Urea, N'-(2,4-difluorophenyl)-N-((4-(2,2-dimethylpropyl)phenyl)methyl)-N-heptyl- (BioDeep_00000177542)

   

human metabolite blood metabolite


代谢物信息卡片


Urea, N-(2,4-difluorophenyl)-N-((4-(2,2-dimethylpropyl)phenyl)methyl)-N-heptyl-

化学式: C26H36F2N2O (430.2796)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 93.94%

分子结构信息

SMILES: CCCCCCCN(CC1=CC=C(C=C1)CC(C)(C)C)C(=O)NC2=C(C=C(C=C2)F)F
InChI: InChI=1S/C26H36F2N2O/c1-5-6-7-8-9-16-30(25(31)29-24-15-14-22(27)17-23(24)28)19-21-12-10-20(11-13-21)18-26(2,3)4/h10-15,17H,5-9,16,18-19H2,1-4H3,(H,29,31)

描述信息

同义名列表

4 个代谢物同义名

Urea, N-(2,4-difluorophenyl)-N-((4-(2,2-dimethylpropyl)phenyl)methyl)-N-heptyl-; N-(2,4-difluororphenyl)-N-((4-(2,2-dimethylpropyl)phenyl)methyl)-N-heptylurea; 1-(2,4-difluorophenyl)-3-{[4-(2,2-dimethylpropyl)phenyl]methyl}-3-heptylurea; DDPMHU



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sebely Pal, Emma Allister, Andrew Thomson, John C L Mamo. Cholesterol esters regulate apoB48 secretion in CaCo2 cells. Atherosclerosis. 2002 Mar; 161(1):55-63. doi: 10.1016/s0021-9150(01)00630-x. [PMID: 11882317]
  • A Tanaka, T Terasawa, H Hagihara, Y Sakuma, N Ishibe, M Sawada, H Takasugi, H Tanaka. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylureas. Journal of medicinal chemistry. 1998 Jun; 41(13):2390-410. doi: 10.1021/jm9800853. [PMID: 9632372]
  • R L Hawke, J M Chapman, D A Winegar, J A Salisbury, R M Welch, A Brown, K W Franzmann, C Sigel. Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity. Journal of lipid research. 1997 Jun; 38(6):1189-203. doi: . [PMID: 9215547]
  • I J Martins, B C Mortimer, T G Redgrave. Effect of the ACAT inhibitor CL 277,082 on apolipoprotein B48 transport in mesenteric lymph and on plasma clearance of chylomicrons and remnants. Arteriosclerosis, thrombosis, and vascular biology. 1997 Jan; 17(1):211-6. doi: 10.1161/01.atv.17.1.211. [PMID: 9012658]
  • A Graham, J L Wood, L J Russell. Cholesterol esterification is not essential for secretion of lipoprotein components by HepG2 cells. Biochimica et biophysica acta. 1996 Jul; 1302(1):46-54. doi: 10.1016/0005-2760(96)00030-6. [PMID: 8695654]
  • R A Harte, S J Yeaman, B Jackson, K E Suckling. Effect of membrane environment on inhibition of acyl-CoA:cholesterol acyltransferase by a range of synthetic inhibitors. Biochimica et biophysica acta. 1995 Oct; 1258(3):241-50. doi: 10.1016/0005-2760(95)00113-q. [PMID: 7548193]
  • R E Burrier, S Deren, D G McGregor, L M Hoos, A A Smith, H R Davis. Demonstration of a direct effect on hepatic acyl CoA: cholesterol acyl transferase (ACAT) activity by an orally administered enzyme inhibitor in the hamster. Biochemical pharmacology. 1994 Apr; 47(9):1545-51. doi: 10.1016/0006-2952(94)90530-4. [PMID: 8185666]
  • T Kumazawa, M Yanase, H Harakawa, H Obase, S Shirakura, E Ohishi, S Oda, K Kubo, K Yamada. Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Synthesis and hypocholesterolemic activity of dibenz[b,e]oxepin-11-carboxanilides. Journal of medicinal chemistry. 1994 Mar; 37(6):804-10. doi: 10.1021/jm00032a014. [PMID: 8145231]
  • D R Sliskovic, B R Krause, J A Picard, M Anderson, R F Bousley, K L Hamelehle, R Homan, T N Julian, Z A Rashidbaigi, R L Stanfield. Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity. Journal of medicinal chemistry. 1994 Mar; 37(5):560-2. doi: 10.1021/jm00031a002. [PMID: 8126693]
  • B R Krause, A Black, R Bousley, A Essenburg, J Cornicelli, A Holmes, R Homan, K Kieft, C Sekerke, M K Shaw-Hes. Divergent pharmacologic activities of PD 132301-2 and CL 277,082, urea inhibitors of acyl-CoA:cholesterol acyltransferase. The Journal of pharmacology and experimental therapeutics. 1993 Nov; 267(2):734-43. doi: NULL. [PMID: 8246149]
  • T Kimura, Y Takase, K Hayashi, H Tanaka, I Ohtsuka, T Saeki, M Kogushi, T Yamada, T Fujimori, I Saitou. Structure-activity relationship of N-[2-(dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy] phenyl]-N'-pentylurea and analogues. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. Journal of medicinal chemistry. 1993 May; 36(11):1630-40. doi: 10.1021/jm00063a013. [PMID: 8496930]
  • P Maechler, C B Wollheim, C L Bentzen, E Niesor. Importance of exogenous cholesterol in diabetic rats: effects of treatment with insulin or with an acyl-CoA:cholesterol acyltransferase inhibitor. Annals of nutrition & metabolism. 1993; 37(4):199-209. doi: 10.1159/000177769. [PMID: 8215237]
  • P Maechler, C B Wollheim, C L Bentzen, E Niesor. Role of the intestinal acyl-CoA:cholesterol acyltransferase activity in the hyperresponse of diabetic rats to dietary cholesterol. Journal of lipid research. 1992 Oct; 33(10):1475-84. doi: 10.1016/s0022-2275(20)41402-6. [PMID: 1431572]
  • W S Harris, C A Dujovne, K von Bergmann, J Neal, J Akester, S L Windsor, D Greene, Z Look. Effects of the ACAT inhibitor CL 277,082 on cholesterol metabolism in humans. Clinical pharmacology and therapeutics. 1990 Aug; 48(2):189-94. doi: 10.1038/clpt.1990.134. [PMID: 2199133]
  • S Balasubramaniam, L A Simons, S Chang, P D Roach, P J Nestel. On the mechanism by which an ACAT inhibitor (CL 277,082) influences plasma lipoproteins in the rat. Atherosclerosis. 1990 May; 82(1-2):1-5. doi: 10.1016/0021-9150(90)90137-8. [PMID: 2360913]
  • E E Largis, C H Wang, V G DeVries, S A Schaffer. CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. Journal of lipid research. 1989 May; 30(5):681-90. doi: 10.1016/s0022-2275(20)38328-0. [PMID: 2760542]
  • J L Kelley, C A Suenram, M M Rozek, S A Schaffer, C J Schwartz. Influence of the acyl-CoA: cholesterol O-acyltransferase inhibitor, CL 277082, on cholesteryl ester accumulation in rabbit macrophage-rich granulomas and hepatic tissue. Biochimica et biophysica acta. 1988 May; 960(1):83-90. doi: 10.1016/0005-2760(88)90012-4. [PMID: 3358947]