Cynandione A (BioDeep_00000177850)

   

human metabolite blood metabolite


代谢物信息卡片


1-[3-(2-acetyl-3,6-dihydroxyphenyl)-2,4-dihydroxyphenyl]ethan-1-one

化学式: C16H14O6 (302.0790344)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1=C(C(=C(C=C1)O)C2=C(C=CC(=C2C(=O)C)O)O)O
InChI: InChI=1S/C16H14O6/c1-7(17)9-3-4-12(21)15(16(9)22)14-11(20)6-5-10(19)13(14)8(2)18/h3-6,19-22H,1-2H3



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Sunggun Kim, Yeo Yeong Yoon, Ye Won Park, Wan-Kyunn Whang, So-Young Park, Kwang Woo Hwang. Cynandione A from Cynanchum wilfordii inhibits hepatic de novo lipogenesis by activating the LKB1/AMPK pathway in HepG2 cells. Journal of natural medicines. 2020 Jan; 74(1):142-152. doi: 10.1007/s11418-019-01356-x. [PMID: 31463669]
  • Hao-Wen Jiang, Shan-Shan Gu, Lei Cao, Sheng-Shi Jiang, Jing Lin, Yan Chen, Ling Wang, He Jiao, Jing-Ya Li, Wei-Min Zhao, Jin-Long Li. Potential hypoglycemic effect of acetophenones from the root bark of Cynanchum wilfordii. Natural product research. 2019 Aug; 33(16):2314-2321. doi: 10.1080/14786419.2018.1443100. [PMID: 29480065]
  • Takashi Uchikura, Hiroaki Tanaka, Hidemi Sugiwaki, Morio Yoshimura, Naoko Sato-Masumoto, Takashi Tsujimoto, Nahoko Uchiyama, Takashi Hakamatsuka, Yoshiaki Amakura. Preliminary Quality Evaluation and Characterization of Phenolic Constituents in Cynanchi Wilfordii Radix. Molecules (Basel, Switzerland). 2018 Mar; 23(3):. doi: 10.3390/molecules23030656. [PMID: 29538318]
  • Sung Hwan Kim, Tae Hoon Lee, Sang Min Lee, Ji Hae Park, Keun Hyung Park, Mira Jung, Hana Jung, Mohamed Antar Aziz Mohamed, Nam-In Baek, In Sik Chung, Jiyoung Kim. Cynandione A attenuates lipopolysaccharide-induced production of inflammatory mediators via MAPK inhibition and NF-κB inactivation in RAW264.7 macrophages and protects mice against endotoxin shock. Experimental biology and medicine (Maywood, N.J.). 2015 Jul; 240(7):946-54. doi: 10.1177/1535370214558022. [PMID: 25361770]
  • Rongcai Yue, Xing Yuan, Xiaojun Liu, Jigang Zhang, Peng Jiang, Cheng He, Lei Shan, Yizhi Yu, Weidong Zhang. Cynandione A mitigates ischemic injuries in rats with cerebral ischemia. Journal of neurochemistry. 2012 May; 121(3):451-64. doi: 10.1111/j.1471-4159.2012.07682.x. [PMID: 22309483]
  • Xi Zhang, Lei Shan, Hao Huang, Xianwen Yang, Xu Liang, Aiting Xing, Haiqiang Huang, Xinru Liu, Juan Su, Weidong Zhang. Rapid identification of acetophenones in two Cynanchum species using liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2009 Apr; 49(3):715-25. doi: 10.1016/j.jpba.2009.01.009. [PMID: 19201126]
  • Yaping Zhang, Lei Shan, Wen Xu, Ming Yang, Weidong Zhang, Haiyun Li. LC-MS/MS method for the determination of cynandione A in rat plasma and tissues. Biomedical chromatography : BMC. 2008 Oct; 22(10):1173-9. doi: 10.1002/bmc.1044. [PMID: 18651611]
  • M K Lee, H Yeo, J Kim, Y C Kim. Protection of rat hepatocytes exposed to CCl4 in-vitro by cynandione A, a biacetophenone from Cynanchum wilfordii. The Journal of pharmacy and pharmacology. 2000 Mar; 52(3):341-5. doi: 10.1211/0022357001773896. [PMID: 10757424]
  • M K Lee, H Yeo, J Kim, G J Markelonis, T H Oh, Y C Kim. Cynandione A from Cynanchum wilfordii protects cultured cortical neurons from toxicity induced by H2O2, L-glutamate, and kainate. Journal of neuroscience research. 2000 Jan; 59(2):259-64. doi: 10.1002/(sici)1097-4547(20000115)59:2<259::aid-jnr12>3.0.co;2-3. [PMID: 10650884]