3,7-Dihydro-8-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione (BioDeep_00000177917)
human metabolite blood metabolite
代谢物信息卡片
8-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
化学式: C10H14N4O2 (222.1116704)
中文名称:
谱图信息:
最多检出来源 Danio rerio(blood) 91.67%
分子结构信息
SMILES: CC(C)CN1C2=C(NC(C)=N2)C(=O)NC1=O
InChI: InChI=1S/C10H14N4O2/c1-5(2)4-14-8-7(11-6(3)12-8)9(15)13-10(14)16/h5H,4H2,1-3H3,(H,11,12)(H,13,15,16)
数据库引用编号
分类词条
相关代谢途径
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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The Journal of biological chemistry.
2012 Mar; 287(14):11164-73. doi:
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Diabetes.
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Poultry science.
2008 Nov; 87(11):2281-6. doi:
10.3382/ps.2008-00086. [PMID: 18931179] - Pascal Lovis, Elodie Roggli, D Ross Laybutt, Sonia Gattesco, Jiang-Yan Yang, Christian Widmann, Amar Abderrahmani, Romano Regazzi. Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction.
Diabetes.
2008 Oct; 57(10):2728-36. doi:
10.2337/db07-1252. [PMID: 18633110] - Suzanne Zeitouni, Brian S Ford, Sean M Harris, Mandolin J Whitney, Carl A Gregory, Darwin J Prockop. Pharmaceutical induction of ApoE secretion by multipotent mesenchymal stromal cells (MSCs).
BMC biotechnology.
2008 Sep; 8(?):75. doi:
10.1186/1472-6750-8-75. [PMID: 18823563] - Shen Yon Toh, Jingyi Gong, Guoli Du, John Zhong Li, Shuqun Yang, Jing Ye, Huilan Yao, Yinxin Zhang, Bofu Xue, Qing Li, Hongyuan Yang, Zilong Wen, Peng Li. Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice.
PloS one.
2008 Aug; 3(8):e2890. doi:
10.1371/journal.pone.0002890. [PMID: 18682832] - Jeung-Hyun Koo, Hyoung Tae Kim, Ha-Yong Yoon, Kang-Beom Kwon, Il-Whan Choi, Sung Hoo Jung, Han-Uk Kim, Byung-Hyun Park, Jin-Woo Park. Effect of xanthohumol on melanogenesis in B16 melanoma cells.
Experimental & molecular medicine.
2008 Jun; 40(3):313-9. doi:
10.3858/emm.2008.40.3.313. [PMID: 18587269] - Yi Xie, James A Schafer. Endogenous ATP release inhibits electrogenic Na⁺ absorption and stimulates Cl⁻ secretion in MDCK cells.
Purinergic signalling.
2008 Jun; 4(2):125-37. doi:
10.1007/s11302-007-9053-3. [PMID: 18368527] - Pernilla Lång, Vanessa van Harmelen, Mikael Rydén, Maria Kaaman, Paolo Parini, Claes Carneheim, A Ian Cassady, David A Hume, Göran Andersson, Peter Arner. Monomeric tartrate resistant acid phosphatase induces insulin sensitive obesity.
PloS one.
2008 Mar; 3(3):e1713. doi:
10.1371/journal.pone.0001713. [PMID: 18320034] - Horst Robenek, Nicholas J Severs. Recent advances in freeze-fracture electron microscopy: the replica immunolabeling technique.
Biological procedures online.
2008 Jan; 10(?):9-19. doi:
10.1251/bpo138. [PMID: 18385807] - Holly J Clarke, Francine Gregoire, Fang Ma, Robert Martin, Spring Zhao, Brian E Lavan. Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR-gamma Agonist.
PPAR research.
2008; 2008(?):465715. doi:
10.1155/2008/465715. [PMID: 18815616] - Mohamed Soliman, Kazuhiro Kimura, Mohamed Ahmed, Daisuke Yamaji, Yukiko Matsushita, Yuko Okamatsu-Ogura, Kennedy Makondo, Masayuki Saito. Inverse regulation of leptin mRNA expression by short- and long-chain fatty acids in cultured bovine adipocytes.
Domestic animal endocrinology.
2007 Nov; 33(4):400-9. doi:
10.1016/j.domaniend.2006.08.005. [PMID: 17011156] - Jin-Kyung Kim, Hongseob So, Myung-Ja Youn, Hyung-Jin Kim, Yunha Kim, Channy Park, Se-Jin Kim, Young-Ae Ha, Kyu-Yun Chai, Shin-Moo Kim, Ki-Young Kim, Raekil Park. Hibiscus sabdariffa L. water extract inhibits the adipocyte differentiation through the PI3-K and MAPK pathway.
Journal of ethnopharmacology.
2007 Nov; 114(2):260-7. doi:
10.1016/j.jep.2007.08.028. [PMID: 17904778] - Cai-Yan Zhao, Jun-Ying Zhou, Liu Yang, Ya-Dong Wang. [Molecular mechanism of ciglitazone inhibiting the expression of extracellular matrix in human hepatic stellate cells].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2007 Nov; 15(11):840-4. doi:
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Pharmacological research.
2007 Oct; 56(4):335-43. doi:
10.1016/j.phrs.2007.08.002. [PMID: 17889553] - Marcella Funicello, Michela Novelli, Maurizio Ragni, Teresa Vottari, Cesare Cocuzza, Joaquin Soriano-Lopez, Chiara Chiellini, Federico Boschi, Pasquina Marzola, Pellegrino Masiello, Paul Saftig, Ferruccio Santini, Rene St-Jacques, Sylvie Desmarais, Nicolas Morin, Joseph Mancini, M David Percival, Aldo Pinchera, Margherita Maffei. Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores.
PloS one.
2007 Aug; 2(8):e683. doi:
10.1371/journal.pone.0000683. [PMID: 17668061] - J K Kim, H Y Yoo, S J Kim, Y-S Hwang, J Han, J A Kim, C S Kim, H S Cho. Effects of sevoflurane on the cAMP-induced short-circuit current in mouse tracheal epithelium and recombinant Cl- (CFTR) and K+ (KCNQ1) channels.
British journal of anaesthesia.
2007 Aug; 99(2):245-51. doi:
10.1093/bja/aem123. [PMID: 17567648] - Lusisizwe Kwezi, Stuart Meier, Lyndon Mungur, Oziniel Ruzvidzo, Helen Irving, Chris Gehring. The Arabidopsis thaliana brassinosteroid receptor (AtBRI1) contains a domain that functions as a guanylyl cyclase in vitro.
PloS one.
2007 May; 2(5):e449. doi:
10.1371/journal.pone.0000449. [PMID: 17520012] - S Mandard, R Stienstra, P Escher, N S Tan, I Kim, F J Gonzalez, W Wahli, B Desvergne, M Müller, S Kersten. Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.
Cellular and molecular life sciences : CMLS.
2007 May; 64(9):1145-57. doi:
10.1007/s00018-007-7006-1. [PMID: 17437057] - Dan-Ning Hu, Steven A McCormick, John A Seedor, David C Ritterband, Mahendra K Shah. Isolation, purification and cultivation of conjunctival melanocytes.
Experimental eye research.
2007 Apr; 84(4):655-62. doi:
10.1016/j.exer.2006.12.003. [PMID: 17292887] - Mark W Gorman, Eric O Feigl, Charles W Buffington. Human plasma ATP concentration.
Clinical chemistry.
2007 Feb; 53(2):318-25. doi:
10.1373/clinchem.2006.076364. [PMID: 17185366] - David J Rickard, Fei-Lan Wang, Ana-Maria Rodriguez-Rojas, Zining Wu, Wen J Trice, Sandra J Hoffman, Bartholomew Votta, George B Stroup, Sanjay Kumar, Mark E Nuttall. Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells.
Bone.
2006 Dec; 39(6):1361-72. doi:
10.1016/j.bone.2006.06.010. [PMID: 16904389] - Tomoko Sonoda, Chieko Mochizuki, Tetsuji Yamashita, Keiko Watanabe-Kaneko, Yohei Miyagi, Yasushi Shigeri, Futoshi Yazama, Kenji Okuda, Susumu Kawamoto. Binding of glutamate receptor delta2 to its scaffold protein, Delphilin, is regulated by PKA.
Biochemical and biophysical research communications.
2006 Nov; 350(3):748-52. doi:
10.1016/j.bbrc.2006.09.109. [PMID: 17027646] - O Dyachok, J Sågetorp, Y Isakov, A Tengholm. cAMP oscillations restrict protein kinase A redistribution in insulin-secreting cells.
Biochemical Society transactions.
2006 Aug; 34(Pt 4):498-501. doi:
10.1042/bst0340498. [PMID: 16856843] - Liye Yang, Jiakun Zheng, Choyang Wang. [The in vitro study of the human adipose tissue-derived stromal cells differentiating into the neuron-like cells].
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.
2006 Aug; 20(8):783-6. doi:
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Nutrition & metabolism.
2006 Jul; 3(?):28. doi:
10.1186/1743-7075-3-28. [PMID: 16854242] - J de Vente, M Markerink-van Ittersum, J S H Vles. The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord.
Journal of chemical neuroanatomy.
2006 Jun; 31(4):275-303. doi:
10.1016/j.jchemneu.2006.02.006. [PMID: 16621445] - Chainarong Tocharus, Yuthana Smitasiri, Rattima Jeenapongsa. Butea superba Roxb. enhances penile erection in rats.
Phytotherapy research : PTR.
2006 Jun; 20(6):484-9. doi:
10.1002/ptr.1883. [PMID: 16619349] - Orsolya Dohán, Antonio De la Vieja, Nancy Carrasco. Hydrocortisone and purinergic signaling stimulate sodium/iodide symporter (NIS)-mediated iodide transport in breast cancer cells.
Molecular endocrinology (Baltimore, Md.).
2006 May; 20(5):1121-37. doi:
10.1210/me.2005-0376. [PMID: 16439463] - Amy Marcinkiewicz, Denise Gauthier, Anne Garcia, Dawn L Brasaemle. The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion.
The Journal of biological chemistry.
2006 Apr; 281(17):11901-9. doi:
10.1074/jbc.m600171200. [PMID: 16488886] - J M A Hannan, L Marenah, L Ali, B Rokeya, P R Flatt, Y H A Abdel-Wahab. Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells.
The Journal of endocrinology.
2006 Apr; 189(1):127-36. doi:
10.1677/joe.1.06615. [PMID: 16614387] - Hidekuni Inadera, Akiko Shimomura. Environmental chemical tributyltin augments adipocyte differentiation.
Toxicology letters.
2005 Dec; 159(3):226-34. doi:
10.1016/j.toxlet.2005.05.015. [PMID: 15993011] - Cristián O'Flaherty, Eve de Lamirande, Claude Gagnon. Reactive oxygen species and protein kinases modulate the level of phospho-MEK-like proteins during human sperm capacitation.
Biology of reproduction.
2005 Jul; 73(1):94-105. doi:
10.1095/biolreprod.104.038794. [PMID: 15772258] - H Poirier, C Rouault, L Clément, I Niot, M-C Monnot, M Guerre-Millo, P Besnard. Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse.
Diabetologia.
2005 Jun; 48(6):1059-65. doi:
10.1007/s00125-005-1765-8. [PMID: 15868135] - E Simón, M T Macarulla, A Fernández-Quintela, V M Rodríguez, M P Portillo. Body fat-lowering effect of conjugated linoleic acid is not due to increased lipolysis.
Journal of physiology and biochemistry.
2005 Jun; 61(2):363-9. doi:
10.1007/bf03167053. [PMID: 16180334]