Diclazuril (BioDeep_00000178226)
human metabolite blood metabolite
代谢物信息卡片
2-(4-chlorophenyl)-2-[2,6-dichloro-4-(5-hydroxy-3-oxo-2,3-dihydro-1,2,4-triazin-2-yl)phenyl]acetonitrile
化学式: C17H9Cl3N4O2 (405.9791064)
中文名称: 地克珠利
谱图信息:
最多检出来源 Homo sapiens(blood) 75%
分子结构信息
SMILES: C1=CC(=CC=C1C(C#N)C2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C=N3)Cl)Cl
InChI: InChI=1S/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:95118
- PubChem: 456389
- HMDB: HMDB0251204
- DrugBank: DB11398
- ChEMBL: CHEMBL284733
- Wikipedia: Diclazuril
- CAS: 101831-37-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pan Chen, Shijie Li, Lijun Zheng, Zhanming Wang, Yanfeng He, Kaili Liu, Manman Li, Yingmin Wang, Aftab Shaukat, Senyang Li, Shucheng Huang, Fuchun Jian. Effects of Radix dichroae extract supplementation on growth performance, oocysts output and gut microbiota in growing lambs with coccidiosis.
Veterinary research communications.
2024 Feb; 48(1):279-290. doi:
10.1007/s11259-023-10209-8. [PMID: 37667094] - Levent Dirikolu, Andreas Fritz Lehner, Thomas Tobin. Plasma concentrations of diclazuril following oral administration of diclazuril and diclazuril sodium salt to cattle.
Journal of veterinary pharmacology and therapeutics.
2022 Jul; 45(4):392-401. doi:
10.1111/jvp.13062. [PMID: 35488857] - Ran Chen, Ru-Jian He, Dong Guo, Zhi-Feng Zhang, Wei-Guang Zhang, Jun Fan. Interactions of diclazuril enantiomers with serum albumins: Multi-spectroscopic and molecular docking approaches.
Journal of molecular recognition : JMR.
2022 04; 35(4):e2948. doi:
10.1002/jmr.2948. [PMID: 35094438] - Fareed Uddin Memon, Imdad Hussain Leghari, Nasir Rajput, Javaid Ali Gadahi, Jam Zaheer Ahmed Sahito, Yunqiao Yang, Mirza Baber Baig, Farooque Laghari, Hamid Ali Memon, Hongbin Si. Immunomodulatory and ameliorative effects of probiotic in combination with diclazuril on broilers under coccidia infection.
Journal of applied microbiology.
2022 Apr; 132(4):3181-3188. doi:
10.1111/jam.15380. [PMID: 34820970] - Nicola Pusterla, Kaitlyn James, Fairfield Bain, D Craig Barnett, Duane Chappell, Earl Gaughan, Bryant Craig, Chrissie Schneider, Wendy Vaala, Mark Papich. Investigation of the Bi-Weekly Administration of Diclazuril on the Antibody Kinetics to Sarcocystis Neurona in Healthy Horses.
Journal of equine veterinary science.
2021 09; 104(?):103713. doi:
10.1016/j.jevs.2021.103713. [PMID: 34416990] - Maria E Nedişan, Adriana Györke, Cristina L Ştefănuţ, Zsuzsa Kalmár, Zsuzsa Friss, Radu Blaga, Amandine Blaizot, Andra Toma-Naic, Viorica Mircean, Gereon Schares, Olgica Djurković-Djaković, Ivana Klun, Isabelle Villena, Vasile Cozma. Experimental infection with Toxoplasma gondii in broiler chickens (Gallus domesticus): seroconversion, tissue cyst distribution, and prophylaxis.
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Journal of agricultural and food chemistry.
2020 Aug; 68(33):8987-8995. doi:
10.1021/acs.jafc.0c03091. [PMID: 32692165] - Yuxiang Xie, Bing Huang, Lingyang Xu, Qiping Zhao, Shunhai Zhu, Huanzhi Zhao, Hui Dong, Hongyu Han. Comparative Transcriptome Analyses of Drug-sensitive and Drug-resistant Strains of Eimeria tenella by RNA-sequencing.
The Journal of eukaryotic microbiology.
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Veterinary parasitology.
2019 Mar; 267(?):4-8. doi:
10.1016/j.vetpar.2019.01.006. [PMID: 30878083] - Laszlo Hunyadi, Mark G Papich, Nicola Pusterla. Diclazuril nonlinear mixed-effects pharmacokinetic modelling of plasma concentrations after oral administration to adult horses every 3-4 days.
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Veterinary parasitology.
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2015 Jun; 38(3):243-8. doi:
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2015 May; 58(9):3830-42. doi:
10.1021/acs.jmedchem.5b00012. [PMID: 25856229] - G Zechner, C Bauer, J Jacobs, L Goossens, G Vertenten, M A Taylor. Efficacy of diclazuril and toltrazuril in the prevention of coccidiosis in dairy calves under field conditions.
The Veterinary record.
2015 Jan; 176(5):126. doi:
10.1136/vr.102237. [PMID: 25371497] - P Philippe, J P Alzieu, M A Taylor, Ph Dorchies. Comparative efficacy of diclazuril (Vecoxan®) and toltrazuril (Baycox bovis®) against natural infections of Eimeria bovis and Eimeria zuernii in French calves.
Veterinary parasitology.
2014 Dec; 206(3-4):129-37. doi:
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2013 Aug; 112 Suppl 1(?):163-8. doi:
10.1007/s00436-013-3440-1. [PMID: 23756962] - Jorge Romero, Rodrigo Sanabria, Gabriel Travería, Leandro Di Paolo, Luis Peralta. Metaphylactic effect of Diclazuril 0.25\% in suckling beef calves, during a coccidiosis outbreak in extensive farming.
Veterinary parasitology.
2013 Mar; 193(1-3):277-80. doi:
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2012 Jun; 110(6):2131-6. doi:
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Tropical animal health and production.
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2011 Nov; 190(2):296-299. doi:
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2010 Mar; 168(3-4):185-9. doi:
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2009 Aug; 105 Suppl 1(?):S141-50. doi:
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Acta veterinaria Scandinavica.
2009 Mar; 51(?):11. doi:
10.1186/1751-0147-51-11. [PMID: 19298670] - B L Pan, Y F Zhang, X Suo, Y Xue. Effect of subcutaneously administered diclazuril on the output of Eimeria species oocysts by experimentally infected rabbits.
The Veterinary record.
2008 Feb; 162(5):153-5. doi:
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2007 Nov; 149(3-4):199-206. doi:
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2005 Apr; 129(1-2):1-9. doi:
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2004 May; 51(4):194-7. doi:
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