Clothiapine (BioDeep_00000177590)
human metabolite blood metabolite
代谢物信息卡片
化学式: C18H18ClN3S (343.09098980000005)
中文名称: 氯噻平
谱图信息:
最多检出来源 Mus musculus(blood) 50%
分子结构信息
SMILES: CN1CCN(CC1)C1=NC2=CC=CC=C2SC2=C1C=C(Cl)C=C2
InChI: InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
描述信息
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AH - Diazepines, oxazepines, thiazepines and oxepines
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties[1].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:108591
- ChEBI: CHEBI:31424
- PubChem: 16351
- HMDB: HMDB0250371
- DrugBank: DB13256
- ChEMBL: CHEMBL304902
- Wikipedia: Clotiapine
- CAS: 2058-52-8
- medchemexpress: HY-117083
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Claudia Carelli, Francesca Freni, Matteo Moretti, Claudia Vignali, Marco Ballardini, Luca Morini. A case report on fatal intoxication by tapentadol: Study of distribution and metabolism.
Forensic science international.
2021 Jul; 324(?):110825. doi:
10.1016/j.forsciint.2021.110825. [PMID: 34000617] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Luca Morini, Claudia Vignali, Paolo Tricomi, Angelo Groppi. Analytical Challenge in Postmortem Toxicology Applied to a Human Body Found into a Lake after Three Years Immersion.
Journal of forensic sciences.
2015 Sep; 60(5):1383-6. doi:
10.1111/1556-4029.12815. [PMID: 26258895] - Ming-Hong Hsieh, Wei-Wen Lin, Shao-Tsu Chen, Kao-Ching Chen, Kuang-Peng Chen, Nan-Ying Chiu, Chao Huang, Ching-Jui Chang, Cheng-Hsiu Lin, Te-Jen Lai. A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting.
Annals of general psychiatry.
2010 Sep; 9(?):35. doi:
10.1186/1744-859x-9-35. [PMID: 20849577] - Emin Aghayev, Christian Jackowski, Andreas Christe, Michael Thali. Radiopaque stomach contents in postmortem CT in suicidal oral medication intoxication: report of three cases.
Journal of forensic and legal medicine.
2010 Apr; 17(3):164-8. doi:
10.1016/j.jflm.2009.10.001. [PMID: 20211459] - Frank Sporkert, Marc Augsburger, Christian Giroud, Clarisse Brossard, Chin B Eap, Patrice Mangin. Determination and distribution of clotiapine (Entumine) in human plasma, post-mortem blood and tissue samples from clotiapine-treated patients and from autopsy cases.
Forensic science international.
2007 Aug; 170(2-3):193-9. doi:
10.1016/j.forsciint.2007.03.037. [PMID: 17614226] - Laura Mercolini, Maria Grillo, Claudio Bartoletti, Giancarlo Boncompagni, Maria Augusta Raggi. Simultaneous analysis of classical neuroleptics, atypical antipsychotics and their metabolites in human plasma.
Analytical and bioanalytical chemistry.
2007 May; 388(1):235-43. doi:
10.1007/s00216-007-1195-1. [PMID: 17340084] - Fabienne Péhourcq. A simple high-performance liquid chromatographic method for detection of hydroxyzine in human plasma after overdose.
Journal of pharmacological and toxicological methods.
2004 Jul; 50(1):41-4. doi:
10.1016/j.vascn.2004.01.001. [PMID: 15233966] - A Pinelli, S Trivulzio, P M Ciapponi. Quantitative opioid withdrawal signs in rats: effects exerted by clothiapine administration.
Fundamental & clinical pharmacology.
1997; 11(4):346-55. doi:
10.1111/j.1472-8206.1997.tb00848.x. [PMID: 9263765] - O Tanaka, T Kondo, S Kaneko, K Mihara, K Otani, N Tokinaga. A method for rapid determination of zotepine by gas chromatography-mass spectrometry.
Therapeutic drug monitoring.
1996 Jun; 18(3):294-6. doi:
10.1097/00007691-199606000-00013. [PMID: 8738771]