Saponin (BioDeep_00000177785)

   

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


10-[(3-{[4,5-dihydroxy-6-(hydroxymethyl)-3-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-2-yl)oxy]-2-hydroxy-4,5,9,9,13,20-hexamethyl-24-oxahexacyclo[15.5.2.0^{1,18}.0^{4,17}.0^{5,14}.0^{8,13}]tetracosane-20-carbaldehyde

化学式: C58H94O27 (1222.5982174)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C2CCC3(C(C2(CCC1OC4C(C(C(CO4)OC5C(C(C(CO5)O)O)O)OC6C(C(C(C(O6)CO)O)O)O)OC7C(C(C(C(O7)CO)O)O)OC8C(C(C(C(O8)CO)O)O)O)C)CCC91C3(CC(C2(C9CC(CC2)(C)C=O)CO1)O)C)C)C
InChI: InChI=1S/C58H94O27/c1-52(2)29-7-11-55(5)30(8-12-58-31-15-53(3,22-62)13-14-57(31,23-77-58)32(64)16-56(55,58)6)54(29,4)10-9-33(52)82-50-46(85-51-45(40(71)37(68)27(19-61)80-51)84-49-43(74)39(70)36(67)26(18-60)79-49)44(83-48-42(73)38(69)35(66)25(17-59)78-48)28(21-76-50)81-47-41(72)34(65)24(63)20-75-47/h22,24-51,59-61,63-74H,7-21,23H2,1-6H3



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yaxin Zhao, Nanshan Zhao, Larwubah Kollie, Dongfeng Yang, Xiaodan Zhang, Haihua Zhang, Zongsuo Liang. Sasanquasaponin from Camellia oleifera Abel Exerts an Anti-Inflammatory Effect in RAW 264.7 Cells via Inhibition of the NF-κB/MAPK Signaling Pathways. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042149. [PMID: 38396824]
  • Wenfeng Li, Yuanshen Mao, Bao Hua, Xin Gu, Chao Lu, Bin Xu, Weixin Pan. Sasanquasaponin inhibited epithelial to mesenchymal transition in prostate cancer by regulating the PI3K/Akt/mTOR and Smad pathways. Pharmaceutical biology. 2022 Dec; 60(1):1865-1875. doi: 10.1080/13880209.2022.2123931. [PMID: 36205544]
  • Jinxia Hou, Lanping Zhong, Jianming Liu, Fanglan Liu, Chunhua Xia. Interaction of the main active components in Shengmai formula mediated by organic anion transporter 1 (OAT1). Journal of ethnopharmacology. 2022 Oct; 296(?):115515. doi: 10.1016/j.jep.2022.115515. [PMID: 35777609]
  • Hanfei Sun, Manman Wang, Tiantian Su, Paipai Guo, Yu Tai, Huijuan Cheng, Zhenduo Zhu, Chunru Jiang, Shangxue Yan, Wei Wei, Lingling Zhang, Qingtong Wang. Ziyuglycoside I attenuates collagen-induced arthritis through inhibiting plasma cell expansion. Journal of ethnopharmacology. 2022 Aug; 294(?):115348. doi: 10.1016/j.jep.2022.115348. [PMID: 35533910]
  • Genbei Wang, Mengyao Yan, Ruijia Hao, Panpan Lv, Yu Wang, Shuli Man, Wenyuan Gao. Q-marker identification of Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz. in pulmonary metastasis of liver cancer mice. Journal of ethnopharmacology. 2022 Jul; 293(?):115311. doi: 10.1016/j.jep.2022.115311. [PMID: 35461989]
  • Haiqin Wang, Xiaojuan Xiao, Zhenzhen Li, Saiqun Luo, Lei Hu, Hui Yi, Ruohong Xiang, Yu Zhu, Yanpeng Wang, Lin Zhu, Ling Xiao, Chongwen Dai, Abdul Aziz, Lingli Yuan, Yajuan Cui, Ruijuan Li, Fanjie Gong, Xifeng Liu, Long Liang, Hongling Peng, Hui Zhou, Jing Liu. Polyphyllin VII, a novel moesin inhibitor, suppresses cell growth and overcomes bortezomib resistance in multiple myeloma. Cancer letters. 2022 07; 537(?):215647. doi: 10.1016/j.canlet.2022.215647. [PMID: 35306105]
  • Sinan Chen, Xinyan Liu, Haoan Zhao, Ni Cheng, Jing Sun, Wei Cao. Beneficial effects of Gynostemma pentaphyllum honey paste on obesity via counteracting oxidative stress and inflammation: An exploration of functional food developed from two independent foods rich in saponins and phenolics. Food research international (Ottawa, Ont.). 2022 Jul; 157(?):111483. doi: 10.1016/j.foodres.2022.111483. [PMID: 35761708]
  • Man-Man Zhang, Guo-Ming Huo, Jie Cheng, Qiu-Ping Zhang, Na-Zhi Li, Min-Xia Guo, Qing Liu, Guang-Hui Xu, Ji-Xiao Zhu, Cheng-Fu Li, Feng Zhou, Li-Tao Yi. Gypenoside XVII, an Active Ingredient from Gynostemma Pentaphyllum, Inhibits C3aR-Associated Synaptic Pruning in Stressed Mice. Nutrients. 2022 Jun; 14(12):. doi: 10.3390/nu14122418. [PMID: 35745148]
  • Wei Ning, Xiaogang Liao, Xingyou Dong, Yangcai Wang, Xingliang Yang, Jie Xu, Shanhong Yi, Zhenxing Yang. Protective effect of astragaloside IV on cadmium-induced spermatogenesis microenvironment damage in rats. Systems biology in reproductive medicine. 2022 Jun; 68(3):203-212. doi: 10.1080/19396368.2021.1983888. [PMID: 34711125]
  • Arafa I Hamed, Ridha Ben Said, Mohamed Ali Ben Aissa, Ibrahim Bayoumi Abdel-Farid, Bogdan Kontek, Mariusz Kowalczyk, Wieslaw Oleszek, Anna Stochmal, Ivona Kowalska, Beata Olas. Comprehensive polyoxypregnane glycosides report in Caralluma quadrangula using UPLC-ESI-Q-TOF and their antioxidant effects in human plasma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):112954. doi: 10.1016/j.biopha.2022.112954. [PMID: 35447547]
  • Akifumi Nagatomo, Naoki Inoue, Takuya Konno, Yin Xu, Chinatsu Sakamoto, Mayuko Sone, Aya Shibasaka, Osamu Muraoka, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yoshiaki Manse, Toshio Morikawa. Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil. Journal of natural medicines. 2022 Jun; 76(3):654-669. doi: 10.1007/s11418-022-01614-5. [PMID: 35292883]
  • Jiafen Qian, Wenjun Chen, Jianmei Wu, Meina Lv, Shaojun Jiang, Zhiwei Zeng, Zongwei Fang, Mingrong Chen, Jinhua Zhang. Effects and Mechanism of Action of Panax notoginseng Saponins on the Pharmacokinetics of Warfarin. European journal of drug metabolism and pharmacokinetics. 2022 May; 47(3):331-342. doi: 10.1007/s13318-022-00753-0. [PMID: 35138605]
  • S P Piragauta, J L Higuita-Castro, N Arbeláez, A M Restrepo, R Archbold, W Quiñones, F Torres, F Echeverri, G Escobar, I D Vélez, A Montoya, S M Robledo. Utility of the combination of hederagenin glucoside saponins and chromane hydrazone in the topical treatment of canine cutaneous leishmaniasis. An observational study. Parasitology research. 2022 May; 121(5):1419-1428. doi: 10.1007/s00436-022-07467-x. [PMID: 35179617]
  • Ruoyu Zhang, Qingfeng Zhai, Yuan Yu, Xuening Li, Fengxiang Zhang, Zhaohua Hou, Yuqing Cao, Jing Feng, Peng Xue. Safety assessment of crude saponins from Chenopodium quinoa willd. husks: 90-day oral toxicity and gut microbiota & metabonomics study in rats. Food chemistry. 2022 May; 375(?):131655. doi: 10.1016/j.foodchem.2021.131655. [PMID: 34903398]
  • Yuyan Fan, Hongyu Fan, Ping Li, Qingshan Liu, Lixia Huang, Yilun Zhou. Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis. Bioengineered. 2022 05; 13(5):11517-11529. doi: 10.1080/21655979.2022.2068822. [PMID: 35510516]
  • Fang-Wei Zhong, Geng-Xi Li, Li Zeng. [Gynostemma pentaphyllum saponins alleviate non-alcoholic fatty liver disease in rats by regulating intestinal flora and short-chain fatty acid metabolism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 May; 47(9):2500-2508. doi: 10.19540/j.cnki.cjcmm.20211208.401. [PMID: 35531697]
  • Q Zou, X Wu, J Wang, D Xia, M Deng, Y Ding, Y Dai, S Zhao, T Chen. [Therapeutic effect of Panax notoginseng saponins combined with cyclophosphamide in mice bearing hepatocellular carcinoma H22 cell xenograft]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2022 Apr; 42(4):538-545. doi: 10.12122/j.issn.1673-4254.2022.04.09. [PMID: 35527489]
  • Peng Li, Mingkun Gao, Jiahuan Fu, Shaojia Yan, Yongfa Liu, Tahir Mahmood, Zengpeng Lv, Yuming Guo. Dietary soya saponin improves the lipid metabolism and intestinal health of laying hens. Poultry science. 2022 Apr; 101(4):101663. doi: 10.1016/j.psj.2021.101663. [PMID: 35172236]
  • Keisuke Hagihara, Kazuto Nunomura, Bangzhong Lin, Megumi Fumimoto, Junko Watanabe, Yasuharu Mizuhara. Gosha-jinki-Gan (GJG) shows anti-aging effects through suppression of TNF-α production by Chikusetsusaponin V. Gene. 2022 Mar; 815(?):146178. doi: 10.1016/j.gene.2021.146178. [PMID: 34995733]
  • Yousra Abdel-Mottaleb, Howaida S Ali, Mohamed K El-Kherbetawy, Amany Y Elkazzaz, Mohamed H ElSayed, Amr Elshormilisy, Amira H Eltrawy, Sally Y Abed, Asma M Alshahrani, Abdullah A Hashish, Eman Saad Alamri, Sawsan A Zaitone. Saponin-rich extract of Tribulus terrestris alleviates systemic inflammation and insulin resistance in dietary obese female rats: Impact on adipokine/hormonal disturbances. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Mar; 147(?):112639. doi: 10.1016/j.biopha.2022.112639. [PMID: 35051859]
  • Célia Cristina Malaguti Figueiredo, Amanda da Costa Gomes, Filipe Oliveira Granero, João Luiz Bronzel Junior, Luciana Pereira Silva, Valdecir Farias Ximenes, Regildo Márcio Gonçalves da Silva. Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release. Journal of integrative medicine. 2022 03; 20(2):153-162. doi: 10.1016/j.joim.2021.12.003. [PMID: 34996732]
  • Hongjiao Geng, Lidan Zhang, Cui Xin, Cheng Zhang, Yanming Xie. Xuesaitong oral preparation as adjuvant therapy for treating acute cerebral infarction: A systematic review and meta-analysis of randomized controlled trials. Journal of ethnopharmacology. 2022 Mar; 285(?):114849. doi: 10.1016/j.jep.2021.114849. [PMID: 34800648]
  • Shuyao Wang, Xin Yu, Siyang Wu, Wei Yang, Yang Gao, Weihua Wang, Qiutao Wang, Mengmeng Wei, Mingying Zhu, Jiarui Wu, Zheng Yuan, Yingfei Li. Simultaneous determination of periplocin, periplocymarin, periplogenin, periplocoside M and periplocoside N of Cortex Periplocae in rat plasma and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2022 Mar; 36(3):e5283. doi: 10.1002/bmc.5283. [PMID: 34816469]
  • Junda Chen, Yu Zhang, Xiao Guan, Hongwei Cao, Lin Li, Jie Yu, Hanlin Liu. Characterization of Saponins from Differently Colored Quinoa Cultivars and Their In Vitro Gastrointestinal Digestion and Fermentation Properties. Journal of agricultural and food chemistry. 2022 Feb; 70(6):1810-1818. doi: 10.1021/acs.jafc.1c06200. [PMID: 35119265]
  • Chenyang Zhang, Bin Zhang, Xuelian Zhang, Min Wang, Xiaobo Sun, Guibo Sun. Panax notoginseng Saponin Protects Against Diabetic Cardiomyopathy Through Lipid Metabolism Modulation. Journal of the American Heart Association. 2022 02; 11(4):e023540. doi: 10.1161/jaha.121.023540. [PMID: 35112884]
  • Xiao-Chen Sun, Xiao Song, Fei Guo, Yao-Hui Yuan, Shu-Yue Wang, Shuai Wang, Kun-Lin Liu, Xi-Yu Lv, Bing Han, Chao Zhang, Jiang-Ting Liu. Terrestrosin D, a spirostanol saponin from Tribulus terrestris L. with potential hepatorenal toxicity. Journal of ethnopharmacology. 2022 Jan; 283(?):114716. doi: 10.1016/j.jep.2021.114716. [PMID: 34626781]
  • Hailun Jiang, Fang Xu, Li Zeng, Chenyang Li, Yan Chen, Linlin Wang, Zhuorong Li, Rui Liu. Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-κB and Ang/Tie-2 pathways. Journal of ethnopharmacology. 2022 Jan; 283(?):114714. doi: 10.1016/j.jep.2021.114714. [PMID: 34624452]
  • Shuang Yuan, Yuanyuan Xu, Tao Yi, Hongjing Wang. The anti-tumor effect of OP-B on ovarian cancer in vitro and in vivo, and its mechanism: An investigation using network pharmacology-based analysis. Journal of ethnopharmacology. 2022 Jan; 283(?):114706. doi: 10.1016/j.jep.2021.114706. [PMID: 34614446]
  • Dnyanesh Ranade, Rajender Jena, Shubham Sancheti, Vicky Deore, Vikas Dogar, Sunil Gairola. Rapid, high throughput protein estimation method for saponin and alhydrogel adjuvanted R21 VLP Malaria vaccine based on intrinsic fluorescence. Vaccine. 2022 01; 40(4):601-611. doi: 10.1016/j.vaccine.2021.12.019. [PMID: 34933766]
  • Xin-Nan Wang, Wen-Rui Xia, Jian-Qun Liu, Fang-Yuan Sun, Zhu-Jun Zhong, Li-Fang Liu, Gui-Zhong Xin. Targeting tryptophan metabolism reveals Clematichinenoside AR alleviates triptolide-induced hepatotoxicity. Journal of pharmaceutical and biomedical analysis. 2022 Jan; 208(?):114461. doi: 10.1016/j.jpba.2021.114461. [PMID: 34775190]
  • Meng Yang, Jieying Ding, Qingqiong Luo, Xu Chen, Fuxiang Chen. Improving the diagnostic efficacy of squamous cell carcinoma antigen for oral squamous cell carcinoma via saponin disruption of serum extracellular vesicles. Clinica chimica acta; international journal of clinical chemistry. 2022 Jan; 525(?):40-45. doi: 10.1016/j.cca.2021.12.012. [PMID: 34921893]
  • Zhongbo Shi, Junhao Jiang, Dezhang Zhao, Baogang Xie, Yan Li, Chao Yu. Effects of Astragaloside IV on the Pharmacokinetics of Metoprolol in Rats and its Mechanism. Current drug metabolism. 2022; 23(2):131-136. doi: 10.2174/1389200223666220128143133. [PMID: 35088663]
  • He Yang, Zuodong Liu, Xiangka Hu, Xiaojuan Liu, Liuming Gui, Zengxiaorui Cai, Chunmei Dai. Protective Effect of Panax Notoginseng Saponins on Apolipoprotein-E-deficient Atherosclerosis-prone Mice. Current pharmaceutical design. 2022; 28(8):671-677. doi: 10.2174/1381612828666220128104636. [PMID: 35088656]
  • Ziyu Li, Wei Yang, Yong Yang, Jianbo Wu, Pei Luo, Yong Liu. The Astragaloside IV Derivative LS-102 Ameliorates Obesity-Related Nephropathy. Drug design, development and therapy. 2022; 16(?):647-664. doi: 10.2147/dddt.s346546. [PMID: 35308255]
  • Yujie Zhong, Ruilin Luo, Qi Liu, Jiachang Zhu, Min Lei, Xiaofei Liang, Xin Wang, Xiaoli Peng. Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022 Jan; 159(?):112697. doi: 10.1016/j.fct.2021.112697. [PMID: 34826549]
  • Yonghui Hu, Wangna Tang, Wenjie Liu, Zhibo Hu, Congqing Pan. Astragaloside IV Alleviates Renal Tubular Epithelial-Mesenchymal Transition via CX3CL1-RAF/MEK/ERK Signaling Pathway in Diabetic Kidney Disease. Drug design, development and therapy. 2022; 16(?):1605-1620. doi: 10.2147/dddt.s360346. [PMID: 35669284]
  • He-Wei Qin, Qin-Sheng Zhang, Yan-Jie Li, Wen-Tao Li, Yuan Wang. [Molecular mechanism of astragaloside Ⅳ against atherosclerosis by regulating miR-17-5p and PCSK9/VLDLR signal pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Jan; 47(2):492-498. doi: 10.19540/j.cnki.cjcmm.20210918.701. [PMID: 35178994]
  • Zhidong Hu, Jian-Ping Chen, Jin-Chuan Xu, Zhen-Yan Chen, Rong Qu, Ling Zhang, Wenrong Yao, Juan Wu, Heng Yang, Douglas B Lowrie, Yong Liu, Xiao-Yong Fan. A two-dose optimum for recombinant S1 protein-based COVID-19 vaccination. Virology. 2022 01; 566(?):56-59. doi: 10.1016/j.virol.2021.11.011. [PMID: 34864488]
  • Xu-Qin Du, Li-Peng Shi, Zhi-Wei Chen, Jin-Yuan Hu, Biao Zuo, Yu Xiong, Wen-Fu Cao. Astragaloside IV Ameliorates Isoprenaline-Induced Cardiac Fibrosis in Mice via Modulating Gut Microbiota and Fecal Metabolites. Frontiers in cellular and infection microbiology. 2022; 12(?):836150. doi: 10.3389/fcimb.2022.836150. [PMID: 35656031]
  • Sheng-Yan Xu, Xiang-Dang Hu, Zong-Liang Yang, An Liu, Yong-Heng He, Hai-Yan Lu. [Effects of astragaloside Ⅳ on inflammatory response and percentage of peripheral blood Th17 cells in mice with ulcerative colitis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Jan; 47(2):469-475. doi: 10.19540/j.cnki.cjcmm.20210827.401. [PMID: 35178991]
  • Zhi-Yong Jiang, Fang-Quan Yu, Rui-Lan Gao, Yue-Min Kuang, Yan Zhu, Yue-Hua Chen, Lin-Jie Li, Gui-Fang Ouyang, Jing Hu, Xiao-Long Wu. Treatment of Chronic Aplastic Anemia with Chinese Patent Medicine Pai-Neng-Da Capsule () for Replacing Androgen Partially: A Clinical Multi-Center Study. Chinese journal of integrative medicine. 2022 Jan; 28(1):20-27. doi: 10.1007/s11655-021-3283-z. [PMID: 33837482]
  • Xiang Guo, Jinyu Ji, Jingkai Zhang, Xiaoqiang Hou, Xianyun Fu, Yanan Luo, Zhigang Mei, Zhitao Feng. Anti-inflammatory and osteoprotective effects of Chikusetsusaponin Ⅳa on rheumatoid arthritis via the JAK/STAT signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Dec; 93(?):153801. doi: 10.1016/j.phymed.2021.153801. [PMID: 34758437]
  • Cuiyun Huang, Shi Qiu, Xiangcheng Fan, Guangyang Jiao, Xun Zhou, Mei Sun, Nan Weng, Shouhong Gao, Xia Tao, Feng Zhang, Wansheng Chen. Evaluation of the effect of Shengxian Decoction on doxorubicin-induced chronic heart failure model rats and a multicomponent comparative pharmacokinetic study after oral administration in normal and model rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Dec; 144(?):112354. doi: 10.1016/j.biopha.2021.112354. [PMID: 34794233]
  • Qin Gong, Mulan Wang, Ya Jiang, Chengliang Zha, Dong Yu, Fan Lei, Yingying Luo, Yulin Feng, Shilin Yang, Jun Li, Lijun Du. The abrupt pathological deterioration of cisplatin-induced acute kidney injury: Emerging of a critical time point. Pharmacology research & perspectives. 2021 12; 9(6):e00895. doi: 10.1002/prp2.895. [PMID: 34817124]
  • Qixia Liu, Xiaohui Chen, Min Kan, Jing Yang, Qian Gong, Rui Jin, Yulong Dai, Juan Jin, Hongmei Zang. Gypenoside XLIX loaded nanoparticles targeting therapy for renal fibrosis and its mechanism. European journal of pharmacology. 2021 Nov; 910(?):174501. doi: 10.1016/j.ejphar.2021.174501. [PMID: 34529980]
  • Xin Huang, Min-Zhou Zhang, Bo Liu, Shi-Yu Ma, Xin Yin, Li-Heng Guo. Astragaloside IV Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction in Rats via IKK/NF-κB Pathway. Chinese journal of integrative medicine. 2021 Nov; 27(11):825-831. doi: 10.1007/s11655-021-2869-9. [PMID: 34432200]
  • Yun-Fang Hao, Ting Luo, Zhong-Yu Lu, Chun-Yan Shen, Jian-Guo Jiang. Targets and underlying mechanisms related to the sedative and hypnotic activities of saponins from Rhodiola rosea L. (crassulaceae). Food & function. 2021 Nov; 12(21):10589-10601. doi: 10.1039/d1fo01178b. [PMID: 34585202]
  • Meina Gao, Hui Li, Chenghao Ye, Kaixian Chen, Hualiang Jiang, Kunqian Yu. Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study. Biomolecules. 2021 10; 11(11):. doi: 10.3390/biom11111586. [PMID: 34827585]
  • Geng-Ruei Chang, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Yu-Wen Lu. The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111383. [PMID: 34768813]
  • Fen Liu, Meng Feng, Julin Xing, Xinxin Zhou. Timosaponin alleviates oxidative stress in rats with high fat diet-induced obesity via activating Nrf2/HO-1 and inhibiting the NF-κB pathway. European journal of pharmacology. 2021 Oct; 909(?):174377. doi: 10.1016/j.ejphar.2021.174377. [PMID: 34302815]
  • Qun Yu, Liuping Fan. Improving the bioactive ingredients and functions of asparagus from efficient to emerging processing technologies: A review. Food chemistry. 2021 Oct; 358(?):129903. doi: 10.1016/j.foodchem.2021.129903. [PMID: 33933971]
  • Xiao Song, Yaohui Yuan, Shuyue Wang, Xiaochen Sun, Chao Zhang, Peng Gao, Lei Shi. Pharmacokinetic comparisons of six steroid saponins in rat plasma following oral administration of crude and stir-fried Fructus Tribuli extracts by UHPLC-MS/MS. Biomedical chromatography : BMC. 2021 Oct; 35(10):e5151. doi: 10.1002/bmc.5151. [PMID: 33939847]
  • Qingqing Li, Yansong Zhang, Yufang Yang, Songqing Huang, Xiaoqin Zou, Congying Wei, Taolin Liang, Xiaobin Zhong. Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):111965. doi: 10.1016/j.biopha.2021.111965. [PMID: 34385105]
  • Tao Yao, Lei Zhang, Ye Fu, Lina Yao, Chengjie Zhou, Guozhong Chen. Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition. Molecular and cellular biology. 2021 09; 41(10):e0033221. doi: 10.1128/mcb.00332-21. [PMID: 34309413]
  • Matthew J Gorman, Nita Patel, Mimi Guebre-Xabier, Alex L Zhu, Caroline Atyeo, Krista M Pullen, Carolin Loos, Yenny Goez-Gazi, Ricardo Carrion, Jing-Hui Tian, Dansu Yuan, Kathryn A Bowman, Bin Zhou, Sonia Maciejewski, Marisa E McGrath, James Logue, Matthew B Frieman, David Montefiori, Colin Mann, Sharon Schendel, Fatima Amanat, Florian Krammer, Erica Ollmann Saphire, Douglas A Lauffenburger, Ann M Greene, Alyse D Portnoff, Michael J Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Galit Alter. Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination. Cell reports. Medicine. 2021 09; 2(9):100405. doi: 10.1016/j.xcrm.2021.100405. [PMID: 34485950]
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