Deepoxy-deoxynivalenol (BioDeep_00000178009)
human metabolite blood metabolite
代谢物信息卡片
3,10-dihydroxy-2-(hydroxymethyl)-1,5-dimethyl-12-methylidene-8-oxatricyclo[7.2.1.0^{2,7}]dodec-5-en-4-one
化学式: C15H20O5 (280.13106700000003)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 97.78%
分子结构信息
SMILES: CC1=CC2C(C(C1=O)O)(C3(CC(C(C3=C)O2)O)C)CO
InChI: InChI=1S/C15H20O5/c1-7-4-10-15(6-16,13(19)11(7)18)14(3)5-9(17)12(20-10)8(14)2/h4,9-10,12-13,16-17,19H,2,5-6H2,1,3H3
描述信息
D009676 - Noxae > D011042 - Poisons > D014255 - Trichothecenes
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kamil Stastny, Hana Stepanova, Karolina Hlavova, Martin Faldyna. Identification and determination of deoxynivalenol (DON) and deepoxy-deoxynivalenol (DOM-1) in pig colostrum and serum using liquid chromatography in combination with high resolution mass spectrometry (LC-MS/MS (HR)).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Sep; 1126-1127(?):121735. doi:
10.1016/j.jchromb.2019.121735. [PMID: 31394401] - Eugènia Miró-Abella, Helena Torrell, Pol Herrero, Núria Canela, Lluís Arola, Francesc Borrull, Rosa Ras, Núria Fontanals. Monitoring and evaluation of the interaction between deoxynivalenol and gut microbiota in Wistar rats by mass spectrometry-based metabolomics and next-generation sequencing.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Nov; 121(?):124-130. doi:
10.1016/j.fct.2018.08.006. [PMID: 30086347] - Chunli Deng, Chenglong Li, Shuang Zhou, Xiaodan Wang, Haibin Xu, Dan Wang, Yun Yun Gong, Michael N Routledge, Yunfeng Zhao, Yongning Wu. Risk assessment of deoxynivalenol in high-risk area of China by human biomonitoring using an improved high throughput UPLC-MS/MS method.
Scientific reports.
2018 03; 8(1):3901. doi:
10.1038/s41598-018-22206-y. [PMID: 29497102] - Heidi E Schwartz-Zimmermann, Christian Hametner, Veronika Nagl, Iris Fiby, Lukas Macheiner, Janine Winkler, Sven Dänicke, Erica Clark, James J Pestka, Franz Berthiller. Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows.
Archives of toxicology.
2017 Dec; 91(12):3857-3872. doi:
10.1007/s00204-017-2012-z. [PMID: 28638985] - Hilda M Guerrero-Netro, Anthony Estienne, Younès Chorfi, Christopher A Price. The mycotoxin metabolite deepoxy- deoxynivalenol increases apoptosis and decreases steroidogenesis in bovine ovarian theca cells.
Biology of reproduction.
2017 Nov; 97(5):746-757. doi:
10.1093/biolre/iox127. [PMID: 29045588] - Nurshad Ali, Meinolf Blaszkewicz, Gisela H Degen. Assessment of deoxynivalenol exposure among Bangladeshi and German adults by a biomarker-based approach.
Toxicology letters.
2016 Sep; 258(?):20-28. doi:
10.1016/j.toxlet.2016.06.006. [PMID: 27298273] - Heidi E Schwartz-Zimmermann, Philipp Fruhmann, Sven Dänicke, Gerlinde Wiesenberger, Sylvia Caha, Julia Weber, Franz Berthiller. Metabolism of deoxynivalenol and deepoxy-deoxynivalenol in broiler chickens, pullets, roosters and turkeys.
Toxins.
2015 Nov; 7(11):4706-29. doi:
10.3390/toxins7114706. [PMID: 26569307] - B Huybrechts, J C Martins, Ph Debongnie, S Uhlig, A Callebaut. Fast and sensitive LC-MS/MS method measuring human mycotoxin exposure using biomarkers in urine.
Archives of toxicology.
2015 Nov; 89(11):1993-2005. doi:
10.1007/s00204-014-1358-8. [PMID: 25209565] - N Broekaert, M Devreese, T De Mil, S Fraeyman, S De Baere, S De Saeger, P De Backer, S Croubels. Development and validation of an LC-MS/MS method for the toxicokinetic study of deoxynivalenol and its acetylated derivatives in chicken and pig plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Nov; 971(?):43-51. doi:
10.1016/j.jchromb.2014.09.012. [PMID: 25264912] - Mohammad Ebrahem, Susanne Kersten, Hana Valenta, Gerhard Breves, Sven Dänicke. Residues of deoxynivalenol (DON) and its metabolite de-epoxy-DON in eggs, plasma and bile of laying hens of different genetic backgrounds.
Archives of animal nutrition.
2014; 68(5):412-22. doi:
10.1080/1745039x.2014.949029. [PMID: 25139221] - Sven Dänicke, Ulrike Brezina. Kinetics and metabolism of the Fusarium toxin deoxynivalenol in farm animals: consequences for diagnosis of exposure and intoxication and carry over.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2013 Oct; 60(?):58-75. doi:
10.1016/j.fct.2013.07.017. [PMID: 23872131] - Silvia W Gratz, Gary Duncan, Anthony J Richardson. The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3-glucoside and may be responsible for urinary deepoxy-deoxynivalenol.
Applied and environmental microbiology.
2013 Mar; 79(6):1821-5. doi:
10.1128/aem.02987-12. [PMID: 23315729] - Malte Lohölter, Ulrich Meyer, Susanne Döll, Remy Manderscheid, Hans-Joachim Weigel, Martin Erbs, Martin Höltershinken, Gerhard Flachowsky, Sven Dänicke. Effects of the thermal environment on metabolism of deoxynivalenol and thermoregulatory response of sheep fed on corn silage grown at enriched atmospheric carbon dioxide and drought.
Mycotoxin research.
2012 Nov; 28(4):219-27. doi:
10.1007/s12550-012-0137-8. [PMID: 23606193] - Sven Dänicke, Hana Valenta, Susanne Kersten. Humic substances failed to prevent the systemic absorption of deoxynivalenol (DON) and its adverse effects on piglets.
Mycotoxin research.
2012 Nov; 28(4):253-60. doi:
10.1007/s12550-012-0138-7. [PMID: 23606197] - Veronika Nagl, Heidi Schwartz, Rudolf Krska, Wulf-Dieter Moll, Siegfried Knasmüller, Mathias Ritzmann, Gerhard Adam, Franz Berthiller. Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats.
Toxicology letters.
2012 Sep; 213(3):367-73. doi:
10.1016/j.toxlet.2012.07.024. [PMID: 22884771] - A Osselaere, M Devreese, A Watteyn, V Vandenbroucke, J Goossens, V Hautekiet, M Eeckhout, S De Saeger, S De Baere, P De Backer, S Croubels. Efficacy and safety testing of mycotoxin-detoxifying agents in broilers following the European Food Safety Authority guidelines.
Poultry science.
2012 Aug; 91(8):2046-54. doi:
10.3382/ps.2012-02245. [PMID: 22802203] - Michele Solfrizzo, Lucia Gambacorta, Veronica M T Lattanzio, Stephen Powers, Angelo Visconti. Simultaneous LC-MS/MS determination of aflatoxin M1, ochratoxin A, deoxynivalenol, de-epoxydeoxynivalenol, α and β-zearalenols and fumonisin B1 in urine as a multi-biomarker method to assess exposure to mycotoxins.
Analytical and bioanalytical chemistry.
2011 Nov; 401(9):2831-41. doi:
10.1007/s00216-011-5354-z. [PMID: 21892639] - S De Baere, J Goossens, A Osselaere, M Devreese, V Vandenbroucke, P De Backer, S Croubels. Quantitative determination of T-2 toxin, HT-2 toxin, deoxynivalenol and deepoxy-deoxynivalenol in animal body fluids using LC-MS/MS detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Aug; 879(24):2403-15. doi:
10.1016/j.jchromb.2011.06.036. [PMID: 21767999] - Veronica M T Lattanzio, Michele Solfrizzo, Annalisa De Girolamo, Sofía N Chulze, Adriana M Torres, Angelo Visconti. LC-MS/MS characterization of the urinary excretion profile of the mycotoxin deoxynivalenol in human and rat.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Apr; 879(11-12):707-15. doi:
10.1016/j.jchromb.2011.01.029. [PMID: 21367675] - Wageha A Awad, Michael Hess, Magdalena Twarużek, Jan Grajewski, Robert Kosicki, Josef Böhm, Jürgen Zentek. The impact of the Fusarium mycotoxin deoxynivalenol on the health and performance of broiler chickens.
International journal of molecular sciences.
2011; 12(11):7996-8012. doi:
10.3390/ijms12117996. [PMID: 22174646] - S Dänicke, M Beyer, G Breves, H Valenta, H-U Humpf. Effects of oral exposure of pigs to deoxynivalenol (DON) sulfonate (DONS) as the non-toxic derivative of DON on tissue residues of DON and de-epoxy-DON and on DONS blood levels.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2010 Nov; 27(11):1558-65. doi:
10.1080/19440049.2010.501036. [PMID: 20677033] - Paul C Turner, Richard P Hopton, Yannick Lecluse, Kay L M White, Julie Fisher, Pierre Lebailly. Determinants of urinary deoxynivalenol and de-epoxy deoxynivalenol in male farmers from Normandy, France.
Journal of agricultural and food chemistry.
2010 Apr; 58(8):5206-12. doi:
10.1021/jf100892v. [PMID: 20349912] - T Goyarts, S Dänicke, K-P Brüssow, H Valenta, K-H Ueberschär, U Tiemann. On the transfer of the Fusarium toxins deoxynivalenol (DON) and zearalenone (ZON) from sows to their fetuses during days 35-70 of gestation.
Toxicology letters.
2007 Jun; 171(1-2):38-49. doi:
10.1016/j.toxlet.2007.04.003. [PMID: 17544604] - N R Worrell, A K Mallett, W M Cook, N C Baldwin, M J Shepherd. The role of gut micro-organisms in the metabolism of deoxynivalenol administered to rats.
Xenobiotica; the fate of foreign compounds in biological systems.
1989 Jan; 19(1):25-32. doi:
10.3109/00498258909034673. [PMID: 2756716] - L M Côté, W Buck, E Jeffery. Lack of hepatic microsomal metabolism of deoxynivalenol and its metabolite, DOM-1.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1987 Apr; 25(4):291-5. doi:
10.1016/0278-6915(87)90125-6. [PMID: 3583156] - D B Prelusky, D M Veira, H L Trenholm, K E Hartin. Excretion profiles of the mycotoxin deoxynivalenol, following oral and intravenous administration to sheep.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1986 Feb; 6(2):356-63. doi:
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