Deflazacort (BioDeep_00000178014)
human metabolite blood metabolite
代谢物信息卡片
2-{11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-6,14,17-trien-8-yl}-2-oxoethyl acetate
化学式: C25H31NO6 (441.2151266)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OCC(=O)C12N=C(C)OC1CC1C3CCC4=CC(=O)C=CC4(C)C3C(O)CC21C
InChI: InChI=1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3
描述信息
同义名列表
4 个代谢物同义名
2-{11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-6,14,17-trien-8-yl}-2-oxoethyl acetate; 2-{11-hydroxy-6,9,13-trimethyl-16-oxo-5-oxa-7-azapentacyclo[10.8.0.0,.0,.0,]icosa-6,14,17-trien-8-yl}-2-oxoethyl acetic acid; 5H-Pregna-1,4-dieno(17,16-d)oxazole-3,20-dione, 21-(acetyloxy)-11-hydroxy-2-methyl-, (11beta,16beta)-; Deflazacort
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shriganesh R Barnela, Sachin S Soni, Sonali S Saboo, Ashish S Bhansali. Medical management of renal stone.
Indian journal of endocrinology and metabolism.
2012 Mar; 16(2):236-9. doi:
10.4103/2230-8210.93741. [PMID: 22470860] - Katherine Wesseling-Perry, Justine Bacchetta. CKD-MBD after kidney transplantation.
Pediatric nephrology (Berlin, Germany).
2011 Dec; 26(12):2143-51. doi:
10.1007/s00467-011-1829-6. [PMID: 21394466] - Christopher Seungkyu Lee, Eui Chun Kang, Kyu Sung Lee, Seok Ho Byeon, Hyoung Jun Koh, Sung Chul Lee. Central serous chorioretinopathy after renal transplantation.
Retina (Philadelphia, Pa.).
2011 Oct; 31(9):1896-903. doi:
10.1097/iae.0b013e31820a69ee. [PMID: 21499191] - Clara Sciorati, Daniela Miglietta, Roberta Buono, Viviana Pisa, Dario Cattaneo, Emanuele Azzoni, Silvia Brunelli, Emilio Clementi. A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.
Pharmacological research.
2011 Sep; 64(3):210-7. doi:
10.1016/j.phrs.2011.05.003. [PMID: 21609764] - Anna Rufo, Andrea Del Fattore, Mattia Capulli, Francesco Carvello, Loredana De Pasquale, Serge Ferrari, Dominique Pierroz, Lucia Morandi, Michele De Simone, Nadia Rucci, Enrico Bertini, Maria Luisa Bianchi, Fabrizio De Benedetti, Anna Teti. Mechanisms inducing low bone density in Duchenne muscular dystrophy in mice and humans.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2011 Aug; 26(8):1891-903. doi:
10.1002/jbmr.410. [PMID: 21509823] - Jonghyeon Choi, Yangsoon Lee, Hae-Sun Chung, Ja-Seung Koo, Dongeun Yong, Yu Sun Kim, Kyungwon Lee, Yunsop Chong. Subcutaneous phaeohyphomycosis caused by Phaeoacremonium species in a kidney transplant patient: the first case in Korea.
The Korean journal of laboratory medicine.
2011 Jul; 31(3):201-4. doi:
10.3343/kjlm.2011.31.3.201. [PMID: 21779196] - Yong Moon Shin. Posttransplantation lymphoproliferative disorder involving liver after renal transplantation.
The Korean journal of hepatology.
2011 Jun; 17(2):165-9. doi:
10.3350/kjhep.2011.17.2.165. [PMID: 21757990] - Maurizio Benucci, Mariangela Manfredi, Sergio Testi, Maria L Iorno, Maurizio Valentini, Francesca Soldaini, Paolo Campi. Spondylarthritis presenting with an allergic immediate systemic reaction to adalimumab in a woman: a case report.
Journal of medical case reports.
2011 Apr; 5(?):155. doi:
10.1186/1752-1947-5-155. [PMID: 21504597] - Subhra Karmakar, Sangita Majumdar, Anasuya Maiti, Monalisa Choudhury, Aniruddha Ghosh, Asankur S Das, Chandan Mitra. Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction.
Journal of osteoporosis.
2011; 2011(?):426863. doi:
10.4061/2011/426863. [PMID: 21772972] - Jorge Vega, Francisco Javier Guarda, Helmuth Goecke, Gonzalo P Méndez. Complete remission of non-HIV collapsing glomerulopathy with deflazacort and lisinopril in an adult patient.
Clinical and experimental nephrology.
2010 Aug; 14(4):385-8. doi:
10.1007/s10157-010-0284-1. [PMID: 20428916] - Jorge R Ferraris, Titania Pasqualini, Guillermo Alonso, Susana Legal, Patricia Sorroche, Ana Galich, Paula Coccia, Lidia Ghezzi, Verónica Ferraris, Liliana Karabatas, Clara Guida, Héctor Jasper. A study on strategies for improving growth and body composition after renal transplantation.
Pediatric nephrology (Berlin, Germany).
2010 Apr; 25(4):753-62. doi:
10.1007/s00467-010-1458-5. [PMID: 20151158] - H E Yim, K H Yoo, Y S Hong, J W Lee. Acute tubulointerstitial nephritis complicated by Salmonella enteritidis gastroenteritis.
Clinical nephrology.
2010 Mar; 73(3):247-9. doi:
10.5414/cnp73247. [PMID: 20178727] - Seong Kwan Jung, Kyu Hee Park, Hyung Eun Yim, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Nam Hee Won. Primary Sjögren's syndrome with mesangial proliferative glomerulonephritis and IgA deposits in a child.
Pediatric nephrology (Berlin, Germany).
2010 Mar; 25(3):567-8. doi:
10.1007/s00467-009-1358-8. [PMID: 19902265] - Kyung Hee Choi, Ah Jeong Kim, In Ja Son, Kyung-Hwan Kim, Ki-Bong Kim, Hyuk Ahn, Eun Bong Lee. Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting.
Journal of Korean medical science.
2010 Mar; 25(3):337-41. doi:
10.3346/jkms.2010.25.3.337. [PMID: 20191029] - N Joshi, K Rajeshwari. Deflazacort.
Journal of postgraduate medicine.
2009 Oct; 55(4):296-300. doi:
10.4103/0022-3859.58942. [PMID: 20083885] - Jérôme Harambat, Pierre Cochat. Growth after renal transplantation.
Pediatric nephrology (Berlin, Germany).
2009 Jul; 24(7):1297-306. doi:
10.1007/s00467-008-0787-0. [PMID: 18365255] - Ciro Romano, Ausilia Sellitto, Umberto De Fanis, Raffaele Rossiello, Luigi Rossiello, Riccardo Giunta, Giacomo Lucivero. A scleroderma-like cutaneous syndrome associated with a marked Th2-type immune response occurring after a prosthetic joint implant.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.
2009 Apr; 15(3):133-7. doi:
10.1097/rhu.0b013e31819e6798. [PMID: 19300283] - Jorge Vega, Helmuth Goecke, Héctor Tapia, Eduardo Labarca, Mario Santamarina, Gonzalo Martínez. Treatment of idiopathic retroperitoneal fibrosis with colchicine and steroids: a case series.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2009 Apr; 53(4):628-37. doi:
10.1053/j.ajkd.2008.09.025. [PMID: 19117656] - J A Moro, L Almenar Bonet, L Martínez-Dolz, R Raso, I Sánchez-Lázaro, J Agüero, Antonio Salvador. Randomized prospective study of the evolution of renal function depending on the anticalcineurin used.
Transplantation proceedings.
2008 Nov; 40(9):2906-8. doi:
10.1016/j.transproceed.2008.08.117. [PMID: 19010143] - Inga-Lill Engvall, Björn Svensson, Birgitta Tengstrand, Kerstin Brismar, Ingiäld Hafström. Impact of low-dose prednisolone on bone synthesis and resorption in early rheumatoid arthritis: experiences from a two-year randomized study.
Arthritis research & therapy.
2008; 10(6):R128. doi:
10.1186/ar2542. [PMID: 18986531] - E M Hodson, N S Willis, J C Craig. Corticosteroid therapy for nephrotic syndrome in children.
The Cochrane database of systematic reviews.
2007 Oct; ?(4):CD001533. doi:
10.1002/14651858.cd001533.pub4. [PMID: 17943754] - G Saviola, L Abdi Ali, S Shams Eddin, A Coppini, F Cavalieri, L Campostrini, S Sacco, M Bucci, G Cirino, M Rossini. Compared clinical efficacy and bone metabolic effects of low-dose deflazacort and methyl prednisolone in male inflammatory arthropathies: a 12-month open randomized pilot study.
Rheumatology (Oxford, England).
2007 Jun; 46(6):994-8. doi:
10.1093/rheumatology/kem030. [PMID: 17384176] - Jorge R Ferraris, Titania Pasqualini, Guillermo Alonso, Susana Legal, Patricia Sorroche, Ana M Galich, Héctor Jasper. Effects of deflazacort vs. methylprednisone: a randomized study in kidney transplant patients.
Pediatric nephrology (Berlin, Germany).
2007 May; 22(5):734-41. doi:
10.1007/s00467-006-0403-0. [PMID: 17294225] - E M Hodson, J F Knight, N S Willis, J C Craig. Corticosteroid therapy for nephrotic syndrome in children.
The Cochrane database of systematic reviews.
2005 Jan; ?(1):CD001533. doi:
10.1002/14651858.cd001533.pub3. [PMID: 15674881] - R T Moxley, S Ashwal, S Pandya, A Connolly, J Florence, K Mathews, L Baumbach, C McDonald, M Sussman, C Wade. Practice parameter: corticosteroid treatment of Duchenne dystrophy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.
Neurology.
2005 Jan; 64(1):13-20. doi:
10.1212/01.wnl.0000148485.00049.b7. [PMID: 15642897] - W D Biggar, L Politano, V A Harris, L Passamano, J Vajsar, B Alman, A Palladino, L I Comi, G Nigro. Deflazacort in Duchenne muscular dystrophy: a comparison of two different protocols.
Neuromuscular disorders : NMD.
2004 Sep; 14(8-9):476-82. doi:
10.1016/j.nmd.2004.05.001. [PMID: 15336688] - M A Tarnopolsky, D J Mahoney, J Vajsar, C Rodriguez, T J Doherty, B D Roy, D Biggar. Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy.
Neurology.
2004 May; 62(10):1771-7. doi:
10.1212/01.wnl.0000125178.18862.9d. [PMID: 15159476] - E M Hodson, J F Knight, N S Willis, J C Craig. Corticosteroid therapy for nephrotic syndrome in children.
The Cochrane database of systematic reviews.
2004; ?(2):CD001533. doi:
10.1002/14651858.cd001533.pub2. [PMID: 15106158] - Jayakumar R Vidhun, Minnie M Sarwal. Corticosteroid avoidance in pediatric renal transplantation: can it be achieved?.
Paediatric drugs.
2004; 6(5):273-87. doi:
10.2165/00148581-200406050-00002. [PMID: 15449967] - R Pérez-Calderón, M A Gonzalo-Garijo, A Chaves, D de Argila. Cheilitis granulomatosa of Melkersson-Rosenthal syndrome: treatment with intralesional corticosteroid injections.
Allergologia et immunopathologia.
2004 Jan; 32(1):36-8. doi:
10.1016/s0301-0546(04)79221-6. [PMID: 14980194] - Titania Pasqualini, Jorge Ferraris. [Chronic renal insufficiency and growth].
Medicina.
2003; 63(6):731-6. doi:
NULL. [PMID: 14719318] - E M Hodson, J F Knight, N S Willis, J C Craig. Corticosteroid therapy for nephrotic syndrome in children.
The Cochrane database of systematic reviews.
2003; ?(1):CD001533. doi:
NULL. [PMID: 12535410] - Sven Diederich, Ekkehard Eigendorff, Patrick Burkhardt, Marcus Quinkler, Christiane Bumke-Vogt, Marina Rochel, Dieter Seidelmann, Peter Esperling, Wolfgang Oelkers, Volker Bähr. 11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids.
The Journal of clinical endocrinology and metabolism.
2002 Dec; 87(12):5695-701. doi:
10.1210/jc.2002-020970. [PMID: 12466373] - G Klaus, N Jeck, M Konrad, B Förster, M Soergel. Risk of steroid withdrawal in pediatric renal transplant patients with suspected steroid toxicity.
Clinical nephrology.
2001 Dec; 56(6):S37-42. doi:
NULL. [PMID: 11770812] - R T Krmar, J R Ferraris, J A Ramirez, C R Galarza, G Waisman, J J Janson, C J Llapur, P Sorroche, S Legal, M I Cámera. Hyperhomocysteinemia in stable pediatric, adolescents, and young adult renal transplant recipients.
Transplantation.
2001 Jun; 71(12):1748-51. doi:
10.1097/00007890-200106270-00008. [PMID: 11455253] - E M Hodson, J F Knight, N S Willis, J C Craig. Corticosteroid therapy for nephrotic syndrome in children.
The Cochrane database of systematic reviews.
2001; ?(2):CD001533. doi:
NULL. [PMID: 11405997]