Cyanoimipramine (BioDeep_00000177779)

   

human metabolite blood metabolite


代谢物信息卡片


2-[3-(dimethylamino)propyl]-2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaene-9-carbonitrile

化学式: C20H23N3 (305.1891878)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)CCCN1C2=CC=CC=C2CC(C#N)C2=CC=CC=C12
InChI: InChI=1S/C20H23N3/c1-22(2)12-7-13-23-19-10-5-3-8-16(19)14-17(15-21)18-9-4-6-11-20(18)23/h3-6,8-11,17H,7,12-14H2,1-2H3



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Arianna D Pranger, Jan-Willem C Alffenaar, A Mireille A Wessels, Ben Greijdanus, Donald R A Uges. Determination of moxifloxacin in human plasma, plasma ultrafiltrate, and cerebrospinal fluid by a rapid and simple liquid chromatography- tandem mass spectrometry method. Journal of analytical toxicology. 2010 Apr; 34(3):135-41. doi: 10.1093/jat/34.3.135. [PMID: 20406537]
  • B M Way, G Laćan, L A Fairbanks, W P Melega. Architectonic distribution of the serotonin transporter within the orbitofrontal cortex of the vervet monkey. Neuroscience. 2007 Sep; 148(4):937-48. doi: 10.1016/j.neuroscience.2007.06.038. [PMID: 17766046]
  • L C Daws, J L Munn, M F Valdez, T Frosto-Burke, J G Hensler. Serotonin transporter function, but not expression, is dependent on brain-derived neurotrophic factor (BDNF): in vivo studies in BDNF-deficient mice. Journal of neurochemistry. 2007 May; 101(3):641-51. doi: 10.1111/j.1471-4159.2006.04392.x. [PMID: 17254018]
  • Akihiro Takano, Tetsuya Suhara, Yasuhiko Sudo, Makoto Inoue, Kenji Hashimoto, Ming-Rong Zhang, Tetsuya Ichimiya, Fumihiko Yasuno, Kazutoshi Suzuki. Comparative evaluation of two serotonin transporter ligands in the human brain: [(11)C](+)McN5652 and [(11)C]cyanoimipramine. European journal of nuclear medicine and molecular imaging. 2002 Oct; 29(10):1289-97. doi: 10.1007/s00259-002-0884-4. [PMID: 12271409]
  • Clive Ballard, Mary Johnson, Margaret Piggott, Robert Perry, John O'Brien, Elise Rowan, Elaine Perry, Peter Lantos, Nigel Cairns, Clive Holmes. A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies. Journal of affective disorders. 2002 May; 69(1-3):219-23. doi: 10.1016/s0165-0327(00)00375-x. [PMID: 12103469]
  • V Arango, M D Underwood, M Boldrini, H Tamir, S A Kassir, S Hsiung, J J Chen, J J Mann. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2001 Dec; 25(6):892-903. doi: 10.1016/s0893-133x(01)00310-4. [PMID: 11750182]
  • H Zafar, S G Shelat, E Redei, S Tejani-Butt. Fetal alcohol exposure alters serotonin transporter sites in rat brain. Brain research. 2000 Feb; 856(1-2):184-92. doi: 10.1016/s0006-8993(99)02350-1. [PMID: 10677625]
  • J M Launay, S Loric, V Mutel, O Kellermann. The 5-HT2B receptor controls the overall 5-HT transport system in the 1C11 serotonergic cell line. Annals of the New York Academy of Sciences. 1998 Dec; 861(?):247. doi: 10.1111/j.1749-6632.1998.tb10204.x. [PMID: 9928270]
  • J C Béïque, N Lavoie, C de Montigny, G Debonnel. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. European journal of pharmacology. 1998 May; 349(1):129-32. doi: 10.1016/s0014-2999(98)00241-6. [PMID: 9669506]
  • T Belej, D Manji, S Sioutis, H M Barros, J N Nobrega. Changes in serotonin and norepinephrine uptake sites after chronic cocaine: pre- vs. post-withdrawal effects. Brain research. 1996 Oct; 736(1-2):287-96. doi: 10.1016/0006-8993(96)00713-5. [PMID: 8930335]
  • E V Gurevich, J N Joyce. Comparison of [3H]paroxetine and [3H]cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 1996 May; 14(5):309-23. doi: 10.1016/0893-133x(95)00139-5. [PMID: 8703300]
  • L Descarries, J P Soucy, F Lafaille, A Mrini, R Tanguay. Evaluation of three transporter ligands as quantitative markers of serotonin innervation density in rat brain. Synapse (New York, N.Y.). 1995 Oct; 21(2):131-9. doi: 10.1002/syn.890210206. [PMID: 8584974]
  • G Piñeyro, L Deveault, P Blier, T Dennis, C de Montigny. Effect of acute and prolonged tianeptine administration on the 5-HT transporter: electrophysiological, biochemical and radioligand binding studies in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. 1995 Feb; 351(2):111-8. doi: 10.1007/bf00169324. [PMID: 7770093]
  • J G Hensler, R C Ferry, D M Labow, G B Kovachich, A Frazer. Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus. Synapse (New York, N.Y.). 1994 May; 17(1):1-15. doi: 10.1002/syn.890170102. [PMID: 8042142]
  • E M DeMet, A Chicz-DeMet, K M Bell, C Reist, R H Gerner. Effects of chronic imipramine treatment on subclasses of platelet 3H-imipramine binding sites and plasma cortisol. Psychiatry research. 1990 Dec; 34(3):303-13. doi: 10.1016/0165-1781(90)90008-s. [PMID: 1963693]
  • H Hojabri, J D Glennon. Determination of cianopramine in human plasma by high-performance liquid chromatography and gas-liquid chromatography with ultraviolet, fluorescence and electron-capture detection. Journal of chromatography. 1985 Jul; 342(1):97-103. doi: 10.1016/s0378-4347(00)84492-8. [PMID: 4044760]
  • A Davis. Reconstitution of [3H]3-cyanoimipramine ([3H]Ro 11-2465) sites solubilised from human platelets. European journal of pharmacology. 1984 Oct; 106(1):159-65. doi: 10.1016/0014-2999(84)90690-3. [PMID: 6529963]
  • M Kenny, T J Lenehan, R Lambe, A Darragh, I Brick, L M Omer. Effects of a single oral dose of 3-cyano-imipramine on serotonin uptake and content of platelets in healthy volunteers. Psychopharmacology. 1983; 79(4):304-7. doi: 10.1007/bf00433406. [PMID: 6407042]
  • T J Lenehan, M Kenny, L M Omer, R Lambe, I Brick, A Darragh. Platelet uptake of serotonin following repeated administration of 3-cyano-imipramine to healthy volunteers. Psychopharmacology. 1983; 81(4):357-8. doi: 10.1007/bf00427578. [PMID: 6419264]
  • P Haefelfinger. Sensitive assay for the tricyclic antidepressant Ro 11-2465 in biological fluids by high-performance liquid chromatography and fluorescence detection. Journal of chromatography. 1982 Dec; 233(?):269-78. doi: 10.1016/s0378-4347(00)81753-3. [PMID: 7161338]