Dialuric acid (BioDeep_00000178166)
human metabolite blood metabolite
代谢物信息卡片
5-hydroxy-1,3-diazinane-2,4,6-trione
化学式: C4H4N2O4 (144.0171064)
中文名称: 径尿酸
谱图信息:
最多检出来源 Homo sapiens(blood) 0.51%
分子结构信息
SMILES: C1(C(=O)NC(=O)NC1=O)O
InChI: InChI=1S/C4H4N2O4/c7-1-2(8)5-4(10)6-3(1)9/h1,7H,(H2,5,6,8,9,10)
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:76452
- PubChem: 179547
- HMDB: HMDB0251131
- MetaCyc: CPD-15999
- chemspider: 156284
- CAS: 444-15-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
12 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(12)
- 5,6-dimethylbenzimidazole biosynthesis I (aerobic):
FMNH2 + O2 ⟶ 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate - adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II:
5,6-dimethylbenzimidazole + NaMN ⟶ α-ribazole 5'-phosphate + H+ + nicotinate - 5,6-dimethylbenzimidazole biosynthesis I (aerobic):
FMNH2 + O2 ⟶ 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate - adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II:
α-ribazole + adenosylcobinamide-GDP ⟶ GMP + H+ + adenosylcobalamin - 5,6-dimethylbenzimidazole biosynthesis I (aerobic):
FMNH2 + O2 ⟶ 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + dialurate - adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II:
α-ribazole + adenosylcobinamide-GDP ⟶ GMP + H+ + adenosylcobalamin - adenosylcobalamin biosynthesis II (aerobic):
H2O + adenosylcobalamin 5'-phosphate ⟶ adenosylcobalamin + phosphate - 5,6-dimethylbenzimidazole biosynthesis I (aerobic):
FMNH2 + NAD(P)+ ⟶ FMN + H+ + NAD(P)H - 5,6-dimethylbenzimidazole biosynthesis I (aerobic):
FMNH2 + NAD(P)+ ⟶ FMN + H+ + NAD(P)H - adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II:
5,6-dimethylbenzimidazole + NaMN ⟶ α-ribazole 5'-phosphate + H+ + nicotinate - adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II:
α-ribazole + adenosylcobinamide-GDP ⟶ GMP + H+ + adenosylcobalamin - adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II:
α-ribazole + adenosylcobinamide-GDP ⟶ GMP + H+ + adenosylcobalamin
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Paramashivam Sathish Kumar, Narayanan Dhiraviam Kannan. A system-level approach to investigate alloxan-induced toxicity in microtubule-binding protein to lead type 2 diabetes mellitus.
Molecular diversity.
2021 May; 25(2):911-924. doi:
10.1007/s11030-020-10075-5. [PMID: 32219736] - Albena Alexandrova, L Petrov, Mila Kessiova, Margarita Kirkova. In vitro effects of alloxan/copper combinations on lipid peroxidation, protein oxidation and antioxidant enzymes.
Acta biologica Hungarica.
2007 Dec; 58(4):359-67. doi:
10.1556/abiol.58.2007.4.3. [PMID: 18277462] - Matthias Elsner, Ewa Gurgul-Convey, Sigurd Lenzen. Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells.
Free radical biology & medicine.
2006 Sep; 41(5):825-34. doi:
10.1016/j.freeradbiomed.2006.06.002. [PMID: 16895803] - A Alexandrova, M Kirkova, E Russanov. In vitro effects of alloxan-vanadium combination on lipid peroxidation and on antioxidant enzyme activity.
General pharmacology.
1998 Sep; 31(3):489-93. doi:
10.1016/s0306-3623(97)00452-7. [PMID: 9703225] - M Stefek, Z Trnkova. The pyridoindole antioxidant stobadine prevents alloxan-induced lipid peroxidation by inhibiting its propagation.
Pharmacology & toxicology.
1996 Feb; 78(2):77-81. doi:
10.1111/j.1600-0773.1996.tb00183.x. [PMID: 8822038] - S R Pillai, J E Steiss, M G Traber, H J Kayden, J C Wright. Comparison of four erythrocyte fragility tests as indicators of vitamin E status in adult dogs.
Journal of comparative pathology.
1992 Nov; 107(4):399-410. doi:
10.1016/0021-9975(92)90014-l. [PMID: 1291588] - S Lenzen, M Mirzaie-Petri. Inhibition of aconitase by alloxan and the differential modes of protection of glucose, 3-O-methylglucose, and mannoheptulose.
Naunyn-Schmiedeberg's archives of pharmacology.
1992 Nov; 346(5):532-6. doi:
10.1007/bf00169009. [PMID: 1470224] - H P Monteiro, C C Winterbourn. Release of iron from ferritin by divicine, isouramil, acid-hydrolyzed vicine, and dialuric acid and initiation of lipid peroxidation.
Archives of biochemistry and biophysics.
1989 Jun; 271(2):536-45. doi:
10.1016/0003-9861(89)90305-6. [PMID: 2730003] - M Langweiler, R D Schultz, B E Sheffy. Effect of vitamin E deficiency on the proliferative response of canine lymphocytes.
American journal of veterinary research.
1981 Oct; 42(10):1681-5. doi:
NULL. [PMID: 7325428] - J Nagai, M Tanaka, H Hibasami, T Ikeda. Inhibition of oxidative hemolysis and lipid peroxidation by mepacrine.
Journal of biochemistry.
1981 Apr; 89(4):1143-8. doi:
". [PMID: 7251575] - M Mino, M Kitagawa, S Nakagawa. Changes of alpha-tocopherol levels in red blood cells and plasma with respect to hemolysis induced by dialuric acid in vitamin E-deficient rats.
Journal of nutritional science and vitaminology.
1981; 27(3):199-207. doi:
10.3177/jnsv.27.199. [PMID: 7288514] - J A Fee, R Bergamini, R G Briggs. Observations on the mechanism of the oxygen/dialuric acid-induced hemolysis of vitamin e-deficient rat red blood cells and the protective roles of catalase and superoxide dismutase.
Archives of biochemistry and biophysics.
1975 Jul; 169(1):160-7. doi:
10.1016/0003-9861(75)90329-x. [PMID: 168815] - J BUNYAN, J GREEN, E E EDWIN, A T DIPLOCK. Studies on vitamin E. 5. Lipid peroxidation in dialuric acid-induced haemolysis of vitamin E-deficient erythrocytes.
The Biochemical journal.
1960 Oct; 77(?):47-51. doi:
10.1042/bj0770047. [PMID: 13688869]