Cyclopenthiazide (BioDeep_00000177830)

   

human metabolite blood metabolite


代谢物信息卡片


6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide

化学式: C13H18ClN3O4S2 (379.0427)
中文名称: 环戊噻嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC(C1)CC1Nc2cc(c(cc2S(=O)(=O)N1)S(=O)(=O)N)Cl
InChI: InChI=1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)

描述信息

C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators

同义名列表

4 个代谢物同义名

6-chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide; cyclopenthiazide; Cyclomethiazide; Navidrex



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • H Krum, B Jackson, E L Conway, L G Howes, C I Johnston, W J Louis. Steady-state pharmacokinetics and pharmacodynamics of cilazapril in the presence and absence of cyclopenthiazide. Journal of cardiovascular pharmacology. 1992 Sep; 20(3):451-7. doi: 10.1097/00005344-199209000-00017. [PMID: 1279292]
  • A P Passmore, E M Whitehead, V Crawford, G E McVeigh, G D Johnston. The antihypertensive and metabolic effects of low and conventional dose cyclopenthiazide in type II diabetics with hypertension. The Quarterly journal of medicine. 1991 Nov; 81(295):919-28. doi: 10.1093/oxfordjournals.qjmed.a068640. [PMID: 1808632]
  • G D Johnston, R Wilson, B J McDermott, G E McVeigh, D Duffin, J Logan. Low-dose cyclopenthiazide in the treatment of hypertension: a one-year community-based study. The Quarterly journal of medicine. 1991 Feb; 78(286):135-43. doi: 10.1093/oxfordjournals.qjmed.a068532. [PMID: 2031076]
  • C Fleck, P Kabath, A Linstedt, U Linstedt, U Scharke, H Bräunlich. Relation between renal and hepatic excretion of drugs. XIV. Elimination of ioglycamic acid after nephrectomy, bile duct ligation, and after treatment with hormones or xenobiotics in young and adult rats. Experimental pathology. 1991; 43(1-2):75-87. doi: 10.1016/s0232-1513(11)80150-7. [PMID: 1783049]
  • C Fleck, H Bräunlich. Age dependent differences in stimulation and compensation of renal and biliary transport processes. Correlation to the physicochemical properties of the exerted substances. Arzneimittel-Forschung. 1990 Sep; 40(9):1047-53. doi: NULL. [PMID: 2080942]
  • G E McVeigh, M McMaster, T Linton, E Whitehead, G D Johnston. A comparison of the haemodynamic and hormonal effects of low and conventional dose cyclopenthiazide in normal volunteers. European journal of clinical pharmacology. 1990; 38(4):351-7. doi: 10.1007/bf00315574. [PMID: 2188845]
  • S Allman, R J Norris. An open, parallel group study comparing a frusemide/amiloride diuretic and a diuretic containing cyclopenthiazide with sustained release potassium in the treatment of congestive cardiac failure--a multicentre general practice study. The Journal of international medical research. 1990; 18 Suppl 2(?):17B-23B. doi: NULL. [PMID: 2193840]
  • G E McVeigh, E B Dulie, A Ravenscroft, D B Galloway, G D Johnston. Low and conventional dose cyclopenthiazide on glucose and lipid metabolism in mild hypertension. British journal of clinical pharmacology. 1989 Apr; 27(4):523-6. doi: 10.1111/j.1365-2125.1989.tb05403.x. [PMID: 2655692]
  • G McVeigh, D Galloway, D Johnston. The case for low dose diuretics in hypertension: comparison of low and conventional doses of cyclopenthiazide. BMJ (Clinical research ed.). 1988 Jul; 297(6641):95-8. doi: 10.1136/bmj.297.6641.95. [PMID: 3044503]
  • C Fleck, M Schultz, D Seidel, H Bräunlich. Relation between renal and hepatic excretion of drugs: X. Excretion of nalorphine in young and adult rats pretreated with hormones or xenobiotics. Experimental pathology. 1988; 34(3):171-80. doi: 10.1016/s0232-1513(88)80008-2. [PMID: 3197801]
  • W J Leahey, J R McMeekin. Determination of cyclopenthiazide in plasma by high-performance liquid chromatography. Journal of chromatography. 1987 Oct; 421(2):401-6. doi: 10.1016/0378-4347(87)80425-5. [PMID: 3429594]
  • C Fleck. Compensation of renal drug excretion after unilateral nephrectomy. Physiologia Bohemoslovaca. 1987; 36(6):511-7. doi: NULL. [PMID: 2964046]
  • L Kersten, H Bräunlich. Influence of diuretics on renal lithium excretion and tissue distribution of some cations in saline loaded young and adult rats. Biomedica biochimica acta. 1987; 46(4):225-36. doi: NULL. [PMID: 3632646]
  • W Ortweiler, F Jahn, H Bräunlich. Increase of 14C-leucine uptake following stimulation of renal tubular transport processes. Biomedica biochimica acta. 1987; 46(4):271-6. doi: NULL. [PMID: 3632651]
  • D E Stewart, H Ikram, E A Espiner, M G Nicholls. Arrhythmogenic potential of diuretic induced hypokalaemia in patients with mild hypertension and ischaemic heart disease. British heart journal. 1985 Sep; 54(3):290-7. doi: 10.1136/hrt.54.3.290. [PMID: 4041299]
  • H Bräunlich. Postnatal development and inducibility of renal tubular transport processes in rats. The International journal of pediatric nephrology. 1985 Jul; 6(3):177-82. doi: NULL. [PMID: 3840464]
  • H Bräunlich. Postnatal development of kidney function in rats receiving thyroid hormones. Experimental and clinical endocrinology. 1984 May; 83(3):243-50. doi: 10.1055/s-0029-1210336. [PMID: 6540694]
  • H Bräunlich, A Woratschek. Influence of neomycin pretreatment on stimulated and maturative renal transport of p-aminohippurate (PAH). Medical biology. 1984; 62(1):49-53. doi: NULL. [PMID: 6748761]
  • M Stopp, H Bräunlich. p-Aminohippurate (PAH) transport and Na-K-ATPase activity in rat renal cortical slices during postnatal maturation and drug-induced stimulation. Biochemical pharmacology. 1983 Dec; 32(24):3675-8. doi: 10.1016/0006-2952(83)90135-1. [PMID: 6318768]
  • H Bräunlich, S Bäumlein, K Luther, L Kersten. Stimulation of renal sodium excretion in mature rats. Mechanisms of ageing and development. 1982 Aug; 19(4):307-13. doi: 10.1016/0047-6374(82)90014-8. [PMID: 7132437]
  • G A MacGregor, R A Banks, N D Markandu, J Roulston. Xipamide and cyclopenthiazide in essential hypertension--comparative effects on blood pressure and plasma potassium. British journal of clinical pharmacology. 1982 Jun; 13(6):859-63. doi: 10.1111/j.1365-2125.1982.tb01879.x. [PMID: 7046777]
  • M J Kerr, D W Harron, C Kinney, R G Shanks. Comparison of the beta-adrenoceptor blocking activity of oxprenolol, slow release oxprenolol and a combined oxprenolol diuretic preparation. British journal of clinical pharmacology. 1981 Dec; 12(6):869-71. doi: 10.1111/j.1365-2125.1981.tb01323.x. [PMID: 6122463]
  • C Fleck, J Bartha, L Kersten, C Hably, H Bräunlich. Renal blood flow after stimulation of p-aminohippurate transport. Archives internationales de pharmacodynamie et de therapie. 1981 Jul; 252(1):133-8. doi: NULL. [PMID: 7305546]
  • D Ballantyne, F C Ballantyne, McMurdo. Effect of slow oxprenolol and a combination of slow oxprenolol and cyclopenthiazide on plasma lipoproteins. Atherosclerosis. 1981 Jun; 39(3):301-6. doi: 10.1016/0021-9150(81)90016-2. [PMID: 7259814]
  • H Bräunlich. Influence of protein biosynthesis inhibitors on stimulated renal p-aminohippurate excretion in rats. Acta physiologica Academiae Scientiarum Hungaricae. 1981; 58(4):321-6. doi: NULL. [PMID: 6897148]
  • C Fleck, H Bräunlich. Stimulation of renal excretion of p-aminohippurate (PAH) after unilateral nephrectomy in adult and ageing rats. Physiologia Bohemoslovaca. 1981; 30(4):341-6. doi: NULL. [PMID: 6458054]
  • C Fleck, H Bräunlich, M Stopp. [Stimulation of the renal transport of foreign substances following unilateral nephrectomy]. Acta biologica et medica Germanica. 1981; 40(7-8):1053-60. doi: NULL. [PMID: 7331632]
  • L E Ramsay, J H Silas, S Freestone. Diuretic treatment of resistant hypertension. British medical journal. 1980 Oct; 281(6248):1101-3. doi: 10.1136/bmj.281.6248.1101. [PMID: 7427599]
  • M Stopp, C Fleck, C Weise, H Bräunlich. Stimulation of kidney function in rats injured by nephrotoxic agents. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 1980; 4(?):208-14. doi: 10.1007/978-3-642-67729-8_44. [PMID: 6933904]
  • H Bräunlich, C Fleck, C Weise, M Stopp. Stimulation of kidney function in rats of different ages injured by nephrotoxic agents. Experimentelle Pathologie. 1979; 17(7-8):486-92. doi: 10.1016/s0014-4908(79)80068-x. [PMID: 510457]
  • A F Ebbutt, R W Elsdon-Dew. A multicentre study examining the substitution of Trasidrex for the free combination of Slow-Trasicor and Navidrex-K. The Journal of international medical research. 1979; 7(6):524-7. doi: 10.1177/030006057900700608. [PMID: 520655]
  • W J Louis, N Christophidis, M Brignell, V Vijayasekaran, J McNeil, F J Vajda. Labetalol: bioavailability, drug plasma levels, plasma renin and catecholamines in acute and chronic treatment of resistant hypertension. Australian and New Zealand journal of medicine. 1978 Dec; 8(6):602-9. doi: 10.1111/j.1445-5994.1978.tb04847.x. [PMID: 285681]
  • M Stopp, R Hartwich, H Bräunlich. Enhancement of p-aminohippurate accumulation in renal cortical slices after repeated administrations of various organic anionic drugs to rats of different ages. Experientia. 1978 Nov; 34(11):1493-4. doi: 10.1007/bf01932372. [PMID: 720483]
  • P Bolli, F O Simpson, H J Waal-Manning. Comparison of tienilic acid with cyclopenthiazide in hyperuricaemic hypertensive patients. Lancet (London, England). 1978 Sep; 2(8090):595-8. doi: 10.1016/s0140-6736(78)92822-2. [PMID: 80525]
  • J B Bourke, M B McIllmurray, G M Mead, M J Langman. Drug-associated primary acute pancreatitis. Lancet (London, England). 1978 Apr; 1(8066):706-8. doi: 10.1016/s0140-6736(78)90814-0. [PMID: 76239]
  • R Storch, H Bräunlich. [Concentration of p-aminohippuric acid in the serum and kidney tissue during stimulation of renal excretion of foreign materials]. Acta biologica et medica Germanica. 1977; 36(2):237-44. doi: NULL. [PMID: 906735]
  • C Davidson, M S McLachlan, L Burkinshaw, D B Morgan. Effect of long-term diuretic treatment on body-potassium in heart-disease. Lancet (London, England). 1976 Nov; 2(7994):1044-7. doi: 10.1016/s0140-6736(76)90965-x. [PMID: 62899]
  • R Davies, N N Payne, J D Slater. Beta adrenergic blockade and diuretic therapy in benign essential hypertension: A dynamic assessment. The American journal of cardiology. 1976 Mar; 37(4):637-41. doi: 10.1016/0002-9149(76)90408-2. [PMID: 3963]
  • M Stopp, C Weise, S Mewes, H Bräunlich. Different inhibitory effects of 2,4-dinitrophenol, iodoacetate, and probenecid on renal excretion of p-aminohippurate, cyclopenthiazide, and sulfamethoxypyridazine in rats. Acta biologica et medica Germanica. 1976; 35(6):787-92. doi: NULL. [PMID: 983625]
  • R Storch, H Bräunlich. [Extent and duration of drug-induced stimulation of renal excretion of p-aminohippuric acid]. Acta biologica et medica Germanica. 1976; 35(10):1365-71. doi: NULL. [PMID: 1020568]
  • H Bräunlich, R Storch. [Inulin-clearance in the stimulation of renal excretion of p-aminohippuric acid through drugs]. Acta biologica et medica Germanica. 1976; 35(10):1411-4. doi: NULL. [PMID: 1020572]
  • K H Beyer, J E Baer. The site and mode of action of some sulfonamide-derived diuretics. The Medical clinics of North America. 1975 May; 59(3):735-50. doi: 10.1016/s0025-7125(16)32020-x. [PMID: 1128017]
  • H J Waal-Manning. Effect of equivalent antihypertensive doses of mefruside and cyclopenthiazide on serum electrolytes, uric acid and glucose tolerance in hypertensive patients. Clinical and experimental pharmacology & physiology. 1975 Mar; 2(2):141-6. doi: 10.1111/j.1440-1681.1975.tb01827.x. [PMID: 1095262]
  • R Storch, H Brünlich. [Stimulation of renal excretion of p-aminohippuric acid by repeated administration of drugs in young and adult rats]. Acta biologica et medica Germanica. 1975; 34(9):1529-39. doi: . [PMID: 1221741]
  • M Stopp, H Bräunlich. [Accumulation of p-aminohippuric acid and cyclopenthiazide in renal cortex slices from rats of various ages and their dependence on the energy supply]. Acta biologica et medica Germanica. 1975; 34(1):89-98. doi: NULL. [PMID: 1179924]
  • M Stopp, H Bräunlich. Characterisation of renal tubular transport processes in rats. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression. 1975; 16(6):373-8. doi: NULL. [PMID: 1232809]
  • R DYBKAER, A FRANTZEN. CYCLOPENTHIAZIDE WITH AND WITHOUT SUPPLEMENTARY POTASSIUM. EFFECTS IN LONG-TERM TREATMENT OF PATIENTS WITH NEGLIGIBLE EXCRETORY ELIMINATION OF OEDEMA. Acta medica Scandinavica. 1964 Feb; 175(?):135-43. doi: NULL. [PMID: 14124627]
  • A JACONO, P VITALE, O DEDIVITIIS, L SCALFI. [TREATMENT OF EDEMATOUS SYNDROMES; COMBINATION OF CYCLOPENTHIAZIDE WITH PREDNISONE]. Il Policlinico. Sezione medica. 1964 Feb; 71(?):1-13. doi: NULL. [PMID: 14143287]
  • P DONOSO, V E CUELLAR, N RAMIREZ, J MANCILLA, H BEHM. [COMPARATIVE STUDY OF THE HYPOSODIC REGIME AND CYCLOPENTHIAZIDE IN THE TREATMENT OF THE EDEMA SYNDROME]. Revista medica de Chile. 1963 Nov; 91(?):845-8. doi: NULL. [PMID: 14125676]
  • P L BALESTRI, A ZAMPIERI. [EFFECT OF A NEW DIURETIC, CYCLOPENTHIAZIDE, ON THE URINARY ELIMINATION OF ELECTROLYTES, ON RENAL FUNCTION AND ON ARTERIAL PRESSURE IN NORMAL AND HYPERTENSIVE SUBJECTS]. Minerva nefrologica. 1963 Oct; 10(?):234-9. doi: NULL. [PMID: 14096867]
  • H ABE. [Clinical effects of cyclopentiazide (Navidrex/CIBA) and its diuretic properties viewed from the electrolyte-transmitting mechanism of the renal tubule]. Naika hokan. Japanese archives of internal medicine. 1961 Sep; 8(?):770-8. doi: NULL. [PMID: 13858871]
  • H J SCHAFROTH. [Experiences with cyclopenthiazide (Navidrex), a new salidiuretic with special reference to serum electrolytes]. Praxis. 1961 Mar; 50(?):200-1. doi: NULL. [PMID: 13747225]