m-Methylhippuric acid (BioDeep_00000017760)
human metabolite Endogenous
代谢物信息卡片
2-[(3-methylphenyl)formamido]acetic acid
化学式: C10H11NO3 (193.0739)
中文名称: N-(间甲苯甲酰基)甘氨酸, 3-甲基马尿酸
谱图信息:
最多检出来源 Mus musculus(not specific) 2.03%
分子结构信息
SMILES: CC1=CC(=CC=C1)C(=O)NCC(=O)O
InChI: InChI=1S/C10H11NO3/c1-7-3-2-4-8(5-7)10(14)11-6-9(12)13/h2-5H,6H2,1H3,(H,11,14)(H,12,13)
描述信息
m-Methylhippuric (m-MHA)acid is the principal metabolite of m-xylene. Most of the m-xylene inhaled by workers will be excreted in urine as m-MHA. [HMDB]
m-Methylhippuric (m-MHA)acid is the principal metabolite of m-xylene. Most of the m-xylene inhaled by workers will be excreted in urine as m-MHA.
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:68500
- PubChem: 99223
- HMDB: HMDB0013245
- ChEMBL: CHEMBL456202
- Wikipedia: Methylhippuric acid
- foodb: FDB029355
- chemspider: 89642
- CAS: 27115-49-7
- PMhub: MS000000148
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Chun-Hui Chiu, Chi-Tsung Chen, Ming-Huei Cheng, Li-Heng Pao, Chi Wang, Gwo-Hwa Wan. Use of urinary hippuric acid and o-/p-/m-methyl hippuric acid to evaluate surgical smoke exposure in operating room healthcare personnel.
Ecotoxicology and environmental safety.
2021 Jul; 217(?):112231. doi:
10.1016/j.ecoenv.2021.112231. [PMID: 33862429] - Axelle Marchand, Rocio Aranda-Rodriguez, Robert Tardif, Andy Nong, Sami Haddad. Evaluation and modeling of the impact of coexposures to VOC mixtures on urinary biomarkers.
Inhalation toxicology.
2016; 28(6):260-73. doi:
10.3109/08958378.2016.1162232. [PMID: 27053005] - Lena Ernstgård, Bengt Sjögren, Margareta Warholm, Gunnar Johanson. Sex differences in the toxicokinetics of inhaled solvent vaporsin humans 1. m-Xylene.
Toxicology and applied pharmacology.
2003 Dec; 193(2):147-57. doi:
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Collegium antropologicum.
2001 Jun; 25(1):357-62. doi:
NULL. [PMID: 11787562] - P Kongtip, J Vararussami, V Pruktharathikul. Modified method for determination of hippuric acid and methylhippuric acid in urine by gas chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Feb; 751(1):199-203. doi:
10.1016/s0378-4347(00)00463-1. [PMID: 11232852] - T Kaneko, J Horiuchi, A Sato. Development of a physiologically based pharmacokinetic model of organic solvent in rats.
Pharmacological research.
2000 Nov; 42(5):465-70. doi:
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International archives of occupational and environmental health.
1999 Mar; 72(2):89-97. doi:
10.1007/s004200050343. [PMID: 10197480] - C Burrini. [The simultaneous determination of hippuric acid, o-, m-, p-methylhippuric acids, mandelic acid and phenylglyoxylic acid in urine by HPLC].
La Medicina del lavoro.
1998 Sep; 89(5):404-11. doi:
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Occupational and environmental medicine.
1994 Mar; 51(3):187-91. doi:
10.1136/oem.51.3.187. [PMID: 8130847] - K J Lee, J J Lee, D C Moon. Application of micellar electrokinetic capillary chromatography for monitoring of hippuric and methylhippuric acid in human urine.
Electrophoresis.
1994 Jan; 15(1):98-102. doi:
10.1002/elps.1150150115. [PMID: 8143687] - O Inoue, K Seiji, T Kawai, T Watanabe, C Jin, S X Cai, Z Chen, Q S Qu, T Zhang, M Ikeda. Excretion of methylhippuric acids in urine of workers exposed to a xylene mixture: comparison among three xylene isomers and toluene.
International archives of occupational and environmental health.
1993; 64(7):533-9. doi:
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Journal of chromatography.
1992 Jan; 573(2):318-22. doi:
10.1016/0378-4347(92)80136-e. [PMID: 1601967] - R S Wang, T Nakajima, K Hata, N Murayama, A Sato. [A method for storage of urine samples in the biological monitoring of organic solvents].
Sangyo igaku. Japanese journal of industrial health.
1992 Jan; 34(1):42-3. doi:
10.1539/joh1959.34.42. [PMID: 1635275] - O Inoue, K Seiji, T Suzuki, T Watanabe, H Nakatsuka, H Satoh, M Ikeda. Simultaneous determination of hippuric acid, o-, m-, and p-methylhippuric acid, phenylglyoxylic acid, and mandelic acid by HPLC.
Bulletin of environmental contamination and toxicology.
1991 Aug; 47(2):204-10. doi:
10.1007/bf01688641. [PMID: 1912696] - J Liira, E Elovaara, H Raunio, V Riihimäki, K Engström. Metabolic interaction and disposition of methyl ethyl ketone and m-xylene in rats at single and repeated inhalation exposures.
Xenobiotica; the fate of foreign compounds in biological systems.
1991 Jan; 21(1):53-63. doi:
10.3109/00498259109039450. [PMID: 2003367] - D de Carvalho, V L Lanchote, P S Bonato, R H Queiroz, A C Santos, S A Dreossi. A new derivatization procedure for the analysis of hippuric acid and m-methyl-hippuric acid by gas chromatography.
International archives of occupational and environmental health.
1991; 63(1):33-7. doi:
10.1007/bf00406195. [PMID: 1856021] - H Matsui, T Sekiya. High-performance liquid chromatographic separation of urinary hippuric and o-, m- and p-methylhippuric acids with a beta-cyclodextrin-bonded column.
Journal of chromatography.
1989 Nov; 496(1):189-93. doi:
10.1016/s0378-4347(00)82565-7. [PMID: 2592511] - R Tardif, J Brodeur, G L Plaa. Simultaneous high-performance liquid chromatographic analysis of hippuric acid and ortho-, meta-, and para-methylhippuric acids in urine.
Journal of analytical toxicology.
1989 Nov; 13(6):313-6. doi:
10.1093/jat/13.6.313. [PMID: 2607759] - M Buratti, G Caravelli, O Pellegrino, D Xaiz, C Valla, R Giampiccolo, A Colombi. [Determination of hippuric and methylhippuric acids with high pressure liquid chromatography: comparison between chromatographic and colorimetric methods].
La Medicina del lavoro.
1988 Nov; 79(6):489-99. doi:
NULL. [PMID: 3246973] - L Campbell, H K Wilson, A M Samuel, D Gompertz. Interactions of m-xylene and aspirin metabolism in man.
British journal of industrial medicine.
1988 Feb; 45(2):127-32. doi:
10.1136/oem.45.2.127. [PMID: 3342195] - M Ogata, T Taguchi. Simultaneous determination of urinary creatinine and metabolites of toluene, xylene, styrene, ethylbenzene and phenol by automated high performance liquid chromatography.
International archives of occupational and environmental health.
1988; 61(1-2):131-40. doi:
10.1007/bf00381617. [PMID: 3198279] - K Engström, V Riihimäki. Determination of methylhippuric acids in urine by gas chromatography.
IARC scientific publications.
1988; ?(85):313-8. doi:
NULL. [PMID: 3182055] - Y Takeuchi, T Sakai, Y Ikeya, T Araki, K Ushio, S Yanagihara. [Improved high performance liquid chromatography determination of hippuric acid and methylhippuric acid isomers in urine].
Sangyo igaku. Japanese journal of industrial health.
1986 Nov; 28(6):455-61. doi:
10.1539/joh1959.28.455. [PMID: 3586389] - C Lacroix, F Inger, S Menager, O Lafont. [Simultaneous determination of urinary hippuric acid and o-, m-, p-methylhippuric acids with liquid chromatography].
Journal of chromatography.
1986 Oct; 382(?):275-9. doi:
NULL. [PMID: 3782394] - I Lundberg, J Sollenberg. Correlation of xylene exposure and methyl hippuric acid excretion in urine among paint industry workers.
Scandinavian journal of work, environment & health.
1986 Apr; 12(2):149-53. doi:
10.5271/sjweh.2164. [PMID: 3726497] - M Ogata, T Taguchi. [Quantitative determination of urinary hippuric acid and o-, m- and p-methyl hippuric acids by high performance liquid chromatography].
Sangyo igaku. Japanese journal of industrial health.
1986 Mar; 28(2):120-1. doi:
10.1539/joh1959.28.120. [PMID: 3761712] - M Ogata, T Taguchi. Quantitative analysis of urinary glycine conjugates by high performance liquid chromatography: excretion of hippuric acid and methylhippuric acids in the urine of subjects exposed to vapours of toluene and xylenes.
International archives of occupational and environmental health.
1986; 58(2):121-9. doi:
10.1007/bf00380763. [PMID: 3744566] - J Sollenberg, F C Phipps, B Stringer, L K Lowry. Determination of methylhippuric acid in human urine by high-performance liquid chromatography and by isotachophoresis.
Journal of chromatography.
1985 Oct; 343(2):419-23. doi:
10.1016/s0378-4347(00)84612-5. [PMID: 4066882] - M Ogata. Estimation of solvent concentrations in ambient air from urinary metabolite levels of workers exposed to solvents.
Industrial health.
1984; 22(4):319-24. doi:
10.2486/indhealth.22.319. [PMID: 6526705] - T Sakai, Y Niinuma, S Yanagihara, K Ushio. Simultaneous determination of hippuric acid and o-, m- and p-methylhippuric acids in urine by high-performance liquid chromatography.
Journal of chromatography.
1983 Aug; 276(1):182-8. doi:
10.1016/s0378-4347(00)85080-x. [PMID: 6672011] - M Morin, P Chambon, R Chambon, N Bichet. Measurement of exposure to xylenes by separate determination of m- and p-methylhippuric acids in urine.
Journal of chromatography.
1981 Jun; 210(2):346-9. doi:
10.1016/s0021-9673(00)97847-6. [PMID: 7263793] - P Labrude, B Teisseire, C Vigneron. Attempts to use carbodiimide (EDCI) to cross-link hemoglobin for transfusions.
Experientia.
1979 May; 35(5):682-3. doi:
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