Butyl-(2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo(2,3-d)pyrimidin-4-yl)ethylamine (BioDeep_00000177700)

   

human metabolite blood metabolite


代谢物信息卡片


N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

  化学式: C23H32N4 (364.2627)
中文名称: N-丁基-N-乙基-2,5-二甲基-7-(2,4,6-三甲基苯基)-7H-吡咯并[2,3-d]嘧啶-4-胺
  谱图信息: 最多检出来源 Homo sapiens(blood) 94.08%

分子结构信息

SMILES: CCCCN(CC)C1=NC(=NC2=C1C(=CN2C3=C(C=C(C=C3C)C)C)C)C
InChI: InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3


描述信息

同义名列表

3 个代谢物同义名

N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; Butyl-(2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo(2,3-d)pyrimidin-4-yl)ethylamine; N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Elena Martínez-Laorden, Javier Navarro-Zaragoza, María-Victoria Milanés, Maria-Luisa Laorden, Pilar Almela. Conditioned aversive memory associated with morphine withdrawal increases brain-derived neurotrophic factor in dentate gyrus and basolateral amygdala. Addiction biology. 2020 07; 25(4):e12792. doi: 10.1111/adb.12792. [PMID: 31282111]
  • Dmitry V Zaretsky, Maria V Zaretskaia, Sumit Sarkar, Daniel E Rusyniak, Joseph A DiMicco. The non-peptide CRH1-antagonist CP-154,526 elicits a paradoxical route-dependent activation of the HPA axis. Neuroscience letters. 2017 Jul; 653(?):1-6. doi: 10.1016/j.neulet.2017.05.012. [PMID: 28511913]
  • M Carmen Lasheras, M Luisa Laorden, M Victoria Milanés, Cristina Núñez. Corticotropin-releasing factor 1 receptor mediates the activity of the reward system evoked by morphine-induced conditioned place preference. Neuropharmacology. 2015 Aug; 95(?):168-80. doi: 10.1016/j.neuropharm.2014.12.021. [PMID: 25556110]
  • Ke Hao, Fan-Ping Kong, Yu-Qi Gao, Jia-Wei Tang, Jian Chen, A Mark Evans, Stafford L Lightman, Xue-Qun Chen, Ji-Zeng Du. Inactivation of corticotropin-releasing hormone-induced insulinotropic role by high-altitude hypoxia. Diabetes. 2015 Mar; 64(3):785-95. doi: 10.2337/db14-0500. [PMID: 25277397]
  • Juan-Antonio García-Carmona, Daymi M Camejo, Pilar Almela, Ana Jiménez, María-Victoria Milanés, Francisca Sevilla, María-Luisa Laorden. CP-154,526 Modifies CREB Phosphorylation and Thioredoxin-1 Expression in the Dentate Gyrus following Morphine-Induced Conditioned Place Preference. PloS one. 2015; 10(8):e0136164. doi: 10.1371/journal.pone.0136164. [PMID: 26313266]
  • J Navarro-Zaragoza, E Martínez-Laorden, L Mora, J Hidalgo, M V Milanés, M L Laorden. Cardiac adverse effects of naloxone-precipitated morphine withdrawal on right ventricle: role of corticotropin-releasing factor (CRF) 1 receptor. Toxicology and applied pharmacology. 2014 Feb; 275(1):28-35. doi: 10.1016/j.taap.2013.12.021. [PMID: 24398105]
  • Alessandro Gozzi, Stefano Lepore, Elena Vicentini, Emilio Merlo-Pich, Angelo Bifone. Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2013 Oct; 38(11):2120-30. doi: 10.1038/npp.2013.109. [PMID: 23736277]
  • Pilar Almela, Javier Navarro-Zaragoza, Juan-Antonio García-Carmona, Lucía Mora, Juana Hidalgo, María-Victoria Milanés, María-Luisa Laorden. Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc). PloS one. 2012; 7(10):e47089. doi: 10.1371/journal.pone.0047089. [PMID: 23071721]
  • Emily G Lowery, Marina Spanos, Montserrat Navarro, Angela M Lyons, Clyde W Hodge, Todd E Thiele. CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2010 May; 35(6):1241-52. doi: 10.1038/npp.2009.209. [PMID: 20130533]
  • Vasiliki Michopoulos, Sarah L Berga, Jay R Kaplan, Mark E Wilson. Social subordination and polymorphisms in the gene encoding the serotonin transporter enhance estradiol inhibition of luteinizing hormone secretion in female rhesus monkeys. Biology of reproduction. 2009 Dec; 81(6):1154-63. doi: 10.1095/biolreprod.109.079038. [PMID: 19605783]
  • Xue-Qun Chen, Jing Dong, Chen-Ying Niu, Jun-Ming Fan, Ji-Zeng Du. Effects of hypoxia on glucose, insulin, glucagon, and modulation by corticotropin-releasing factor receptor type 1 in the rat. Endocrinology. 2007 Jul; 148(7):3271-8. doi: 10.1210/en.2006-1224. [PMID: 17379644]
  • Jian-Fen Xu, Xue-Qun Chen, Ji-Zeng Du. CRH receptor type 1 mediates continual hypoxia-induced changes of immunoreactive prolactin and prolactin mRNA expression in rat pituitary. Hormones and behavior. 2006 Feb; 49(2):181-9. doi: 10.1016/j.yhbeh.2005.06.004. [PMID: 16099461]
  • Adriana T Ramos, Lanfranco R P Troncone, Sergio Tufik. Suppression of adrenocorticotrophic hormone secretion by simultaneous antagonism of vasopressin 1b and CRH-1 receptors on three different stress models. Neuroendocrinology. 2006; 84(5):309-16. doi: 10.1159/000097587. [PMID: 17135717]
  • Jian-Fen Xu, Xue-Qun Chen, Ji-Zeng Du, Tong-Ying Wang. CRF receptor type 1 mediates continual hypoxia-induced CRF peptide and CRF mRNA expression increase in hypothalamic PVN of rats. Peptides. 2005 Apr; 26(4):639-46. doi: 10.1016/j.peptides.2004.11.014. [PMID: 15752579]
  • Shoshiro Okada, Takahiro Shimizu, Kunihiko Yokotani. Extrahypothalamic corticotropin-releasing hormone mediates (-)-nicotine-induced elevation of plasma corticosterone in rats. European journal of pharmacology. 2003 Jul; 473(2-3):217-23. doi: 10.1016/s0014-2999(03)01966-6. [PMID: 12892841]
  • Nick E Goeders, David M Clampitt. Potential role for the hypothalamo-pituitary-adrenal axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats. Psychopharmacology. 2002 May; 161(3):222-32. doi: 10.1007/s00213-002-1007-4. [PMID: 12021825]
  • Caroline Keller, Armin Bruelisauer, Michel Lemaire, Albert Enz. Brain pharmacokinetics of a nonpeptidic corticotropin-releasing factor receptor antagonist. Drug metabolism and disposition: the biological fate of chemicals. 2002 Feb; 30(2):173-6. doi: 10.1124/dmd.30.2.173. [PMID: 11792687]
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  • M J Nijsen, G Croiset, R Stam, A Bruijnzeel, M Diamant, D de Wied, V M Wiegant. The role of the CRH type 1 receptor in autonomic responses to corticotropin- releasing hormone in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2000 Apr; 22(4):388-99. doi: 10.1016/s0893-133x(99)00126-8. [PMID: 10700658]
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  • R J Chorvat, R Bakthavatchalam, J P Beck, P J Gilligan, R G Wilde, A J Cocuzza, F W Hobbs, R S Cheeseman, M Curry, J P Rescinito, P Krenitsky, D Chidester, J A Yarem, J D Klaczkiewicz, C N Hodge, P E Aldrich, Z R Wasserman, C H Fernandez, R Zaczek, L W Fitzgerald, S M Huang, H L Shen, Y N Wong, B M Chien, A Arvanitis. Synthesis, corticotropin-releasing factor receptor binding affinity, and pharmacokinetic properties of triazolo-, imidazo-, and pyrrolopyrimidines and -pyridines. Journal of medicinal chemistry. 1999 Mar; 42(5):833-48. doi: 10.1021/jm980224g. [PMID: 10072681]
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