Dalamid (BioDeep_00000177933)
human metabolite blood metabolite
代谢物信息卡片
化学式: C28H38N6O6S (586.2573408000001)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 95%
分子结构信息
SMILES: CC(C(=O)NCC(=O)NC(CC1=CC=CC=C1)C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC2=CC=C(C=C2)O)N
InChI: InChI=1S/C28H38N6O6S/c1-17(32-27(39)21(29)14-19-8-10-20(35)11-9-19)26(38)31-16-24(36)33-23(15-18-6-4-3-5-7-18)28(40)34-22(25(30)37)12-13-41-2/h3-11,17,21-23,35H,12-16,29H2,1-2H3,(H2,30,37)(H,31,38)(H,32,39)(H,33,36)(H,34,40)
描述信息
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
D018377 - Neurotransmitter Agents > D004745 - Enkephalins
同义名列表
15 个代谢物同义名
2-{[2-({2-[(2-{[2-amino-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxypropylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxy-3-phenylpropylidene]amino}-4-(methylsulphanyl)butanimidic acid; 2-{[2-({2-[(2-{[2-amino-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxypropylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxy-3-phenylpropylidene]amino}-4-(methylsulphanyl)butanimidate; 2-{[2-({2-[(2-{[2-amino-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino}-1-hydroxypropylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxy-3-phenylpropylidene]amino}-4-(methylsulfanyl)butanimidate; 2-[2-(2-{2-[2-amino-3-(4-hydroxyphenyl)propanamido]propanamido}acetamido)-3-phenylpropanamido]-4-(methylsulfanyl)butanamide; D-Ala(2)-methionine-enkephalinamide; Enkephalinamide, ala(2), met(5); D-Ala(2)-met(5)-enkephalinamide; D-Ala(2)-leu(5)-enkephalinamide; Ala(2)-met(5)-enkephalinamide; 2-Ala-met-enkephalinamide; D-Enkephalin; Dalamide; Dalamid; DAME; DALA
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- N A Shahabi, B M Sharp. Delta opioid agonists inhibit proliferation of highlypurified murine CD4+ and CD8+ T-cells.
Advances in experimental medicine and biology.
1995; 373(?):29-36. doi:
10.1007/978-1-4615-1951-5_5. [PMID: 7668157] - L Wang, D Toledo-Velasquez, D Schwegler-Berry, J K Ma, Y Rojanasakul. Transport and hydrolysis of enkephalins in cultured alveolar epithelial monolayers.
Pharmaceutical research.
1993 Nov; 10(11):1662-7. doi:
10.1023/a:1018941223967. [PMID: 8290482] - T V Bilfinger, G Stefano. Evidence of immunocyte stimulatory molecule(s) in plasma of patients undergoing cardiopulmonary bypass.
The Journal of cardiovascular surgery.
1993 Apr; 34(2):129-33. doi:
NULL. [PMID: 8320246] - D R Kapusta, S Y Jones, U C Kopp, G F Dibona. Role of renal nerves in excretory responses to exogenous and endogenous opioid peptides.
The Journal of pharmacology and experimental therapeutics.
1989 Mar; 248(3):1039-47. doi:
NULL. [PMID: 2703962] - J R Kirsch, D F Hanley, D A Wilson, R J Traystman. Effect of centrally administered encephalinamides on regional cerebral blood flow in the dog.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1988 Jun; 8(3):385-94. doi:
10.1038/jcbfm.1988.74. [PMID: 3366800] - S Mukherjee, B I Baker, D J Bird, J C Buckingham. Hypothalamo-pituitary-interrenal responses to opioid substances in the trout. II. Effects of morphine and D-Ala2, Met5-enkephalinamide on plasma cortisol titres in vivo.
General and comparative endocrinology.
1987 Oct; 68(1):40-8. doi:
10.1016/0016-6480(87)90058-x. [PMID: 2822527] - K Hashimoto, S Suemaru, N Ono, T Hattori, H Inoue, T Takao, M Sugawara, J Kageyama, Z Ota. Dual effects of (D-Ala2,Met5)-enkephalinamide on CRF and ACTH secretion.
Peptides.
1987 Jan; 8(1):113-8. doi:
10.1016/0196-9781(87)90173-2. [PMID: 3033617] - P Hartvig, K Någren, P O Lundberg, C Muhr, L Terenius, H Lundqvist, L Lärkfors, B Långström. Kinetics of four 11C-labelled enkephalin peptides in the brain, pituitary and plasma of rhesus monkeys.
Regulatory peptides.
1986 Dec; 16(1):1-13. doi:
10.1016/0167-0115(86)90190-4. [PMID: 3492729] - K Hashimoto, S Suemaru, T Hattori, T Takao, H Inoue, M Sugawara, J Kageyama, Z Ota. Effects of (D-ala2, met5)-enkephalinamide and naloxone on ACTH and corticosterone secretion.
Endocrinologia japonica.
1986 Dec; 33(6):813-20. doi:
10.1507/endocrj1954.33.813. [PMID: 3034557] - H Tsushima, M Mori, T Matsuda. Antidiuretic effects of methionine-enkephalin and 2-D-alanine-5-methionine-enkephalinamide microinjected into the hypothalamic supraoptic and paraventricular nuclei in a water-loaded and ethanol-anesthetized rat.
Japanese journal of pharmacology.
1986 Dec; 42(4):507-15. doi:
10.1254/jjp.42.507. [PMID: 3807052] - G Mazzocchi, C Robba, P Rebuffat, G Gottardo, G G Nussdorfer. Investigations on the effects of long-term administration of a methionine-enkephalin analogue on the adrenal zona fasciculata of rats treated with dexamethasone or dexamethasone and ACTH.
Journal of steroid biochemistry.
1986 Oct; 25(4):535-40. doi:
10.1016/0022-4731(86)90399-7. [PMID: 3022077] - J M Crowder, D K Norris, H F Bradford. Morphine inhibition of calcium fluxes, neurotransmitter release and protein and lipid phosphorylation in brain slices and synaptosomes.
Biochemical pharmacology.
1986 Aug; 35(15):2501-7. doi:
10.1016/0006-2952(86)90046-8. [PMID: 2874808] - C Robba, G Mazzocchi, G G Nussdorfer. Effects of chronic administration of a methionine-enkephalin analogue on the zona glomerulosa of the rat adrenal cortex.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.
1986; 186(3):173-8. doi:
10.1007/bf01852042. [PMID: 3016848] - R A Ahokas, J Seydoux, J Llanos-Q, T A Mashburn, C M Blatteis. Hypothalamic opioids and the acute-phase glycoprotein response in guinea pigs.
Brain research bulletin.
1985 Dec; 15(6):603-8. doi:
10.1016/0361-9230(85)90210-2. [PMID: 2417670] - S Benyhe, G Tóth, J Kevei, M Szücs, A Borsodi, K Di Gléria, J Szécsi, H Süli-Vargha, K Medzihradszky. Characterization of rat brain opioid receptors by [Tyr-3,5-3H]1, D-Ala2, Leu5-enkephalin binding.
Neurochemical research.
1985 May; 10(5):627-35. doi:
10.1007/bf00964402. [PMID: 2989719] - C W Yeung. Radioiodinated [D-Ala2, Met5] enkephalin. Preparation, purification by high performance liquid chromatography and binding characteristics.
International journal of peptide and protein research.
1984 Dec; 24(6):636-44. doi:
. [PMID: 6099338] - Y Numao, M Saito, N Terui, M Kumada. Physiological and pharmacological properties of the three subsystems constituting the aortic nerve-renal sympathetic reflex in rabbits.
Journal of the autonomic nervous system.
1983 Nov; 9(2-3):361-80. doi:
10.1016/0165-1838(83)90002-4. [PMID: 6319475] - S Kito, E Itoga, T Kishida, M Togo. Morphological study of neurotransmitter receptors in the rat brain.
Advances in biochemical psychopharmacology.
1983; 36(?):245-58. doi:
NULL. [PMID: 6305151] - E B De Souza, G R Van Loon. D-Ala2-Met-enkephalinamide, a potent opioid peptide, alters pituitary-adrenocortical secretion in rats.
Endocrinology.
1982 Nov; 111(5):1483-90. doi:
10.1210/endo-111-5-1483. [PMID: 6290184] - G R Van Loon, N M Appel. Plasma norepinephrine, epinephrine and dopamine responses to intracerebral administration of a met-enkephalin analog, D-ala2-met-enkephalinamide, in rats.
Neuroendocrinology.
1981 Sep; 33(3):153-7. doi:
10.1159/000123221. [PMID: 6270584] - J P Huidobro-Toro, F Huidobro. Central effects of morphine, levorphanol, (-)-methadone and the opioid-like peptides beta-endorphin and D-alanine2- methionine enkephalinamide on urine volume outflow and electrolytes.
The Journal of pharmacology and experimental therapeutics.
1981 Jun; 217(3):579-85. doi:
NULL. [PMID: 6262490] - NULL. [CLINICO-PATHOLOGICAL conference (Hopital Notre-Dame)].
L'union medicale du Canada.
1959 Dec; 88(?):1567-73. doi:
NULL. [PMID: 13858418]