Perflubutane (BioDeep_00000177996)
human metabolite blood metabolite
代谢物信息卡片
Perfluorobutane sulfonate
化学式: C4F10 (237.984)
中文名称: 全氟丁烷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C(F)(F)F)(F)F)(C(F)(F)F)(F)F
InChI: InChI=1S/C4F10/c5-1(6,3(9,10)11)2(7,8)4(12,13)14
描述信息
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:134964
- PubChem: 9638
- HMDB: HMDB0250914
- DrugBank: DB12821
- ChEMBL: CHEMBL2104979
- Wikipedia: Perfluorobutane
- CAS: 355-25-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Yichun Yang, Chengkai Liu, Jin Yan, Kebing Liu. Perfluorobutane contrast-enhanced ultrasonography for the diagnosis of HCC: a systematic review and meta-analysis.
Abdominal radiology (New York).
2021 10; 46(10):4619-4628. doi:
10.1007/s00261-021-03141-5. [PMID: 34086090] - Qiang Wu, Christophoros Mannaris, Jonathan P May, Luca Bau, Anastasia Polydorou, Sara Ferri, Dario Carugo, Nicholas D Evans, Eleanor Stride. Investigation of the Acoustic Vaporization Threshold of Lipid-Coated Perfluorobutane Nanodroplets Using Both High-Speed Optical Imaging and Acoustic Methods.
Ultrasound in medicine & biology.
2021 07; 47(7):1826-1843. doi:
10.1016/j.ultrasmedbio.2021.02.019. [PMID: 33820668] - Darrah A Merillat, Arvin Honari, Shashank R Sirsi. Production of Membrane-Filtered Phase-Shift Decafluorobutane Nanodroplets from Preformed Microbubbles.
Journal of visualized experiments : JoVE.
2021 03; ?(169):. doi:
10.3791/62203. [PMID: 33843933] - Brandon L Helfield, Kimoon Yoo, Jingjing Liu, Ross Williams, Paul S Sheeran, David E Goertz, Peter N Burns. Investigating the Accumulation of Submicron Phase-Change Droplets in Tumors.
Ultrasound in medicine & biology.
2020 10; 46(10):2861-2870. doi:
10.1016/j.ultrasmedbio.2020.06.021. [PMID: 32732167] - Xin-Yuan Cao, Juan Liu, Ya-Jie Zhang, Ya Wang, Jian-Wei Xiong, Jie Wu, Ling Chen. Exposure of adult mice to perfluorobutanesulfonate impacts ovarian functions through hypothyroxinemia leading to down-regulation of Akt-mTOR signaling.
Chemosphere.
2020 Apr; 244(?):125497. doi:
10.1016/j.chemosphere.2019.125497. [PMID: 31809938] - Antonia M Calafat, Kayoko Kato, Kendra Hubbard, Tao Jia, Julianne Cook Botelho, Lee-Yang Wong. Legacy and alternative per- and polyfluoroalkyl substances in the U.S. general population: Paired serum-urine data from the 2013-2014 National Health and Nutrition Examination Survey.
Environment international.
2019 10; 131(?):105048. doi:
10.1016/j.envint.2019.105048. [PMID: 31376596] - Daiki Omata, Tamotsu Maruyama, Johan Unga, Fumiko Hagiwara, Lisa Munakata, Saori Kageyama, Tadamitsu Shima, Yuno Suzuki, Kazuo Maruyama, Ryo Suzuki. Effects of encapsulated gas on stability of lipid-based microbubbles and ultrasound-triggered drug delivery.
Journal of controlled release : official journal of the Controlled Release Society.
2019 10; 311-312(?):65-73. doi:
10.1016/j.jconrel.2019.08.023. [PMID: 31461665] - Andrew M Siedlecki, Carol Benson, Mary Frates, Jamil Azzi, Ryan J Hoffman, Edgar Milford, Astrid Weins, Anil Chandraker, Nathan Mc Donald, Jason Philip White, Reza Abdi. First Report of Perfluorobutane Microsphere-Enhanced Ultrasound in the Transplant Kidney.
Transplantation.
2019 10; 103(10):e283-e284. doi:
10.1097/tp.0000000000002856. [PMID: 31335773] - Jaewoo Hwang, Kyuyong Kang, Jiwon Kang, Jihye Nam, Saechol Park, Junghee Yoon, Mincheol Choi. Effect of catheter diameter and injection rate of flush solution on renal contrast-enhanced ultrasonography with perfluorobutane in dogs.
American journal of veterinary research.
2019 Sep; 80(9):825-831. doi:
10.2460/ajvr.80.9.825. [PMID: 31449446] - Aina Jansen, Mette H B Müller, Randi Grønnestad, Ole Klungsøyr, Anuschka Polder, Eystein Skjerve, Jan Aaseth, Jan L Lyche. Decreased plasma levels of perfluoroalkylated substances one year after bariatric surgery.
The Science of the total environment.
2019 Mar; 657(?):863-870. doi:
10.1016/j.scitotenv.2018.11.453. [PMID: 30677951] - Zhe Jin, Miao Chi, Quan He, Yuanjiang Pan, Cuirong Sun. Perfluoroalkane sulfonyl fluorides non-covalently bind to human serum albumin at Sudlow's sites.
Toxicology letters.
2019 Feb; 301(?):17-23. doi:
10.1016/j.toxlet.2018.11.001. [PMID: 30408508] - Yiwen Wang, Wenchao Han, Caifeng Wang, Yijun Zhou, Rong Shi, Eva Cecilie Bonefeld-Jørgensen, Qian Yao, Tao Yuan, Yu Gao, Jun Zhang, Ying Tian. Efficiency of maternal-fetal transfer of perfluoroalkyl and polyfluoroalkyl substances.
Environmental science and pollution research international.
2019 Jan; 26(3):2691-2698. doi:
10.1007/s11356-018-3686-3. [PMID: 30484044] - Shuyan Zhao, Tiankun Liang, Tao Zhou, Dongqi Li, Bohui Wang, Jingjing Zhan, Lifen Liu. Biotransformation and responses of antioxidant enzymes in hydroponically cultured soybean and pumpkin exposed to perfluorooctane sulfonamide (FOSA).
Ecotoxicology and environmental safety.
2018 10; 161(?):669-675. doi:
10.1016/j.ecoenv.2018.06.048. [PMID: 29935431] - Zhixiong Zhong, Gongke Li, Lingchuan Guo, Jing Yao, Zhe Liu, Jianchao Deng. Solid-phase extraction based on amino-functionalized graphene oxide nanocomposites for analysis of short-chain perfluorinated alkyl acids in human serum by ion chromatography mass spectrometry.
Biomedical chromatography : BMC.
2018 Jul; 32(7):e4223. doi:
10.1002/bmc.4223. [PMID: 29495074] - Shuyan Zhao, Tao Zhou, Lingyan Zhu, Bohui Wang, Ze Li, Liping Yang, Lifen Liu. Uptake, translocation and biotransformation of N-ethyl perfluorooctanesulfonamide (N-EtFOSA) by hydroponically grown plants.
Environmental pollution (Barking, Essex : 1987).
2018 Apr; 235(?):404-410. doi:
10.1016/j.envpol.2017.12.053. [PMID: 29306808] - Tingru Yin, Huiting Chen, Martin Reinhard, Xinzhu Yi, Yiliang He, Karina Yew-Hoong Gin. Perfluoroalkyl and polyfluoroalkyl substances removal in a full-scale tropical constructed wetland system treating landfill leachate.
Water research.
2017 11; 125(?):418-426. doi:
10.1016/j.watres.2017.08.071. [PMID: 28892769] - Chang Ho Yu, Bhupendra Patel, Marilou Palencia, Zhihua Tina Fan. A sensitive and accurate method for the determination of perfluoroalkyl and polyfluoroalkyl substances in human serum using a high performance liquid chromatography-online solid phase extraction-tandem mass spectrometry.
Journal of chromatography. A.
2017 Jan; 1480(?):1-10. doi:
10.1016/j.chroma.2016.11.063. [PMID: 27993395] - Shiying Wang, Claudia Y Wang, Sunil Unnikrishnan, Alexander L Klibanov, John A Hossack, F William Mauldin. Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results.
Investigative radiology.
2015 Nov; 50(11):772-84. doi:
10.1097/rli.0000000000000185. [PMID: 26135018] - Hangbiao Jin, Yifeng Zhang, Lingyan Zhu, Jonathan W Martin. Isomer profiles of perfluoroalkyl substances in water and soil surrounding a chinese fluorochemical manufacturing park.
Environmental science & technology.
2015 Apr; 49(8):4946-54. doi:
10.1021/acs.est.5b00212. [PMID: 25798817] - Lianying Zhang, Xiao-Min Ren, Bin Wan, Liang-Hong Guo. Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ.
Toxicology and applied pharmacology.
2014 Sep; 279(3):275-283. doi:
10.1016/j.taap.2014.06.020. [PMID: 24998974] - Robert J Paproski, Alexander Forbrich, Mary Hitt, Roger Zemp. RNA biomarker release with ultrasound and phase-change nanodroplets.
Ultrasound in medicine & biology.
2014 Aug; 40(8):1847-56. doi:
10.1016/j.ultrasmedbio.2014.01.011. [PMID: 24792584] - Shaogang Chu, Robert J Letcher. In vitro metabolic formation of perfluoroalkyl sulfonamides from copolymer surfactants of pre- and post-2002 scotchgard fabric protector products.
Environmental science & technology.
2014 Jun; 48(11):6184-91. doi:
10.1021/es500169x. [PMID: 24784168] - Paul A Mountford, Shashank R Sirsi, Mark A Borden. Condensation phase diagrams for lipid-coated perfluorobutane microbubbles.
Langmuir : the ACS journal of surfaces and colloids.
2014 Jun; 30(21):6209-18. doi:
10.1021/la501004u. [PMID: 24824162] - Jia Bao, Yungling Leo Lee, Pau-Chung Chen, Yi-He Jin, Guang-Hui Dong. Perfluoroalkyl acids in blood serum samples from children in Taiwan.
Environmental science and pollution research international.
2014 Jun; 21(12):7650-5. doi:
10.1007/s11356-014-2594-4. [PMID: 24622984] - Jingam Park, Donghee Park, Unchul Shin, Sanghyub Moon, Chihyun Kim, Han Sung Kim, Hyunjin Park, Kiju Choi, Bongkwang Jung, Jaemin Oh, Jongbum Seo. Synthesis of laboratory Ultrasound Contrast Agents.
Molecules (Basel, Switzerland).
2013 Oct; 18(10):13078-95. doi:
10.3390/molecules181013078. [PMID: 24152677] - Sumit Garg, Alex A Thomas, Mark A Borden. The effect of lipid monolayer in-plane rigidity on in vivo microbubble circulation persistence.
Biomaterials.
2013 Sep; 34(28):6862-70. doi:
10.1016/j.biomaterials.2013.05.053. [PMID: 23787108] - Debra J Cox, James L Thomas. Temperature-dependent biphasic shrinkage of lipid-coated bubbles in ultrasound.
Langmuir : the ACS journal of surfaces and colloids.
2013 Apr; 29(14):4485-91. doi:
10.1021/la400536e. [PMID: 23488632] - Janine Kowalczyk, Susan Ehlers, Anja Oberhausen, Marion Tischer, Peter Fürst, Helmut Schafft, Monika Lahrssen-Wiederholt. Absorption, distribution, and milk secretion of the perfluoroalkyl acids PFBS, PFHxS, PFOS, and PFOA by dairy cows fed naturally contaminated feed.
Journal of agricultural and food chemistry.
2013 Mar; 61(12):2903-12. doi:
10.1021/jf304680j. [PMID: 23441933] - M Takahashi, K Hasegawa, J Arita, S Hata, T Aoki, Y Sakamoto, Y Sugawara, N Kokudo. Contrast-enhanced intraoperative ultrasonography using perfluorobutane microbubbles for the enumeration of colorectal liver metastases.
The British journal of surgery.
2012 Sep; 99(9):1271-7. doi:
10.1002/bjs.8844. [PMID: 22829436] - E Davis Oldham, Wei Xie, Amir M Farnoud, Jennifer Fiegel, Hans-Joachim Lehmler. Disruption of phosphatidylcholine monolayers and bilayers by perfluorobutane sulfonate.
The journal of physical chemistry. B.
2012 Aug; 116(33):9999-10007. doi:
10.1021/jp304412p. [PMID: 22834732] - Paul S Sheeran, Samantha Luois, Paul A Dayton, Terry O Matsunaga. Formulation and acoustic studies of a new phase-shift agent for diagnostic and therapeutic ultrasound.
Langmuir : the ACS journal of surfaces and colloids.
2011 Sep; 27(17):10412-20. doi:
10.1021/la2013705. [PMID: 21744860] - Silvia Bijland, Patrick C N Rensen, Elsbet J Pieterman, Annemarie C E Maas, José W van der Hoorn, Marjan J van Erk, Louis M Havekes, Ko Willems van Dijk, Shu-Ching Chang, David J Ehresman, John L Butenhoff, Hans M G Princen. Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-Leiden CETP mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2011 Sep; 123(1):290-303. doi:
10.1093/toxsci/kfr142. [PMID: 21705711] - Debra J Cox, James L Thomas. Ultrasound-induced dissolution of lipid-coated and uncoated gas bubbles.
Langmuir : the ACS journal of surfaces and colloids.
2010 Sep; 26(18):14774-81. doi:
10.1021/la102583k. [PMID: 20722377] - Minseok Seo, Ivan Gorelikov, Ross Williams, Naomi Matsuura. Microfluidic assembly of monodisperse, nanoparticle-incorporated perfluorocarbon microbubbles for medical imaging and therapy.
Langmuir : the ACS journal of surfaces and colloids.
2010 Sep; 26(17):13855-60. doi:
10.1021/la102272d. [PMID: 20666507] - Carl Solis, Flemming Forsberg, Margaret A Wheatley. Preserving enhancement in freeze-dried contrast agent ST68: Examination of excipients.
International journal of pharmaceutics.
2010 Aug; 396(1-2):30-8. doi:
10.1016/j.ijpharm.2010.06.004. [PMID: 20540998] - Kazushi Numata, Wen Luo, Manabu Morimoto, Masaaki Kondo, Yosuke Kunishi, Tomohiko Sasaki, Akito Nozaki, Katsuaki Tanaka. Contrast enhanced ultrasound of hepatocellular carcinoma.
World journal of radiology.
2010 Feb; 2(2):68-82. doi:
10.4329/wjr.v2.i2.68. [PMID: 21160920] - Jürgen Hölzer, Thomas Göen, Knut Rauchfuss, Martin Kraft, Jürgen Angerer, Peter Kleeschulte, Michael Wilhelm. One-year follow-up of perfluorinated compounds in plasma of German residents from Arnsberg formerly exposed to PFOA-contaminated drinking water.
International journal of hygiene and environmental health.
2009 Sep; 212(5):499-504. doi:
10.1016/j.ijheh.2009.04.003. [PMID: 19464951] - Lutz Ahrens, Sebastian Felizeter, Renate Sturm, Zhiyong Xie, Ralf Ebinghaus. Polyfluorinated compounds in waste water treatment plant effluents and surface waters along the River Elbe, Germany.
Marine pollution bulletin.
2009 Sep; 58(9):1326-33. doi:
10.1016/j.marpolbul.2009.04.028. [PMID: 19501845] - Geary W Olsen, Shu-Ching Chang, Patricia E Noker, Gregory S Gorman, David J Ehresman, Paul H Lieder, John L Butenhoff. A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans.
Toxicology.
2009 Feb; 256(1-2):65-74. doi:
10.1016/j.tox.2008.11.008. [PMID: 19059455] - Geary W Olsen, David C Mair, Timothy R Church, Mark E Ellefson, William K Reagen, Theresa M Boyd, Ross M Herron, Zahra Medhdizadehkashi, John B Nobiletti, Jorge A Rios, John L Butenhoff, Larry R Zobel. Decline in perfluorooctanesulfonate and other polyfluoroalkyl chemicals in American Red Cross adult blood donors, 2000-2006.
Environmental science & technology.
2008 Jul; 42(13):4989-95. doi:
10.1021/es800071x. [PMID: 18678038] - J L Newsted, Susan A Beach, S P Gallagher, J P Giesy. Acute and chronic effects of perfluorobutane sulfonate (PFBS) on the mallard and northern bobwhite quail.
Archives of environmental contamination and toxicology.
2008 Apr; 54(3):535-45. doi:
10.1007/s00244-007-9039-8. [PMID: 17917760] - Kazushi Numata, Manabu Morimoto, Takashi Ogura, Kazuya Sugimori, Shigeo Takebayashi, Masahiro Okada, Katsuaki Tanaka. Ablation therapy guided by contrast-enhanced sonography with Sonazoid for hepatocellular carcinoma lesions not detected by conventional sonography.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.
2008 Mar; 27(3):395-406. doi:
10.7863/jum.2008.27.3.395. [PMID: 18314518] - Julie A Straub, Donald E Chickering, Thomas G Hartman, Carol A Gloff, Howard Bernstein. AI-700 pharmacokinetics, tissue distribution and exhaled elimination kinetics in rats.
International journal of pharmaceutics.
2007 Jan; 328(1):35-41. doi:
10.1016/j.ijpharm.2006.07.052. [PMID: 16950578] - A L Klibanov, J J Rychak, W C Yang, S Alikhani, B Li, S Acton, J R Lindner, K Ley, S Kaul. Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow.
Contrast media & molecular imaging.
2006 Nov; 1(6):259-66. doi:
10.1002/cmmi.113. [PMID: 17191766] - Kim Gunnar Toft, Svein Olaf Hustvedt, Petter-Arnt Hals, Inger Oulie, Steinar Uran, Kristin Landmark, Per Trygve Normann, Tore Skotland. Disposition of perfluorobutane in rats after intravenous injection of Sonazoid.
Ultrasound in medicine & biology.
2006 Jan; 32(1):107-14. doi:
10.1016/j.ultrasmedbio.2005.09.008. [PMID: 16364802] - Kristin Inneke Van de Vijver, Philippe Hoff, Krishna Das, Sophie Brasseur, Walter Van Dongen, Eddy Esmans, Peter Reijnders, Ronny Blust, Wim De Coen. Tissue distribution of perfluorinated chemicals in harbor seals (Phoca vitulina) from the Dutch Wadden Sea.
Environmental science & technology.
2005 Sep; 39(18):6978-84. doi:
10.1021/es050942+. [PMID: 16201619] - Steinar Uran, Kristin Landmark, Per Trygve Normann, Petter-Arnt Hals, Kim Gunnar Toft, Tore Skotland. A respiration-metabolism chamber system and a GC-MS method developed for studying exhalation of perfluorobutane in rats after intravenous injection of the ultrasound contrast agent Sonazoid.
Journal of pharmaceutical and biomedical analysis.
2005 Sep; 39(3-4):746-51. doi:
10.1016/j.jpba.2005.04.038. [PMID: 15964732] - Nicholas N Kipshidze, Thomas R Porter, George Dangas, Hamid Yazdi, Fermin Tio, Feng Xie, David Hellinga, Jana Fournadjiev, Roswitha Wolfram, Rufus Seabron, Ron Waksman, Alexander Abizaid, Gary Roubin, Sriram Iyer, Martin B Leon, Jeffrey W Moses, Patrick Iversen. Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model.
Cardiovascular radiation medicine.
2003 Jul; 4(3):152-9. doi:
10.1016/s1522-1865(03)00184-7. [PMID: 14984716] - Donovan J May, John S Allen, Katherine W Ferrara. Dynamics and fragmentation of thick-shelled microbubbles.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control.
2002 Oct; 49(10):1400-10. doi:
10.1109/tuffc.2002.1041081. [PMID: 12403141] - Gregory E R Weller, Flordeliza S Villanueva, Alexander L Klibanov, William R Wagner. Modulating targeted adhesion of an ultrasound contrast agent to dysfunctional endothelium.
Annals of biomedical engineering.
2002 Sep; 30(8):1012-9. doi:
10.1114/1.1513565. [PMID: 12449762] - Raffaella Basilico, Martin J K Blomley, David O Cosgrove, Jean-Bernard Liull, Anne Broillet, Albrecht Bauer, Lorenzo Bonomo. The first phase I study of a novel ultrasound contrast agent (BR14): assessment of safety and efficacy in liver and kidneys.
Academic radiology.
2002 Aug; 9 Suppl 2(?):S380-1. doi:
10.1016/s1076-6332(03)80237-4. [PMID: 12188282] - E Hvattum, P T Normann, I Oulie, S Uran, O Ringstad, T Skotland. Determination of perfluorobutane in rat blood by automatic headspace capillary gas chromatography and selected ion monitoring mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2001 Jan; 24(3):487-94. doi:
10.1016/s0731-7085(00)00432-5. [PMID: 11199228] - F Forsberg, R Basude, J B Liu, J Alessandro, W T Shi, N M Rawool, B B Goldberg, M A Wheatley. Effect of filling gases on the backscatter from contrast microbubbles: theory and in vivo measurements.
Ultrasound in medicine & biology.
1999 Oct; 25(8):1203-11. doi:
10.1016/s0301-5629(99)00079-4. [PMID: 10576263] - F S Villanueva, R J Jankowski, S Klibanov, M L Pina, S M Alber, S C Watkins, G H Brandenburger, W R Wagner. Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells.
Circulation.
1998 Jul; 98(1):1-5. doi:
10.1161/01.cir.98.1.1. [PMID: 9665051]
