Ciprofibrate (BioDeep_00000177517)
human metabolite blood metabolite
代谢物信息卡片
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
化学式: C13H14Cl2O3 (288.0319954)
中文名称: 环丙贝特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C(=O)O)OC1=CC=C(C=C1)C2CC2(Cl)Cl
InChI: InChI=1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98150 - Fibrate Antilipidemic Agent
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AB - Fibrates
D009676 - Noxae > D002273 - Carcinogens > D020025 - Peroxisome Proliferators
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
Ciprofibrate (Win35833) is a potent peroxisome proliferator and increases the phosphorylation level of the PPARalpha[1]. Ciprofibrate acts as an orally active hypolipidaemic agent and can be used for the research of primary hyperlipidaemias[2].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:50867
- PubChem: 2763
- HMDB: HMDB0250268
- DrugBank: DB09064
- ChEMBL: CHEMBL557555
- Wikipedia: Ciprofibrate
- CAS: 52214-84-3
- medchemexpress: HY-B0664
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Obesity (Silver Spring, Md.).
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Cell reports.
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BMC genomics.
2007 Feb; 8(?):58. doi:
10.1186/1471-2164-8-58. [PMID: 17324256] - Rinke Stienstra, Caroline Duval, Michael Müller, Sander Kersten. PPARs, Obesity, and Inflammation.
PPAR research.
2007; 2007(?):95974. doi:
10.1155/2007/95974. [PMID: 17389767] - Jutta Dierkes, Claus Luley, Sabine Westphal. Effect of lipid-lowering and anti-hypertensive drugs on plasma homocysteine levels.
Vascular health and risk management.
2007; 3(1):99-108. doi:
. [PMID: 17583180] - György Paragh, Ildikó Seres, Mariann Harangi, Annamária Erdei, Mária Audikovszky, Lóránd Debreczeni, Anna Kovácsay, László Illyés, Gyula Pados. Ciprofibrate increases paraoxonase activity in patients with metabolic syndrome.
British journal of clinical pharmacology.
2006 Jun; 61(6):694-701. doi:
10.1111/j.1365-2125.2006.02565.x. [PMID: 16722831] - John K Leighton, Paul Brown, Amy Ellis, Patricia Harlow, Wafa Harrouk, P Scott Pine, Timothy Robison, Lilliam Rosario, Karol Thompson. Workgroup report: Review of genomics data based on experience with mock submissions--view of the CDER Pharmacology Toxicology Nonclinical Pharmacogenomics Subcommittee.
Environmental health perspectives.
2006 Apr; 114(4):573-8. doi:
10.1289/ehp.8318. [PMID: 16581548] - Alexis Zamble, Marie Carpentier, Abdelmejid Kandoussi, Sevser Sahpaz, Olivier Petrault, Tawarak Ouk, Nathalie Hennuyer, Jean-Charles Fruchart, Bart Staels, Régis Bordet, Patrick Duriez, François Bailleul, Françoise Martin-Nizard. Paullinia pinnata extracts rich in polyphenols promote vascular relaxation via endothelium-dependent mechanisms.
Journal of cardiovascular pharmacology.
2006 Apr; 47(4):599-608. doi:
10.1097/01.fjc.0000211734.53798.1d. [PMID: 16680075] - Raúl A Espinosa, Elsy Rodríguez-Roa, Elena Nagy, Mercedes E Mijares, Alvaro Rodríguez-Larralde, Amparo Gil, Ulf Lundberg, Zoila Carvajal, Luis Castillo, Carmen L Arocha-Piñango. [Changes in serum lipids, plasma fibrinogen and other haemostatic parameters induced by ciprofibrate action in hyperlipidemic patients with and without coronary artery disease].
Investigacion clinica.
2006 Mar; 47(1):35-48. doi:
NULL. [PMID: 16562643] - M Dobiásová. [AIP--atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice].
Vnitrni lekarstvi.
2006 Jan; 52(1):64-71. doi:
NULL. [PMID: 16526201] - Zoë D Burke, Chia-Ning Shen, Kate L Ralphs, David Tosh. Characterization of liver function in transdifferentiated hepatocytes.
Journal of cellular physiology.
2006 Jan; 206(1):147-59. doi:
10.1002/jcp.20438. [PMID: 15965953] - Konstantinos Tziomalos, Vasilios G Athyros. Fenofibrate: a novel formulation (Triglide) in the treatment of lipid disorders: a review.
International journal of nanomedicine.
2006; 1(2):129-47. doi:
10.2147/nano.2006.1.2.129. [PMID: 17722529] - Tom C Martinsen, Ingunn Bakke, Duan Chen, Arne K Sandvik, Kolbjørn Zahlsen, Trond Aamo, Helge L Waldum. Ciprofibrate stimulates the gastrin-producing cell by acting luminally on antral PPAR-alpha.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Dec; 289(6):G1052-60. doi:
10.1152/ajpgi.00268.2005. [PMID: 16099866] - Bogusław Okopień, Robert Krysiak, Jan Kowalski, Andrzej Madej, Dariusz Belowski, Marek Zieliński, Zbigniew S Herman. Monocyte release of tumor necrosis factor-alpha and interleukin-1beta in primary type IIa and IIb dyslipidemic patients treated with statins or fibrates.
Journal of cardiovascular pharmacology.
2005 Sep; 46(3):377-86. doi:
10.1097/01.fjc.0000175455.46245.c8. [PMID: 16116345] - Jihong Xu, Paul D Storer, Janet A Chavis, Michael K Racke, Paul D Drew. Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.
Journal of neuroscience research.
2005 Aug; 81(3):403-11. doi:
10.1002/jnr.20518. [PMID: 15968640] - Amelie Lupp, Elke Karge, Manfred Danz, Thomas Deufel, Herbert Oelschläger, Wolfgang Klinger. Single and chronic administration of ciprofibrate or of ciprofibrate-glycinate in male Fischer 344 rats: comparison of the effects on morphological and biochemical parameters in liver and blood.
European journal of drug metabolism and pharmacokinetics.
2005 Jul; 30(3):203-18. doi:
10.1007/bf03190621. [PMID: 16250258] - G M Ledda-Columbano, A Perra, M Pibiri, F Molotzu, A Columbano. Induction of pancreatic acinar cell proliferation by thyroid hormone.
The Journal of endocrinology.
2005 Jun; 185(3):393-9. doi:
10.1677/joe.1.06110. [PMID: 15930165] - Agnes M Rimando, Rangaswamy Nagmani, Dennis R Feller, Wallace Yokoyama. Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters.
Journal of agricultural and food chemistry.
2005 May; 53(9):3403-7. doi:
10.1021/jf0580364. [PMID: 15853379] - James M Backes, Cheryl A Gibson, Patricia A Howard. Optimal lipid modification: the rationale for combination therapy.
Vascular health and risk management.
2005; 1(4):317-31. doi:
10.2147/vhrm.2005.1.4.317. [PMID: 17315604] - Elisabetta Albi, Samuela Cataldi, Mariapia Viola Magni, Claudia Sartori. Plasmalogens in rat liver chromatin: new molecules involved in cell proliferation.
Journal of cellular physiology.
2004 Dec; 201(3):439-46. doi:
10.1002/jcp.20086. [PMID: 15389549] - Mostafa Kabine, Zakaria El Kebbaj, David Oaxaca-Castillo, Marie-Claude Clémencet, M'hammed Said El Kebbaj, Norbert Latruffe, Mustapha Cherkaoui-Malki. Peroxisome proliferator-activated receptors as regulators of lipid metabolism; tissue differential expression in adipose tissues during cold acclimatization and hibernation of jerboa (Jaculus orientalis).
Biochimie.
2004 Nov; 86(11):763-70. doi:
10.1016/j.biochi.2004.10.003. [PMID: 15589684] - J Okapcova, D Gabor. The levels of soluble adhesion molecules in diabetic and nondiabetic patients with combined hyperlipoproteinemia and the effect of ciprofibrate therapy.
Angiology.
2004 Nov; 55(6):629-39. doi:
10.1177/00033197040550i604. [PMID: 15547649] - A Benani, T Heurtaux, P Netter, A Minn. Activation of peroxisome proliferator-activated receptor alpha in rat spinal cord after peripheral noxious stimulation.
Neuroscience letters.
2004 Oct; 369(1):59-63. doi:
10.1016/j.neulet.2004.07.056. [PMID: 15380308] - Boguslaw Okopień, Robert Krysiak, Jan Kowalski, Andrzej Madej, Dariusz Belowski, Marek Zieliński, Krzysztof Labuzek, Zbigniew S Herman. The effect of statins and fibrates on interferon-gamma and interleukin-2 release in patients with primary type II dyslipidemia.
Atherosclerosis.
2004 Oct; 176(2):327-35. doi:
10.1016/j.atherosclerosis.2004.05.009. [PMID: 15380456] - Shamilah Lachal, Joanne Ford, Arthur Shulkes, Graham S Baldwin. PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells.
Regulatory peptides.
2004 Aug; 120(1-3):243-51. doi:
10.1016/j.regpep.2004.03.015. [PMID: 15177943] - Carlos A Aguilar-Salinas, Andréia Assis-Luores-Vale, Benjamín Stockins, Hector Mario Rengifo, José Dondici Filho, Abrahão Afiune Neto, Lísia Marcílio Rabelo, Kerginaldo Paulo Torres, José Egídio Paulo de Oliveira, Carlos Alberto Machado, Eliana Reyes, Victor Saavedra, Fernando Florenzano, Ma Victoria Hernández, Sergio Hernandez Jiménez, Erika Ramírez, Cuauhtémoc Vazquez, Saul Salinas, Ismael Hernández, Octavio Medel, Ricardo Moreno, Paula Lugo, Ricardo Alvarado, Roopa Mehta, Victor Gutierrez, Francisco J Gómez Pérez. Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL)-cholesterol: greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study).
Cardiovascular diabetology.
2004 Jul; 3(?):8. doi:
10.1186/1475-2840-3-8. [PMID: 15272932] - Tao Fu, Debnath Mukhopadhyay, Nicholas O Davidson, Jayme Borensztajn. The peroxisome proliferator-activated receptor alpha (PPARalpha) agonist ciprofibrate inhibits apolipoprotein B mRNA editing in low density lipoprotein receptor-deficient mice: effects on plasma lipoproteins and the development of atherosclerotic lesions.
The Journal of biological chemistry.
2004 Jul; 279(27):28662-9. doi:
10.1074/jbc.m403271200. [PMID: 15123680] - Afroditi P Tambaki, Evangelos Rizos, Vasilis Tsimihodimos, Alexandros D Tselepis, Moses Elisaf. Effects of antihypertensive and hypolipidemic drugs on plasma and high-density lipoprotein-associated platelet activating factor-acetylhydrolase activity.
Journal of cardiovascular pharmacology and therapeutics.
2004 Jun; 9(2):91-5. doi:
10.1177/107424840400900204. [PMID: 15309245] - Melvin R Hayden, Suresh C Tyagi. Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation.
Nutrition journal.
2004 May; 3(?):4. doi:
10.1186/1475-2891-3-4. [PMID: 15134582] - Catherine Le Jossic-Corcos, Gabriela M Pastori, Sandrine Duclos, Yoshiki Kawabe, Thierry Pineau, Paulette Bournot. Peroxisome proliferator-activated receptor alpha (PPARalpha) activators induce hepatic farnesyl diphosphate synthase gene expression in rodents.
The Journal of steroid biochemistry and molecular biology.
2004 Feb; 88(2):203-11. doi:
10.1016/j.jsbmb.2003.11.011. [PMID: 15084352] - Tao Fu, Karen F Kozarsky, Jayme Borensztajn. Overexpression of SR-BI by adenoviral vector reverses the fibrateinduced hypercholesterolemia of apolipoprotein E-deficient mice.
The Journal of biological chemistry.
2003 Dec; 278(52):52559-63. doi:
10.1074/jbc.m310892200. [PMID: 14570884] - Luciane C Alberici, Helena C F Oliveira, Eliete J B Bighetti, Eliana C de Faria, Giovana R Degaspari, Claudio T Souza, Anibal E Vercesi. Hypertriglyceridemia increases mitochondrial resting respiration and susceptibility to permeability transition.
Journal of bioenergetics and biomembranes.
2003 Oct; 35(5):451-7. doi:
10.1023/a:1027343915452. [PMID: 14740893] - Fekadu Yadetie, Astrid Laegreid, Ingunn Bakke, Waclaw Kusnierczyk, Jan Komorowski, Helge L Waldum, Arne K Sandvik. Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-alpha agonist ciprofibrate.
Physiological genomics.
2003 Sep; 15(1):9-19. doi:
10.1152/physiolgenomics.00064.2003. [PMID: 12851464] - Tao Fu, Papreddy Kashireddy, Jayme Borensztajn. The peroxisome-proliferator-activated receptor alpha agonist ciprofibrate severely aggravates hypercholesterolaemia and accelerates the development of atherosclerosis in mice lacking apolipoprotein E.
The Biochemical journal.
2003 Aug; 373(Pt 3):941-7. doi:
10.1042/bj20030105. [PMID: 12713444] - Maryse Guerin, Wilfried Le Goff, Eric Frisdal, Séverine Schneider, Dragana Milosavljevic, Eric Bruckert, M John Chapman. Action of ciprofibrate in type IIb hyperlipoproteinemia: modulation of the atherogenic lipoprotein phenotype and stimulation of high-density lipoprotein-mediated cellular cholesterol efflux.
The Journal of clinical endocrinology and metabolism.
2003 Aug; 88(8):3738-46. doi:
10.1210/jc.2003-030191. [PMID: 12915663] - M Zeman, A Zák, M Vecka, S Romaniv. [Long-term hypolipidemic treatment of mixed hyperlipidemia with a combination of statins and fibrates].
Casopis lekaru ceskych.
2003 Aug; 142(8):500-4. doi:
NULL. [PMID: 14626567] - Dimitrios N Kiortsis, Spyridon Nikas, Katerina Hatzidimou, Epaminondas Tsianos, Moses S Elisaf. Lipid-lowering drugs and serum liver enzymes: the effects of body weight and baseline enzyme levels.
Fundamental & clinical pharmacology.
2003 Aug; 17(4):491-4. doi:
10.1046/j.1472-8206.2003.00176.x. [PMID: 12914553] - Marja Riitta Taskinen. LDL-cholesterol, HDL-cholesterol or triglycerides--which is the culprit?.
Diabetes research and clinical practice.
2003 Jul; 61 Suppl 1(?):S19-26. doi:
10.1016/s0168-8227(03)00126-8. [PMID: 12880691] - Mostafa Kabine, Marie Claude Clémencet, Jacqueline Bride, M'hammed Saïd El Kebbaj, Norbert Latruffe, Mustapha Cherkaoui-Malki. Changes of peroxisomal fatty acid metabolism during cold acclimatization in hibernating jerboa (Jaculus orientalis).
Biochimie.
2003 Jul; 85(7):707-14. doi:
10.1016/s0300-9084(03)00117-2. [PMID: 14505827]