Ciproxifan (BioDeep_00000177520)

   

human metabolite blood metabolite


代谢物信息卡片


Cyclopropyl-(4-(3-1H-imidazol-4-yl)propyloxyphenyl)ketone

化学式: C16H18N2O2 (270.1368208)
中文名称: Ciproxifan
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC1C(=O)C2=CC=C(C=C2)OCCCC3=CN=CN3
InChI: InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)

描述信息

D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists

同义名列表

5 个代谢物同义名

Cyclopropyl-(4-(3-1H-imidazol-4-yl)propyloxyphenyl)ketone; 5-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole; Ciproxifan; FUB 359; FUB-359



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guillermo Aquino-Miranda, Nayeli Rivera-Ramírez, Ricardo Márquez-Gómez, Juan Escamilla-Sánchez, Raúl González-Pantoja, Laura-Elisa Ramos-Languren, Iván Perez-Neri, Antonio Bueno-Nava, Camilo Ríos, José-Antonio Arias-Montaño. Histamine H3 receptor activation reduces the impairment in prepulse inhibition (PPI) of the acoustic startle response and Akt phosphorylation induced by MK-801 (dizocilpine), antagonist at N-Methyl-d-Aspartate (NMDA) receptors. Progress in neuro-psychopharmacology & biological psychiatry. 2019 08; 94(?):109653. doi: 10.1016/j.pnpbp.2019.109653. [PMID: 31108178]
  • Frédéric Chauveau, Elodie De Job, Betty Poly-Thomasson, Raphaël Cavroy, Julien Thomasson, Dominique Fromage, Daniel Beracochea. Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress. CNS neuroscience & therapeutics. 2019 08; 25(8):832-841. doi: 10.1111/cns.13113. [PMID: 31094061]
  • Ajeet Kumar, Shalini Dogra, Chandan Sona, Deepmala Umrao, Mamunur Rashid, Sandeep K Singh, Muhammad Wahajuddin, Prem N Yadav. Chronic histamine 3 receptor antagonism alleviates depression like conditions in mice via modulation of brain-derived neurotrophic factor and hypothalamus-pituitary adrenal axis. Psychoneuroendocrinology. 2019 03; 101(?):128-137. doi: 10.1016/j.psyneuen.2018.11.007. [PMID: 30458370]
  • Vasudevan Mani, Siti Murnirah Jaafar, Nur Syamimi Mohd Azahan, Kalavathy Ramasamy, Siong Meng Lim, Long Chiau Ming, Abu Bakar Abdul Majeed. Ciproxifan improves cholinergic transmission, attenuates neuroinflammation and oxidative stress but does not reduce amyloid level in transgenic mice. Life sciences. 2017 Jul; 180(?):23-35. doi: 10.1016/j.lfs.2017.05.013. [PMID: 28501482]
  • Ramakrishna Nirogi, Vishwottam Kandikere, Gopinadh Bhyrapuneni, Nageswararao Muddana, Ramanatha Saralaya, Ranjith Kumar Ponnamaneni, Arun Kumar Manoharan. In vivo receptor occupancy assay of histamine H₃ receptor antagonist in rats using non-radiolabeled tracer. Journal of pharmacological and toxicological methods. 2012 May; 65(3):115-21. doi: 10.1016/j.vascn.2012.03.003. [PMID: 22487318]
  • Saara Nuutinen, Minnamaija Lintunen, Jenni Vanhanen, Tiia Ojala, Stanislav Rozov, Pertti Panula. Evidence for the role of histamine H3 receptor in alcohol consumption and alcohol reward in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2011 Sep; 36(10):2030-40. doi: 10.1038/npp.2011.90. [PMID: 21654737]
  • Sharon Ashworth, Eugenii A Rabiner, Roger N Gunn, Christophe Plisson, Alan A Wilson, Robert A Comley, Robert Y K Lai, Antony D Gee, Marc Laruelle, Vincent J Cunningham. Evaluation of 11C-GSK189254 as a novel radioligand for the H3 receptor in humans using PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2010 Jul; 51(7):1021-9. doi: 10.2967/jnumed.109.071753. [PMID: 20554726]
  • Thomas R Miller, John L Baranowski, Brian R Estvander, David G Witte, Tracy L Carr, Arlene M Manelli, Kathleen M Krueger, Marlon D Cowart, Jorge D Brioni, Timothy A Esbenshade. A robust and high-capacity [(35)S]GTPgammaS binding assay for determining antagonist and inverse agonist pharmacological parameters of histamine H(3) receptor ligands. Assay and drug development technologies. 2008 Jun; 6(3):339-49. doi: 10.1089/adt.2007.118. [PMID: 18593375]
  • X Ligneau, D Perrin, L Landais, J-C Camelin, T P G Calmels, I Berrebi-Bertrand, J-M Lecomte, R Parmentier, C Anaclet, J-S Lin, V Bertaina-Anglade, C Drieu la Rochelle, F d'Aniello, A Rouleau, F Gbahou, J-M Arrang, C R Ganellin, H Stark, W Schunack, J-C Schwartz. BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. The Journal of pharmacology and experimental therapeutics. 2007 Jan; 320(1):365-75. doi: 10.1124/jpet.106.111039. [PMID: 17005916]
  • Kathleen M Krueger, David G Witte, Lynne Ireland-Denny, Thomas R Miller, John L Baranowski, Steve Buckner, Ivan Milicic, Timothy A Esbenshade, Arthur A Hancock. G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. The Journal of pharmacology and experimental therapeutics. 2005 Jul; 314(1):271-81. doi: 10.1124/jpet.104.078865. [PMID: 15821027]
  • Kazuhiko Takahashi, Shigeru Tokita, Hidehito Kotani. Generation and characterization of highly constitutive active histamine H3 receptors. The Journal of pharmacology and experimental therapeutics. 2003 Oct; 307(1):213-8. doi: 10.1124/jpet.103.053249. [PMID: 12954820]
  • Y Boucher, S Hofman, Y Joulin, J Azérad. Effects of BP 2-94, a selective H(3)-receptor agonist, on blood flow and vascular permeability of the rat mandibular incisor pulp. Archives of oral biology. 2001 Jan; 46(1):83-92. doi: 10.1016/s0003-9969(00)00080-7. [PMID: 11163599]
  • H Stark, B Sadek, M Krause, A Hüls, X Ligneau, C R Ganellin, J M Arrang, J C Schwartz, W Schunack. Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. Journal of medicinal chemistry. 2000 Oct; 43(21):3987-94. doi: 10.1021/jm000966l. [PMID: 11052804]
  • X Ligneau, J Lin, G Vanni-Mercier, M Jouvet, J L Muir, C R Ganellin, H Stark, S Elz, W Schunack, J Schwartz. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. The Journal of pharmacology and experimental therapeutics. 1998 Nov; 287(2):658-66. doi: NULL. [PMID: 9808693]