Diaveridine (BioDeep_00000178179)

   

human metabolite blood metabolite


代谢物信息卡片


5-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-diimine

化学式: C13H16N4O2 (260.12731959999996)
中文名称: 敌菌净
谱图信息: 最多检出来源 Homo sapiens(blood) 99.34%

分子结构信息

SMILES: COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC
InChI: InChI=1S/C13H16N4O2/c1-18-10-4-3-8(6-11(10)19-2)5-9-7-16-13(15)17-12(9)14/h3-4,6-7H,5H2,1-2H3,(H4,14,15,16,17)

描述信息

C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent

同义名列表

11 个代谢物同义名

5-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydropyrimidine-2,4-diimine; 5-((3,4-Dimethoxyphenyl)methyl)-2,4-pyrimidinediamine; 5-(3,4-Dimethoxy-benzyl)-pyrimidine-2,4-diamine; 2,4-Diamino-5-(3,4-dimethoxybenzyl)pyrimidine; 2,4-Diamino-5-veratrylpyrimidine; Diaveridine monohydrochloride; Diaveridinum; Diaveridina; DIAVERIDINE; Diaveridin; EGIS-5645



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Liye Wang, Lihua Wen, Yuanhu Pan, Zhenli Liu, Chenyun Zhang, Zonghui Yuan, Lingli Huang. Development of radioactive tracing coupled with LC/MS-IT-TOF methodology for the discovery and identification of diaveridine metabolites in pigs. Food chemistry. 2021 Nov; 363(?):130200. doi: 10.1016/j.foodchem.2021.130200. [PMID: 34120054]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Y-F Li, H-Y Guo, F Yang, L-G Zhou, X-H Huang, H-Z Ding, Z-L Zeng. Comparative pharmacokinetics of diaveridine in pigs and chickens following single intravenous and oral administration. Journal of veterinary pharmacology and therapeutics. 2017 Oct; 40(5):500-504. doi: 10.1111/jvp.12384. [PMID: 28093774]
  • Yongjun Li, Shijin Bu. Determination of sulphachloropyrazine-diaveridine residues by high performance liquid chromatography in broiler edible tissues. The Journal of veterinary medical science. 2016 Jan; 77(12):1555-63. doi: 10.1292/jvms.14-0605. [PMID: 26212255]
  • Xu Wang, Shijia Su, Awais Ihsan, Qin Huang, Dongmei Chen, Guyue Cheng, Zhenli Liu, Yulian Wang, Zonghui Yuan. Acute and sub-chronic toxicity study of diaveridine in Wistar rats. Regulatory toxicology and pharmacology : RTP. 2015 Oct; 73(1):232-40. doi: 10.1016/j.yrtph.2015.07.010. [PMID: 26209270]
  • Hui Wang, Bo Yuan, Zhenling Zeng, Limin He, Huanzhong Ding, Chunna Guo, Xiangkai Kong, Wei Wang, Xianhui Huang. Identification and elucidation of the structure of in vivo metabolites of diaveridine in chicken. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Aug; 965(?):91-9. doi: 10.1016/j.jchromb.2014.06.010. [PMID: 24999617]
  • P Tömpe, G Giegler. [Polarographic determination of diaveridine in biological samples]. Acta pharmaceutica Hungarica. 1990 Jan; 60(1):23-9. doi: NULL. [PMID: 2327254]
  • T Sakano, S Masuda, T Amano. Determination of residual diaveridine and sulfaquinoxaline in Hen's egg, chicken plasma and tissues by high-performance liquid chromatography. Chemical & pharmaceutical bulletin. 1981 Aug; 29(8):2290-5. doi: 10.1248/cpb.29.2290. [PMID: 7318037]