p-Methylhippuric acid (BioDeep_00000017761)
human metabolite Endogenous
代谢物信息卡片
2-[(4-methylphenyl)formamido]acetic acid
化学式: C10H11NO3 (193.0738896)
中文名称: N-(对甲苯甲酰基)甘氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=C(C=C1)C(=O)NCC(=O)O
InChI: InChI=1S/C10H11NO3/c1-7-2-4-8(5-3-7)10(14)11-6-9(12)13/h2-5H,6H2,1H3,(H,11,14)(H,12,13)
描述信息
p-Methylhippuric (p-MHA)acid is the principal metabolite of p-xylene. Most of the p-xylene inhaled by workers will be excreted in urine as p-MHA. [HMDB]
p-Methylhippuric (p-MHA)acid is the principal metabolite of p-xylene. Most of the p-xylene inhaled by workers will be excreted in urine as p-MHA.
同义名列表
15 个代谢物同义名
2-[(4-methylphenyl)formamido]acetic acid; [(4-methylphenyl)formamido]acetic acid; (4-Methyl-benzoylamino)-acetic acid; ((4-Methylbenzoyl)amino)acetic acid; N-(4-Methylbenzoyl)glycine; Para-methylhippuric acid; N-(P-Toluoyl)-glycine; 4-Methylhippuric acid; p-Methylhippuric acid; N-(P-Toluoyl)glycine; 4-Methylhippic acid; p-Methylhippic acid; p-Methylhippate; 4-Methylhippate; P-Toluric acid
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:68552
- PubChem: 97479
- HMDB: HMDB0013292
- ChEMBL: CHEMBL274877
- Wikipedia: Methylhippuric acid
- foodb: FDB029366
- chemspider: 87986
- CAS: 27115-50-0
- PMhub: MS000000149
- RefMet: p-Methylhippuric acid
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Carolina Nasser Boscari, Giovanna Rodrigues Mazzuia, Célio Wisniewski, Keyller Bastos Borges, Eduardo Costa Figueiredo. Molecularly imprinted probe for solid-phase extraction of hippuric and 4-methylhippuric acids directly from human urine samples followed by MEKC analysis.
Electrophoresis.
2017 04; 38(7):1083-1090. doi:
10.1002/elps.201600382. [PMID: 27982439] - Henricus A M Mutsaers, Lambertus P van den Heuvel, Lauke H J Ringens, Anita C A Dankers, Frans G M Russel, Jack F M Wetzels, Joost G Hoenderop, Rosalinde Masereeuw. Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.
PloS one.
2011 Apr; 6(4):e18438. doi:
10.1371/journal.pone.0018438. [PMID: 21483698] - Aurélie Berthet, Michèle Berode, Michèle Bouchard. Gas-chromatography mass-spectrometry determination of phthalic acid in human urine as a biomarker of folpet exposure.
Analytical and bioanalytical chemistry.
2011 Apr; 400(2):493-502. doi:
10.1007/s00216-011-4753-5. [PMID: 21336936] - Adriaan A S Marais, Johannes B Laurens. Analysis of urinary biomarkers for exposure to alkyl benzenes by isotope dilution gas chromatography-mass spectrometry.
Journal of separation science.
2005 Dec; 28(18):2526-33. doi:
10.1002/jssc.200500205. [PMID: 16405184] - Stefano Marchese, Roberta Curini, Alessandra Gentili, Daniela Perret, Lucia Mainero Rocca. Simultaneous determination of the urinary metabolites of benzene, toluene, xylene and styrene using high-performance liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2004; 18(3):265-72. doi:
10.1002/rcm.1323. [PMID: 14755610] - Peter Terry Mayer, Tian-Xiang Xiang, Riku Niemi, Bradley D Anderson. A hydrophobicity scale for the lipid bilayer barrier domain from peptide permeabilities: nonadditivities in residue contributions.
Biochemistry.
2003 Feb; 42(6):1624-36. doi:
10.1021/bi026701l. [PMID: 12578376] - J B Laurens, X Y Mbianda, J H Spies, J B Ubbink, W J H Vermaak. Validated method for quantitation of biomarkers for benzene and its alkylated analogues in urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Jul; 774(2):173-85. doi:
10.1016/s1570-0232(02)00206-4. [PMID: 12076687] - Peter T Mayer, Bradley D Anderson. Transport across 1,9-decadiene precisely mimics the chemical selectivity of the barrier domain in egg lecithin bilayers.
Journal of pharmaceutical sciences.
2002 Mar; 91(3):640-6. doi:
10.1002/jps.10067. [PMID: 11920749] - P Kongtip, J Vararussami, V Pruktharathikul. Modified method for determination of hippuric acid and methylhippuric acid in urine by gas chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Feb; 751(1):199-203. doi:
10.1016/s0378-4347(00)00463-1. [PMID: 11232852] - T X Xiang, J Chen, B D Anderson. A quantitative model for the dependence of solute permeability on peptide and cholesterol content in biomembranes.
The Journal of membrane biology.
2000 Sep; 177(2):137-48. doi:
10.1007/s002320001107. [PMID: 11003688] - P T Mayer, T X Xiang, B D Anderson. Independence of substituent contributions to the transport of small molecule permeants in lipid bilayers.
AAPS pharmSci.
2000; 2(2):E14. doi:
10.1208/ps020214. [PMID: 11741230] - C Burrini. [The simultaneous determination of hippuric acid, o-, m-, p-methylhippuric acids, mandelic acid and phenylglyoxylic acid in urine by HPLC].
La Medicina del lavoro.
1998 Sep; 89(5):404-11. doi:
. [PMID: 10064945] - K J Lee, J J Lee, D C Moon. Application of micellar electrokinetic capillary chromatography for monitoring of hippuric and methylhippuric acid in human urine.
Electrophoresis.
1994 Jan; 15(1):98-102. doi:
10.1002/elps.1150150115. [PMID: 8143687] - O Inoue, K Seiji, T Kawai, T Watanabe, C Jin, S X Cai, Z Chen, Q S Qu, T Zhang, M Ikeda. Excretion of methylhippuric acids in urine of workers exposed to a xylene mixture: comparison among three xylene isomers and toluene.
International archives of occupational and environmental health.
1993; 64(7):533-9. doi:
10.1007/bf00381104. [PMID: 8482596] - O Inoue, K Seiji, T Suzuki, T Watanabe, H Nakatsuka, H Satoh, M Ikeda. Simultaneous determination of hippuric acid, o-, m-, and p-methylhippuric acid, phenylglyoxylic acid, and mandelic acid by HPLC.
Bulletin of environmental contamination and toxicology.
1991 Aug; 47(2):204-10. doi:
10.1007/bf01688641. [PMID: 1912696] - H Matsui, T Sekiya. High-performance liquid chromatographic separation of urinary hippuric and o-, m- and p-methylhippuric acids with a beta-cyclodextrin-bonded column.
Journal of chromatography.
1989 Nov; 496(1):189-93. doi:
10.1016/s0378-4347(00)82565-7. [PMID: 2592511] - R Tardif, J Brodeur, G L Plaa. Simultaneous high-performance liquid chromatographic analysis of hippuric acid and ortho-, meta-, and para-methylhippuric acids in urine.
Journal of analytical toxicology.
1989 Nov; 13(6):313-6. doi:
10.1093/jat/13.6.313. [PMID: 2607759] - M Buratti, G Caravelli, O Pellegrino, D Xaiz, C Valla, R Giampiccolo, A Colombi. [Determination of hippuric and methylhippuric acids with high pressure liquid chromatography: comparison between chromatographic and colorimetric methods].
La Medicina del lavoro.
1988 Nov; 79(6):489-99. doi:
NULL. [PMID: 3246973] - K Engström, V Riihimäki. Determination of methylhippuric acids in urine by gas chromatography.
IARC scientific publications.
1988; ?(85):313-8. doi:
NULL. [PMID: 3182055] - Y Takeuchi, T Sakai, Y Ikeya, T Araki, K Ushio, S Yanagihara. [Improved high performance liquid chromatography determination of hippuric acid and methylhippuric acid isomers in urine].
Sangyo igaku. Japanese journal of industrial health.
1986 Nov; 28(6):455-61. doi:
10.1539/joh1959.28.455. [PMID: 3586389] - C Lacroix, F Inger, S Menager, O Lafont. [Simultaneous determination of urinary hippuric acid and o-, m-, p-methylhippuric acids with liquid chromatography].
Journal of chromatography.
1986 Oct; 382(?):275-9. doi:
NULL. [PMID: 3782394] - I Lundberg, J Sollenberg. Correlation of xylene exposure and methyl hippuric acid excretion in urine among paint industry workers.
Scandinavian journal of work, environment & health.
1986 Apr; 12(2):149-53. doi:
10.5271/sjweh.2164. [PMID: 3726497] - M Ogata, T Taguchi. [Quantitative determination of urinary hippuric acid and o-, m- and p-methyl hippuric acids by high performance liquid chromatography].
Sangyo igaku. Japanese journal of industrial health.
1986 Mar; 28(2):120-1. doi:
10.1539/joh1959.28.120. [PMID: 3761712] - M Ogata, T Taguchi. Quantitative analysis of urinary glycine conjugates by high performance liquid chromatography: excretion of hippuric acid and methylhippuric acids in the urine of subjects exposed to vapours of toluene and xylenes.
International archives of occupational and environmental health.
1986; 58(2):121-9. doi:
10.1007/bf00380763. [PMID: 3744566] - M Ogata. Estimation of solvent concentrations in ambient air from urinary metabolite levels of workers exposed to solvents.
Industrial health.
1984; 22(4):319-24. doi:
10.2486/indhealth.22.319. [PMID: 6526705] - T Sakai, Y Niinuma, S Yanagihara, K Ushio. Simultaneous determination of hippuric acid and o-, m- and p-methylhippuric acids in urine by high-performance liquid chromatography.
Journal of chromatography.
1983 Aug; 276(1):182-8. doi:
10.1016/s0378-4347(00)85080-x. [PMID: 6672011] - G Bieniek, T Wilczok. Thin-layer chromatography of hippuric and m-methylhippuric acid in urine after mixed exposure to toluene and xylene.
British journal of industrial medicine.
1981 Aug; 38(3):304-6. doi:
10.1136/oem.38.3.304. [PMID: 7272246] - M Morin, P Chambon, R Chambon, N Bichet. Measurement of exposure to xylenes by separate determination of m- and p-methylhippuric acids in urine.
Journal of chromatography.
1981 Jun; 210(2):346-9. doi:
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