3-methyladipate (BioDeep_00000017771)

 

Secondary id: BioDeep_00000405303

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(3S)-3-methylhexanedioic acid

化学式: C7H12O4 (160.0735552)
中文名称: (R)-3-甲基己二酸, 3-甲基己二酸
谱图信息: 最多检出来源 Homo sapiens(feces) 61.43%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

3-methyladipate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/3-methyladipate (retrieved 2024-11-22) (BioDeep RN: BioDeep_00000017771). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CC(CCC(=O)O)CC(=O)O
InChI: InChI=1S/C7H12O4/c1-5(4-7(10)11)2-3-6(8)9/h5H,2-4H2,1H3,(H,8,9)(H,10,11)

描述信息

3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. Patients with adult Refsums disease (ARD) are unable to detoxify phytanic acid by alpha-oxidation, and so the w-oxidation pathway is the only metabolic pathway available for phytanic acid degradation. This pathway produces 3-methyladipic acid as the final metabolite, which is excreted in the urine (Wanders et al. 2001). Activity of the w-oxidation pathway is approximately doubled in ARD patients compared with normal individuals (PMID: 11948235). [HMDB]
3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. Patients with adult Refsums disease (ARD) are unable to detoxify phytanic acid by alpha-oxidation, and so the w-oxidation pathway is the only metabolic pathway available for phytanic acid degradation. This pathway produces 3-methyladipic acid as the final metabolite, which is excreted in the urine (Wanders et al. 2001). Activity of the w-oxidation pathway is approximately doubled in ARD patients compared with normal individuals (PMID: 11948235).
3-Methyladipic acid is the final metabolite in the ω-oxidation pathway.

同义名列表

17 个代谢物同义名

(3S)-3-methylhexanedioic acid; (r)-3-methylhexanedioic acid; (+/-)-3-methyladipic acid; 3-methyl-hexanedioic acid; (3S)-3-Methylhexanedioate; 3-Methylhexanedioic acid; beta-Methyl-adipic acid; beta-Methyladipic acid; 3-Methyl-hexanedioate; b-Methyl-adipic acid; 3-Methylhexanedioate; 3-METHYLADIPIC ACID; b-Methyladipic acid; beta-Methyladipate; 3-Methyladipate; b-Methyladipate; 3-Methyladipic acid



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anthony S Wierzbicki, Phillip D Mayne, Matthew D Lloyd, David Burston, Guam Mei, Margaret C Sidey, Michael D Feher, F Brian Gibberd. Metabolism of phytanic acid and 3-methyl-adipic acid excretion in patients with adult Refsum disease. Journal of lipid research. 2003 Aug; 44(8):1481-8. doi: 10.1194/jlr.m300121-jlr200. [PMID: 12700346]
  • Alexandra Muth, Jochen Jung, Steffi Bilke, Annette Scharrer, Armin Mosandl, Adrian C Sewell, Hans Böhles. Simultaneous enantioselective analysis of chiral urinary metabolites in patients with Zellweger syndrome. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 792(2):269-77. doi: 10.1016/s1570-0232(03)00285-x. [PMID: 12860034]
  • S Krywawych, D P Brenton, M J Jackson, C Forte, D K Walker, A M Lawson. 3-Methyladipate excretion in animals fed a phytol supplement with reference to Refsum's disease. Journal of inherited metabolic disease. 1985; 8 Suppl 2(?):147-8. doi: 10.1007/bf01811502. [PMID: 2413274]
  • G Steen, L Ransnäs. Organic acids or urine in multiple sclerosis. Acta neurologica Scandinavica. 1983 Oct; 68(4):231-40. doi: 10.1111/j.1600-0404.1983.tb04831.x. [PMID: 6659864]
  • J Greter, S Lindstedt, G Steen. 2,6-Dimethyloctanedioic acid--a metabolite of phytanic acid in Refsum's disease. Clinical chemistry. 1983 Mar; 29(3):434-7. doi: 10.1093/clinchem/29.3.434. [PMID: 6186413]
  • D P Brenton, S Krywawych. 3-Methyladipate excretion in Refsum's disease. Lancet (London, England). 1982 Mar; 1(8272):624. doi: 10.1016/s0140-6736(82)91780-9. [PMID: 6174838]
  • J D Billimoria, M E Clemens, F B Gibberd, M N Whitelaw. Metabolism of phytanic acid in Refsum's disease. Lancet (London, England). 1982 Jan; 1(8265):194-6. doi: 10.1016/s0140-6736(82)90760-7. [PMID: 6172683]