Cyclin D1 (BioDeep_00000177793)
human metabolite blood metabolite
代谢物信息卡片
2-[2-(2-{2-[2-(2-{2-[2-(2-amino-4-methylpentanamido)-4-methylpentanamido]acetamido}propanamido)-3-hydroxybutanamido]-3-sulfanylpropanamido}-4-(methylsulfanyl)butanamido)-3-phenylpropanamido]-3-methylbutanoic acid
化学式: C43H71N9O11S2 (953.4714216)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 2.08%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(CS)C(=O)NC(CCSC)C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)C)C(=O)O)N
InChI: InChI=1S/C43H71N9O11S2/c1-22(2)17-28(44)37(56)48-30(18-23(3)4)38(57)45-20-33(54)46-25(7)36(55)52-35(26(8)53)42(61)50-32(21-64)41(60)47-29(15-16-65-9)39(58)49-31(19-27-13-11-10-12-14-27)40(59)51-34(24(5)6)43(62)63/h10-14,22-26,28-32,34-35,53,64H,15-21,44H2,1-9H3,(H,45,57)(H,46,54)(H,47,60)(H,48,56)(H,49,58)(H,50,61)(H,51,59)(H,52,55)(H,62,63)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yiwen Zhang, Feng Lu. Molecular mechanism of triptolide in myocardial fibrosis through the Wnt/β-catenin signaling pathway.
Scandinavian cardiovascular journal : SCJ.
2024 Dec; 58(1):2295785. doi:
10.1080/14017431.2023.2295785. [PMID: 38164796] - Ran Huo, Wen-Jing Yang, Yu Liu, Te Liu, Tong Li, Chu-Yu Wang, Bai-Shen Pan, Bei-Li Wang, Wei Guo. Stigmasterol: Remodeling gut microbiota and suppressing tumor growth through Treg and CD8+ T cells in hepatocellular carcinoma.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155225. doi:
10.1016/j.phymed.2023.155225. [PMID: 38678948] - Yuanhui Wang, Ling Wang, Dongke Xie, Bo Chen. Investigating the molecular mechanism of Mori Cortex against osteosarcoma by bioinformatics analysis and in vitro experimental.
Medicine.
2024 May; 103(20):e38261. doi:
10.1097/md.0000000000038261. [PMID: 38758844] - Caijie Zheng, Yi Wang, Beilei Bi, Wencheng Zhou, Xinran Cao, Chenyang Zhang, Wentian Lu, Yang Sun, Jiao Qu, Wen Lv. Gallic acid ameliorates endometrial hyperplasia through the inhibition of the PI3K/AKT pathway and the down-regulation of cyclin D1 expression.
Journal of pharmacological sciences.
2024 May; 155(1):1-13. doi:
10.1016/j.jphs.2024.02.015. [PMID: 38553133] - Xiaokang Jia, Qiliang Chen, Ciyu Yao, Tetsuya Asakawa, Yuanyuan Zhang. α-synuclein regulates Cyclin D1 to promote abnormal initiation of the cell cycle and induce apoptosis in dopamine neurons.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Apr; 173(?):116444. doi:
10.1016/j.biopha.2024.116444. [PMID: 38503238] - Lianjie Hou, Zhiming Zou, Yu Wang, Hui Pi, Zeyue Yuan, Qin He, Yongfang Kuang, Guojun Zhao. Exploring the anti-atherosclerosis mechanism of ginsenoside Rb1 by integrating network pharmacology and experimental verification.
Aging.
2024 Mar; 16(8):6745-6756. doi:
10.18632/aging.205680. [PMID: 38546402] - Tomas Perecko, Jana Pereckova, Zuzana Hoferova, Martin Falk. Cell-type specific anti-cancerous effects of nitro-oleic acid and its combination with gamma irradiation.
Biological chemistry.
2024 Mar; 405(3):177-187. doi:
10.1515/hsz-2023-0150. [PMID: 37712609] - Yi-Fang Jiang, Yu-Qing Huang, Yan-E Hu, Yi Yang, Chuan Zheng, Feng-Ming You, Zi-Yi Zhao. [Banxia Xiexin Decoction inhibiting colitis-associated colorectal cancer infected with Fusobacterium nucleatum by regulating Wnt/β-catenin pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Mar; 49(5):1266-1274. doi:
10.19540/j.cnki.cjcmm.20231114.701. [PMID: 38621974] - Tao Zhang, Fenfen Xiang, Xiaoxiao Li, Zixi Chen, Jun Wang, Jiahui Guo, Shanshan Zhu, Jun Zhou, Xiangdong Kang, Rong Wu. Mechanistic study on ursolic acid inhibiting the growth of colorectal cancer cells through the downregulation of TGF-β3 by miR-140-5p.
Journal of biochemical and molecular toxicology.
2024 Jan; 38(1):e23581. doi:
10.1002/jbt.23581. [PMID: 38044485] - Adewale Adetutu, Abiodun Bukunmi Aborisade, Faith Ayotunde Ogunsina, Peter Ifeoluwa Adegbola, Temitope Deborah Olaniyi. Ginger mitigated the health risks associated with arsenic-contamination of rats feed via inflammatory and apoptosis regulation.
Ecotoxicology and environmental safety.
2024 Jan; 269(?):115768. doi:
10.1016/j.ecoenv.2023.115768. [PMID: 38064790] - Na Li, Yazhuo Wang, Lin Liu, Pei Wang, Xiaohua Wu. Effects of MFG-E8 expression on the biological characteristics of ovarian cancer cells via the AKT/mTOR/S6K signalling pathway.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.
2023 Dec; 43(1):2151354. doi:
10.1080/01443615.2022.2151354. [PMID: 36484512] - Zhongwen Qi, Zhipeng Yan, Ke Zhu, Yueyao Wang, Yajie Fan, Tingting Li, Junping Zhang. Novel treatment from a botanical formulation Si-Miao-Yong-an decoction inhibits vasa vasorum angiogenesis and stabilizes atherosclerosis plaques via the Wnt1/β-catenin signalling pathway.
Pharmaceutical biology.
2023 Dec; 61(1):1364-1373. doi:
10.1080/13880209.2023.2249061. [PMID: 37651108] - Xianwei Huang, Xiong Liu, Jiyan Lin. Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.
Cell cycle (Georgetown, Tex.).
2023 Nov; 22(21-22):2361-2380. doi:
10.1080/15384101.2023.2287367. [PMID: 38057958] - Xuan Dai, Yage Liu, Tianyuan Liu, Yueyi Zhang, Shan Wang, Tianshu Xu, Jiyuan Yin, Hanfen Shi, Zimengwei Ye, Ruyuan Zhu, Junfeng Gao, Guangtong Dong, Dandan Zhao, Sihua Gao, Xinxiang Wang, Marc Prentki, Dieter Brὂmme, Lili Wang, Dongwei Zhang. SiJunZi decoction ameliorates bone quality and redox homeostasis and regulates advanced glycation end products/receptor for advanced glycation end products and WNT/β-catenin signaling pathways in diabetic mice.
Journal of ethnopharmacology.
2023 Sep; ?(?):117167. doi:
10.1016/j.jep.2023.117167. [PMID: 37716489] - Ning Zhang, Tao Ye, Xu Lu, Zi-Hui Li, Ling Li. Radix Scrophulariae Extracts Exert Effect on Hyperthyroidism via MST1/Hippo Signaling Pathway.
Chinese journal of integrative medicine.
2023 Sep; ?(?):. doi:
10.1007/s11655-023-3744-7. [PMID: 37661231] - R P Guo, L Y Yang, J F Zhao, J Su. [Advance on cyclin D1 and CDK4 in cutaneous melanoma].
Zhonghua bing li xue za zhi = Chinese journal of pathology.
2023 Jul; 52(7):767-770. doi:
10.3760/cma.j.cn112151-20221230-01090. [PMID: 37408419] - Samaneh Safarpour, Farshad Mirzavi, Farzad Rahmani, Fatemeh Forouzanfar, Hamid Reza Sadeghnia, Baratali Mashkani, Daryoush Hamidi Alamdari, Mohammad Soukhtanloo. Fenugreek Seed Extract Regulates Human Umbilical Vein Endothelial Cell Angiogenesis and Proliferation via the PI3K/Akt/Cyclin D1 Pathway.
Alternatives to laboratory animals : ATLA.
2023 Jul; 51(4):249-257. doi:
10.1177/02611929231181623. [PMID: 37345436] - Farman Ali, Di Wang, Ying Cheng, Meizhu Wu, Muhammad Zubair Saleem, Lihui Wei, Yi Xie, Mengchao Yan, Jiangfeng Chu, Yanyan Yang, Aling Shen, Jun Peng. Quercetin attenuates angiotensin II-induced proliferation of vascular smooth muscle cells and p53 pathway activation in vitro and in vivo.
BioFactors (Oxford, England).
2023 Jun; ?(?):. doi:
10.1002/biof.1959. [PMID: 37296538] - Basma G Eid, Thikryat Neamatallah, Lenah S Binmahfouz, Amina M Bagher, Abdulmohsin J Alamoudi, Hibah Mubarak Aldawsari, Abeer Hanafy, Atif Hasan, Hany M El-Bassossy, Ashraf B Abdel-Naim, Kiran Vemuri, Alexandros Makriyannis. Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic syndrome-induced prostatic hyperplasia in rats.
Biomolecules and biomedicine.
2023 May; ?(?):. doi:
10.17305/bb.2023.9173. [PMID: 37212036] - Jing Zhou, Fan Yuan, Chun-Mei Luo, Kun Zhu, Bo-Yan Liu, Yue Chang, Yao-Dong You. [Effects of Qilan Prescription on the proliferation and apoptosis of human prostate cancer DU145 cells and its action mechanism].
Zhonghua nan ke xue = National journal of andrology.
2023 Mar; 29(3):255-263. doi:
". [PMID: 38597708] - Changlin Du, Jiahui Dong, Qi Wang, Chuanting Xu, Shiqi Feng, Rui Feng, Xiongwen Lv, Jun Li, Lei Zhang, Cheng Huang, Taotao Ma. Hastatoside attenuatescarbon tetrachloride-induced liver fibrosis by targeting glycogen synthase kinase-3β.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 109(?):154585. doi:
10.1016/j.phymed.2022.154585. [PMID: 36610117] - Sina Mohammadinejad, Davoud Jafari-Gharabaghlou, Nosratollah Zarghami. Development of PEGylated PLGA Nanoparticles Co-Loaded with Bioactive Compounds: Potential Anticancer Effect on Breast Cancer Cell Lines.
Asian Pacific journal of cancer prevention : APJCP.
2022 Dec; 23(12):4063-4072. doi:
10.31557/apjcp.2022.23.12.4063. [PMID: 36579986] - M A Hamzawy, A M Abo-Youssef, M N Malak, M M Khalaf. Multiple targets of Nrf 2 inhibitor; trigonelline in combating urethane-induced lung cancer by caspase-executioner apoptosis, cGMP and limitation of cyclin D1 and Bcl2.
European review for medical and pharmacological sciences.
2022 12; 26(24):9393-9408. doi:
10.26355/eurrev_202212_30690. [PMID: 36591848] - Shengen Yi, Xiaoxin Jin, Bo Liu, Peidong Wu, Wang Xiao, Weidong Chen. Portulaca oleracea extract reduces gut microbiota imbalance and inhibits colorectal cancer progression via inactivation of the Wnt/β-catenin signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Oct; 105(?):154279. doi:
10.1016/j.phymed.2022.154279. [PMID: 35963192] - Chun Pan, Haixiang Qin, Haibo Jin, Wenyuan Chen, Hongqian Guo, Xiaodong Han. Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
Toxicology.
2022 10; 480(?):153326. doi:
10.1016/j.tox.2022.153326. [PMID: 36115647] - Paradon Sonsomnuek, Mayuri Tarasuk, Tullayakorn Plengsuriyakarn, Kanyarat Boonprasert, Kesara Na-Bangchang. Apoptotic and Anti-metastatic Effects of Atractylodes lancea (Thunb.) DC. in a Hamster Model of Cholangiocarcinoma.
Asian Pacific journal of cancer prevention : APJCP.
2022 Sep; 23(9):3093-3101. doi:
10.31557/apjcp.2022.23.9.3093. [PMID: 36172672] - Qiyun Shi, Lu Huang, Jiahao Duan, Gaoyan Kuang, Min Lu, Xuyi Tan. The effects of Jiawei Duhuo Jisheng mixture on Wnt/β-catenin signaling pathway in the synovium inflamed by knee osteoarthritis: An in vitro and in vivo experiment.
Journal of ethnopharmacology.
2022 Aug; 294(?):115363. doi:
10.1016/j.jep.2022.115363. [PMID: 35551975] - Heba S Zaky, Somaia A Abdel-Sattar, Albatoul Allam, Hebatalla I Ahmed. Further insights into the impact of rebamipide on gentamicin-induced nephrotoxicity in rats: modulation of SIRT1 and β-catenin/cyclin D1 pathways.
Drug and chemical toxicology.
2022 Jul; ?(?):1-13. doi:
10.1080/01480545.2022.2104867. [PMID: 35899710] - Yanli Li, Yalan Chen, Ziyu Liu, Beisi Lin, Xiaoyi Deng, Qiwen Xiao, Zhishan Chen, Huiyu Ye, Danrui Chen, Yanna Su, Wangen Li, Wen Xu. Downregulation of Kcnq1ot1 attenuates β-cell proliferation and insulin secretion via the miR-15b-5p/Ccnd1 and Ccnd2 axis.
Acta diabetologica.
2022 Jul; 59(7):885-899. doi:
10.1007/s00592-022-01871-6. [PMID: 35347427] - Liu Yang, Jingyun Zhang, Xiaoxiao Han, Chenchi Li, Ranyang Liu, Zihua Ma, Bing Han, Rujia Xie, Qin Yang. [Rat serum containing oxymatrine inhibits the proliferation of LX2 human hepatic stellate cells induced by sodium arsenite via blocking PI3K/AKT pathway].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2022 Jul; 38(7):598-604. doi:
. [PMID: 35786453] - Yosuke Osaki, Marika Manolopoulou, Alla V Ivanova, Nicholas Vartanian, Melanie Phillips Mignemi, Justin Kern, Jianchun Chen, Haichun Yang, Agnes B Fogo, Mingzhi Zhang, Cassianne Robinson-Cohen, Leslie S Gewin. Blocking cell cycle progression through CDK4/6 protects against chronic kidney disease.
JCI insight.
2022 06; 7(12):. doi:
10.1172/jci.insight.158754. [PMID: 35730565] - Y Fang, S Wang, Q Yang, S You, X Xing. [Chaihu Guizhi Decoction plus or minus formula combined with capecitabine inhibits IL-6/STAT3 signaling to suppress triple-negative breast cancer xenografts in nude mice].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2022 Jun; 42(6):905-912. doi:
10.12122/j.issn.1673-4254.2022.06.15. [PMID: 35790442] - Saroor A Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K Richardson, Jianfeng Ge, Saiful E Syafruddin, Alyson Speed, Evangelia K Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dóra Bihary, Cissy Yong, David J Harrison, Grant D Stewart, Mitchell J Machiela, Mark P Purdue, Stephen J Chanock, Anne Y Warren, Shamith A Samarajiwa, Jason S Carroll, Sakari Vanharanta. The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
Nature.
2022 06; 606(7916):999-1006. doi:
10.1038/s41586-022-04809-8. [PMID: 35676472] - K Lei, W Xie, T Sun, Y Liu, X Wang. [MiR-744-5p inhibits the proliferation, invasion, and migration of clear-cell renal cell carcinoma cells by targeting CCND1].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2022 May; 42(5):712-717. doi:
10.12122/j.issn.1673-4254.2022.05.12. [PMID: 35673915] - Ziye Liu, Yongsheng Wu. Arctiin elevates osteogenic differentiation of MC3T3-E1 cells by modulating cyclin D1.
Bioengineered.
2022 04; 13(4):10866-10874. doi:
10.1080/21655979.2022.2066047. [PMID: 35473505] - Ahmed A Mohamed, Randa A Zaghloul, Amr M Abdelghany, Amal M El Gayar. Selenium nanoparticles and quercetin suppress thioacetamide-induced hepatocellular carcinoma in rats: Attenuation of inflammation involvement.
Journal of biochemical and molecular toxicology.
2022 Apr; 36(4):e22989. doi:
10.1002/jbt.22989. [PMID: 35179263] - Sangeetha Hareendran, Bassam Albraidy, Xuyu Yang, Aiyi Liu, Anne Breggia, Clark C Chen, Y Peng Loh. Exosomal Carboxypeptidase E (CPE) and CPE-shRNA-Loaded Exosomes Regulate Metastatic Phenotype of Tumor Cells.
International journal of molecular sciences.
2022 Mar; 23(6):. doi:
10.3390/ijms23063113. [PMID: 35328535] - Dao-Fang Ding, Yan Xue, Jun-Peng Zhang, Zeng-Qiao Zhang, Wen-Yao Li, Yue-Long Cao, Jian-Guang Xu. Similarities and differences between rat and mouse chondrocyte gene expression induced by IL-1β.
Journal of orthopaedic surgery and research.
2022 Feb; 17(1):70. doi:
10.1186/s13018-021-02889-2. [PMID: 35120538] - Taiji Hamada, Toshiaki Akahane, Seiya Yokoyama, Nayuta Higa, Mari Kirishima, Kei Matsuo, Michiko Shimokawa, Koji Yoshimoto, Akihide Tanimoto. An oncogenic splice variant of PDGFRα in adult glioblastoma as a therapeutic target for selective CDK4/6 inhibitors.
Scientific reports.
2022 01; 12(1):1275. doi:
10.1038/s41598-022-05391-9. [PMID: 35075231] - Zhonglin Liu, Yan Yang. Ginkgolide A Participates in LPS-Induced PMVEC Injury by Regulating miR-224 and Inhibiting p21 in a Targeted Manner.
Contrast media & molecular imaging.
2022; 2022(?):6384334. doi:
10.1155/2022/6384334. [PMID: 36134118] - Rohina Bashir, Ovais Ahmad Zargar, Abid Hamid Dar, Nalli Yedukondalu, Qazi Parvaiz, Rabia Hamid. The modulation of PI3K/Akt pathway by 3β hydroxylup-12-en-28-oic acid isolated from Thymus linearis induces cell death in HCT-116 cells.
Chemical biology & drug design.
2022 01; 99(1):162-178. doi:
10.1111/cbdd.13957. [PMID: 34558199] - Renjie Xu, Jiahui Yu, Shangjin Song, Dazhi Sun, Lijuan Xiu, Jinyu Xu, Jing Zhao, Xuan Liu, Qing Ji, Xiaoqiang Yue. Long non-coding RNA ncRuPAR regulates gastric cancer cell proliferation and apoptosis via phosphoinositide 3-kinase/protein kinase B signaling.
International journal of medical sciences.
2022; 19(13):1835-1846. doi:
10.7150/ijms.76664. [PMID: 36438913] - Amee Sanghavi, Ananth Srivatsa, Divya Adiga, Aditi Chopra, Richard Lobo, Shama Prasada Kabekkodu, Shivaprasada Gadag, Usha Nayak, Karthik Sivaraman, Ashmeet Shah. Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study.
F1000Research.
2022; 11(?):1563. doi:
10.12688/f1000research.129250.3. [PMID: 36761830] - Shireen S Mahmoud, Samia Hussein, Hayam Rashed, Eman M A Abdelghany, Alaa I Ali. Anticancer Effects of Tacrolimus on Induced Hepatocellular Carcinoma in Mice.
Current molecular pharmacology.
2022; 15(2):434-445. doi:
10.2174/1874467214666210531164546. [PMID: 34061012] - Zhenyan Song, Chunxiang He, Wenjing Yu, Miao Yang, Ze Li, Ping Li, Xu Zhu, Chen Xiao, Shaowu Cheng. Baicalin Attenuated Aβ 1-42-Induced Apoptosis in SH-SY5Y Cells by Inhibiting the Ras-ERK Signaling Pathway.
BioMed research international.
2022; 2022(?):9491755. doi:
10.1155/2022/9491755. [PMID: 35528169] - Nuray Kepil, Şebnem Batur, Zeynep Ecem Kain, Gamze Özcan, Şenol Emre, Rahşan Özcan, Tülin Tiraje Celkan, Nil Çomunoğlu. Role of Immunohistochemistry in the Differential Diagnosis of Pediatric Renal Tumors: Expression of Cyclin D1, Beta-Catenin , PDGFR-Alpha, and PTEN.
Turk patoloji dergisi.
2022; 38(2):83-89. doi:
10.5146/tjpath.2022.01568. [PMID: 35147974] - Paula Dietrich, Shanta Alli, Megan K Mulligan, Rachel Cox, David G Ashbrook, Robert W Williams, Ioannis Dragatsis. Identification of cyclin D1 as a major modulator of 3-nitropropionic acid-induced striatal neurodegeneration.
Neurobiology of disease.
2022 01; 162(?):105581. doi:
10.1016/j.nbd.2021.105581. [PMID: 34871739] - Jun Liu, Jing Lin, Xuefeng Wang, Xiaobin Zheng, Xuan Gao, Yingying Huang, Gang Chen, Jiani Xiong, Bin Lan, Chuanben Chen, Lu Si, Yu Chen. CCND1 Amplification Profiling Identifies a Subtype of Melanoma Associated With Poor Survival and an Immunosuppressive Tumor Microenvironment.
Frontiers in immunology.
2022; 13(?):725679. doi:
10.3389/fimmu.2022.725679. [PMID: 35844619] - Jing An, Bo Chen, Ding Tian, Yunshan Guo, Yuzhu Yan, Hao Yang. Regulation of Neurogenesis and Neuronal Differentiation by Natural Compounds.
Current stem cell research & therapy.
2022; 17(8):756-771. doi:
10.2174/1574888x16666210907141447. [PMID: 34493197] - Zigui Chen, Yingying Xie, Hongcheng Luo, Ye Song, Tianshi Que, Rentong Hu, Huatuo Huang, Kunxiang Luo, Chuanyu Li, Chengjian Qin, Chuanhua Zheng, Weiyi Fang, Longyang Liu, Hao Long, Qisheng Luo. NAP1L1 promotes proliferation and chemoresistance in glioma by inducing CCND1/CDK4/CDK6 expression through its interaction with HDGF and activation of c-Jun.
Aging.
2021 12; 13(24):26180-26200. doi:
10.18632/aging.203805. [PMID: 34959221] - Kari Hemminki, Asta Försti, Richard Houlston, Amit Sud. Epidemiology, genetics and treatment of multiple myeloma and precursor diseases.
International journal of cancer.
2021 12; 149(12):1980-1996. doi:
10.1002/ijc.33762. [PMID: 34398972] - Suqing Li, Cong Qin, Yike Chen, Dan Wei, Zhijun Tan, Jiadong Meng. Implications of cell division cycle associated 4 on the Wilm's tumor cells viability via AKT/mTOR signaling pathway.
Renal failure.
2021 Dec; 43(1):1470-1478. doi:
10.1080/0886022x.2021.1994994. [PMID: 34723730] - Jingru Qin, Chao Guo, Lu Yang, Xiao Liang, Aijun Jiao, Keng Po Lai, Bin Yang. Bioinformatics and in-silico findings reveal medical features and pharmacological targets of biochanin A against colorectal cancer and COVID-19.
Bioengineered.
2021 12; 12(2):12461-12469. doi:
10.1080/21655979.2021.2005876. [PMID: 34931923] - Amal M H Ghanim, Nancy S Younis, Heba A Metwaly. Vanillin augments liver regeneration effectively in Thioacetamide induced liver fibrosis rat model.
Life sciences.
2021 Dec; 286(?):120036. doi:
10.1016/j.lfs.2021.120036. [PMID: 34637793] - Geu Rim Song, Yoon Jung Choi, Soo Jin Park, Subeen Shin, Giseong Lee, Hui Ji Choi, Do Yup Lee, Gyu-Yong Song, Sangtaek Oh. Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/β-Catenin Pathway.
Journal of microbiology and biotechnology.
2021 Nov; 31(11):1559-1567. doi:
10.4014/jmb.2109.09002. [PMID: 34584036] - Vikram Singh, Kirti Gupta, Aastha Saraswati, Nitin J Peters, Amita Trehan. Role of Cyclin D1 and BCOR Immunohistochemistry in Differentiating Clear Cell Sarcoma of Kidney From its Mimics.
Journal of pediatric hematology/oncology.
2021 Nov; 43(8):294-300. doi:
10.1097/mph.0000000000002262. [PMID: 34673711] - Andrew J Massey, Karen Benwell, Mike Burbridge, Andras Kotschy, David Lee Walmsley. Targeting DYRK1A/B kinases to modulate p21-cyclin D1-p27 signalling and induce anti-tumour activity in a model of human glioblastoma.
Journal of cellular and molecular medicine.
2021 11; 25(22):10650-10662. doi:
10.1111/jcmm.17002. [PMID: 34708541] - YaHui Liu, XiaoNing Li, YeWei Zhang, Yao Tang, WeiYi Fang, Xiong Liu, Zhen Liu. NAP1L1 targeting suppresses the proliferation of nasopharyngeal carcinoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112096. doi:
10.1016/j.biopha.2021.112096. [PMID: 34563951] - Zhipeng Li, Zeyu Zhu, Yanjun Wang, Ying Wang, Weibing Li, Zhigang Wang, Xinyuan Zhou, Yuhua Bao. hsa‑miR‑15a‑5p inhibits colon cell carcinoma via targeting CCND1.
Molecular medicine reports.
2021 10; 24(4):. doi:
10.3892/mmr.2021.12375. [PMID: 34414457] - Khaleel I Al-Obaidy, Liang Cheng. Renal oncocytoma with adverse pathologic features: a clinical and pathologic study of 50 cases.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
2021 10; 34(10):1947-1954. doi:
10.1038/s41379-021-00849-z. [PMID: 34103666] - Jaime Alvarez-Benayas, Nikolaos Trasanidis, Alexia Katsarou, Kanagaraju Ponnusamy, Aristeidis Chaidos, Philippa C May, Xiaolin Xiao, Marco Bua, Maria Atta, Irene A G Roberts, Holger W Auner, Evdoxia Hatjiharissi, Maria Papaioannou, Valentina S Caputo, Ian M Sudbery, Anastasios Karadimitris. Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myeloma.
Nature communications.
2021 09; 12(1):5450. doi:
10.1038/s41467-021-25704-2. [PMID: 34521827] - Salsabeel Z Basha, Gamal A Mohamed, Ashraf B Abdel-Naim, Atif Hasan, Ahmed Abdel-Lateff. Cucurbitacin E glucoside from Citrullus colocynthis inhibits testosterone-induced benign prostatic hyperplasia in mice.
Drug and chemical toxicology.
2021 Sep; 44(5):533-543. doi:
10.1080/01480545.2019.1635149. [PMID: 31298051] - Pu Zhang, Weiping Wang, Meilan Li. Circ_0010283/miR-377-3p/Cyclin D1 Axis Is Associated With Proliferation, Apoptosis, Migration, and Inflammation of Oxidized Low-density Lipoprotein-Stimulated Vascular Smooth Muscle Cells.
Journal of cardiovascular pharmacology.
2021 09; 78(3):437-447. doi:
10.1097/fjc.0000000000001076. [PMID: 34516453] - Yibing Zhang, Dongsheng Xu, Peng Huang, Yang Zhang, Qi Li, Zhimin Fan, Liqun Ren. Essential role of protein kinase C βI in icariin-mediated protection against atherosclerosis.
The Journal of pharmacy and pharmacology.
2021 Aug; 73(9):1169-1179. doi:
10.1093/jpp/rgab040. [PMID: 33822184] - Oleksandr Kravtsov, Sounak Gupta, John C Cheville, William R Sukov, Ross Rowsey, Loren P Herrera-Hernandez, Christine M Lohse, Ryan Knudson, Bradley C Leibovich, Rafael E Jimenez. Low-Grade Oncocytic Tumor of Kidney (CK7-Positive, CD117-Negative): Incidence in a single institutional experience with clinicopathological and molecular characteristics.
Human pathology.
2021 08; 114(?):9-18. doi:
10.1016/j.humpath.2021.04.013. [PMID: 33961838] - Tong Sun, Yu-Jia Xu, Shuo-Yi Jiang, Zhuan Xu, Bi-Yin Cao, Gautam Sethi, Yuan-Ying Zeng, Yan Kong, Xin-Liang Mao. Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis.
Acta pharmacologica Sinica.
2021 Aug; 42(8):1338-1346. doi:
10.1038/s41401-020-00551-x. [PMID: 33184448] - Fan Xue, Zhenlei Zhao, Yanpei Gu, Jianxin Han, Keqiang Ye, Ying Zhang. 7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis.
eLife.
2021 07; 10(?):. doi:
10.7554/elife.64872. [PMID: 34227467] - Letícia A Apolinário, Leandra N Z Ramalho, Motahareh Hashemi Moosavi, Alessandra V Jager, Marlei J Augusto, Maurício R Trotta, Tânia Petta, Amin Mousavi Khaneghah, Carlos A F Oliveira, Fernando S Ramalho. Oncogenic and tumor suppressor pathways in subchronic aflatoxicosis in rats: Association with serum and urinary aflatoxin exposure biomarkers.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Jul; 153(?):112263. doi:
10.1016/j.fct.2021.112263. [PMID: 34015426] - Xue Yang, Ying Feng, Yao Liu, Xieqiong Ye, Xiaomin Ji, Le Sun, Fangyuan Gao, Qun Zhang, Yuxin Li, Bingbing Zhu, XianBo Wang. Fuzheng Jiedu Xiaoji formulation inhibits hepatocellular carcinoma progression in patients by targeting the AKT/CyclinD1/p21/p27 pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jul; 87(?):153575. doi:
10.1016/j.phymed.2021.153575. [PMID: 33984593] - Mariko Yabe, Neval Ozkaya, Daphne de Jong, Umut Aypar, M Stella Ritorto, Ellis Barbé, Iris H C Miedema, Filiz Sen, Jessica R Chapman, Heather J Landau, Ahmet Dogan. Localized Peritumoral AL Amyloidosis Associated With Mantle Cell Lymphoma With Plasmacytic Differentiation.
The American journal of surgical pathology.
2021 07; 45(7):939-944. doi:
10.1097/pas.0000000000001684. [PMID: 33739787] - Mengqi Zhuang, Xiaotong Ding, Wenli Song, Huimin Chen, Hui Guan, Yang Yu, Zicheng Zhang, Xinzhe Dong. Correlation of IL-6 and JAK2/STAT3 signaling pathway with prognosis of nasopharyngeal carcinoma patients.
Aging.
2021 06; 13(12):16667-16683. doi:
10.18632/aging.203186. [PMID: 34165442] - Paula Moyano, José Manuel García, Jimena García, Adela Pelayo, Pilar Muñoz-Calero, María Teresa Frejo, Maria Jose Anadon, Maria Victoria Naval, Andrea Flores, Vega Alejandra Mirat, Javier Del Pino. Chlorpyrifos induces cell proliferation in MCF-7 and MDA-MB-231 cells, through cholinergic and Wnt/β-catenin signaling disruption, AChE-R upregulation and oxidative stress generation after single and repeated treatment.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Jun; 152(?):112241. doi:
10.1016/j.fct.2021.112241. [PMID: 33930485] - Gyeong-Seok Lee, Hee-Yeon Jeong, Hyeon-Gung Yang, Young-Ran Seo, Eui-Gil Jung, Yong-Seok Lee, Kung-Woo Nam, Wan-Jong Kim. Astragaloside IV Suppresses Hepatic Proliferation in Regenerating Rat Liver after 70\% Partial Hepatectomy via Down-Regulation of Cell Cycle Pathway and DNA Replication.
Molecules (Basel, Switzerland).
2021 May; 26(10):. doi:
10.3390/molecules26102895. [PMID: 34068164] - Kai Furuya, Tao Wu, Ai Orimoto, Eriko Sugano, Hiroshi Tomita, Tohru Kiyono, Takahiro Kurose, Yoshihiro Takai, Tomokazu Fukuda. The transcriptome of wild-type and immortalized corneal epithelial cells.
Scientific data.
2021 05; 8(1):126. doi:
10.1038/s41597-021-00908-9. [PMID: 33963195] - Wen-Lan Wang, Xiao-Ming Luo, Qin Zhang, Hai-Qiao Zhu, Guo-Qing Chen, Qin Zhou. The lncRNA PVT1/miR-590-5p/FSTL1 axis modulates the proliferation and migration of airway smooth muscle cells in asthma.
Autoimmunity.
2021 05; 54(3):138-147. doi:
10.1080/08916934.2021.1897977. [PMID: 33825599] - Marcelina W Musiałek, Joanna Deckert, Dorota Rybaczek. Hydroxyurea and Caffeine Impact pRb-like Protein-Dependent Chromatin Architecture Profiles in Interphase Cells of Vicia faba.
International journal of molecular sciences.
2021 Apr; 22(9):. doi:
10.3390/ijms22094572. [PMID: 33925461] - Lixiao Liu, Anzi Yang, Wen Luo, Huaxiao Liu, Xuan Liu, Wenbo Zhao. Ultrasensitive detection of cyclin D1 by a self-enhanced ECL immunosensor based on Bi2S3 quantum dots.
The Analyst.
2021 Mar; 146(6):2057-2064. doi:
10.1039/d0an02296a. [PMID: 33538277] - Hadi Bakhtiari, Ali Gheysarzadeh, Mustafa Ghanadian, Mahmoud Aghaei. 15-Hydroxy-8(17),13(E)-labdadiene-19-carboxylic acid (HLCA) inhibits proliferation and induces cell cycle arrest and apoptosis in ovarian cancer cells.
Life sciences.
2021 Feb; 267(?):118981. doi:
10.1016/j.lfs.2020.118981. [PMID: 33385409] - Zhi Cao, Xiaolei Shi, Feng Tian, Yu Fang, Jason Boyang Wu, Stefan Mrdenovic, Xinwen Nian, Jin Ji, Huan Xu, Chen Kong, Yalong Xu, Xi Chen, Yuhua Huang, Xuedong Wei, Yongwei Yu, Bo Yang, Leland W K Chung, Fubo Wang. KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer.
Cell death & disease.
2021 01; 12(1):2. doi:
10.1038/s41419-020-03354-4. [PMID: 33414463] - Gauri Panse, Antonio Subtil, Jennifer M McNiff, Earl J Glusac, Christine J Ko, Anjela Galan, Peggy Myung, Mina L Xu. Cutaneous Involvement in Plasma Cell Myeloma.
American journal of clinical pathology.
2021 01; 155(1):106-116. doi:
10.1093/ajcp/aqaa122. [PMID: 32885235] - Heng Zhou, Juling Xu, Sanxiong Huang, Ying He, Xiaowei He, Lu Guo, Shi Yin, Sheng Lu. Blocking the Hepatic Branch of the Vagus Aggravates Hepatic Ischemia-Reperfusion Injury via Inhibiting the Expression of IL-22 in the Liver.
Journal of immunology research.
2021; 2021(?):6666428. doi:
10.1155/2021/6666428. [PMID: 34514001] - Yanhong Wang, Qian Wang, Xibei Li, Gongwen Luo, Mou Shen, Jia Shi, Xueliang Wang, Lu Tang. Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/β-Catenin Axis.
Drug design, development and therapy.
2021; 15(?):245-257. doi:
10.2147/dddt.s278002. [PMID: 33519190] - Armin Soave, Lan Kluwe, Hang Yu, Michael Rink, Philipp Gild, Malte W Vetterlein, Philipp Marks, Guido Sauter, Margit Fisch, Christian P Meyer, Tim Ludwig, Roland Dahlem, Sarah Minner, Klaus Pantel, Bettina Steinbach, Heidi Schwarzenbach. Copy number variations in primary tumor, serum and lymph node metastasis of bladder cancer patients treated with radical cystectomy.
Scientific reports.
2020 12; 10(1):21562. doi:
10.1038/s41598-020-75869-x. [PMID: 33298978] - Ruixue Zhang, Mengqin Shen, Chunhua Wu, Yumei Chen, Jiani Lu, Jiajin Li, Li Zhao, Huannan Meng, Xiang Zhou, Gang Huang, Xiaoping Zhao, Jianjun Liu. HDAC8-dependent deacetylation of PKM2 directs nuclear localization and glycolysis to promote proliferation in hepatocellular carcinoma.
Cell death & disease.
2020 12; 11(12):1036. doi:
10.1038/s41419-020-03212-3. [PMID: 33279948] - Minghua Liu, Ying Yang, Dajun Liu, Ye Cao, Yan Li. Parthenolide increases the sensitivity of gastric cancer cells to chemotherapy.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2020 12; 40(6):908-916. doi:
10.19852/j.cnki.jtcm.2020.06.002. [PMID: 33258341] - Xiang Li, Meng Wang, Ning Du, Ting Liang, Guo-Dong Xiao, Kai Li, Ji-Chang Wang, Chong-Wen Xu, Zi-Yang Peng, Shou-Ching Tang, Xin Sun. Matrine Inhibitory Effect on Self-renewal and Re-sensitization of 5-FU Resistant NSCLC Stem Cells were through Let-7b dependent Downregulation of CCND1.
Cell cycle (Georgetown, Tex.).
2020 12; 19(23):3249-3259. doi:
10.1080/15384101.2020.1838791. [PMID: 33164645] - Jiayu Gao, Yu Qin, Keke Luo, Xilan Wang, Chun Yu, Aihua Zhang, Xueli Pan. Downregulation of miR-4755-5p promotes fluoride-induced osteoblast activation via tageting Cyclin D1.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2020 Dec; 62(?):126626. doi:
10.1016/j.jtemb.2020.126626. [PMID: 32731110] - Ignacio Romero, M Jesús Rubio, Manuel Medina, Xavier Matias-Guiu, Maria Santacana, Juan-Antonio Schoenenberger, Eva Maria Guerra, Alfonso Cortés, Lucas Minig, Pluvio Coronado, Juan Fernando Cueva, Lourdes Gómez, Andrea Malfettone, Miguel Sampayo, Antonio Llombart-Cussac, Andrés Poveda. An olaparib window-of-opportunity trial in patients with early-stage endometrial carcinoma: POLEN study.
Gynecologic oncology.
2020 12; 159(3):721-731. doi:
10.1016/j.ygyno.2020.09.013. [PMID: 32988624] - Jing Xu, Shan Jin, Fei Gan, Hui Xiong, Zhinan Mei, Yu Chen, Guangzhong Yang. Polycyclic polyprenylated acylphloroglucinols from Garcinia xanthochymus fruits exhibit antitumor effects through inhibition of the STAT3 signaling pathway.
Food & function.
2020 Dec; 11(12):10568-10579. doi:
10.1039/d0fo02535f. [PMID: 33185634] - Xiaoying Li, Pengxi Zheng, Tingting Ji, Bo Tang, Yakun Wang, Shoujun Bai. LINC00052 ameliorates acute kidney injury by sponging miR-532-3p and activating the Wnt signaling pathway.
Aging.
2020 11; 13(1):340-350. doi:
10.18632/aging.104152. [PMID: 33231561] - Jean-Baptiste Alberge, Florence Magrangeas, Mirko Wagner, Soline Denié, Catherine Guérin-Charbonnel, Loïc Campion, Michel Attal, Hervé Avet-Loiseau, Thomas Carell, Philippe Moreau, Stéphane Minvielle, Aurélien A Sérandour. DNA hydroxymethylation is associated with disease severity and persists at enhancers of oncogenic regions in multiple myeloma.
Clinical epigenetics.
2020 11; 12(1):163. doi:
10.1186/s13148-020-00953-y. [PMID: 33138842] - Dandan Zheng, Yuchuan Jiang, Chen Qu, Hui Yuan, Kaishun Hu, Lu He, Peng Chen, Jinying Li, Mengxian Tu, Lehang Lin, Hengxing Chen, Zelong Lin, Wenyu Lin, Jun Fan, Guohua Cheng, Jian Hong. Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis.
The American journal of pathology.
2020 11; 190(11):2267-2281. doi:
10.1016/j.ajpath.2020.08.002. [PMID: 32805235] - Weiguo Wang, Jian Xin, Wenming Chen, Lizhong Jing, Peng Zhang. Icariin alleviates hypoxia-induced damage in MC3T3-E1 cells by downregulating TALNEC2.
Biotechnology and applied biochemistry.
2020 Nov; 67(6):1000-1010. doi:
10.1002/bab.1874. [PMID: 31845407] - Yanfang Gao, Hui Yang, Yanhong Wang, Jihua Tian, Rongshan Li, Xiaoshuang Zhou. Evaluation of the inhibitory effect of tacrolimus combined with mycophenolate mofetil on mesangial cell proliferation based on the cell cycle.
International journal of molecular medicine.
2020 Oct; 46(4):1582-1592. doi:
10.3892/ijmm.2020.4696. [PMID: 32945359] - Xi Chen, Hansen Chen, Yachong He, Shuping Fu, Haosheng Liu, Qi Wang, Jiangang Shen. Proteomics-Guided Study on Buyang Huanwu Decoction for Its Neuroprotective and Neurogenic Mechanisms for Transient Ischemic Stroke: Involvements of EGFR/PI3K/Akt/Bad/14-3-3 and Jak2/Stat3/Cyclin D1 Signaling Cascades.
Molecular neurobiology.
2020 Oct; 57(10):4305-4321. doi:
10.1007/s12035-020-02016-y. [PMID: 32700252] - Ming Qi, Dong-Mei Liu, Wei Ji, Hai-Ling Wang. ATP6V0D2, a subunit associated with proton transport, serves an oncogenic role in esophagus cancer and is correlated with epithelial-mesenchymal transition.
Esophagus : official journal of the Japan Esophageal Society.
2020 10; 17(4):456-467. doi:
10.1007/s10388-020-00735-8. [PMID: 32240421] - Vipin Rai, Sushil Kumar Aggarwal, Sumit Singh Verma, Nikee Awasthee, Anupam Dhasmana, Sadhna Aggarwal, Satya N Das, Mangalam S Nair, Sanjay Yadav, Subash C Gupta. Epoxyazadiradione exhibit activities in head and neck squamous cell carcinoma by targeting multiple pathways.
Apoptosis : an international journal on programmed cell death.
2020 10; 25(9-10):763-782. doi:
10.1007/s10495-020-01633-1. [PMID: 32894380] - Eunsu Yoo, Jaehak Lee, Pattawika Lertpatipanpong, Junsun Ryu, Chong-Tai Kim, Eul-Yong Park, Seung Joon Baek. Anti-proliferative activity of A. Oxyphylla and its bioactive constituent nootkatone in colorectal cancer cells.
BMC cancer.
2020 Sep; 20(1):881. doi:
10.1186/s12885-020-07379-y. [PMID: 32928152] - Jing Jin, Yongdong Guo, Xiaoping Dong, Jianghui Liu, Yutong He. Methylation-associated silencing of miR-193b improves the radiotherapy sensitivity of esophageal cancer cells by targeting cyclin D1 in areas with zinc deficiency.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
2020 09; 150(?):104-113. doi:
10.1016/j.radonc.2020.06.022. [PMID: 32580002]