Dapansutrile (BioDeep_00000177954)
human metabolite blood metabolite
代谢物信息卡片
化学式: C4H7NO2S (133.0197482)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)CCC#N
InChI: InChI=1S/C4H7NO2S/c1-8(6,7)4-2-3-5/h2,4H2,1H3
描述信息
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000893 - Anti-Inflammatory Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 12714644
- HMDB: HMDB0250857
- ChEMBL: CHEMBL3989943
- Wikipedia: Dapansutrile
- chemspider: 14967771
- CAS: 54863-37-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mohamed S Elsayed, Nashwa M Abu-Elsaad, Manar A Nader. The NLRP3 inhibitor dapansutrile attenuates folic acid induced nephrotoxicity via inhibiting inflammasome/caspase-1/IL axis and regulating autophagy/proliferation.
Life sciences.
2021 Nov; 285(?):119974. doi:
10.1016/j.lfs.2021.119974
. [PMID: 34560082] - Te-Sheng Lien, Der-Shan Sun, Cheng-Yeu Wu, Hsin-Hou Chang. Exposure to Dengue Envelope Protein Domain III Induces Nlrp3 Inflammasome-Dependent Endothelial Dysfunction and Hemorrhage in Mice.
Frontiers in immunology.
2021; 12(?):617251. doi:
10.3389/fimmu.2021.617251
. [PMID: 33717109] - Niklas Lonnemann, Shirin Hosseini, Carlo Marchetti, Damaris B Skouras, Davide Stefanoni, Angelo D'Alessandro, Charles A Dinarello, Martin Korte. The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America.
2020 12; 117(50):32145-32154. doi:
10.1073/pnas.2009680117
. [PMID: 33257576] - V Quagliariello, A Bonelli, A Caronna, M C Lombari, G Conforti, M Libutti, R V Iaffaioli, M Berretta, G Botti, N Maurea. SARS-CoV-2 infection: NLRP3 inflammasome as plausible target to prevent cardiopulmonary complications?.
European review for medical and pharmacological sciences.
2020 09; 24(17):9169-9171. doi:
10.26355/eurrev_202009_22867
. [PMID: 32965010] - Stefano Toldo, Adolfo Gabriele Mauro, Zachary Cutter, Benjamin W Van Tassell, Eleonora Mezzaroma, Marco Giuseppe Del Buono, Andrea Prestamburgo, Nicola Potere, Antonio Abbate. The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse.
Journal of cardiovascular pharmacology.
2019 04; 73(4):215-222. doi:
10.1097/fjc.0000000000000658
. [PMID: 30747785] - Carlo Marchetti, Benjamin Swartzwelter, Marije I Koenders, Tania Azam, Isak W Tengesdal, Nick Powers, Dennis M de Graaf, Charles A Dinarello, Leo A B Joosten. NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis.
Arthritis research & therapy.
2018 08; 20(1):169. doi:
10.1186/s13075-018-1664-2
. [PMID: 30075804] - Carlo Marchetti, Benjamin Swartzwelter, Fabia Gamboni, Charles P Neff, Katrin Richter, Tania Azam, Sonia Carta, Isak Tengesdal, Travis Nemkov, Angelo D'Alessandro, Curtis Henry, Gerald S Jones, Scott A Goodrich, Joseph P St Laurent, Terry M Jones, Curtis L Scribner, Robert B Barrow, Roy D Altman, Damaris B Skouras, Marco Gattorno, Veronika Grau, Sabina Janciauskiene, Anna Rubartelli, Leo A B Joosten, Charles A Dinarello. OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Proceedings of the National Academy of Sciences of the United States of America.
2018 02; 115(7):E1530-E1539. doi:
10.1073/pnas.1716095115
. [PMID: 29378952]