Alanylproline (BioDeep_00000017818)

   

human metabolite Endogenous natural product


代谢物信息卡片


(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carboxylic acid

化学式: C8H14N2O3 (186.1004374)
中文名称: 水合丙氨酸, L-丙氨酰-L-脯氨酸
谱图信息: 最多检出来源 Homo sapiens(feces) 13.87%

分子结构信息

SMILES: CC(C(=O)N1CCCC1C(=O)O)N
InChI: InChI=1S/C8H14N2O3/c1-5(9)7(11)10-4-2-3-6(10)8(12)13/h5-6H,2-4,9H2,1H3,(H,12,13)/t5-,6-/m0/s1

描述信息

Alanylproline is a dipeptide composed of alanine and proline. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.

同义名列表

21 个代谢物同义名

(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carboxylic acid; Alanine proline dipeptide; Alanine-proline dipeptide; L-alpha-Alanyl-L-proline; L-Α-alanyl-L-proline; 1-L-Alanyl-L-proline; N-L-Alanyl-L-proline; L-Alanyl-L-proline; 1-L-Alanylproline; N-Alanylproline; alanyl-proline; a-p Dipeptide; Alanylproline; H-Ala-Pro-OH; AP dipeptide; L-Ala-L-pro; NSC 97932; Ala-pro; A-P; AP; Ala-Pro



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J Schilz, U Binder, L Friedrich, M Gebauer, C Lutz, M Schlapschy, A Schiefner, A Skerra. Molecular recognition of structurally disordered Pro/Ala-rich sequences (PAS) by antibodies involves an Ala residue at the hot spot of the epitope. Journal of molecular biology. 2021 09; 433(18):167113. doi: 10.1016/j.jmb.2021.167113. [PMID: 34161780]
  • Ningning Zhang, Tristen Wright, Paige Caraway, Jianfeng Xu. Enhanced secretion of human α1-antitrypsin expressed with a novel glycosylation module in tobacco BY-2 cell culture. Bioengineered. 2019 12; 10(1):87-97. doi: 10.1080/21655979.2019.1604037. [PMID: 30957636]
  • Gang Liu, Kazuko Nakayama, Shiro Awata, Shuhan Tang, Noriko Kitaoka, Masanobu Manabe, Hiroyuki Kodama. Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors. Pediatric research. 2007 Jul; 62(1):54-9. doi: 10.1203/pdr.0b013e3180676d05. [PMID: 17515839]
  • G Fang, R Friesen, F Lanfermeijer, A Hagting, B Poolman, W N Konings. Manipulation of activity and orientation of membrane-reconstituted di-tripeptide transport protein DtpT of Lactococcus lactis. Molecular membrane biology. 1999 Oct; 16(4):297-304. doi: 10.1080/096876899294517. [PMID: 10766129]
  • I Naasani, K Sato, K Iseki, M Sugawara, M Kobayashi, K Miyazaki. Comparison of the transport characteristics of ceftibuten in rat renal and intestinal brush-border membranes. Biochimica et biophysica acta. 1995 Sep; 1231(2):163-8. doi: 10.1016/0005-2728(95)00073-r. [PMID: 7662695]
  • J Butterworth, D A Priestman. Presence in human cells and tissues of two prolidases and their alteration in prolidase deficiency. Journal of inherited metabolic disease. 1985; 8(4):193-7. doi: 10.1007/bf01805434. [PMID: 3939542]