosamine; Di(2-hydroxypropyl)nitrosamine; N-Nitrosodiisopropanolamine; Nitroso-di-isopropanolamine; Diisopropanolnitrosamine; 2,2-BHP; DHPN
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:131518
- PubChem: 40828
- HMDB: HMDB0251355
- ChEMBL: CHEMBL350868
- chemspider: 37291
- CAS: 53609-64-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xu Zheng, Bin Jia, Xue Song, Qing-You Kong, Mo-Li Wu, Ze-Wen Qiu, Hong Li, Jia Liu. Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis.
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Cancer science.
2006 Oct; 97(10):1031-6. doi:
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Cancer science.
2006 May; 97(5):368-73. doi:
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2005 Aug; 86(2):258-63. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2005 Jul; 86(1):61-7. doi:
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Cancer letters.
2005 Jun; 223(1):37-46. doi:
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2004 Sep; 81(1):50-9. doi:
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Toxicologic pathology.
2004 Jul; 32(4):474-81. doi:
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Toxicologic pathology.
2004 May; 32(3):338-44. doi:
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Toxicologic pathology.
2004 Mar; 32(2):250-7. doi:
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Toxicology.
2003 Jun; 188(2-3):275-83. doi:
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Cancer science.
2003 Apr; 94(4):334-7. doi:
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Cancer letters.
2003 Feb; 191(1):49-57. doi:
10.1016/s0304-3835(02)00629-8. [PMID: 12609709] - Hwa-Young Son, Akiyoshi Nishikawa, Kazushi Okazaki, Keita Kanki, Megumi Yamagishi, Takayoshi Imazawa, Takashi Umemura, Masao Hirose. Prolonged effects of beta-estradiol 3-benzoate on thyroid tumorigenesis in gonadectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Cancer letters.
2003 Feb; 190(1):21-9. doi:
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Endocrine research.
2003 Feb; 29(1):43-51. doi:
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Cancer letters.
2002 Apr; 178(1):1-9. doi:
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2001 May; 26(2):85-94. doi:
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2001 Apr; 22(4):613-8. doi:
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Carcinogenesis.
2000 Feb; 21(2):251-6. doi:
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Cancer letters.
1999 Dec; 147(1-2):221-7. doi:
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Anticancer research.
1999 Sep; 19(5A):3665-70. doi:
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Cancer letters.
1999 Aug; 142(2):161-71. doi:
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The Journal of toxicological sciences.
1999 Aug; 24(3):145-55. doi:
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1999 Jan; 20(1):173-6. doi:
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Toxicologic pathology.
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Japanese journal of cancer research : Gann.
1996 Jun; 87(6):589-94. doi:
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Cancer letters.
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1995 Sep; 96(2):209-18. doi:
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1995 Sep; 96(2):155-61. doi:
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Cancer letters.
1995 Jul; 94(1):113-21. doi:
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Cancer letters.
1995 Jun; 92(2):193-202. doi:
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1991 May; 12(5):873-7. doi:
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Japanese journal of cancer research : Gann.
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Chemical research in toxicology.
1990 Mar; 3(2):150-6. doi:
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Carcinogenesis.
1989 Dec; 10(12):2255-9. doi:
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Nihon Geka Gakkai zasshi.
1989 Dec; 90(12):2000-7. doi:
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Pancreas.
1989; 4(4):429-35. doi:
10.1097/00006676-198908000-00006. [PMID: 2762272] - Y Kitahori, T Shimoyama, M Ohshima, H Matsuki, H Hashimoto, S Minami, N Konishi, Y Hiasa. Effects of trisodium nitrilotriacetate monohydrate, nitrilotriacetic acid and ammonium chloride on urinary bladder carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl) nitrosamine.
Cancer letters.
1988 Dec; 43(1-2):105-10. doi:
10.1016/0304-3835(88)90221-2. [PMID: 3203320] - K Mizumoto, S Kitazawa, T Eguchi, A Nakajima, M Tsutsumi, S Ito, A Danda, Y Konishi. Modulation of N-nitrosobis(2-hydroxypropyl)amine-induced carcinogenesis by clofibrate in hamsters.
Carcinogenesis.
1988 Aug; 9(8):1421-5. doi:
10.1093/carcin/9.8.1421. [PMID: 3402039] - Y Kitahori, Y Hiasa, Y Katoh, N Konishi, M Ohshima, H Hashimoto, S Minami, Y Sakaguchi. Promotive effect of 4,4'-methylenebis(N,N-dimethyl)benzenamine on N-bis(2-hydroxypropyl)nitrosamine-induced thyroid tumors in Wistar rats.
Cancer letters.
1988 Jun; 40(3):275-81. doi:
10.1016/0304-3835(88)90086-9. [PMID: 3289735] - Y Yokose, K Yamamoto, A Nakajima, H Eimoto, H Maruyama, Y Mori, Y Konishi. Carcinogenic potency of N-nitrosomethyl(2-hydroxypropyl)amine and other metabolic relatives of N-nitrosobis(2-hydroxypropyl)amine by single intraperitoneal injection on the lung of rats.
Japanese journal of cancer research : Gann.
1988 Jun; 79(6):698-704. doi:
10.1111/j.1349-7006.1988.tb02225.x. [PMID: 3137196] - T Shirai, A Masuda, K Imaida, T Ogiso, N Ito. Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Japanese journal of cancer research : Gann.
1988 Apr; 79(4):460-5. doi:
10.1111/j.1349-7006.1988.tb01614.x. [PMID: 3133336] - Y Hiasa, M Ohshima, Y Kitahori, N Konishi, T Shimoyama, Y Sakaguchi, H Hashimoto, S Minami, Y Kato. The promoting effects of food dyes, erythrosine (Red 3) and rose bengal B (Red 105), on thyroid tumors in partially thyroidectomized N-bis(2-hydroxypropyl)-nitrosamine-treated rats.
Japanese journal of cancer research : Gann.
1988 Mar; 79(3):314-9. doi:
10.1111/j.1349-7006.1988.tb01593.x. [PMID: 2836348] - Y Hiasa, Y Kitahori, Y Kato, M Ohshima, N Konishi, T Shimoyama, Y Sakaguchi, H Hashimoto, S Minami, Y Murata. Potassium perchlorate, potassium iodide, and propylthiouracil: promoting effect on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)-nitrosamine.
Japanese journal of cancer research : Gann.
1987 Dec; 78(12):1335-40. doi:
. [PMID: 2828294] - M Matsuzaki, M Katsuragi, T Obara, H Ura, S Ito, M Tsutsumi, Y Konishi. Pancreatic tumor antigen in transplantable adenocarcinomas induced by N-bis(2-hydroxypropyl)nitrosamine in hamsters.
Pancreas.
1987; 2(5):545-50. doi:
10.1097/00006676-198709000-00009. [PMID: 2444968] - C J Michejda, S R Koepke, M B Kroeger-Koepke, W Bosan. Recent findings on the metabolism of beta-hydroxyalkylnitrosamines.
IARC scientific publications.
1987; ?(84):77-82. doi:
NULL. [PMID: 3316003] - T Shirai, H Tsuda, T Ogiso, M Hirose, N Ito. Organ specific modifying potential of ethinyl estradiol on carcinogenesis initiated with different carcinogens.
Carcinogenesis.
1987 Jan; 8(1):115-9. doi:
10.1093/carcin/8.1.115. [PMID: 3802386] - M A Moore, T Nakamura, T Shirai, A Ichihara, N Ito. Immunohistochemical demonstration of increased glucose-6-phosphate dehydrogenase in preneoplastic and neoplastic lesions induced by propylnitrosamines in F344 rats and Syrian hamsters.
Japanese journal of cancer research : Gann.
1986 Feb; 77(2):131-8. doi:
NULL. [PMID: 3082825] - D M Kokkinakis, P F Hollenberg, D G Scarpelli. Major urinary metabolites in hamsters and rats treated with N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine.
Cancer research.
1985 Aug; 45(8):3586-92. doi:
NULL. [PMID: 4016739] - Y Mori, H Yamazaki, K Toyoshi, T Makino, T Obara, Y Yokose, Y Konishi. Mutagenic activation of carcinogenic N-nitrosopropylamines by rat liver: evidence for a cytochrome P-450 dependent reaction.
Carcinogenesis.
1985 Mar; 6(3):415-20. doi:
10.1093/carcin/6.3.415. [PMID: 3884171] - Y Mori, H Takahashi, H Yamazaki, K Toyoshi, T Makino, Y Yokose, Y Konishi. Distribution, metabolism and excretion of N-nitrosobis(2-hydroxypropyl)amine in Wistar rats.
Carcinogenesis.
1984 Nov; 5(11):1443-7. doi:
10.1093/carcin/5.11.1443. [PMID: 6488468] - B Underwood, W Lijinsky. Comparative metabolism of the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine in rats, hamsters and guinea pigs.
Chemico-biological interactions.
1984 Jul; 50(2):175-88. doi:
10.1016/0009-2797(84)90094-2. [PMID: 6744463] - T Shirai, Y Kurata, S Fukushima, N Ito. Dose-related induction of lung, thyroid and kidney tumors by N-bis(2-hydroxypropyl)nitrosamine given orally to F344 rats.
Gan.
1984 Jun; 75(6):502-7. doi:
NULL. [PMID: 6468838] - Y Kitahori, Y Hiasa, N Konishi, N Enoki, T Shimoyama, A Miyashiro. Effect of propylthiouracil on the thyroid tumorigenesis induced by N-bis(2-hydroxypropyl)nitrosamine in rats.
Carcinogenesis.
1984 May; 5(5):657-60. doi:
10.1093/carcin/5.5.657. [PMID: 6722982] - Y Hiasa, Y Kitahori, N Enoki, N Konishi, T Shimoyama. 4,4'-Diaminodiphenylmethane: promoting effect on the development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine.
Journal of the National Cancer Institute.
1984 Feb; 72(2):471-6. doi:
. [PMID: 6582329] - Y Hiasa, Y Kitahori, N Konishi, N Enoki, T Fujita. Promoting effect of phenobarbital on N-bis (2-hydroxypropyl)nitrosamine thyroid tumorigenesis in rats. Effect of varying duration of exposure to phenobarbital.
IARC scientific publications.
1984; ?(56):77-82. doi:
NULL. [PMID: 6536611] - Y Mori, H Takahashi, H Yamazaki, K Toyoshi, T Obara, T Makino, D Nakae, S Takahashi, Y Konishi. Distribution and metabolism of N-nitrosobis(2-hydroxypropyl)amine in rats.
IARC scientific publications.
1984; ?(57):411-6. doi:
NULL. [PMID: 6533030] - Y Konishi, A Denda, S Takahashi, H Maruyama, Y Yokose, Y Mori, M Matsui, K Toyoshi. Organotropic effect of N-nitroso-bis-(2-hydroxypropyl)-amine: production of lung adenocarcinoma in rats by a single intraperitoneal injection.
IARC scientific publications.
1982; ?(41):611-8. doi:
NULL. [PMID: 7141568] - Y Hiasa, Y Kitahori, M Ohshima, T Fujita, T Yuasa, N Konishi, A Miyashiro. Promoting effects of phenobarbital and barbital on development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine.
Carcinogenesis.
1982; 3(10):1187-90. doi:
10.1093/carcin/3.10.1187. [PMID: 7172417] - P M Pour, S Z Salmasi. Comparative studies of neoplastic response to a single dose of nitroso compounds. The effect of N-nitrosobis (2-hydroxypropyl)amine in Syrian golden hamsters.
Journal of cancer research and clinical oncology.
1982; 102(3):265-9. doi:
10.1007/bf00411346. [PMID: 7061573] - Y Konishi, T Ikeda, A Kawabata, H Katada, R Higashiguchi, H Maruyama, H Yoshimura. Carcinogenic effect of N-bis-(2-hydroxypropyl)nitrosamine in newborn rats.
Experimentelle Pathologie.
1980; 18(2):136-40. doi:
10.1016/s0014-4908(80)80063-9. [PMID: 7379904] - R Gingell, G Brunk, D Nagel, P Pour. Metabolism of three radiolabeled pancreatic carcinogenic nitrosamines in hamsters and rats.
Cancer research.
1979 Nov; 39(11):4579-83. doi:
NULL. [PMID: 227588] - D Walton, S Nakazawa, M Kajikawa, Y Naito, M Ichikawa, E Kimoto, H Sano, Y Suzuki, T Asai. RNase levels in golden hamster with DHPN induced pancreatic cancer.
Gastroenterologia Japonica.
1979; 14(1):74-9. doi:
10.1007/bf02774607. [PMID: 446989] - Y Konishi, A Denda, H Kondo, S Takahashi. Lung carcinomas induced by oral administration of N-bis(2-hydroxypropyl)nitrosamine in rats.
Gan.
1976 Dec; 67(6):773-80. doi:
NULL. [PMID: 1021505] - R Gingell, L Wallcave, D Nagel, R Kupper, P Pour. Metabolism of the pancreatic carcinogens N-nitroso-bis(2-oxopropyl)amine and N-nitroso-bis(2-hydroxypropyl)amine in the Syrian hamster.
Journal of the National Cancer Institute.
1976 Nov; 57(5):1175-8. doi:
10.1093/jnci/57.5.1175. [PMID: 1003547]