Dasabuvir (BioDeep_00000177966)
human metabolite blood metabolite
代谢物信息卡片
N-{6-[3-tert-butyl-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide
化学式: C26H27N3O5S (493.1671332000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O
InChI: InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)
描述信息
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AP - Antivirals for treatment of hcv infections
C254 - Anti-Infective Agent > C281 - Antiviral Agent
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:85182
- PubChem: 56640146
- HMDB: HMDB0250872
- DrugBank: DB09183
- ChEMBL: CHEMBL3137312
- Wikipedia: Dasabuvir
- chemspider: 29776744
- CAS: 1132935-63-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xenia Bacinschi, Gabriel Cristian Popescu, Anca Zgura, Laurentia Gales, Anghel Rodica, Adriana Mercan, Dragos Serban, Bogdan Haineala, Letitia Toma, Laura Iliescu. A Real-World Study to Compare the Safety and Efficacy of Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir, with or without Ribavirin, in 587 Patients with Chronic Hepatitis C at the Fundeni Clinical Institute, Bucharest, Romania.
Medical science monitor : international medical journal of experimental and clinical research.
2022 Jul; 28(?):e936706. doi:
10.12659/msm.936706. [PMID: 35787600] - Xenia Bacinschi, Adriana Mercan-Stanciu, Letitia Toma, Anca Zgura, Nicolae Bacalbasa, Chen-Peng Ifrim, Camelia Diaconu, Laura Iliescu, Radu Valeriu Toma. Glycemic Control in Patients Undergoing Treatment With Paritaprevir/Ombitasvir/Ritonavir and Dasabuvir for Chronic Hepatitis C Infection.
In vivo (Athens, Greece).
2022 May; 36(3):1438-1443. doi:
10.21873/invivo.12849. [PMID: 35478152] - Tsuyoshi Hayashi, Kosuke Murakami, Junki Hirano, Yoshiki Fujii, Yoko Yamaoka, Hirofumi Ohashi, Koichi Watashi, Mary K Estes, Masamichi Muramatsu. Dasabuvir Inhibits Human Norovirus Infection in Human Intestinal Enteroids.
mSphere.
2021 12; 6(6):e0062321. doi:
10.1128/msphere.00623-21. [PMID: 34730374] - Fabrizio Fabrizi, Cristina Alonso, Ana Palazzo, Margarita Anders, Maria Virginia Reggiardo, Hugo Cheinquer, Maria Grazia Videla Zuain, Sebastian Figueroa, Manuel Mendizabal, Marcelo Silva, Ezequiel Ridruejo. 'Real-life' experience with direct-acting antiviral agents for HCV after kidney transplant.
Annals of hepatology.
2021 Nov; 25(?):100337. doi:
10.1016/j.aohep.2021.100337. [PMID: 33684523] - Donald D Anthony, Mark S Sulkowski, Laura M Smeaton, Sofi Damjanovska, Carey L Shive, Corinne M Kowal, Daniel E Cohen, Debika Bhattacharya, Beverly L Alston-Smith, Ashwin Balagopal, David L Wyles. Hepatitis C Virus (HCV) Direct-Acting Antiviral Therapy in Persons With Human Immunodeficiency Virus-HCV Genotype 1 Coinfection Resulting in High Rate of Sustained Virologic Response and Variable in Normalization of Soluble Markers of Immune Activation.
The Journal of infectious diseases.
2020 09; 222(8):1334-1344. doi:
10.1093/infdis/jiaa254. [PMID: 32406487] - Ashwin Balagopal, Laura M Smeaton, Jeffrey Quinn, Charles S Venuto, Gene D Morse, Vincent Vu, Beverly Alston-Smith, Daniel E Cohen, Jorge L Santana-Bagur, Donald D Anthony, Mark S Sulkowski, David L Wyles, Andrew H Talal. Intrahepatic Viral Kinetics During Direct-Acting Antivirals for Hepatitis C in Human Immunodeficiency Virus Coinfection: The AIDS Clinical Trials Group A5335S Substudy.
The Journal of infectious diseases.
2020 07; 222(4):601-610. doi:
10.1093/infdis/jiaa126. [PMID: 32201883] - Aliyah Almomen, Hadir M Maher, Nourah Z Alzoman, Shereen M Shehata, Shorog M Al-Taweel, Ashwaq A Alanazi. Development and validation of UPLC-MS/MS method for studying the pharmacokinetic interaction of dasabuvir and tamoxifen, 4-hydroxytamoxifen in Wistar rats.
Scientific reports.
2020 02; 10(1):3521. doi:
10.1038/s41598-020-60613-2. [PMID: 32103133] - Elena Laura Iliescu, Adriana Mercan-Stanciu, Letitia Toma. Safety and efficacy of direct-acting antivirals for chronic hepatitis C in patients with chronic kidney disease.
BMC nephrology.
2020 01; 21(1):21. doi:
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British journal of clinical pharmacology.
2020 01; 86(1):132-142. doi:
10.1111/bcp.14148. [PMID: 31656054] - Ezequiel Ridruejo, Rebeca Garcia-Agudo, Manuel Mendizabal, Sami Aoufi-Rabih, Vivek Dixit, Marcelo Silva, Fabrizio Fabrizi. Efficacy and safety of direct-acting antiviral agents for HCV in mild-to-moderate chronic kidney disease.
Nefrologia.
2020 Jan; 40(1):46-52. doi:
10.1016/j.nefro.2019.03.013. [PMID: 31229261] - Bengu Tatar, Şükran Köse, Nadide Colak Ergun, Melda Turken, Yusuf Onlen, Yusuf Yılmaz, Sıla Akhan. Response to direct-acting antiviral agents in chronic hepatitis C patients with end-stage renal disease: a clinical experience.
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2019 Dec; 65(12):1470-1475. doi:
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European journal of gastroenterology & hepatology.
2019 Nov; 31(11):1424-1431. doi:
10.1097/meg.0000000000001426. [PMID: 31589184] - Nikolina Bukal, Vesna Furic-Cunko, Ivana Juric, Lea Katalinic, Antonia Dedo, Nikolina Basic-Jukic. Severe hepatotoxicity of ritonavir, ombitasvir, paritaprevir, and dasabuvir in a kidney transplant recipient.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2019 Sep; 30(5):1184-1186. doi:
10.4103/1319-2442.270279. [PMID: 31696862] - Nilay Danış, Hüseyin Toz, Nalan Ünal, Mümtaz Yılmaz, İlker Turan, Fulya Günşar, Zeki Karasu, Galip Ersöz, Mehmet Özkahya, Ulus Salih Akarca. Paritaprevir, ritonavir, ombitasvir, and dasabuvir treatment in renal transplant patients with hepatitis C virus infection.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2019 Aug; 30(8):695-701. doi:
10.5152/tjg.2019.18833. [PMID: 31418413] - Serkan Yaraş, Enver Üçbilek, Osman Özdoğan, Fehmi Ateş, Engin Altıntaş, Orhan Sezgin. Real-life results of treatment with ombitasvir, paritaprevir, dasabuvir, and ritonavir combination in patients with chronic renal failure infected with HCV in Turkey.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2019 Apr; 30(4):331-335. doi:
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European journal of gastroenterology & hepatology.
2019 04; 31(4):534-539. doi:
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Gastroenterologia y hepatologia.
2019 Mar; 42(3):164-170. doi:
10.1016/j.gastrohep.2018.07.015. [PMID: 30293914] - Diğdem Özer Etik, Nuretdin Suna, Serkan Öcal, Haldun Selçuk, Ülkü Dağlı, Turan Çolak, Fatih Hilmioğlu, Ahmet Sedat Boyacıoğlu, Mehmet Haberal. Successful Treatment With Direct-Acting Antiviral Agents of Hepatitis C in Patients With End-Stage Renal Disease and Kidney Transplant Recipients.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2019 02; 17(1):52-58. doi:
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European journal of drug metabolism and pharmacokinetics.
2019 Feb; 44(1):43-52. doi:
10.1007/s13318-018-0492-8. [PMID: 29909549] - María-Carlota Londoño, Mar Riveiro-Barciela, Adriana Ahumada, Raquel Muñoz-Gómez, Mercé Roget, María J Devesa-Medina, Miguel Ángel Serra, Carmen A Navascués, Carme Baliellas, Teresa Aldamiz-Echevarría, María L Gutiérrez, Benjamín Polo-Lorduy, Isabel Carmona, Salvador Benlloch, Lucía Bonet, Javier García-Samaniego, Miguel Jiménez-Pérez, Senador Morán-Sánchez, Ángeles Castro, Manuel Delgado, Francisco Gea-Rodríguez, Ignacio Martín-Granizo, María Luisa Montes, Luís Morano, Manuel A Castaño, Ignacio de Los Santos, Montserrat Laguno, Juan Emilio Losa, Marta Montero-Alonso, Antonio Rivero, Cristina de Álvaro, Amanda Manzanares, Josep Mallolas, Guillermina Barril, Emilio González-Parra, Luisa García-Buey. Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice - Vie-KinD study.
PloS one.
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10.1371/journal.pone.0221567. [PMID: 31550267] - Faisal M Sanai, Abdullah S Alghamdi, Ahmad A Afghani, Khalid Alswat, Adnan AlZanbagi, Mosfer N Alghamdi, Abdallah AlMousa, Mohammed Aseeri, Abdullah M Assiri, Mohamed A Babatin. High Efficacy of ombitasvir/paritaprevir/ritonavir plus dasabuvir in hepatitis C genotypes 4 and 1-infected patients with severe chronic kidney disease.
Liver international : official journal of the International Association for the Study of the Liver.
2018 08; 38(8):1395-1401. doi:
10.1111/liv.13674. [PMID: 29288514] - W Abdel-Razek, I Waked. Editorial: is sofosbuvir-based therapy suitable for patients with advanced chronic kidney disease?.
Alimentary pharmacology & therapeutics.
2018 08; 48(3):379-380. doi:
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Alimentary pharmacology & therapeutics.
2018 07; 48(1):35-43. doi:
10.1111/apt.14799. [PMID: 29797514] - Jan Sperl, Miluse Kreidlova, Dusan Merta, Klara Chmelova, Renata Senkerikova, Sona Frankova. Paritaprevir/Ritonavir/Ombitasvir Plus Dasabuvir Regimen in the Treatment of Genotype 1 Chronic Hepatitis C Infection in Patients with Severe Renal Impairment and End-Stage Renal Disease: a Real-Life Cohort.
Kidney & blood pressure research.
2018; 43(2):594-605. doi:
10.1159/000488965. [PMID: 29669332] - Massimo Tempestilli, Gabriele Fabbri, Ilaria Mastrorosa, Laura Timelli, Stefania Notari, Rita Bellagamba, Raffaella Libertone, Federico Lupi, Mauro Zaccarelli, Andrea Antinori, Chiara Agrati, Adriana Ammassari. Plasma trough concentrations of antiretrovirals in HIV-infected persons treated with direct-acting antiviral agents for hepatitis C in the real world.
The Journal of antimicrobial chemotherapy.
2018 Jan; 73(1):160-164. doi:
10.1093/jac/dkx348. [PMID: 29106584] - Yi-Chung Hsieh, Wen-Juei Jeng, Chien-Hao Huang, Wei Teng, Wei-Ting Chen, Yi-Cheng Chen, Shi-Ming Lin, Dar-In Tai, Chun-Yen Lin, I-Shyan Sheen. Hepatic decompensation during paritaprevir/ritonavir/ombitasvir/dasabuvir treatment for genotype 1b chronic hepatitis C patients with advanced fibrosis and compensated cirrhosis.
PloS one.
2018; 13(8):e0202777. doi:
10.1371/journal.pone.0202777. [PMID: 30138456] - Fabrizio Fabrizi, Francesco Negro, Mark Bondin, Patrice Cacoub. Expert opinion on the management of renal manifestations of chronic HCV infection.
Antiviral therapy.
2018; 23(Suppl 2):57-67. doi:
10.3851/imp3247. [PMID: 30451153] - Jennifer E Stark, Jennifer Cole. Successful treatment of chronic hepatitis C virus infection in a patient receiving daily peritoneal dialysis.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2017 Oct; 74(19):1541-1544. doi:
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Clinical pharmacokinetics.
2017 10; 56(10):1115-1124. doi:
10.1007/s40262-017-0519-3. [PMID: 28258380] - Adeel Ajwad Butt, Peng Yan, Tracey G Simon, Abdul-Badi Abou-Samra. Effect of Paritaprevir/Ritonavir/Ombitasvir/Dasabuvir and Ledipasvir/Sofosbuvir Regimens on Survival Compared With Untreated Hepatitis C Virus-Infected Persons: Results From ERCHIVES.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2017 Sep; 65(6):1006-1011. doi:
10.1093/cid/cix364. [PMID: 28903508] - Francesca Romana Ponziani, Massimo Siciliano, Raffaella Lionetti, Caterina Pasquazzi, Laura Gianserra, Gianpiero D'Offizi, Antonio Gasbarrini, Maurizio Pompili. Effectiveness of Paritaprevir/Ritonavir/Ombitasvir/Dasabuvir in Hemodialysis Patients With Hepatitis C Virus Infection and Advanced Liver Fibrosis: Case Reports.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2017 Aug; 70(2):297-300. doi:
10.1053/j.ajkd.2017.01.037. [PMID: 28258770] - Mohamad Shebley, Jinrong Liu, Olga Kavetskaia, Jens Sydor, Sonia M de Morais, Volker Fischer, Marjoleen J M A Nijsen, Daniel A J Bow. Mechanisms and Predictions of Drug-Drug Interactions of the Hepatitis C Virus Three Direct-Acting Antiviral Regimen: Paritaprevir/Ritonavir, Ombitasvir, and Dasabuvir.
Drug metabolism and disposition: the biological fate of chemicals.
2017 07; 45(7):755-764. doi:
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Journal of virological methods.
2017 07; 245(?):14-18. doi:
10.1016/j.jviromet.2017.03.002. [PMID: 28359920] - Akshanth R Polepally, Prajakta S Badri, Doerthe Eckert, Sven Mensing, Rajeev M Menon. Effects of Mild and Moderate Renal Impairment on Ombitasvir, Paritaprevir, Ritonavir, Dasabuvir, and Ribavirin Pharmacokinetics in Patients with Chronic HCV Infection.
European journal of drug metabolism and pharmacokinetics.
2017 Apr; 42(2):333-339. doi:
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British journal of clinical pharmacology.
2017 03; 83(3):527-539. doi:
10.1111/bcp.13138. [PMID: 27662429] - David Wyles, Michael Saag, Rolando M Viani, Jacob Lalezari, Oluwatoyin Adeyemi, Laveeza Bhatti, Amit Khatri, Jennifer R King, Yiran B Hu, Roger Trinh, Nancy S Shulman, Peter Ruane. TURQUOISE-I Part 1b: Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with Ribavirin for Hepatitis C Virus Infection in HIV-1 Coinfected Patients on Darunavir.
The Journal of infectious diseases.
2017 02; 215(4):599-605. doi:
10.1093/infdis/jiw597. [PMID: 28329334] - Amit Khatri, Sandeep Dutta, Thomas C Marbury, Richard A Preston, Lino Rodrigues, Haoyu Wang, Walid M Awni, Rajeev M Menon. Pharmacokinetics and Tolerability of Anti-Hepatitis C Virus Treatment with Ombitasvir, Paritaprevir, Ritonavir, with or Without Dasabuvir, in Subjects with Renal Impairment.
Clinical pharmacokinetics.
2017 02; 56(2):153-163. doi:
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Antimicrobial agents and chemotherapy.
2017 02; 61(2):. doi:
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Journal of gastrointestinal and liver diseases : JGLD.
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Medicine.
2016 Nov; 95(47):e5304. doi:
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Antimicrobial agents and chemotherapy.
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Australian family physician.
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Clinical pharmacokinetics.
2016 08; 55(8):1003-14. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
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Gastroenterology.
2016 Jun; 150(7):1590-1598. doi:
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Therapeutic drug monitoring.
2016 06; 38(3):285-7. doi:
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Journal of viral hepatitis.
2016 Feb; 23(2):96-104. doi:
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2015 Oct; 63(4):805-12. doi:
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2015 Sep; 47(9):727-33. doi:
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