Clevidipine (BioDeep_00000177553)

   

human metabolite blood metabolite


代谢物信息卡片


Methyl 5-{[(butanoyloxy)methoxy]carbonyl}-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid

化学式: C21H23Cl2NO6 (455.0902358)
中文名称: 氯维地平
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC(=O)OCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(Cl)=C1Cl)C(=O)OC
InChI: InChI=1S/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3

描述信息

C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

7 个代谢物同义名

Methyl 5-{[(butanoyloxy)methoxy]carbonyl}-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid; methyl 5-{[(butanoyloxy)methoxy]carbonyl}-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate; Butyroxymethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Clevidipine butyric acid; Clevidipine butyrate; Clevidipine; Cleviprex



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sara Saldana, James Breslin, Jennifer Hanify, Theodore Heierman, Kristina Larizadeh, Michael Sanchez, William Phipps. Comparison of Clevidipine and Nicardipine for Acute Blood Pressure Reduction in Hemorrhagic Stroke. Neurocritical care. 2022 06; 36(3):983-992. doi: 10.1007/s12028-021-01407-w. [PMID: 34904214]
  • Bo Xu, Zhen Chen, Gaorui Tang. The Current Role of Clevidipine in the Management of Hypertension. American journal of cardiovascular drugs : drugs, devices, and other interventions. 2022 Mar; 22(2):127-139. doi: 10.1007/s40256-021-00494-6. [PMID: 34472038]
  • Yujia Zhang, Shunbo Zhao, Huan Zhou, Li Ding. Development and validation of samples stabilization strategy and LC-MS/MS method for simultaneous determination of clevidipine and its primary metabolite in human plasma: Application to clinical pharmacokinetic study in Chinese healthy volunteers. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Dec; 1161(?):122448. doi: 10.1016/j.jchromb.2020.122448. [PMID: 33246284]
  • May Wu, Kathleen R Ryan, David N Rosenthal, Ozzie Jahadi, Jeffrey Moss, David M Kwiatkowski. The Use of Clevidipine for Hypertension in Pediatric Patients Receiving Mechanical Circulatory Support. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2020 12; 21(12):e1134-e1139. doi: 10.1097/pcc.0000000000002562. [PMID: 32796396]
  • Zachary Rosenfeldt, Katelyn Conklen, Breck Jones, Don Ferrill, Maithili Deshpande, Fazeel M Siddiqui. Comparison of Nicardipine with Clevidipine in the Management of Hypertension in Acute Cerebrovascular Diseases. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2018 Aug; 27(8):2067-2073. doi: 10.1016/j.jstrokecerebrovasdis.2018.03.001. [PMID: 29627171]
  • María J Pascual, José A Sastre, José M Calvo. Intraoperative clevidipine use to manage an acute hypertensive episode in a patient with a simultaneous kidney-pancreatic transplant. Journal of clinical anesthesia. 2018 03; 45(?):53-54. doi: 10.1016/j.jclinane.2017.11.017. [PMID: 29275266]
  • Yan Wang, Lanting Zhao, Tengfei Li, Wen Yang, Qian Li, Luning Sun, Li Ding. Pharmacokinetics and tissue distribution study of clevidipine and its primary metabolite H152/81 in rats. Biomedical chromatography : BMC. 2018 Feb; 32(2):. doi: 10.1002/bmc.4048. [PMID: 28707762]
  • Xin Wang, Xue-Yuan Guo, Liang Xu, Bin Liu, Ling-Ling Zhou, Xiao-Fang Wang, Dan Wang, Ting Sun. Studies on the competitive binding of cleviprex and flavonoids to plasma protein by multi-spectroscopic methods: A prediction of food-drug interaction. Journal of photochemistry and photobiology. B, Biology. 2017 Oct; 175(?):192-199. doi: 10.1016/j.jphotobiol.2017.08.037. [PMID: 28892755]
  • Yuxia Zhou, Qiaogen Zou, Lili Sun, Ping Wei, Pingkai Ouyang. Determination of clevidipine and its primary metabolite in rat plasma by a dispersive liquid-liquid microextraction method. Journal of chromatographic science. 2015 May; 53(5):830-5. doi: 10.1093/chromsci/bmu100. [PMID: 25480456]
  • Ying Zhou, Xiao-Meng He, Hu-Qun Li, Yang Ni, Ming-Zhen Xu, Hui Chen, Wei-Yong Li. Pharmacokinetics and tissue distribution of clevidipine and its metabolite in dogs and rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 2014 Dec; 34(6):856-860. doi: 10.1007/s11596-014-1364-3. [PMID: 25480581]
  • Huihui Wei, Yuan Gu, Yanping Liu, Yong Chen, Changxiao Liu, Duanyun Si. Quantitation of clevidipine in dog blood by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Nov; 971(?):52-7. doi: 10.1016/j.jchromb.2014.09.019. [PMID: 25270056]
  • Ying Zhou, Huqun Li, Xiaomeng He, Mengmeng Jia, Yang Ni, Mingzhen Xu, Hui Chen, Weiyong Li. Simultaneous determination of clevidipine and its primary metabolite in dog plasma by liquid chromatography-tandem mass spectrometry: Application to pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2014 Nov; 100(?):294-299. doi: 10.1016/j.jpba.2014.08.018. [PMID: 25194342]
  • ". Clevidipine. Hypertensive crises during surgery: no advance. Prescrire international. 2014 Oct; 23(153):236. doi: ". [PMID: 25964966]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Mitesh Patel, Thomas Meyer, Ajit Tharakan, Joseph D Tobias. Intraoperative administration of clevidipine to prevent vasospasm after radial and internal mammary artery grafts during coronary artery bypass grafting. American journal of therapeutics. 2012 May; 19(3):e114-7. doi: 10.1097/mjt.0b013e3181e907b9. [PMID: 20634670]
  • Joseph D Tobias. Clevidipine for controlled hypotension during spinal surgery in adolescents. Middle East journal of anaesthesiology. 2011 Jun; 21(2):269-74. doi: . [PMID: 22435279]
  • W Frank Peacock, Joseph Varon, Ramin Ebrahimi, Lala Dunbar, Charles V Pollack. Clevidipine for severe hypertension in patients with renal dysfunction: a VELOCITY trial analysis. Blood pressure. Supplement. 2011 Apr; 1(?):20-5. doi: 10.3109/08037051.2010.539317. [PMID: 21091269]
  • Alex Bekker, Sorosch Didehvar, Sunmi Kim, John G Golfinos, Erik Parker, Andrew Sapson, Michael Haile, Richard Kline, Mitchell Lee. Efficacy of clevidipine in controlling perioperative hypertension in neurosurgical patients: initial single-center experience. Journal of neurosurgical anesthesiology. 2010 Oct; 22(4):330-5. doi: 10.1097/ana.0b013e3181e3077b. [PMID: 20622687]
  • Ahmed S Awad, Michael E Goldberg. Role of clevidipine butyrate in the treatment of acute hypertension in the critical care setting: a review. Vascular health and risk management. 2010 Aug; 6(?):457-64. doi: 10.2147/vhrm.s5839. [PMID: 20730061]
  • Abbie L Erickson, Jeremy R DeGrado, John R Fanikos. Clevidipine: a short-acting intravenous dihydropyridine calcium channel blocker for the management of hypertension. Pharmacotherapy. 2010 May; 30(5):515-28. doi: 10.1592/phco.30.5.515. [PMID: 20412001]
  • Lendita Prlesi, Angela Cheng-Lai. Clevidipine: a novel ultra-short-acting calcium antagonist. Cardiology in review. 2009 May; 17(3):147-52. doi: 10.1097/crd.0b013e31819fe23c. [PMID: 19384089]
  • Emma D Deeks, Gillian M Keating, Susan J Keam. Clevidipine: a review of its use in the management of acute hypertension. American journal of cardiovascular drugs : drugs, devices, and other interventions. 2009; 9(2):117-34. doi: 10.2165/00129784-200909020-00006. [PMID: 19331440]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Neil Singla, David C Warltier, Sweeta D Gandhi, Philip D Lumb, Robert N Sladen, Solomon Aronson, Mark F Newman, Howard L Corwin. Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial. Anesthesia and analgesia. 2008 Jul; 107(1):59-67. doi: 10.1213/ane.0b013e3181732e53. [PMID: 18635468]
  • Jerrold H Levy, Miguel Y Mancao, Richard Gitter, Dean J Kereiakes, Alina M Grigore, Solomon Aronson, Mark F Newman. Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: the results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1. Anesthesia and analgesia. 2007 Oct; 105(4):918-25, table of contents. doi: 10.1213/01.ane.0000281443.13712.b9. [PMID: 17898366]
  • Qing-Dong Wang, Daisuke Segawa, Hans Ericsson, Per-Ove Sjöquist, Lars Johansson, Lars Rydén. Time-dependent cardioprotection with calcium antagonism and experimental studies with clevidipine in ischemic-reperfused pig hearts: part I. Journal of cardiovascular pharmacology. 2002 Aug; 40(2):228-34. doi: 10.1097/00005344-200208000-00008. [PMID: 12131552]
  • Christopher T Stephens, Bhagavan S Jandhyala. Effects of fenoldopam, a dopamine D-1 agonist, and clevidipine, a calcium channel antagonist, in acute renal failure in anesthetized rats. Clinical and experimental hypertension (New York, N.Y. : 1993). 2002 May; 24(4):301-13. doi: 10.1081/ceh-120004233. [PMID: 12069360]
  • James M Bailey, Wei Lu, Jerrold H Levy, James G Ramsay, Linda Shore-Lesserson, Richard C Prielipp, Neil W Brister, Gary W Roach, Ase Jolin-Mellgard, Margareta Nordlander. Clevidipine in adult cardiac surgical patients: a dose-finding study. Anesthesiology. 2002 May; 96(5):1086-94. doi: 10.1097/00000542-200205000-00010. [PMID: 11981147]
  • D Segawa, P O Sjöquist, Q D Wang, A Gonon, M Nordlander, L Rydén. Calcium antagonist protects the myocardium from reperfusion injury by interfering with mechanisms directly related to reperfusion: an experimental study with the ultrashort-acting calcium antagonist clevidipine. Journal of cardiovascular pharmacology. 2000 Sep; 36(3):338-43. doi: 10.1097/00005344-200009000-00009. [PMID: 10975591]
  • H Ericsson, B Tholander, C G Regårdh. In vitro hydrolysis rate and protein binding of clevidipine, a new ultrashort-acting calcium antagonist metabolised by esterases, in different animal species and man. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 1999 Apr; 8(1):29-37. doi: 10.1016/s0928-0987(98)00058-x. [PMID: 10072476]
  • H Ericsson, C Fakt, L Höglund, A Jolin-Mellgård, M Nordlander, M Sunzel, C G Regårdh. Pharmacokinetics and pharmacodynamics of clevidipine in healthy volunteers after intravenous infusion. European journal of clinical pharmacology. 1999 Mar; 55(1):61-7. doi: 10.1007/s002280050594. [PMID: 10206087]