D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (BioDeep_00000177900)
human metabolite blood metabolite
代谢物信息卡片
6-amino-2-(2-{2-[2-(2-amino-3-phenylpropanamido)-3-sulfanylpropanamido]-3-(4-hydroxyphenyl)propanamido}-3-(1H-indol-3-yl)propanamido)-N-{1-[(1-{[1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-sulfanylethyl)carbamoyl]-2-methylpropyl}hexanamide
化学式: C57H72N12O9S2 (1132.4986382)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CC(C)C(C(=O)NC(CS)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)N)NC(=O)C(CCCCN)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(CS)NC(=O)C(CC6=CC=CC=C6)N
InChI: InChI=1S/C57H72N12O9S2/c1-32(2)49(57(78)68-48(31-80)55(76)64-44(50(60)71)26-35-28-61-41-16-8-6-14-38(35)41)69-52(73)43(18-10-11-23-58)63-54(75)46(27-36-29-62-42-17-9-7-15-39(36)42)66-53(74)45(25-34-19-21-37(70)22-20-34)65-56(77)47(30-79)67-51(72)40(59)24-33-12-4-3-5-13-33/h3-9,12-17,19-22,28-29,32,40,43-49,61-62,70,79-80H,10-11,18,23-27,30-31,58-59H2,1-2H3,(H2,60,71)(H,63,75)(H,64,76)(H,65,77)(H,66,74)(H,67,72)(H,68,78)(H,69,73)
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000970 - Antineoplastic Agents
同义名列表
3 个代谢物同义名
6-amino-2-(2-{2-[2-(2-amino-3-phenylpropanamido)-3-sulfanylpropanamido]-3-(4-hydroxyphenyl)propanamido}-3-(1H-indol-3-yl)propanamido)-N-{1-[(1-{[1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-sulfanylethyl)carbamoyl]-2-methylpropyl}hexanamide; H-DL-Phe-DL-Cys-DL-Tyr-DL-Trp-DL-Lys-DL-Val-DL-Cys-DL-Trp-NH2; D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ahmed A H Abdellatif. A plausible way for excretion of metal nanoparticles via active targeting.
Drug development and industrial pharmacy.
2020 May; 46(5):744-750. doi:
10.1080/03639045.2020.1752710. [PMID: 32250174] - Sergei Spitsin, Florin Tuluc, John Meshki, Jian Ping Lai, Richard Tustin Iii, Steven D Douglas. Analog of somatostatin vapreotide exhibits biological effects in vitro via interaction with neurokinin-1 receptor.
Neuroimmunomodulation.
2013; 20(5):247-55. doi:
10.1159/000350468. [PMID: 23921645] - María J Blanco-Príeto, Miguel A Campanero, Kamel Besseghir, F Heimgatner, Bruno Gander. Importance of single or blended polymer types for controlled in vitro release and plasma levels of a somatostatin analogue entrapped in PLA/PLGA microspheres.
Journal of controlled release : official journal of the Controlled Release Society.
2004 May; 96(3):437-48. doi:
10.1016/j.jconrel.2004.02.015. [PMID: 15120900] - Ch B Felder, M J Blanco-Príeto, J Heizmann, H P Merkle, B Gander. Ultrasonic atomization and subsequent polymer desolvation for peptide and protein microencapsulation into biodegradable polyesters.
Journal of microencapsulation.
2003 Sep; 20(5):553-67. doi:
10.1080/0265204031000148059. [PMID: 12909541] - David González-Barcena, Andrew V Schally, Manuel Vadillo-Buenfil, Adolfo Cortez-Morales, Victor Hernández L, Imelda Cardenas-Cornejo, Ana Maria Comaru-Schally. Response of patients with advanced prostatic cancer to administration of somatostatin analog RC-160 (vapreotide) at the time of relapse.
The Prostate.
2003 Aug; 56(3):183-91. doi:
10.1002/pros.10232. [PMID: 12772187] - Marylis Hortala, Geraldine Ferjoux, Agnes Estival, Claudine Bertrand, Stefan Schulz, Lucien Pradayrol, Christiane Susini, Francois Clemente. Inhibitory role of the somatostatin receptor SST2 on the intracrine-regulated cell proliferation induced by the 210-amino acid fibroblast growth factor-2 isoform: implication of JAK2.
The Journal of biological chemistry.
2003 Jun; 278(23):20574-81. doi:
10.1074/jbc.m210767200. [PMID: 12665520] - Artur Plonowski, Andrew V Schally, Markus Letsch, Magdalena Krupa, Francine Hebert, Rebeca Busto, Kate Groot, Jozsef L Varga. Inhibition of proliferation of PC-3 human prostate cancer by antagonists of growth hormone-releasing hormone: lack of correlation with the levels of serum IGF-I and expression of tumoral IGF-II and vascular endothelial growth factor.
The Prostate.
2002 Aug; 52(3):173-82. doi:
10.1002/pros.10105. [PMID: 12111694] - I Chatzistamou, A V Schally, J L Varga, K Groot, P Armatis, R Busto, G Halmos. Antagonists of growth hormone-releasing hormone and somatostatin analog RC-160 inhibit the growth of the OV-1063 human epithelial ovarian cancer cell line xenografted into nude mice.
The Journal of clinical endocrinology and metabolism.
2001 May; 86(5):2144-52. doi:
10.1210/jcem.86.5.7487. [PMID: 11344219] - M J Blanco-Príeto, K Besseghir, O Zerbe, D Andris, P Orsolini, F Heimgartner, H P Merkle, B Gander. In vitro and in vivo evaluation of a somatostatin analogue released from PLGA microspheres.
Journal of controlled release : official journal of the Controlled Release Society.
2000 Jun; 67(1):19-28. doi:
10.1016/s0168-3659(99)00289-8. [PMID: 10773325] - P Dasgupta, A T Singh, R Mukherjee. Lipophilization of somatostatin analog RC-160 with long chain fatty acid improves its anti-proliferative activity on human oral carcinoma cells in vitro.
Life sciences.
2000 Mar; 66(17):1557-70. doi:
10.1016/s0024-3205(00)00476-8. [PMID: 11261586] - Z Helyes, M Thán, G Oroszi, E Pintér, J Németh, G Kéri, J Szolcsányi. Anti-nociceptive effect induced by somatostatin released from sensory nerve terminals and by synthetic somatostatin analogues in the rat.
Neuroscience letters.
2000 Jan; 278(3):185-8. doi:
10.1016/s0304-3940(99)00936-2. [PMID: 10653024] - P Dasgupta, R Mukherjee. Lipophilization of somatostatin analog RC-160 with long chain fatty acid improves its antiproliferative and antiangiogenic activity in vitro.
British journal of pharmacology.
2000 Jan; 129(1):101-9. doi:
10.1038/sj.bjp.0702990. [PMID: 10694208] - M Mishima, T Yano, H Jimbo, N Yano, Y Morita, H Yoshikawa, A V Schally, Y Taketani. Inhibition of human endometrial cancer cell growth in vitro and in vivo by somatostatin analog RC-160.
American journal of obstetrics and gynecology.
1999 Sep; 181(3):583-90. doi:
10.1016/s0002-9378(99)70496-5. [PMID: 10486467] - M J Blanco-Príeto, K Besseghir, P Orsolini, F Heimgartner, C Deuschel, H P Merkle, H Nam-Trân, B Gander. Importance of the test medium for the release kinetics of a somatostatin analogue from poly(D,L-lactide-co-glycolide) microspheres.
International journal of pharmaceutics.
1999 Jul; 184(2):243-50. doi:
10.1016/s0378-5173(99)00118-0. [PMID: 10387954] - P Dasgupta, A T Singh, R Mukherjee. Lipophilization of somatostatin analog RC-160 improves its bioactivity and stability.
Pharmaceutical research.
1999 Jul; 16(7):1047-53. doi:
10.1023/a:1018935800052. [PMID: 10450929] - K J O'Byrne, N Dobbs, D J Propper, J P Braybrooke, M I Koukourakis, K Mitchell, J Woodhull, D C Talbot, A V Schally, A L Harris. Phase II study of RC-160 (vapreotide), an octapeptide analogue of somatostatin, in the treatment of metastatic breast cancer.
British journal of cancer.
1999 Mar; 79(9-10):1413-8. doi:
10.1038/sj.bjc.6690226. [PMID: 10188884] - M A Ritz, J Drewe, A Ziel, P Hildebrand, P Schneider, N Lahlou, C Beglinger. The effects of vapreotide, a somatostatin analogue, on gastric acidity, gallbladder emptying and hormone release after 1 week of continuous subcutaneous infusion in normal subjects.
British journal of clinical pharmacology.
1999 Feb; 47(2):195-201. doi:
10.1046/j.1365-2125.1999.00878.x. [PMID: 10190655] - A Jungwirth, A V Schally, G Halmos, K Groot, K Szepeshazi, J Pinski, P Armatis. Inhibition of the growth of Caki-I human renal adenocarcinoma in vivo by luteinizing hormone-releasing hormone antagonist Cetrorelix, somatostatin analog RC-160, and bombesin antagonist RC-3940-II.
Cancer.
1998 Mar; 82(5):909-17. doi:
10.1002/(sici)1097-0142(19980301)82:5<909::aid-cncr16>3.0.co;2-4. [PMID: 9486581] - W A Breeman, P M van Hagen, D J Kwekkeboom, T J Visser, E P Krenning. Somatostatin receptor scintigraphy using [111In-DTPA0]RC-160 in humans: a comparison with [111In-DTPA0]octreotide.
European journal of nuclear medicine.
1998 Feb; 25(2):182-6. doi:
10.1007/s002590050213. [PMID: 9473268] - F Lopez, J P Estève, L Buscail, N Delesque, N Saint-Laurent, N Vaysse, C Susini. Molecular mechanisms of antiproliferative effect of somatostatin: involvement of a tyrosine phosphatase.
Metabolism: clinical and experimental.
1996 Aug; 45(8 Suppl 1):14-6. doi:
10.1016/s0026-0495(96)90071-2. [PMID: 8769371] - J Pinski, A V Schally, G Halmos, K Szepeshazi, K Groot. Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice.
International journal of cancer.
1996 Mar; 65(6):870-4. doi:
10.1002/(sici)1097-0215(19960315)65:6<870::aid-ijc27>3.0.co;2-6. [PMID: 8631606] - X Q Ding, D Chen, E Rosengren, L Persson, R Hakanson. Comparison between activation of ornithine decarboxylase and histidine decarboxylase in rat stomach.
The American journal of physiology.
1996 Mar; 270(3 Pt 1):G476-86. doi:
10.1152/ajpgi.1996.270.3.g476. [PMID: 8638714] - B Eriksson, E T Janson, N D Bax, M Mignon, R Morant, P Opolon, P Rougier, K E Oberg. The use of new somatostatin analogues, lanreotide and octastatin, in neuroendocrine gastro-intestinal tumours.
Digestion.
1996; 57 Suppl 1(?):77-80. doi:
10.1159/000201402. [PMID: 8813476] - L Buscail, J P Estève, N Saint-Laurent, V Bertrand, T Reisine, A M O'Carroll, G I Bell, A V Schally, N Vaysse, C Susini. Inhibition of cell proliferation by the somatostatin analogue RC-160 is mediated by somatostatin receptor subtypes SSTR2 and SSTR5 through different mechanisms.
Proceedings of the National Academy of Sciences of the United States of America.
1995 Feb; 92(5):1580-4. doi:
10.1073/pnas.92.5.1580. [PMID: 7878022] - J Pinski, A V Schally, G Halmos, K Szepeshazi, K Groot. Somatostatin analogues and bombesin/gastrin-releasing peptide antagonist RC-3095 inhibit the growth of human glioblastomas in vitro and in vivo.
Cancer research.
1994 Nov; 54(22):5895-901. doi:
NULL. [PMID: 7954420] - J Pinski, A V Schally, G Halmos, K Szepeshazi, K Groot, K O'Byrne, R Z Cai. Effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonists on the growth of human small-cell and non-small-cell lung carcinomas in nude mice.
British journal of cancer.
1994 Nov; 70(5):886-92. doi:
10.1038/bjc.1994.415. [PMID: 7947094] - J Pinski, G Halmos, T Yano, K Szepeshazi, Y Qin, T Ertl, A V Schally. Inhibition of growth of MKN45 human gastric-carcinoma xenografts in nude mice by treatment with bombesin/gastrin-releasing-peptide antagonist (RC-3095) and somatostatin analogue RC-160.
International journal of cancer.
1994 May; 57(4):574-80. doi:
10.1002/ijc.2910570422. [PMID: 7910153] - J Pinski, H Reile, G Halmos, K Groot, A V Schally. Inhibitory effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonist RC-3095 on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer.
Cancer research.
1994 Jan; 54(1):169-74. doi:
NULL. [PMID: 7903203] - J Pinski, A V Schally, G Halmos, K Szepeshazi. Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude mice.
International journal of cancer.
1993 Dec; 55(6):963-7. doi:
10.1002/ijc.2910550615. [PMID: 7902829] - G Weckbecker, F Raulf, B Stolz, C Bruns. Somatostatin analogs for diagnosis and treatment of cancer.
Pharmacology & therapeutics.
1993 Nov; 60(2):245-64. doi:
10.1016/0163-7258(93)90009-3. [PMID: 7912834] - J Pinski, G Halmos, A V Schally. Somatostatin analog RC-160 and bombesin/gastrin-releasing peptide antagonist RC-3095 inhibit the growth of androgen-independent DU-145 human prostate cancer line in nude mice.
Cancer letters.
1993 Jul; 71(1-3):189-96. doi:
10.1016/0304-3835(93)90115-p. [PMID: 8103419] - P M Girard, E Goldschmidt, D Vittecoq, P Massip, J Gastiaburu, M C Meyohas, J P Coulaud, A V Schally. Vapreotide, a somatostatin analogue, in cryptosporidiosis and other AIDS-related diarrhoeal diseases.
AIDS (London, England).
1992 Jul; 6(7):715-8. doi:
10.1097/00002030-199207000-00015. [PMID: 1354449] - T Yano, J Pinski, K Szepeshazi, S R Milovanovic, K Groot, A V Schally. Effect of microcapsules of luteinizing hormone-releasing hormone antagonist SB-75 and somatostatin analog RC-160 on endocrine status and tumor growth in the Dunning R-3327H rat prostate cancer model.
The Prostate.
1992; 20(4):297-310. doi:
10.1002/pros.2990200405. [PMID: 1351672] - S R Milovanovic, S Radulovic, K Groot, A V Schally. Inhibition of growth of PC-82 human prostate cancer line xenografts in nude mice by bombesin antagonist RC-3095 or combination of agonist [D-Trp6]-luteinizing hormone-releasing hormone and somatostatin analog RC-160.
The Prostate.
1992; 20(4):269-80. doi:
10.1002/pros.2990200403. [PMID: 1376910] - W A Banks, A V Schally, C M Barrera, M B Fasold, D A Durham, V J Csernus, K Groot, A J Kastin. Permeability of the murine blood-brain barrier to some octapeptide analogs of somatostatin.
Proceedings of the National Academy of Sciences of the United States of America.
1990 Sep; 87(17):6762-6. doi:
10.1073/pnas.87.17.6762. [PMID: 1975697] - L Bokser, A V Schally. Delayed release formulation of the somatostatin analog RC-160 inhibits the growth hormone (GH) response to GH-releasing factor-(1-29)NH2 and decreases elevated prolactin levels in rats.
Endocrinology.
1988 Oct; 123(4):1735-9. doi:
10.1210/endo-123-4-1735. [PMID: 2901338] - M Mason-Garcia, M Vaccarella, J Horvath, T W Redding, K Groot, P Orsolini, A V Schally. Radioimmunoassay for octapeptide analogs of somatostatin: measurement of serum levels after administration of long-acting microcapsule formulations.
Proceedings of the National Academy of Sciences of the United States of America.
1988 Aug; 85(15):5688-92. doi:
10.1073/pnas.85.15.5688. [PMID: 2899894] - T Karashima, A V Schally. Superactive somatostatin analog decreases plasma glucose and glucagon levels in diabetic rats.
Peptides.
1988 May; 9(3):561-5. doi:
10.1016/0196-9781(88)90164-7. [PMID: 2901737] - T Karashima, R Z Cai, A V Schally. Effects of highly potent octapeptide analogs of somatostatin on growth hormone, insulin and glucagon release.
Life sciences.
1987 Aug; 41(8):1011-9. doi:
10.1016/0024-3205(87)90690-4. [PMID: 2886886]