Dihydralazine (BioDeep_00000178281)
human metabolite blood metabolite
代谢物信息卡片
Altana pharma oranienburg brand OF dihydralazine sulfate
化学式: C8H10N6 (190.09669000000002)
中文名称: 双肼屈嗪
谱图信息:
最多检出来源 Homo sapiens(blood) 16.67%
分子结构信息
SMILES: C1=CC=C2C(=C1)C(=NN=C2NN)NN
InChI: InChI=1S/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,11,13)(H,12,14)
描述信息
C - Cardiovascular system > C02 - Antihypertensives > C02D - Arteriolar smooth muscle, agents acting on > C02DB - Hydrazinophthalazine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:134841
- PubChem: 10230
- HMDB: HMDB0251288
- DrugBank: DB12945
- ChEMBL: CHEMBL35505
- Wikipedia: Dihydralazine
- MeSH: Dihydralazine
- chemspider: 9813
- CAS: 484-23-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Suqin Han, Zheyan Fan, Xiaoxia Chen, Yunfang Wu, Jianbo Wang. Determination of dihydralazine based on chemiluminescence resonance energy transfer of hollow carbon nanodots.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2017 Aug; 183(?):103-108. doi:
10.1016/j.saa.2017.04.009. [PMID: 28441537] - Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Toxicological sciences : an official journal of the Society of Toxicology.
2014 Jan; 137(1):189-211. doi:
10.1093/toxsci/kft223. [PMID: 24085192] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Jean-Pascal Fournier, Maryse Lapeyre-Mestre, Agnès Sommet, Julie Dupouy, Jean-Christophe Poutrain, Jean-Louis Montastruc. Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study.
PloS one.
2012; 7(3):e34187. doi:
10.1371/journal.pone.0034187. [PMID: 22479557] - Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jan; 40(1):130-8. doi:
10.1124/dmd.111.040758. [PMID: 21965623] - Yiqun Wu, Yonghua Hu, Xun Tang, Liu He, Tao Ren, Qiushan Tao, Xueying Qin, Ningling Sun, Hongyi Wang, Weihua Cao, Tao Wu, Siyan Zhan, Jin Wang, Weihua Chen, Liming Li. Long-term efficacy and tolerability of a fixed-dose combination of antihypertensive agents: an open-label surveillance study in China.
Clinical drug investigation.
2011 Nov; 31(11):769-77. doi:
10.1007/bf03256917. [PMID: 21671689] - Min Zhang, Yong Meng, Yongli Yang, Yancai Liu, Caiqin Dong, Jianming Xiao, Ling Zhao, Fang Li. Major inducing factors of hypertensive complications and the interventions required to reduce their prevalence: an epidemiological study of hypertension in a rural population in China.
BMC public health.
2011 May; 11(?):301. doi:
10.1186/1471-2458-11-301. [PMID: 21569365] - R Serreau. [Drugs during preeclampsia. Fetal risks and pharmacology].
Annales francaises d'anesthesie et de reanimation.
2010 Apr; 29(4):e37-46. doi:
10.1016/j.annfar.2010.02.016. [PMID: 20347563] - Fernanda S Zamo, Silvia Lacchini, Cristiano Mostarda, Silvana Chiavegatto, Ivana C M Silva, Edilamar Menezes Oliveira, Maria Claudia Irigoyen. Hemodynamic, morphometric and autonomic patterns in hypertensive rats - Renin-Angiotensin system modulation.
Clinics (Sao Paulo, Brazil).
2010; 65(1):85-92. doi:
10.1590/s1807-59322010000100013. [PMID: 20126350] - Chunyan Yang, Zhujun Zhang, Jinli Wang. Flow-injection chemiluminescence determination of dihydralazine sulfate in serum using luminol and diperiodatocuprate (III) system.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2010 Jan; 75(1):77-82. doi:
10.1016/j.saa.2009.09.044. [PMID: 19910243] - Bo Wang, Shu-Feng Zhou. Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development.
Current medicinal chemistry.
2009; 16(31):4066-218. doi:
10.2174/092986709789378198. [PMID: 19754423] - Henrik Vase, Thomas Guldager Lauridsen, Jesper Nørgaard Bech, Erling Bjerregaard Pedersen. Effects of dihydralazine on renal water and aquaporin-2 excretion in humans.
Scandinavian journal of clinical and laboratory investigation.
2009; 69(1):45-51. doi:
10.1080/00365510802295706. [PMID: 18728933] - Grzegorz Piecha, Nadezda Koleganova, Marie-Luise Gross, Aman Geldyyev, Marcin Adamczak, Eberhard Ritz. Regression of glomerulosclerosis in subtotally nephrectomized rats: effects of monotherapy with losartan, spironolactone, and their combination.
American journal of physiology. Renal physiology.
2008 Jul; 295(1):F137-44. doi:
10.1152/ajprenal.00065.2008. [PMID: 18434388] - H Valensise, B Vasapollo, G P Novelli, G Giorgi, P Verallo, A Galante, D Arduini. Maternal and fetal hemodynamic effects induced by nitric oxide donors and plasma volume expansion in pregnancies with gestational hypertension complicated by intrauterine growth restriction with absent end-diastolic flow in the umbilical artery.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.
2008 Jan; 31(1):55-64. doi:
10.1002/uog.5234. [PMID: 18098350] - Yasuhiro Masubuchi, Toshiharu Horie. Toxicological significance of mechanism-based inactivation of cytochrome p450 enzymes by drugs.
Critical reviews in toxicology.
2007 Jun; 37(5):389-412. doi:
10.1080/10408440701215233. [PMID: 17612953] - Daniel G Mascher, Werner Tscherwenka, Hermann J Mascher. Method development for dihydralazine with HPLC-MS/MS--an old but tricky substance in human plasma.
Journal of pharmaceutical and biomedical analysis.
2007 Jan; 43(2):631-45. doi:
10.1016/j.jpba.2006.07.041. [PMID: 16950590] - M I J Withagen, H C S Wallenburg, E A P Steegers, W C J Hop, W Visser. Morbidity and development in childhood of infants born after temporising treatment of early onset pre-eclampsia.
BJOG : an international journal of obstetrics and gynaecology.
2005 Jul; 112(7):910-4. doi:
10.1111/j.1471-0528.2005.00614.x. [PMID: 15957991] - Julia Thumfart, Dominik Müller, Birgit Rudolph, Miriam Zimmering, Uwe Querfeld, Dieter Haffner. Isolated sarcoid granulomatous interstitial nephritis responding to infliximab therapy.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2005 Feb; 45(2):411-4. doi:
10.1053/j.ajkd.2004.10.011. [PMID: 15685521] - Marusia Lilova. Hypertension in children with chronic renal failure.
The Turkish journal of pediatrics.
2005; 47 Suppl(?):28-31. doi:
NULL. [PMID: 15884664] - Lisa M Kaminskas, Simon M Pyke, Philip C Burcham. Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde.
Organic & biomolecular chemistry.
2004 Sep; 2(18):2578-84. doi:
10.1039/b408796h. [PMID: 15351821] - Jae Min Jeong, Jaetae Lee, Chang Hum Paik, Dae-Kee Kim, Dong Soo Lee, June-Key Chung, Myung Chul Lee. Site-specific 99mTc-labeling of antibody using dihydrazinophthalazine (DHZ) conjugation to Fc region of heavy chain.
Archives of pharmacal research.
2004 Sep; 27(9):961-7. doi:
10.1007/bf02975851. [PMID: 15473668] - Wessel Ganzevoort, Annelies Rep, Gouke J Bonsel, Johanna I P de Vries, Hans Wolf. Plasma volume and blood pressure regulation in hypertensive pregnancy.
Journal of hypertension.
2004 Jul; 22(7):1235-42. doi:
10.1097/01.hjh.0000125436.28861.09. [PMID: 15201535] - S M E Boito, P C Struijk, G A M Pop, W Visser, E A P Steegers, J W Wladimiroff. The impact of maternal plasma volume expansion and antihypertensive treatment with intravenous dihydralazine on fetal and maternal hemodynamics during pre-eclampsia: a clinical, echo-Doppler and viscometric study.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.
2004 Apr; 23(4):327-32. doi:
10.1002/uog.1012. [PMID: 15065180] - Philip C Burcham, Frank R Fontaine, Lisa M Kaminskas, Dennis R Petersen, Simon M Pyke. Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against acrolein-mediated toxicity.
Molecular pharmacology.
2004 Mar; 65(3):655-64. doi:
10.1124/mol.65.3.655. [PMID: 14978244] - Philip C Burcham, Lisa M Kaminskas, Frank R Fontaine, Dennis R Petersen, Simon M Pyke. Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products.
Toxicology.
2002 Dec; 181-182(?):229-36. doi:
10.1016/s0300-483x(02)00287-1. [PMID: 12505316] - Lars Pape, Juergen Strehlau, Kay Latta, Jochen Hh Ehrich, Gisela Offner. Drug-induced lupus as a cause of relapsing inflammatory disease after renal transplantation.
Pediatric transplantation.
2002 Aug; 6(4):337-9. doi:
10.1034/j.1399-3046.2002.02002.x. [PMID: 12234276] - M Schulz, J Wacker, G Bastert. [Effect of Urapidil in antihypertensive therapy of preeclampsia on newborns].
Zentralblatt fur Gynakologie.
2001 Sep; 123(9):529-33. doi:
10.1055/s-2001-18226. [PMID: 11709746] - G Wolf, U Wenzel, R A Stahl, B Hüneke. [Hypertensive disorders in pregnancy].
Medizinische Klinik (Munich, Germany : 1983).
2001 Feb; 96(2):78-86. doi:
10.1007/pl00002182. [PMID: 11253286] - M Johansson, M Elam, B Rundqvist, G Eisenhofer, H Herlitz, G Jensen, P Friberg. Differentiated response of the sympathetic nervous system to angiotensin-converting enzyme inhibition in hypertension.
Hypertension (Dallas, Tex. : 1979).
2000 Oct; 36(4):543-8. doi:
10.1161/01.hyp.36.4.543. [PMID: 11040233] - P Obermayer-Straub, C P Strassburg, M P Manns. Target proteins in human autoimmunity: cytochromes P450 and UDP- glucuronosyltransferases.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie.
2000 May; 14(5):429-39. doi:
10.1155/2000/910107. [PMID: 10851284] - Y Masubuchi, T Horie. Mechanism-based inactivation of cytochrome P450s 1A2 and 3A4 by dihydralazine in human liver microsomes.
Chemical research in toxicology.
1999 Oct; 12(10):1028-32. doi:
10.1021/tx9901276. [PMID: 10525281] - A C Bolte, J van Eyck, H H Kanhai, H W Bruinse, H P van Geijn, G A Dekker. Ketanserin versus dihydralazine in the management of severe early-onset preeclampsia: maternal outcome.
American journal of obstetrics and gynecology.
1999 Feb; 180(2 Pt 1):371-7. doi:
10.1016/s0002-9378(99)70216-4. [PMID: 9988803] - P M Dansette, E Bonierbale, C Minoletti, P H Beaune, D Pessayre, D Mansuy. Drug-induced immunotoxicity.
European journal of drug metabolism and pharmacokinetics.
1998 Oct; 23(4):443-51. doi:
10.1007/bf03189993. [PMID: 10323325] - Y Masubuchi, T Horie. Dihydralazine-induced inactivation of cytochrome P450 enzymes in rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals.
1998 Apr; 26(4):338-42. doi:
NULL. [PMID: 9531521] - P H Beaune, S Lecoeur. Immunotoxicology of the liver: adverse reactions to drugs.
Journal of hepatology.
1997; 26 Suppl 2(?):37-42. doi:
10.1016/s0168-8278(97)80495-3. [PMID: 9204408] - M Bourdi, W Chen, R M Peter, J L Martin, J T Buters, S D Nelson, L R Pohl. Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis.
Chemical research in toxicology.
1996 Oct; 9(7):1159-66. doi:
10.1021/tx960083q. [PMID: 8902272] - W R Schaefer, R J Seufert, F W Casper, H P Zahradnik. Urinary excretion of 2,3-dinor-6-keto-PGF1 alpha and 11-dehydro-TXB2 by the gravid spontaneously hypertensive rat.
Prostaglandins.
1996 Jul; 52(1):1-11. doi:
10.1016/0090-6980(96)00049-4. [PMID: 8875634] - P H Beaune, S Lecoeur, M Bourdi, A Gauffre, C Belloc, P Dansette, D Mansuy. Anti-cytochrome P450 autoantibodies in drug-induced disease.
European journal of haematology. Supplementum.
1996; 60(?):89-92. doi:
10.1111/j.1600-0609.1996.tb01652.x. [PMID: 8987248] - W Visser, H C Wallenburg. Maternal and perinatal outcome of temporizing management in 254 consecutive patients with severe pre-eclampsia remote from term.
European journal of obstetrics, gynecology, and reproductive biology.
1995 Dec; 63(2):147-54. doi:
10.1016/0301-2115(95)02260-0. [PMID: 8903771] - M Charbit, M Déchaux, I Blazy, R Vargas, D Laouari, D Brocart, M Lacoste, M C Gubler, C Sachs. Deleterious effects of inhibition of the renin-angiotensin system in neonatal rats.
Pediatric nephrology (Berlin, Germany).
1995 Jun; 9(3):303-8. doi:
10.1007/bf02254192. [PMID: 7632518] - M A Lee, M Böhm, S Kim, S Bachmann, J Bachmann, M Bader, D Ganten. Differential gene expression of renin and angiotensinogen in the TGR(mREN-2)27 transgenic rat.
Hypertension (Dallas, Tex. : 1979).
1995 Apr; 25(4 Pt 1):570-80. doi:
10.1161/01.hyp.25.4.570. [PMID: 7721400] - S Lecoeur, E Bonierbale, D Challine, J C Gautier, P Valadon, P M Dansette, R Catinot, F Ballet, D Mansuy, P H Beaune. Specificity of in vitro covalent binding of tienilic acid metabolites to human liver microsomes in relationship to the type of hepatotoxicity: comparison with two directly hepatotoxic drugs.
Chemical research in toxicology.
1994 May; 7(3):434-42. doi:
10.1021/tx00039a023. [PMID: 8075377] - D Fliser, R Nowack, G Wolf, E Ritz. Differential effects of ACE inhibitors and vasodilators on renal function curve in patients with primary hypertension.
Blood pressure.
1993 Dec; 2(4):296-300. doi:
10.3109/08037059309077171. [PMID: 8173699] - C Damase-Michel, G Tavernier, P Giraud, J L Montastruc, P Montastruc, M A Tran. Effects of clonidine, dihydralazine and splanchnic nerve stimulation on the release of neuropeptide Y, MET-enkephalin and catecholamines from dog adrenal medulla.
Naunyn-Schmiedeberg's archives of pharmacology.
1993 Oct; 348(4):379-84. doi:
10.1007/bf00171337. [PMID: 7904052] - M A Tran, C Damase-Michel, G Tavernier, P Giraud, J L Montastruc, P Montastruc. [Co-release of neuropeptides and catecholamines by adrenal medulla].
Archives des maladies du coeur et des vaisseaux.
1993 Aug; 86(8):1253-6. doi:
NULL. [PMID: 8129538] - H Herlitz, P Hjemdahl, R Volkmann, G Jensen, M Aurell. Renal and systemic sympathetic counterregulation in response to vasodilators in renovascular hypertension.
Clinical science (London, England : 1979).
1993 Jan; 84(1):41-5. doi:
10.1042/cs0840041. [PMID: 8382132] - C Diehm, O Jacobsen, K Amendt. The effects of tertatolol on lipid profile.
Cardiology.
1993; 83 Suppl 1(?):32-40. doi:
10.1159/000176008. [PMID: 7903213] - K W Florijn, F H Derkx, W Visser, J A Hofman, F M Rosmalen, H C Wallenburg, M A Schalekamp. Plasma immunoreactive endothelin-1 in pregnant women with and without pre-eclampsia.
Journal of cardiovascular pharmacology.
1991; 17 Suppl 7(?):S446-8. doi:
10.1097/00005344-199100177-00128. [PMID: 1725408] - M Andersson, A Hanson, G Englund, B Dahlbäck. Inhibition of complement components C3 and C4 by cadralazine and its active metabolite.
European journal of clinical pharmacology.
1991; 40(3):261-5. doi:
10.1007/bf00315206. [PMID: 2060562] - M Bourdi, D Larrey, J Nataf, J Bernuau, D Pessayre, M Iwasaki, F P Guengerich, P H Beaune. Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis.
The Journal of clinical investigation.
1990 Jun; 85(6):1967-73. doi:
10.1172/jci114660. [PMID: 2347920] - E Zander, N Conde, P Heinke, G Zander, J Strese, G Gums, B Schulz. The effect of antihypertensive treatment on kidney function in insulin-dependent (type I) diabetics with renal failure.
Experimental and clinical endocrinology.
1990 Feb; 95(1):70-6. doi:
10.1055/s-0029-1210936. [PMID: 2335182] - M Maliszewska, A Jezierski, G Micera, K Gasiorowski, H Kozłowski. Influence of dihydralazine on the generation of hydroxyl radicals by human granulocytes.
Biomedica biochimica acta.
1990; 49(5):347-51. doi:
". [PMID: 2176782] - M Wehling, T Müller, J M Heim, R Lorenz, H Witzgall, J Weil, R Gerzer. Effects of clonidine and dihydralazine on atrial natriuretic factor and cGMP in humans.
Journal of applied physiology (Bethesda, Md. : 1985).
1989 Sep; 67(3):938-44. doi:
10.1152/jappl.1989.67.3.938. [PMID: 2551880] - M Belfort, P Uys, J Dommisse, D A Davey. Haemodynamic changes in gestational proteinuric hypertension: the effects of rapid volume expansion and vasodilator therapy.
British journal of obstetrics and gynaecology.
1989 Jun; 96(6):634-41. doi:
10.1111/j.1471-0528.1989.tb03276.x. [PMID: 2803986] - W Linz, B A Schölkens, D Ganten. Converting enzyme inhibition specifically prevents the development and induces regression of cardiac hypertrophy in rats.
Clinical and experimental hypertension. Part A, Theory and practice.
1989; 11(7):1325-50. doi:
10.3109/10641968909038172. [PMID: 2530011] - T Schneider, W Siegmund, M Zschiesche, R Kallwellis. [The quantitative determination of dihydralazine and selected metabolites in man].
Die Pharmazie.
1988 Oct; 43(10):704-6. doi:
NULL. [PMID: 3212018] - B Tidgren, P Hjemdahl. Reflex activation of renal nerves in humans: differential effects on noradrenaline, dopamine and renin overflow to renal venous plasma.
Acta physiologica Scandinavica.
1988 Sep; 134(1):23-34. doi:
10.1111/j.1748-1716.1988.tb08455.x. [PMID: 3239422] - B Bourreli, M Pinaud, N Passuti, J P Gunst, J C Drouet, J P Remi. Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1988 May; 35(3 ( Pt 1)):242-8. doi:
10.1007/bf03010617. [PMID: 3383316] - H E Eliahou, D Cohen, D Herzog, P Shechter, I Serban, S Kapuler, G Schiby, S Gavendo. The control of hypertension and its effect on renal function in rat remnant kidney.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1988; 3(1):38-44. doi:
10.1093/oxfordjournals.ndt.a091617. [PMID: 3132638] - G Mohácsi, S Sonkodi. Comparison of BAY e 5009 (nitrendipine) with dihydralazine in Wistar rats with experimentally induced nephritis.
Journal of cardiovascular pharmacology.
1988; 12 Suppl 4(?):S117-9. doi:
10.1097/00005344-198806124-00025. [PMID: 2468852] - T Schneider, W Siegmund, M Zschiesche, R Kallwellis, A Scherber. [The quantitative identification of metabolites of dihydralazine in the human].
Die Pharmazie.
1988 Jan; 43(1):33-6. doi:
NULL. [PMID: 3375299] - W Siegmund, M Zschiesche, L Schröder, G Franke, E Udvary, H Hüller. [Pharmacokinetics of dihydralazine following intravenous administration in laboratory animals].
Die Pharmazie.
1987 Aug; 42(8):527-30. doi:
NULL. [PMID: 3432333] - R P Hof, J P Evenou, A Hof-Miyashita. Similar increase in circulating renin after equihypotensive doses of nitroprusside, dihydralazine or isradipine in conscious rabbits.
European journal of pharmacology.
1987 Apr; 136(2):251-4. doi:
10.1016/0014-2999(87)90720-5. [PMID: 2954832] - W Siegmund, M Kairies, G Franke, I Donner, K E Biebler. Interactions of dihydralazine with furosemide in hypertonic patients.
International journal of clinical pharmacology, therapy, and toxicology.
1987 Mar; 25(3):148-51. doi:
NULL. [PMID: 3557742] - T Müller, J M Heim, J Weil, M Wehling, H Witzgall, R Gerzer. Effects of clonidine and dihydralazine on plasma ANF and cyclic GMP levels in humans during volume loading.
Journal of cardiovascular pharmacology.
1987; 10 Suppl 12(?):S163-6. doi:
NULL. [PMID: 2455172] - A Panagiotopoulos, U Frei, K Goeschen. [Complicated pregnancy course following kidney transplantation].
Geburtshilfe und Frauenheilkunde.
1986 Oct; 46(10):752-3. doi:
10.1055/s-2008-1035958. [PMID: 3542694] - T Schneider, W Siegmund, G Franke, G Kraatz, A Scherber. [The binding of propranolol, dihydralazine and selected metabolites to adsorbent resins for hemoperfusion].
Die Pharmazie.
1986 Oct; 41(10):742-3. doi:
". [PMID: 3823123] - H J Gröne, U Helmchen. Impairment and recovery of the clipped kidney in two kidney, one clip hypertensive rats during and after antihypertensive therapy.
Laboratory investigation; a journal of technical methods and pathology.
1986 Jun; 54(6):645-55. doi:
NULL. [PMID: 3012198] - A Villar, M C Terencio, M Paya. Hypotensive effect of Rhamnus lycioides extracts.
Journal of ethnopharmacology.
1986 Jun; 16(2-3):269-73. doi:
10.1016/0378-8741(86)90093-0. [PMID: 3528675] - J B Michel, J C Dussaule, L Choudat, C Auzan, D Nochy, P Corvol, J Menard. Effects of antihypertensive treatment in one-clip, two kidney hypertension in rats.
Kidney international.
1986 May; 29(5):1011-20. doi:
10.1038/ki.1986.101. [PMID: 3014201] - G Franke, P Pietsch, T Schneider, W Siegmund, D Grabow, H Schütz. Studies on the kinetics and distribution of dihydralazine in pregnancy.
Biological research in pregnancy and perinatology.
1986; 7(1):30-3. doi:
NULL. [PMID: 3955125] - H Herlitz, K Delin, T Hedner, G Granerus, M Aurell. Dissociation of renin and noradrenaline release in the renal circulation. Studies on patients with renal hypertension.
Scandinavian journal of urology and nephrology.
1986; 20(3):213-6. doi:
10.3109/00365598609024497. [PMID: 3538373] - P Hoffmann, T Bartels, S Heinemann, J Beitz, C Taube. Cardiovascular actions of dihydralazine as modified by dietary linoleic acid.
Biomedica biochimica acta.
1986; 45(8):1057-67. doi:
NULL. [PMID: 3535786] - M C Rouan, J Campestrini. Liquid chromatographic determination of dihydralazine and hydralazine in human plasma and its application to pharmacokinetic studies of dihydralazine.
Journal of pharmaceutical sciences.
1985 Dec; 74(12):1270-3. doi:
10.1002/jps.2600741206. [PMID: 4087193] - W Siegmund, M Zschiesche, R Kallwellis, G Franke, T Schneider, U Sill, A Scherber, H Hüller. [Quantitative determination and kinetics of dihydralazine in hypertension patients].
Die Pharmazie.
1985 Nov; 40(11):779-81. doi:
NULL. [PMID: 4095128] - J L Montastruc, M Rostin, F Lhoste, G Gaillard-Plaza, P Montastruc. [Role of the adrenal medulla in the effect of antihypertensive drugs].
Archives des maladies du coeur et des vaisseaux.
1985 Oct; 78(11):1647-51. doi:
NULL. [PMID: 3938235] - R Eggertsen, L Hansson. Vasodilators in hypertension--a review with special emphasis on the combined use of vasodilators and beta-adrenoceptor blockers.
International journal of clinical pharmacology, therapy, and toxicology.
1985 Aug; 23(8):411-23. doi:
NULL. [PMID: 2864319] - U Lips. [Drug therapy in eclampsia].
Deutsche medizinische Wochenschrift (1946).
1985 Jun; 110(25):1007-8. doi:
10.1055/s-2008-1068950. [PMID: 3924543] - M Germond, H Bossart. [Importance of treating hypertension in pregnancy: clinical attitude].
Revue medicale de la Suisse romande.
1985 Feb; 105(2):109-21. doi:
NULL. [PMID: 2858913] - I W Reimann, D Ratge, H Wisser, J C Frölich. Influence of prostaglandin inhibition on dihydralazine induced acute effects in patients with essential hypertension.
Clinical and experimental pharmacology & physiology.
1985 Jan; 12(1):79-89. doi:
10.1111/j.1440-1681.1985.tb00306.x. [PMID: 3891171] - P Jouppila, P Kirkinen, A Koivula, O Ylikorkala. Effects of dihydralazine infusion on the fetoplacental blood flow and maternal prostanoids.
Obstetrics and gynecology.
1985 Jan; 65(1):115-8. doi:
NULL. [PMID: 3838110] - S Bacher, O Kraupp, A Beck, H Skoda, G Raberger. Characterization of vasodilators by comparison of their effects on blood pressure, counterregulation and myocardial oxygen demand in conscious normotensive dogs.
Arzneimittel-Forschung.
1985; 35(1A):288-91. doi:
NULL. [PMID: 3885964] - K D Kunze, H Porst, J Lohmann, L Tschöpel. [Liver lesions induced by dihydralazine and propranolol].
Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie.
1985; 130(1):19-29. doi:
NULL. [PMID: 3984541] - P Sassano, G Chatellier, A M Amiot, F Alhenc-Gelas, P Corvol, J Ménard. A double-blind randomized evaluation of converting enzyme inhibition as the first-step treatment of mild to moderate hypertension.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
1984 Dec; 2(2):S75-80. doi:
NULL. [PMID: 6100880] - J C Dussaule, J B Michel, C Auzan, F Alhenc-Gélas, P Corvol, J Ménard. [Comparison of the cardiac, renal and endocrine effects of converting enzyme inhibition with those of a classical triple therapy in experimental renal hypertension].
Archives des maladies du coeur et des vaisseaux.
1984 Oct; 77(11):1220-5. doi:
NULL. [PMID: 6098234] - S Bacher, O Kraupp, A Beck, R Seitelberger, G Raberger. Altered blood pressure response to propyldazine after repeated oral administration in conscious normotensive dogs: role of the renin-angiotensin system.
Basic research in cardiology.
1984 Sep; 79(5):588-97. doi:
10.1007/bf01910488. [PMID: 6391464] - S Bacher, O Kraupp, A Beck, R Seitelberger, G Raberger. Blood pressure response and renin release following 4 days of treatment with dihydralazine and urapidil in conscious dogs.
Cardiovascular research.
1984 Feb; 18(2):67-74. doi:
10.1093/cvr/18.2.67. [PMID: 6365312] - S Kazda, B Garthoff, G Luckhaus. Mode of antihypertensive action of nitrendipine.
Journal of cardiovascular pharmacology.
1984; 6 Suppl 7(?):S956-62. doi:
. [PMID: 6085384] - C Taube, H Höhler, S Lorenz, W Förster. The role of TXA2 in hypertension.
Biomedica biochimica acta.
1984; 43(8-9):S208-11. doi:
NULL. [PMID: 6549128] - S Björck, K Delin, H Herlitz, O Larsson, M Aurell. Renin secretion in advanced diabetic nephropathy.
Scandinavian journal of urology and nephrology. Supplementum.
1984; 79(?):53-7. doi:
NULL. [PMID: 6382585] - P Hoffmann, C Taube, T Bartels, S Heinemann, W Förster. Cardiovascular effects of antihypertensive drugs as affected by dietary polyunsaturates.
Biomedica biochimica acta.
1984; 43(8-9):S195-8. doi:
NULL. [PMID: 6393965] - R Mäntylä, P Männistö, S Nykänen, A Koponen, U Lamminsivu. Pharmacokinetic interactions of timolol with vasodilating drugs, food and phenobarbitone in healthy human volunteers.
European journal of clinical pharmacology.
1983; 24(2):227-30. doi:
10.1007/bf00613822. [PMID: 6840172] - K Delin, M Aurell, G Granerus. Renal vein renin on acute stimulation in diagnosis of renal hypertension.
Acta medica Scandinavica. Supplementum.
1983; 677(?):85-8. doi:
10.1111/j.0954-6820.1984.tb08637.x. [PMID: 6367378] - P H Degen, S Brechbühler, W Schneider, P Zbinden. Determination of apparent dihydralazine in plasma by gas--liquid chromatography and electron-capture detection.
Journal of chromatography.
1982 Dec; 233(?):375-80. doi:
10.1016/s0378-4347(00)81771-5. [PMID: 7161351] - M Marre, J Misumi, K D Raemsch, P Corvol, J Menard. Diuretic and natriuretic effects of nifedipine on isolated perfused rat kidneys.
The Journal of pharmacology and experimental therapeutics.
1982 Oct; 223(1):263-70. doi:
NULL. [PMID: 6750082] - G Bönner, D Beck, M Deeg, M Marin-Grez, F Gross. Effect of dihydralazine on the renal kallikrein-kinin system of the rat.
European journal of pharmacology.
1982 Feb; 78(2):219-23. doi:
10.1016/0014-2999(82)90239-4. [PMID: 6918300] - S de Flora, P Zanacchi, C Bennicelli, A Camoirano, M Cavanna, L Sciabà, E Cajelli, P Faggin, G Brambilla. In vivo and in vitro genotoxicity of three antihypertensive hydrazine derivatives (hydralazine, dihydralazine, and endralazine).
Environmental mutagenesis.
1982; 4(5):605-19. doi:
10.1002/em.2860040512. [PMID: 7140679]