Cystemustine (BioDeep_00000177864)
human metabolite blood metabolite
代谢物信息卡片
化学式: C6H12ClN3O4S (257.0237022)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)CCNC(=O)N(CCCl)N=O
InChI: InChI=1S/C6H12ClN3O4S/c1-15(13,14)5-3-8-6(11)10(9-12)4-2-7/h2-5H2,1H3,(H,8,11)
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 119545
- HMDB: HMDB0250711
- ChEMBL: CHEMBL26085
- chemspider: 106751
- CAS: 79955-36-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xavier Durando, Emilie Thivat, Marie-Chantal Farges, Eric Cellarier, Michel D'Incan, Aïcha Demidem, Marie-Paule Vasson, Chantal Barthomeuf, Philippe Chollet. Optimal methionine-free diet duration for nitrourea treatment: a Phase I clinical trial.
Nutrition and cancer.
2008; 60(1):23-30. doi:
10.1080/01635580701525877. [PMID: 18444132] - Emilie Thivat, Xavier Durando, Aïcha Demidem, Marie-Chantal Farges, Maryse Rapp, Eric Cellarier, Samuel Guenin, Michel D'Incan, Marie-Paule Vasson, Philippe Chollet. A methionine-free diet associated with nitrosourea treatment down-regulates methylguanine-DNA methyl transferase activity in patients with metastatic cancer.
Anticancer research.
2007 Jul; 27(4C):2779-83. doi:
NULL. [PMID: 17695447] - N Martineau-Pivoteau, F Levi, C Rolhion, F Kwiatkowski, G Lemaigre, E Filipski, P Chollet. Circadian rhythm in toxic effects of cystemustine in mice: relevance for chronomodulated delivery.
International journal of cancer.
1996 Nov; 68(5):669-74. doi:
10.1002/(sici)1097-0215(19961127)68:5<669::aid-ijc18>3.0.co;2-x. [PMID: 8938151] - J Chauvergne, P Kerbrat, A Adenis, P Chollet, P Fargeot, E Pujade-Lauraine, V Dieras, J C Madelmont, M A Lentz, C Toulouse. Phase II study of cystemustine in advanced renal cancer.
European journal of cancer (Oxford, England : 1990).
1995; 31A(1):130-1. doi:
10.1016/0959-8049(94)00375-f. [PMID: 7695969] - D Godeneche, P Labarre, M F Moreau, J C Madelmont, M Rapp, J Papon, A Veyre. Main urinary metabolites of two cysteamine-containing 2-(chloroethyl) nitrosoureas in rats.
Drug metabolism and disposition: the biological fate of chemicals.
1993 Jan; 21(1):93-9. doi:
. [PMID: 8095233] - D Godenèche, J C Madelmont, P Labarre, R Plagne, G Meyniel. Disposition of new sulphur-containing 2-(chloroethyl)nitrosoureas in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
1987 Jan; 17(1):59-70. doi:
10.3109/00498258709047175. [PMID: 3825177] - C Bourut, E Chenu, D Godenèche, J C Madelmont, R Maral, G Mathé, G Meyniel. Cytostatic action of two nitrosoureas derived from cysteamine.
British journal of pharmacology.
1986 Nov; 89(3):539-46. doi:
10.1111/j.1476-5381.1986.tb11154.x. [PMID: 3801787] - J C Madelmont, D Godeneche, D Parry, J Duprat, J L Chabard, R Plagne, G Mathe, G Meyniel. New cysteamine (2-chloroethyl)nitrosoureas. Synthesis and preliminary antitumor results.
Journal of medicinal chemistry.
1985 Sep; 28(9):1346-50. doi:
10.1021/jm00147a040. [PMID: 4032435]