Clopidogrel carboxylic acid (BioDeep_00000177579)

   

human metabolite blood metabolite


代谢物信息卡片


2-(2-Chlorophenyl)-2-(6,7-dihydro-4H-thieno(3,2-c)pyridin-5-yl)acetic acid

化学式: C15H14ClNO2S (307.0434)
中文名称: 氯吡格雷杂质A
谱图信息: 最多检出来源 Homo sapiens(blood) 15.77%

分子结构信息

SMILES: C1CN(CC2=C1SC=C2)C(C3=CC=CC=C3Cl)C(=O)O
InChI: InChI=1S/C15H14ClNO2S/c16-12-4-2-1-3-11(12)14(15(18)19)17-7-5-13-10(9-17)6-8-20-13/h1-4,6,8,14H,5,7,9H2,(H,18,19)

描述信息

D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors

同义名列表

6 个代谢物同义名

2-(2-Chlorophenyl)-2-(6,7-dihydro-4H-thieno(3,2-c)pyridin-5-yl)acetic acid; 2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetic acid; (2-chlorophenyl)(4H,6H,7H-thieno[3,2-c]pyridin-5-yl)acetic acid; rac-Clopidogrel Carboxylic Acid; clopidogrel carboxylic acid; Clopidogrel carboxylate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Urszula Adamiak-Giera, Anna Czerkawska, Szymon Olędzki, Mateusz Kurzawski, Krzysztof Safranow, Maria Jastrzębska, Barbara Gawrońska-Szklarz. Impact of selected genetic factors on clopidogrel inactive metabolite level and antiplatelet response in patients after percutaneous coronary intervention. Pharmacological reports : PR. 2021 Apr; 73(2):583-593. doi: 10.1007/s43440-020-00197-w. [PMID: 33270185]
  • Yan Wu, Hua Yu, Hai-Qin Tang, Yong Su, Tian-Lu Shi, Sheng Liu, Quan Xia, Du-Juan Xu. PXR polymorphisms have impact on the clinical efficacy of clopidogrel in patients undergoing percutaneous coronary intervention. Gene. 2018 May; 653(?):22-28. doi: 10.1016/j.gene.2018.02.022. [PMID: 29432831]
  • Helinä Kahma, Anne M Filppula, Mikko Neuvonen, E Katriina Tarkiainen, Aleksi Tornio, Mikko T Holmberg, Matti K Itkonen, Moshe Finel, Pertti J Neuvonen, Mikko Niemi, Janne T Backman. Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions . Drug metabolism and disposition: the biological fate of chemicals. 2018 02; 46(2):141-150. doi: 10.1124/dmd.117.078162. [PMID: 29138287]
  • Janne G Lyngby, Michael H Court, Pamela M Lee. Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. 2017 Aug; 19(4):384-395. doi: 10.1016/j.jvc.2017.03.004. [PMID: 28602635]
  • Liping Li, Feifeng Song, Meijuan Tu, Kai Wang, Lei Zhao, Xiaodan Wu, Hui Zhou, Zongling Xia, Huidi Jiang. In vitro interaction of clopidogrel and its hydrolysate with OCT1, OCT2 and OAT1. International journal of pharmaceutics. 2014 Apr; 465(1-2):5-10. doi: 10.1016/j.ijpharm.2014.02.003. [PMID: 24530383]
  • Maya A Farha, Kalinka Koteva, Robert T Gale, Edward W Sewell, Gerard D Wright, Eric D Brown. Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites. Bioorganic & medicinal chemistry letters. 2014 Feb; 24(3):905-10. doi: 10.1016/j.bmcl.2013.12.069. [PMID: 24393581]
  • Paul W Elsinghorst. Quantitative determination of clopidogrel and its metabolites in biological samples: a mini-review. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Feb; 917-918(?):48-52. doi: 10.1016/j.jchromb.2012.12.024. [PMID: 23369880]
  • Marta Karaźniewicz-Łada, Dorota Danielak, Artur Teżyk, Czesław Zaba, Gilles Tuffal, Franciszek Główka. HPLC-MS/MS method for the simultaneous determination of clopidogrel, its carboxylic acid metabolite and derivatized isomers of thiol metabolite in clinical samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Dec; 911(?):105-12. doi: 10.1016/j.jchromb.2012.11.005. [PMID: 23217313]
  • Daniel J Cushing, Paul F Souney, Warren D Cooper, Gerald L Mosher, Michael P Adams, Stephen Machatha, Bing Zhang, Peter R Kowey. Pharmacokinetics and platelet aggregation inhibitory effects of a novel intravenous formulation of clopidogrel in humans. Clinical and experimental pharmacology & physiology. 2012 Jan; 39(1):3-8. doi: 10.1111/j.1440-1681.2011.05616.x. [PMID: 21933229]
  • Luigi Silvestro, Mihaela Gheorghe, Adriana Iordachescu, Valentin Ciuca, Ariana Tudoroniu, Simona Rizea Savu, Isabela Tarcomnicu. Development and validation of an HPLC-MS/MS method to quantify clopidogrel acyl glucuronide, clopidogrel acid metabolite, and clopidogrel in plasma samples avoiding analyte back-conversion. Analytical and bioanalytical chemistry. 2011 Aug; 401(3):1023-34. doi: 10.1007/s00216-011-5147-4. [PMID: 21656175]
  • A-M Yousef, T Arafat, N R Bulatova, R Al-Zumyli. Smoking behaviour modulates pharmacokinetics of orally administered clopidogrel. Journal of clinical pharmacy and therapeutics. 2008 Aug; 33(4):439-49. doi: 10.1111/j.1365-2710.2008.00936.x. [PMID: 18613862]
  • Helen Mani, Stefan W Toennes, Birgit Linnemann, Dorota A Urbanek, Jan Schwonberg, Gerold F Kauert, Edelgard Lindhoff-Last. Determination of clopidogrel main metabolite in plasma: a useful tool for monitoring therapy?. Therapeutic drug monitoring. 2008 Feb; 30(1):84-9. doi: 10.1097/ftd.0b013e31815c13fd. [PMID: 18223467]