Dazmegrel (BioDeep_00000177976)
human metabolite blood metabolite
代谢物信息卡片
3-{3-[(1H-imidazol-1-yl)methyl]-2-methyl-1H-indol-1-yl}propanoic acid
化学式: C16H17N3O2 (283.1320702)
中文名称: 达美格雷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C2=CC=CC=C2N1CCC(=O)O)CN3C=CN=C3
InChI: InChI=1S/C16H17N3O2/c1-12-14(10-18-9-7-17-11-18)13-4-2-3-5-15(13)19(12)8-6-16(20)21/h2-5,7,9,11H,6,8,10H2,1H3,(H,20,21)
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C1327 - Antiplatelet Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D004791 - Enzyme Inhibitors
C471 - Enzyme Inhibitor
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jihong Jiang, Linda Tran, Harish Vasudevan, Zhengyuan Xia, Violet G Yuen, John H McNeill. Endothelin-1 blockade prevents COX2 induction and TXA2 production in the fructose hypertensive rat.
Canadian journal of physiology and pharmacology.
2007 Mar; 85(3-4):422-9. doi:
10.1139/y06-088. [PMID: 17612651] - D Galipeau, E Arikawa, I Sekirov, J H McNeill. Chronic thromboxane synthase inhibition prevents fructose-induced hypertension.
Hypertension (Dallas, Tex. : 1979).
2001 Oct; 38(4):872-6. doi:
10.1161/hyp.38.4.872. [PMID: 11641301] - O Büyükgebiz, A O Aktan, G Haklar, S Bilsel, M Dülger. The effects of thromboxane synthase inhibition on reperfusion injury and endothelin-1,2 levels in allograft kidney transplantation in rats.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.
1999 Apr; 198(6):289-98. doi:
10.1007/s004330050112. [PMID: 10369085] - E H Horn, E Hardy, J Cooper, S Heptinstall, P C Rubin. Platelet reactivity in vitro in relation to thromboxane in healthy pregnancy.
Thrombosis and haemostasis.
1996 Feb; 75(2):346-51. doi:
10.1055/s-0038-1650272. [PMID: 8815588] - J X Li, J R Oliver, C Y Lu, J B Philips. Delayed thromboxane or tumor necrosis factor-alpha, but not leukotriene inhibition, attenuates prolonged pulmonary hypertension in endotoxemia.
The American journal of the medical sciences.
1995 Sep; 310(3):103-10. doi:
10.1097/00000441-199531030-00004. [PMID: 7668305] - M A Kuzu, C Köksoy, I Alaçayir, O Yazar, E Kuterdem. Thromboxane synthase inhibitor, UK 38485, prevents renal injury in the rabbit isolated perfused kidney exposed to cold ischemia.
Transplantation.
1995 Apr; 59(8):1096-9. doi:
10.1097/00007890-199504270-00004. [PMID: 7732553] - M Friedman, S Y Wang, F W Sellke, A Franklin, R M Weintraub, R G Johnson. Pulmonary injury after total or partial cardiopulmonary bypass with thromboxane synthesis inhibition.
The Annals of thoracic surgery.
1995 Mar; 59(3):598-603. doi:
10.1016/0003-4975(94)00919-8. [PMID: 7887696] - S W Chang. TNF potentiates PAF-induced pulmonary vasoconstriction in the rat: role of neutrophils and thromboxane A2.
Journal of applied physiology (Bethesda, Md. : 1985).
1994 Dec; 77(6):2817-26. doi:
10.1152/jappl.1994.77.6.2817. [PMID: 7896627] - Z Greenfeld, M Rathaus, M Brezis. Functional significance of pharmacological blocking of renal thromboxane in old and young rat kidneys.
Annals of the New York Academy of Sciences.
1994 Jun; 717(?):213-5. doi:
10.1111/j.1749-6632.1994.tb12090.x. [PMID: 8030837] - E S Barefield, T P Hicks, J B Philips. Thromboxane and pulmonary morphometry in the development of the pulmonary hypertensive response to group B streptococcus.
Critical care medicine.
1994 Mar; 22(3):506-14. doi:
10.1097/00003246-199403000-00023. [PMID: 8125003] - E Girardin, G E Grau, L Paunier, C Le Coultre. Early hemodynamic and renal effects of tumor necrosis factor alpha: role of thromboxane.
Circulatory shock.
1994 Jan; 42(1):20-6. doi:
NULL. [PMID: 8149506] - A O Aktan, O Büyükgebiz, C Yegen, S H Yalçin, G Haklar, R Yalin, S Ercan. Does PGE2 act as a mediator for endothelin release?.
Prostaglandins, leukotrienes, and essential fatty acids.
1994 Jan; 50(1):37-41. doi:
10.1016/0952-3278(94)90103-1. [PMID: 7511821] - J X Li, B M Gray, D G Pritchard, J R Oliver, K D Grantham, J B Philips. Capsular type-specific polysaccharide partially inhibits group B Streptococcus-induced pulmonary hypertension.
The American review of respiratory disease.
1993 Jul; 148(1):152-7. doi:
10.1164/ajrccm/148.1.152. [PMID: 8317791] - M H Sullivan, Y Ahmed, M G Elder. Effects of a thromboxane synthetase inhibitor on platelet function; possible risks of use in pregnancy.
Prostaglandins.
1993 Jul; 46(1):21-6. doi:
10.1016/0090-6980(93)90059-g. [PMID: 8378539] - B J Tucker, C M Anderson, R S Thies, R C Collins, R C Blantz. Glomerular hemodynamic alterations during acute hyperinsulinemia in normal and diabetic rats.
Kidney international.
1992 Nov; 42(5):1160-8. doi:
10.1038/ki.1992.400. [PMID: 1453601] - M A Boim, H Ajzen, O L Ramos, N Schor. Glomerular hemodynamics and hormonal evaluation during starvation in rats.
Kidney international.
1992 Sep; 42(3):567-72. doi:
10.1038/ki.1992.320. [PMID: 1405335] - J X Li, B M Gray, J R Oliver, C Y Lu, J B Philips. Delayed thromboxane synthesis inhibition, but not cholinergic blockade, reverses group B streptococcus-induced pulmonary hypertension.
Developmental pharmacology and therapeutics.
1992; 19(1):40-9. doi:
10.1159/000457461. [PMID: 1307345] - C S Wilcox, W J Welch, H Snellen. Thromboxane mediates renal hemodynamic response to infused angiotensin II.
Kidney international.
1991 Dec; 40(6):1090-7. doi:
10.1038/ki.1991.319. [PMID: 1837063] - O F dos Santos, M A Boim, E J Barros, E Pirotzky, P Braquet, N Schor. Nephrotoxicity of cyclosporine: the role of platelet-activating factor and thromboxane.
Lipids.
1991 Dec; 26(12):1320-3. doi:
10.1007/bf02536557. [PMID: 1819724] - Z S Ercan, S Sindel, R Türker. Possible thromboxane A2 mediated effect of angiotensin II in the rabbit isolated perfused kidney.
Archives internationales de physiologie, de biochimie et de biophysique.
1991 Dec; 99(6):397-400. doi:
NULL. [PMID: 1725738] - R P Gladue, M F Newborg. The protective effects of the thromboxane synthetase inhibitor Dazmegrel on nephrotoxicity in cyclosporine-treated rats.
Transplantation.
1991 Nov; 52(5):837-41. doi:
10.1097/00007890-199111000-00016. [PMID: 1949170] - D R Morel, M Skoskiewicz, D R Robinson, K J Bloch, D C Hoaglin, W M Zapol. Leukotrienes, thromboxane A2, and prostaglandins during systemic anaphylaxis in sheep.
The American journal of physiology.
1991 Sep; 261(3 Pt 2):H782-92. doi:
10.1152/ajpheart.1991.261.3.h782. [PMID: 1716064] - E Hasanoğlu, O Uluoğlu, Z S Ercan. The protective effects of Iloprost and thromboxane synthetase inhibitor, UK 38485, against glycerol--induced acute renal failure in rats.
Prostaglandins, leukotrienes, and essential fatty acids.
1991 Jun; 43(2):99-102. doi:
10.1016/0952-3278(91)90179-9. [PMID: 1715995] - G O Rankin, M A Valentovic, V J Teets, D W Nicoll, D K Anestis, P I Brown. Effect of autacoid modulation on N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity.
Toxicology.
1991; 70(3):327-44. doi:
10.1016/0300-483x(91)90007-n. [PMID: 1771640] - B van Ooijen, W J Kort, C J Tinga, J H Wilson. Significance of thromboxane A2 and prostaglandin I2 in acute necrotizing pancreatitis in rats.
Digestive diseases and sciences.
1990 Sep; 35(9):1078-84. doi:
10.1007/bf01537578. [PMID: 1697236] - G O Rankin, M A Valentovic, V J Teets, D W Nicoll, P I Brown. Autacoid modulation and N-(3,5-dichlorophenyl)succinimide nephrotoxicity.
Toxicology letters.
1990 Sep; 53(1-2):207-9. doi:
10.1016/0378-4274(90)90128-9. [PMID: 2219169] - R A Stahl, F Thaiss, S Kahf, W Schoeppe, U M Helmchen. Immune-mediated mesangial cell injury--biosynthesis and function of prostanoids.
Kidney international.
1990 Aug; 38(2):273-81. doi:
10.1038/ki.1990.196. [PMID: 2119468] - M A Giembycz, C Kroegel, P J Barnes. Platelet activating factor stimulates cyclo-oxygenase activity in guinea pig eosinophils. Concerted biosynthesis of thromboxane A2 and E-series prostaglandins.
Journal of immunology (Baltimore, Md. : 1950).
1990 May; 144(9):3489-97. doi:
. [PMID: 2158510] - M Mistry, A Nasjletti. Contrasting effect of thromboxane synthase inhibitors and a thromboxane receptor antagonist on the development of angiotensin II-salt-induced hypertension in rats.
The Journal of pharmacology and experimental therapeutics.
1990 Apr; 253(1):90-4. doi:
NULL. [PMID: 2139470] - C S Wilcox, W J Welch. Thromboxane mediation of the pressor response to infused angiotensin II.
American journal of hypertension.
1990 Mar; 3(3):242-9. doi:
10.1093/ajh/3.3.242. [PMID: 2322437] - M Mistry, E E Muirhead, Y Yamaguchi, A Nasjletti. Renal function in rats with angiotensin II-salt-induced hypertension: effect of thromboxane synthesis inhibition and receptor blockade.
Journal of hypertension.
1990 Jan; 8(1):75-83. doi:
10.1097/00004872-199001000-00012. [PMID: 2157760] - M V Rebec, V A Skrinska. Pharmacology of UK-38485 (dazmegrel), a specific inhibitor of thromboxane A2 synthetase.
Prostaglandins, leukotrienes, and essential fatty acids.
1989 Dec; 38(3):207-12. doi:
10.1016/0952-3278(89)90074-4. [PMID: 2622975] - W J Welch, C S Wilcox, K R Dunbar. Modulation of renin by thromboxane: studies with thromboxane synthase inhibitor, receptor antagonists, and mimetic.
The American journal of physiology.
1989 Oct; 257(4 Pt 2):F554-60. doi:
10.1152/ajprenal.1989.257.4.f554. [PMID: 2508488] - P Morsing, A Stenberg, A E Persson. Effect of thromboxane inhibition on tubuloglomerular feedback in hydronephrotic kidneys.
Kidney international.
1989 Sep; 36(3):447-52. doi:
10.1038/ki.1989.215. [PMID: 2593488] - S I Himmelstein, P E Klotman. The role of thromboxane in two-kidney, one-clip Goldblatt hypertension in rats.
The American journal of physiology.
1989 Aug; 257(2 Pt 2):F190-6. doi:
10.1152/ajprenal.1989.257.2.f190. [PMID: 2527469] - R L Archer, A C Cunningham, P F Moore, J A Potter, M L Bliven, I G Otterness. Effects of dazmegrel, piroxicam and cyclophosphamide on the NZB/W model of SLE.
Agents and actions.
1989 Jun; 27(3-4):369-74. doi:
10.1007/bf01972825. [PMID: 2801326] - C LaLonde, R H Demling. Inhibition of thromboxane synthetase accentuates hemodynamic instability and burn edema in the anesthetized sheep model.
Surgery.
1989 May; 105(5):638-44. doi:
NULL. [PMID: 2705099] - B van Ooijen, W J Kort, C J Tinga, J H Wilson, D L Westbroek. Significance of prostaglandin E2 in acute necrotising pancreatitis in rats.
Gut.
1989 May; 30(5):671-4. doi:
10.1136/gut.30.5.671. [PMID: 2731761] - G R Martinez, K A Walker, D R Hirschfeld, P J Maloney, D S Yang, R P Rosenkranz. [(1H-imidazol-1-yl)methyl]- and [(3-pyridinyl)methyl]pyrroles as thromboxane synthetase inhibitors.
Journal of medicinal chemistry.
1989 Apr; 32(4):890-7. doi:
10.1021/jm00124a027. [PMID: 2704033] - D J Leehey, M T Uckerman, M A Rahman. Role of prostaglandins and thromboxane in the control of renal hemodynamics in experimental liver cirrhosis.
The Journal of laboratory and clinical medicine.
1989 Mar; 113(3):309-15. doi:
NULL. [PMID: 2926239] - M Mistry, A Nasjletti. Role of TXA2 in the pathogenesis of severe angiotensin II-salt hypertension.
Advances in prostaglandin, thromboxane, and leukotriene research.
1989; 19(?):207-10. doi:
NULL. [PMID: 2526469] - F Thaiss, P J Germann, S Kahf, W Schoeppe, U Helmchen, R A Stahl. Effect of thromboxane synthesis inhibition in a model of membranous nephropathy.
Kidney international.
1989 Jan; 35(1):76-83. doi:
10.1038/ki.1989.10. [PMID: 2709663] - E M Bullivant, C S Wilcox, W J Welch. Intrarenal vasoconstriction during hyperchloremia: role of thromboxane.
The American journal of physiology.
1989 Jan; 256(1 Pt 2):F152-7. doi:
10.1152/ajprenal.1989.256.1.f152. [PMID: 2912160] - C T Stier, I F Benter, S Levine. Thromboxane A2 in severe hypertension and stroke in stroke-prone spontaneously hypertensive rats.
Stroke.
1988 Sep; 19(9):1145-50. doi:
10.1161/01.str.19.9.1145. [PMID: 3413813] - M P Fink, P E Morrissey, K L Stein, R E Clement, V Fiallo, W M Gardiner. Systemic and regional hemodynamic effects of cyclo-oxygenase and thromboxane synthetase inhibition in normal and hyperdynamic endotoxemic rabbits.
Circulatory shock.
1988 Sep; 26(1):41-57. doi:
NULL. [PMID: 3142697] - V A Skrinska, M Konieczkowski, R G Gerrity, C F Galang, M V Rebec. Suppression of foam cell lesions in hypercholesterolemic rabbits by inhibition of thromboxane A2 synthesis.
Arteriosclerosis (Dallas, Tex.).
1988 Jul; 8(4):359-67. doi:
10.1161/01.atv.8.4.359. [PMID: 3134880] - W J Welch, C S Wilcox. Modulating role for thromboxane in the tubuloglomerular feedback response in the rat.
The Journal of clinical investigation.
1988 Jun; 81(6):1843-9. doi:
10.1172/jci113529. [PMID: 2968365] - M Mistry, A Nasjletti. Role of pressor prostanoids in rats with angiotensin II-salt-induced hypertension.
Hypertension (Dallas, Tex. : 1979).
1988 Jun; 11(6 Pt 2):758-62. doi:
10.1161/01.hyp.11.6.758. [PMID: 3164706] - M Reinke, K Brune. A monoclonal anti-thromboxane B2 antibody.
FEBS letters.
1988 May; 232(1):46-50. doi:
10.1016/0014-5793(88)80383-1. [PMID: 3130275] - J E Robillard, K T Nakamura, V A Varille, A A Andresen, G P Matherne, D E VanOrden. Ontogeny of the renal response to natriuretic peptide in sheep.
The American journal of physiology.
1988 May; 254(5 Pt 2):F634-41. doi:
10.1152/ajprenal.1988.254.5.f634. [PMID: 3364574] - M Franco, P D Bell, L G Navar. Evaluation of prostaglandins as mediators of tubuloglomerular feedback.
The American journal of physiology.
1988 May; 254(5 Pt 2):F642-9. doi:
10.1152/ajprenal.1988.254.5.f642. [PMID: 3364575] - E K Jackson, F Goto, H D Uderman, R J Workman, W A Herzer, G A FitzGerald, R A Branch. Effects of thromboxane synthase inhibitors on renal function.
Naunyn-Schmiedeberg's archives of pharmacology.
1988 Feb; 337(2):183-90. doi:
10.1007/bf00169247. [PMID: 3285227] - L E Edstrom, M Balkovich, G J Slotman. Effect of ischemic skin flap elevation on tissue and plasma thromboxane A2 and prostacyclin production: modification by thromboxane synthetase inhibition.
Annals of plastic surgery.
1988 Feb; 20(2):106-11. doi:
10.1097/00000637-198802000-00002. [PMID: 3281544] - J Frøkiaer, F Tågehøj Jensen, S E Husted, J Mortensen, J C Djurhuus. Renal blood flow and pelvic pressure after 4 weeks of total upper urinary tract obstruction in the pig. The effect of a TxA2 synthetase inhibitor on active preglomerular vasoconstriction.
Urological research.
1988; 16(3):167-71. doi:
10.1007/bf00256014. [PMID: 3413908] - F Goto, E K Jackson, A Ohnishi, W Herzer, R A Branch. Effect of cyclooxygenase and thromboxane synthase inhibition on the response to angiotensin II in the hypoperfused canine kidney.
The Journal of pharmacology and experimental therapeutics.
1987 Dec; 243(3):799-803. doi:
NULL. [PMID: 3121844] - R P Kaufman, H Anner, L Kobzik, C R Valeri, D Shepro, H B Hechtman. A high plasma prostaglandin to thromboxane ratio protects against renal ischemia.
Surgery, gynecology & obstetrics.
1987 Nov; 165(5):404-9. doi:
. [PMID: 3672299] - M A Rahman, S N Emancipator, M J Dunn. Immune complex effects on glomerular eicosanoid production and renal hemodynamics.
Kidney international.
1987 Jun; 31(6):1317-26. doi:
10.1038/ki.1987.145. [PMID: 2441106] - R A Stahl, S Kudelka, U Helmchen. High protein intake stimulates glomerular prostaglandin formation in remnant kidneys.
The American journal of physiology.
1987 Jun; 252(6 Pt 2):F1088-94. doi:
10.1152/ajprenal.1987.252.6.f1088. [PMID: 3473940] - C Zoja, A Benigni, P Verroust, P Ronco, T Bertani, G Remuzzi. Indomethacin reduces proteinuria in passive Heymann nephritis in rats.
Kidney international.
1987 Jun; 31(6):1335-43. doi:
10.1038/ki.1987.147. [PMID: 2956450] - R A Stahl, S Adler, P J Baker, Y P Chen, P M Pritzl, W G Couser. Enhanced glomerular prostaglandin formation in experimental membranous nephropathy.
Kidney international.
1987 May; 31(5):1126-31. doi:
10.1038/ki.1987.118. [PMID: 3474470] - C P Gibbons, K N Wiley, N J Lindsey, M Fox, S Beck, D N Slater, F E Preston, C B Brown, A T Raftery. Cortical and vascular prostaglandin synthesis during renal allograft rejection in the rat.
Transplantation.
1987 Apr; 43(4):472-8. doi:
10.1097/00007890-198704000-00003. [PMID: 3554639] - P E Ganey, R A Roth. Thromboxane does not mediate pulmonary vascular response to monocrotaline pyrrole.
The American journal of physiology.
1987 Apr; 252(4 Pt 2):H743-8. doi:
10.1152/ajpheart.1987.252.4.h743. [PMID: 2952022] - R A Branch, F Goto, A Ohnishi, W Herzer, E K Jackson. Renal thromboxane A2 release stimulated by angiotensin II in the hypoperfused canine kidney.
Advances in prostaglandin, thromboxane, and leukotriene research.
1987; 17B(?):749-52. doi:
NULL. [PMID: 2960184] - I A Reilly, G A FitzGerald. Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs.
Blood.
1987 Jan; 69(1):180-6. doi:
NULL. [PMID: 3790723] - J Gower, B Fuller, C Green. Lipid peroxidation in the cortex and medulla of rabbit kidneys subjected to cold ischaemia and the value of protective agents.
Free radical research communications.
1987; 3(1-5):107-15. doi:
10.3109/10715768709069776. [PMID: 3508424] - J H Newman, B J Butka, K L Brigham. Thromboxane A2 and prostacyclin do not modulate pulmonary hemodynamics during exercise in sheep.
Journal of applied physiology (Bethesda, Md. : 1985).
1986 Nov; 61(5):1706-11. doi:
10.1152/jappl.1986.61.5.1706. [PMID: 3536839] - H T Cook, V Cattell, J Smith, J A Salmon, S Moncada. Effect of a thromboxane synthetase inhibitor on eicosanoid synthesis and glomerular injury during acute unilateral glomerulonephritis in the rat.
Clinical nephrology.
1986 Oct; 26(4):195-202. doi:
NULL. [PMID: 3490944] - K J Dallinger, M Toop, O H Gyde, A H Barnett. Specific thromboxane synthetase inhibition and haemostasis in insulin-dependent diabetics.
Diabetes research (Edinburgh, Scotland).
1986 Sep; 3(7):377-80. doi:
NULL. [PMID: 2946509] - I F Stamford, P B Melhuish, M A Carroll, C J Corrigan, S Patel, A Bennett. Survival of mice with NC carcinoma is unchanged by drugs that are thought to inhibit thromboxane synthesis or increase prostacyclin formation.
British journal of cancer.
1986 Aug; 54(2):257-63. doi:
10.1038/bjc.1986.171. [PMID: 3755610] - L A Lindsay, R W Olson, Y Sakane, R Ghai, E F Smith. Dazoxiben, UK 38,485 and aspirin: duration of effect for preventing thrombotic sudden death in rabbits.
Thrombosis research.
1986 Jul; 43(2):177-86. doi:
10.1016/0049-3848(86)90058-7. [PMID: 3090734] - S L Wang, J P Waymack, J W Alexander. Effect of Dazmegrel (UK-38,485) on immune function in a burned guinea-pig model.
Burns, including thermal injury.
1986 Jun; 12(5):307-11. doi:
10.1016/0305-4179(86)90099-9. [PMID: 3730909] - D Langleben, A C Carvalho, L M Reid. The platelet thromboxane inhibitor, dazmegrel, does not reduce monocrotaline-induced pulmonary hypertension.
The American review of respiratory disease.
1986 May; 133(5):789-91. doi:
NULL. [PMID: 3085563] - M M Hardee, J N Moore, G E Hardee. Effects of flunixin meglumine, phenylbutazone and a selective thromboxane synthetase inhibitor (UK-38,485) on thromboxane and prostacyclin production in healthy horses.
Research in veterinary science.
1986 Mar; 40(2):152-6. doi:
10.1016/s0034-5288(18)30505-8. [PMID: 3517992] - H J Grone, R S Grippo, W J Arendshorst, M J Dunn. Role of thromboxane in control of arterial pressure and renal function in young spontaneously hypertensive rats.
The American journal of physiology.
1986 Mar; 250(3 Pt 2):F488-96. doi:
10.1152/ajprenal.1986.250.3.f488. [PMID: 3953827] - R L Lorenz, S Fischer, W Wober, H A Wagner, P C Weber. Effects on prostanoid formation and pharmacokinetics of dazmegrel (UK-38,485), a novel thromboxane synthase inhibitor, in man.
Biochemical pharmacology.
1986 Mar; 35(5):761-6. doi:
10.1016/0006-2952(86)90243-1. [PMID: 3513767] - P E Klotman, S R Smith, B D Volpp, T M Coffman, W E Yarger. Thromboxane synthetase inhibition improves function of hydronephrotic rat kidneys.
The American journal of physiology.
1986 Feb; 250(2 Pt 2):F282-7. doi:
10.1152/ajprenal.1986.250.2.f282. [PMID: 3456211] - L A Scharschmidt, J G Douglas, M J Dunn. Angiotensin II and eicosanoids in the control of glomerular size in the rat and human.
The American journal of physiology.
1986 Feb; 250(2 Pt 2):F348-56. doi:
10.1152/ajprenal.1986.250.2.f348. [PMID: 2936254] - J N Moore, M M Hardee, G E Hardee. Modulation of arachidonic acid metabolism in endotoxic horses: comparison of flunixin meglumine, phenylbutazone, and a selective thromboxane synthetase inhibitor.
American journal of veterinary research.
1986 Jan; 47(1):110-3. doi:
. [PMID: 3080926] - R A Stahl, S Kudelka, M Paravicini, P Schollmeyer. Prostaglandin and thromboxane formation in glomeruli from rats with reduced renal mass.
Nephron.
1986; 42(3):252-7. doi:
10.1159/000183676. [PMID: 3456090] - J E Stork, M J Dunn. Hemodynamic roles of thromboxane A2 and prostaglandin E2 in glomerulonephritis.
The Journal of pharmacology and experimental therapeutics.
1985 Jun; 233(3):672-8. doi:
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The American journal of physiology.
1985 Jun; 248(6 Pt 2):F753-6. doi:
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Journal of cardiovascular pharmacology.
1985 Mar; 7(2):327-34. doi:
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The Journal of clinical investigation.
1985 Jan; 75(1):94-101. doi:
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Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.
1985; 185(2):107-13. doi:
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1984 Sep; 6(5):969-72. doi:
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Lancet (London, England).
1984 Jun; 1(8390):1322-5. doi:
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