Desfuroyl Ceftiofur (BioDeep_00000178098)

   

human metabolite blood metabolite


代谢物信息卡片


7-[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-3-(sulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

化学式: C14H15N5O5S3 (429.02353000000005)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: CON=C(C(=O)NC1C2SCC(CS)=C(N2C1=O)C(O)=O)C1=CSC(N)=N1
InChI: InChI=1S/C14H15N5O5S3/c1-24-18-7(6-4-27-14(15)16-6)10(20)17-8-11(21)19-9(13(22)23)5(2-25)3-26-12(8)19/h4,8,12,25H,2-3H2,1H3,(H2,15,16)(H,17,20)(H,22,23)

描述信息

同义名列表

3 个代谢物同义名

7-[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-3-(sulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Desfuroyl Ceftiofur; Desfuroylceftiofur



数据库引用编号

2 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J S Woodrow, M Caldwell, S Cox, M Hines, B C Credille. Comparative plasma pharmacokinetics of ceftiofur sodium and ceftiofur crystalline-free acid in neonatal calves. Journal of veterinary pharmacology and therapeutics. 2016 Jun; 39(3):271-6. doi: 10.1111/jvp.12275. [PMID: 26542633]
  • O A Chiesa, S Feng, P Kijak, E A Smith, H Li, J Qiu. Plasma pharmacokinetics of ceftiofur metabolite desfuroylceftiofur cysteine disulfide in holstein steers: application of nonlinear mixed-effects modeling. Journal of veterinary pharmacology and therapeutics. 2016 Apr; 39(2):149-56. doi: 10.1111/jvp.12245. [PMID: 26112893]
  • Anne Beyer, Sven Baumann, Gesine Scherz, Jessica Stahl, Martin von Bergen, Anika Friese, Uwe Roesler, Manfred Kietzmann, Walther Honscha. Effects of ceftiofur treatment on the susceptibility of commensal porcine E.coli--comparison between treated and untreated animals housed in the same stable. BMC veterinary research. 2015 Oct; 11(?):265. doi: 10.1186/s12917-015-0578-3. [PMID: 26472561]
  • L Fultz, S Giguère, L J Berghaus, G S Grover, D A Merritt. Pulmonary pharmacokinetics of desfuroylceftiofur acetamide after nebulisation or intramuscular administration of ceftiofur sodium to weanling foals. Equine veterinary journal. 2015 Jul; 47(4):473-7. doi: 10.1111/evj.12316. [PMID: 24975449]
  • Shixia Feng, Oscar A Chiesa, Philip Kijak, Chaitali Chattopadhaya, Vicki Lancaster, Elizabeth A Smith, Lauren Girard, Sara Sklenka, Hui Li. Determination of ceftiofur metabolite desfuroylceftiofur cysteine disulfide in bovine tissues using liquid chromatography-tandem mass spectrometry as a surrogate marker residue for ceftiofur. Journal of agricultural and food chemistry. 2014 Jun; 62(22):5011-9. doi: 10.1021/jf405423e. [PMID: 24819974]
  • Sarah M Churgin, Kari E Musgrave, Sherry K Cox, Kurt K Sladky. Pharmacokinetics of subcutaneous versus intramuscular administration of ceftiofur crystalline-free acid to bearded dragons (Pogona vitticeps). American journal of veterinary research. 2014 May; 75(5):453-9. doi: 10.2460/ajvr.75.5.453. [PMID: 24762017]
  • L Fultz, S Giguère, L J Berghaus, J L Davis. Plasma and pulmonary pharmacokinetics of desfuroylceftiofur acetamide after weekly administration of ceftiofur crystalline free acid to adult horses. Equine veterinary journal. 2014 Mar; 46(2):252-5. doi: 10.1111/evj.12107. [PMID: 23679100]
  • M L Macpherson, S Giguère, J N Hatzel, M Pozor, S Benson, M Diaw, L C Sanchez, T W Vickroy, L Tell, S Wetzlich, J Sims. Disposition of desfuroylceftiofur acetamide in serum, placental tissue, fetal fluids, and fetal tissues after administration of ceftiofur crystalline free acid (CCFA) to pony mares with placentitis. Journal of veterinary pharmacology and therapeutics. 2013 Feb; 36(1):59-67. doi: 10.1111/j.1365-2885.2012.01392.x. [PMID: 22449008]
  • Michael J Adkesson, Randall E Junge, Matthew C Allender, Tomás Martín-Jiménez. Pharmacokinetics of a long-acting ceftiofur crystalline-free acid formulation in Asian elephants (Elephas maximus). American journal of veterinary research. 2012 Oct; 73(10):1512-8. doi: 10.2460/ajvr.73.10.1512. [PMID: 23013176]
  • B C Credille, S Giguère, L J Berghaus, A J Burton, T L Sturgill, G S Grover, J M Donecker, S A Brown. Plasma and pulmonary disposition of ceftiofur and its metabolites after intramuscular administration of ceftiofur crystalline free acid in weanling foals. Journal of veterinary pharmacology and therapeutics. 2012 Jun; 35(3):259-64. doi: 10.1111/j.1365-2885.2011.01311.x. [PMID: 21605128]
  • Shixia Feng, Chaitali Chattopadhaya, Philip Kijak, Oscar A Chiesa, Elizabeth A Tall. A determinative and confirmatory method for ceftiofur metabolite desfuroylceftiofur cysteine disulfide in bovine kidney by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jun; 898(?):62-8. doi: 10.1016/j.jchromb.2012.04.020. [PMID: 22580013]
  • Katharine L Hope, Lisa A Tell, Barbara A Byrne, Suzan Murray, Scott E Wetzlich, Lisa H Ware, Warren Lynch, Luis R Padilla, Nancy C Boedeker. Pharmacokinetics of a single intramuscular injection of ceftiofur crystalline-free acid in American black ducks (Anas rubripes). American journal of veterinary research. 2012 May; 73(5):620-7. doi: 10.2460/ajvr.73.5.620. [PMID: 22533392]
  • Kimberlee B Wojick, Jennifer N Langan, Michael J Adkesson, Sherry K Cox, Kathryn C Gamble. Pharmacokinetics of long-acting ceftiofur crystalline-free acid in helmeted guineafowl (Numida meleagris) after a single intramuscular injection. American journal of veterinary research. 2011 Nov; 72(11):1514-8. doi: 10.2460/ajvr.72.11.1514. [PMID: 22023130]
  • Katerina Mastovska, Alan R Lightfield. Streamlining methodology for the multiresidue analysis of beta-lactam antibiotics in bovine kidney using liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2008 Aug; 1202(2):118-23. doi: 10.1016/j.chroma.2008.07.009. [PMID: 18656204]
  • G A Jacobson, S Martinod, C P Cunningham. Determination of ceftiofur in bovine plasma by HPLC-DAD. Journal of pharmaceutical and biomedical analysis. 2006 Mar; 40(5):1249-52. doi: 10.1016/j.jpba.2005.09.010. [PMID: 16242891]
  • S C Olson, M G Beconi-Barker, E B Smith, R A Martin, T J Vidmar, L D Adams. In vitro metabolism of ceftiofur in bovine tissues. Journal of veterinary pharmacology and therapeutics. 1998 Apr; 21(2):112-20. doi: 10.1046/j.1365-2885.1998.00118.x. [PMID: 9597648]
  • C R Clarke, S A Brown, R N Streeter, J M Clarke, P J Hamlow, J K Callahan, V L Hubbard, A K Speedy, G E Burrows. Penetration of parenterally administered ceftiofur into sterile vs. Pasteurella haemolytica-infected tissue chambers in cattle. Journal of veterinary pharmacology and therapeutics. 1996 Oct; 19(5):376-81. doi: 10.1111/j.1365-2885.1996.tb00067.x. [PMID: 8905572]
  • S A Salmon, J L Watts, R J Yancey. In vitro activity of ceftiofur and its primary metabolite, desfuroylceftiofur, against organisms of veterinary importance. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 1996 Jul; 8(3):332-6. doi: 10.1177/104063879600800309. [PMID: 8844576]
  • S A Brown, S T Chester, E J Robb. Effects of age on the pharmacokinetics of single dose ceftiofur sodium administered intramuscularly or intravenously to cattle. Journal of veterinary pharmacology and therapeutics. 1996 Feb; 19(1):32-8. doi: 10.1111/j.1365-2885.1996.tb00005.x. [PMID: 8992023]
  • M G Beconi-Barker, R D Roof, L Millerioux, F M Kausche, T H Vidmar, E B Smith, J K Callahan, V L Hubbard, G A Smith, T J Gilbertson. Determination of ceftiofur and its desfuroylceftiofur-related metabolites in swine tissues by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1995 Nov; 673(2):231-44. doi: 10.1016/0378-4347(95)00258-1. [PMID: 8611957]
  • B G Rose, C Kamps-Holtzapple, L H Stanker. Competitive indirect ELISA for ceftiofur sodium and the effect of different immunizing and coating antigen conjugates. Bioconjugate chemistry. 1995 Sep; 6(5):529-35. doi: 10.1021/bc00035a005. [PMID: 8974450]
  • P S Jaglan, R D Roof, F S Yein, T S Arnold, S A Brown, T J Gilbertson. Concentration of ceftiofur metabolites in the plasma and lungs of horses following intramuscular treatment. Journal of veterinary pharmacology and therapeutics. 1994 Feb; 17(1):24-30. doi: 10.1111/j.1365-2885.1994.tb00517.x. [PMID: 8196090]
  • K L Tyczkowska, R D Voyksner, K L Anderson, A L Aronson. Determination of ceftiofur and its metabolite desfuroylceftiofur in bovine serum and milk by ion-paired liquid chromatography. Journal of chromatography. 1993 Apr; 614(1):123-34. doi: 10.1016/0378-4347(93)80231-r. [PMID: 8496272]
  • P S Jaglan, B L Cox, T S Arnold, M F Kubicek, D J Stuart, T J Gilbertson. Liquid chromatographic determination of desfuroylceftiofur metabolite of ceftiofur as residue in cattle plasma. Journal - Association of Official Analytical Chemists. 1990 Jan; 73(1):26-30. doi: NULL. [PMID: 2312509]