Cutamesine (BioDeep_00000177767)

   

human metabolite blood metabolite


代谢物信息卡片


1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride

化学式: C23H32N2O2 (368.24636519999996)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 16.45%

分子结构信息

SMILES: COC1=C(C=C(C=C1)CCN2CCN(CC2)CCCC3=CC=CC=C3)OC
InChI: InChI=1S/C23H32N2O2/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3

描述信息

C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents

同义名列表

3 个代谢物同义名

1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride; 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine; Cutamesine



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Gopinadh Bhyrapuneni, Jagadeesh Babu Thentu, Abdul Rasheed Mohammed, Raghupathi Reddy Aleti, Nagasurya Prakash Padala, Devender Reddy Ajjala, Ramakrishna Nirogi. Assessment of sigma-1 receptor occupancy in mice with non-radiolabelled FTC-146 as a tracer. Journal of receptor and signal transduction research. 2018 Aug; 38(4):290-298. doi: 10.1080/10799893.2018.1478855. [PMID: 29912606]
  • Christina M Maher, Jeffrey D Thomas, Derick A Haas, Charles G Longen, Halley M Oyer, Jane Y Tong, Felix J Kim. Small-Molecule Sigma1 Modulator Induces Autophagic Degradation of PD-L1. Molecular cancer research : MCR. 2018 02; 16(2):243-255. doi: 10.1158/1541-7786.mcr-17-0166. [PMID: 29117944]
  • Nisha K Ramakrishnan, Anniek K D Visser, Anna A Rybczynska, Csaba J Nyakas, Paul G M Luiten, Chantal Kwizera, Jurgen W A Sijbesma, Philip H Elsinga, Kiichi Ishiwata, Rudi A J O Dierckx, Aren van Waarde. Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [(11)C]SA4503. Molecular imaging and biology. 2016 08; 18(4):588-97. doi: 10.1007/s11307-015-0917-6. [PMID: 26637208]
  • Yasuharu Shinoda, Hideaki Tagashira, Md Shenuarin Bhuiyan, Hideyuki Hasegawa, Hiroshi Kanai, Chen Zhang, Feng Han, Kohji Fukunaga. Corticosteroids Mediate Heart Failure-Induced Depression through Reduced σ1-Receptor Expression. PloS one. 2016; 11(10):e0163992. doi: 10.1371/journal.pone.0163992. [PMID: 27741227]
  • Kristoffer Sahlholm, Jurgen W A Sijbesma, Bram Maas, Chantal Kwizera, Daniel Marcellino, Nisha K Ramakrishnan, Rudi A J O Dierckx, Philip H Elsinga, Aren van Waarde. Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses. Psychopharmacology. 2015 Sep; 232(18):3443-53. doi: 10.1007/s00213-015-3997-8. [PMID: 26159455]
  • Nisha K Ramakrishnan, Anniek K D Visser, Marianne Schepers, Gert Luurtsema, Csaba J Nyakas, Philip H Elsinga, Kiichi Ishiwata, Rudi A J O Dierckx, Aren van Waarde. Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with (11)C-SA4503 and microPET. Psychopharmacology. 2014 Oct; 231(20):3997-4006. doi: 10.1007/s00213-014-3533-2. [PMID: 24639047]
  • Yoko Ono, Hirotaka Tanaka, Masafumi Takata, Yuki Nagahara, Yasuhiro Noda, Kazuhiro Tsuruma, Masamitsu Shimazawa, Isao Hozumi, Hideaki Hara. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neuroscience letters. 2014 Jan; 559(?):174-8. doi: 10.1016/j.neulet.2013.12.005. [PMID: 24334165]
  • Nisha K Ramakrishnan, Anna A Rybczynska, Anniek K D Visser, Krisztina Marosi, Csaba J Nyakas, Chantal Kwizera, Jurgen W A Sijbesma, Philip H Elsinga, Kiichi Ishiwata, Jan Pruim, Rudi A J O Dierckx, Aren van Waarde. Small-animal PET with a σ-ligand, 11C-SA4503, detects spontaneous pituitary tumors in aged rats. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013 Aug; 54(8):1377-83. doi: 10.2967/jnumed.112.115931. [PMID: 23785170]
  • E J Cobos, J M Entrena, F R Nieto, C M Cendán, E Del Pozo. Pharmacology and therapeutic potential of sigma(1) receptor ligands. Current neuropharmacology. 2008 Dec; 6(4):344-66. doi: 10.2174/157015908787386113. [PMID: 19587856]
  • Tomoko Nishimura, Tamaki Ishima, Masaomi Iyo, Kenji Hashimoto. Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways. PloS one. 2008 Jul; 3(7):e2558. doi: 10.1371/journal.pone.0002558. [PMID: 18596927]
  • Kiichi Ishiwata, Kenji Ishii, Yuichi Kimura, Kazunori Kawamura, Keiichi Oda, Toru Sasaki, Muneyuki Sakata, Michio Senda. Successive positron emission tomography measurement of cerebral blood flow and neuroreceptors in the human brain: an 11C-SA4503 study. Annals of nuclear medicine. 2008 Jun; 22(5):411-6. doi: 10.1007/s12149-008-0133-4. [PMID: 18600419]
  • Masahiro Mishina, Masashi Ohyama, Kenji Ishii, Shin Kitamura, Yuichi Kimura, Kei-ichi Oda, Kazunori Kawamura, Toru Sasaki, Shiro Kobayashi, Yasuo Katayama, Kiichi Ishiwata. Low density of sigma1 receptors in early Alzheimer's disease. Annals of nuclear medicine. 2008 Apr; 22(3):151-6. doi: 10.1007/s12149-007-0094-z. [PMID: 18498028]
  • Muneyuki Sakata, Yuichi Kimura, Mika Naganawa, Keiichi Oda, Kenji Ishii, Kunihiro Chihara, Kiichi Ishiwata. Mapping of human cerebral sigma1 receptors using positron emission tomography and [11C]SA4503. NeuroImage. 2007 Mar; 35(1):1-8. doi: 10.1016/j.neuroimage.2006.11.055. [PMID: 17240168]
  • Masahiko Hirata, Tetsuya Mori, Seigo Soga, Takuya Umeda, Yoshiro Ohmomo. In vivo evaluation of radioiodinated 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-piperazine derivatives as new ligands for sigma receptor imaging using single photon emission computed tomography. Biological & pharmaceutical bulletin. 2006 Oct; 29(10):2009-15. doi: 10.1248/bpb.29.2009. [PMID: 17015942]
  • M Mishina, K Ishiwata, K Ishii, S Kitamura, Y Kimura, K Kawamura, K Oda, T Sasaki, O Sakayori, M Hamamoto, S Kobayashi, Y Katayama. Function of sigma1 receptors in Parkinson's disease. Acta neurologica Scandinavica. 2005 Aug; 112(2):103-7. doi: 10.1111/j.1600-0404.2005.00432.x. [PMID: 16008536]
  • Aren van Waarde, Anne Rixt Buursma, Geke A P Hospers, Kazunori Kawamura, Tadayuki Kobayashi, Kenji Ishii, Keiichi Oda, Kiichi Ishiwata, Willem Vaalburg, Philip H Elsinga. Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2004 Nov; 45(11):1939-45. doi: NULL. [PMID: 15534066]
  • G Skuza, K Wedzony. Behavioral pharmacology of sigma-ligands. Pharmacopsychiatry. 2004 Nov; 37 Suppl 3(?):S183-8. doi: 10.1055/s-2004-832676. [PMID: 15547784]
  • Kazunori Kawamura, Yuichi Kimura, Hideo Tsukada, Tadayuki Kobayashi, Shingo Nishiyama, Takeharu Kakiuchi, Hiroyuki Ohba, Norihiro Harada, Kiyoshi Matsuno, Kenji Ishii, Kiichi Ishiwata. An increase of sigma receptors in the aged monkey brain. Neurobiology of aging. 2003 Sep; 24(5):745-52. doi: 10.1016/s0197-4580(02)00152-5. [PMID: 12885582]
  • P H Elsinga, K Kawamura, T Kobayashi, H Tsukada, M Senda, W Vaalburg, K Ishiwata. Synthesis and evaluation of [18F]fluoroethyl SA4503 as a PET ligand for the sigma receptor. Synapse (New York, N.Y.). 2002 Mar; 43(4):259-67. doi: 10.1002/syn.10045. [PMID: 11835521]
  • K Ishiwata, T Kobayashi, K Kawamura, K Matsuno, M Senda. [11C]Raclopride binding was reduced in vivo by sigma(1) receptor ligand SA4503 in the mouse brain, while [11C]SA4503 binding was not by raclopride. Nuclear medicine and biology. 2001 Oct; 28(7):787-92. doi: 10.1016/s0969-8051(01)00238-4. [PMID: 11578899]
  • K Kawamura, K Ishiwata, Y Shimada, Y Kimura, T Kobayashi, K Matsuno, Y Homma, M Senda. Preclinical evaluation of [11C]SA4503: radiation dosimetry, in vivo selectivity and PET imaging of sigma1 receptors in the cat brain. Annals of nuclear medicine. 2000 Aug; 14(4):285-92. doi: 10.1007/bf02988211. [PMID: 11023029]
  • K Kawamura, K Ishiwata, H Tajima, S Ishii, K Matsuno, Y Homma, M Senda. In vivo evaluation of [(11)C]SA4503 as a PET ligand for mapping CNS sigma(1) receptors. Nuclear medicine and biology. 2000 Apr; 27(3):255-61. doi: 10.1016/s0969-8051(00)00081-0. [PMID: 10832082]